CZ2001486A3 - Nové farmaceutické pouľití inhibitorů NOS - Google Patents

Nové farmaceutické pouľití inhibitorů NOS Download PDF

Info

Publication number: CZ2001486A3
Authority: CZ; Czechia
Prior art keywords: formula; compound; pyridin; ylamine; pharmaceutically acceptable
Prior art date: 1998-08-11

Application number

CZ2001486A

Other languages

Czech (cs)

English (en)

Inventor

John Adams Lowe Iii.

Jolanta Nowakowski

Robert Alfred Volkmann

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-11

Filing date

1999-08-05

Publication date

2002-06-12

1999-08-05 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2002-06-12 Publication of CZ2001486A3 publication Critical patent/CZ2001486A3/cs

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CZ2001486A 1998-08-11 1999-08-05 Nové farmaceutické pouľití inhibitorů NOS CZ2001486A3 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9615298P	1998-08-11	1998-08-11

Publications (1)

Publication Number	Publication Date
CZ2001486A3 true CZ2001486A3 (cs)	2002-06-12

Family

ID=22255853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ2001486A CZ2001486A3 (cs)	1998-08-11	1999-08-05	Nové farmaceutické pouľití inhibitorů NOS

Country Status (37)

Country	Link
US (1)	US20020151572A1 (es)
EP (1)	EP1109556A2 (es)
JP (1)	JP2002522498A (es)
KR (1)	KR20010085364A (es)
CN (1)	CN1323211A (es)
AP (1)	AP2001002067A0 (es)
AR (1)	AR020009A1 (es)
AU (1)	AU749439B2 (es)
BR (1)	BR9912906A (es)
CA (1)	CA2340200A1 (es)
CO (1)	CO5130011A1 (es)
CR (1)	CR6302A (es)
CZ (1)	CZ2001486A3 (es)
DZ (1)	DZ2867A1 (es)
EA (1)	EA200100125A1 (es)
EE (1)	EE200100084A (es)
GE (1)	GEP20043252B (es)
GT (1)	GT199900127A (es)
HK (1)	HK1041819A1 (es)
HR (1)	HRP20010099A2 (es)
HU (1)	HUP0103113A3 (es)
ID (1)	ID28227A (es)
IL (1)	IL141031A0 (es)
IS (1)	IS5814A (es)
MA (1)	MA26670A1 (es)
NO (1)	NO20010685L (es)
NZ (1)	NZ509298A (es)
OA (1)	OA11595A (es)
PA (1)	PA8479801A1 (es)
PE (1)	PE20001025A1 (es)
PL (1)	PL346842A1 (es)
SK (1)	SK1702001A3 (es)
SV (1)	SV1999000121A (es)
TN (1)	TNSN99154A1 (es)
TR (3)	TR200401803T2 (es)
WO (1)	WO2000009130A2 (es)
YU (1)	YU9601A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20010049379A1 (en)	1997-08-27	2001-12-06	Lowe John Adams	2-aminopyridines containing fused ring substituents
AU2001235284A1 (en) *	2000-02-22	2001-09-03	Cellegy Canada Inc.	Methods and compositions for improving sleep
US20030219494A1 (en) *	2002-03-20	2003-11-27	Smith Maree Therese	Compositions and methods of using them
WO2005007627A1 (ja) *	2003-07-18	2005-01-27	Nihon Nohyaku Co., Ltd.	フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤
US9120750B2 (en)	2013-03-07	2015-09-01	Northwestern University	2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
US10759791B2 (en)	2014-11-04	2020-09-01	Northwestern University	Mammalian and bacterial nitric oxide synthase inhibitors
WO2016073623A2 (en)	2014-11-04	2016-05-12	Northwestern University	Mammalian and bacterial nitric oxide synthase inhibitors
US12213973B2 (en)	2021-10-18	2025-02-04	Northwestern University	Bacterial nitric oxide synthase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69728138T2 (de) *	1996-03-29	2004-09-16	Pfizer Inc.	6-phenylpyridinderivate
HN1997000027A (es) *	1996-12-06	1997-06-05	Pfizer Prod Inc	Derivados de 6-fenil piridil - 2 amina
KR100460399B1 (ko) *	1997-