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DE05075889T1 - Herstellung von menschlichem Papilloma-Virus HBV-11-Capsid-Protein L1 und virusähnlichen Teilchen - Google Patents

Herstellung von menschlichem Papilloma-Virus HBV-11-Capsid-Protein L1 und virusähnlichen Teilchen Download PDF

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Publication number
DE05075889T1
DE05075889T1 DE05075889T DE05075889T DE05075889T1 DE 05075889 T1 DE05075889 T1 DE 05075889T1 DE 05075889 T DE05075889 T DE 05075889T DE 05075889 T DE05075889 T DE 05075889T DE 05075889 T1 DE05075889 T1 DE 05075889T1
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virus
human
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protein
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Robert C. Rose
William Bonnez
Richard C. Reichman
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University of Rochester
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University of Rochester
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26703787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE05075889(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/028,517 external-priority patent/US8062642B1/en
Application filed by University of Rochester filed Critical University of Rochester
Publication of DE05075889T1 publication Critical patent/DE05075889T1/de
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    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
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Abstract

Polynukleotid, das L1-Capsid-Protein von HPV-11 kodiert, wobei der untranslatierte 3'-Bereich der hieraus transkribierten mRNA die Sequenz AUUUA nicht enthält.

Claims (13)

  1. Polynukleotid, das L1-Capsid-Protein von HPV-11 kodiert, wobei der untranslatierte 3'-Bereich der hieraus transkribierten mRNA die Sequenz AUUUA nicht enthält.
  2. Polynukleotid, das L1-Capsid-Protein von HPV-11 kodiert, wobei der untranslatierte 3'-Bereich der hieraus transkribierten mRNA die Sequenz AUUUA in der Nachbarschaft des L1-Stoppcodons nicht enthält.
  3. Polynukleotid nach Anspruch 1 oder 2, bei dem die mRNA die Sequenz AUUUA nicht innerhalb von 30 Nukleotiden des Stoppcodons der L1-kodierenden Sequenz enthält.
  4. Expressionsvektor, der ein Polynukleotid nach Anspruch 1 oder 2 enthält.
  5. Expressionsvektor nach Anspruch 4, der ein Baculo-Virus-Expressions-Vektor ist.
  6. Wirtszelle, die einen Expressionsvektor nach Anspruch 4 oder 5 enthält.
  7. Wirtszelle, die den Vektor nach Anspruch 5 enthält, wobei die Wirtszelle eine Insektenzelle ist.
  8. Verfahren zur Herstellung eines dem menschlichen Papillomavirus ähnlichen Teilchens oder Capsomers, wobei das Verfahren das Kultivieren einer Wirtszelle nach Anspruch 6 oder 7 und das Gewinnen dieses virusartigen Teilchens oder Capsomers aus dieser Zelle umfasst.
  9. Verfahren nach Anspruch 8, bei dem das L1-Capsid-Protein von einer ein L1-Protein kodierenden Sequenz exprimiert ist, die ein Protein oder einen Proteinkomplex erzeugt, der immunologische und morphologische Merkmale besitzt, die denen eines nativen Papillomavirus ähnlich sind, wobei dieses Teilchen oder Capsomer in der Lage ist, Antikörper in menschlichen Seren zu erkennen, die von Personen stammen, von denen bekannt ist, dass sie mit einem homologen Virus infiziert sind.
  10. Verfahren nach Anspruch 8 oder 9, bei dem das virusähnliche Teilchen oder Capsomer gereinigt wird.
  11. Verfahren zur Herstellung eines Impfstoffes gegen menschliche Papillomaviren, wobei das Verfahren das Erhalten eines dem menschlichen Papillomavirus ähnlichen Teilchens oder Capsomers nach einem der Ansprüche 8 bis 10 und seine Kombination mit einem Adjuvans umfasst.
  12. Verfahren zur Herstellung einer Kombination von menschlichen Papillomaviren ähnlichen Teilchen, wobei das Verfahren das Herstellen eines dem menschlichen Papillomavirus ähnlichen Teilchens umfasst, das ein L1-Capsid-Protein von HPV-11 umfasst, gemäß dem Verfahren nach einem der Ansprüche 8 bis 10 und Kombinieren mit einem oder mehreren virusähnlichen Teilchen, die ein L1-Protein von einem oder mehreren verschiedenen menschlichen Papillomaviren umfassen.
  13. Verfahren zur Herstellung eines multivalenten Impfstoffes gegen menschliche Papillomaviren, wobei das Verfahren das Gewinnen einer Kombination von menschlichen Papillomaviren ähnlichen Teilchen gemäß Anspruch 12 und eine Kombination mit einem Adjuvans umfasst.
DE05075889T 1993-03-09 1994-03-08 Herstellung von menschlichem Papilloma-Virus HBV-11-Capsid-Protein L1 und virusähnlichen Teilchen Pending DE05075889T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/028,517 US8062642B1 (en) 1993-03-09 1993-03-09 Production of papillomavirus capsid protein and virus-like particles
US28517 1993-03-09
US20730994A 1994-03-07 1994-03-07
US207309 1994-03-07

Publications (1)

Publication Number Publication Date
DE05075889T1 true DE05075889T1 (de) 2006-10-05

Family

ID=26703787

Family Applications (9)

Application Number Title Priority Date Filing Date
DE69434383T Expired - Lifetime DE69434383T2 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen
DE1994634383 Pending DE122007000014I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papillomavirus Hüllprotein und virus-ähnlichen Teilchen
DE05075889T Pending DE05075889T1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papilloma-Virus HBV-11-Capsid-Protein L1 und virusähnlichen Teilchen
DE69435331T Expired - Lifetime DE69435331D1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichen papillomavirus HBV-11 Kapsidprotein L1 und Virus-ähnliche Partikeln
DE122007000090C Pending DE122007000090I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen
DE69435332T Expired - Lifetime DE69435332D1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papillomaviren Hüllprotein und Virus-ähnlichen Teilchen
DE122007000089C Pending DE122007000089I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen
DE05075369T Pending DE05075369T1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papilloma-Virus-Capsid-Protein und virusähnlichen Teilchen
DE201112100018 Pending DE122011100018I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papilloma-Virus-Capsid-Protein und virusahnlichen Teilchen.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69434383T Expired - Lifetime DE69434383T2 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen
DE1994634383 Pending DE122007000014I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papillomavirus Hüllprotein und virus-ähnlichen Teilchen

Family Applications After (6)

Application Number Title Priority Date Filing Date
DE69435331T Expired - Lifetime DE69435331D1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichen papillomavirus HBV-11 Kapsidprotein L1 und Virus-ähnliche Partikeln
DE122007000090C Pending DE122007000090I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen
DE69435332T Expired - Lifetime DE69435332D1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papillomaviren Hüllprotein und Virus-ähnlichen Teilchen
DE122007000089C Pending DE122007000089I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen
DE05075369T Pending DE05075369T1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papilloma-Virus-Capsid-Protein und virusähnlichen Teilchen
DE201112100018 Pending DE122011100018I1 (de) 1993-03-09 1994-03-08 Herstellung von menschlichem Papilloma-Virus-Capsid-Protein und virusahnlichen Teilchen.

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EP (3) EP1588713B1 (de)
JP (4) JPH08507685A (de)
AT (3) ATE296111T1 (de)
AU (3) AU688759C (de)
CA (1) CA2157932C (de)
DE (9) DE69434383T2 (de)
DK (2) DK1618888T3 (de)
ES (3) ES2242955T4 (de)
FR (1) FR11C0022I2 (de)
LU (3) LU91313I2 (de)
NL (3) NL300265I2 (de)
PT (2) PT1618888E (de)
WO (1) WO1994020137A1 (de)

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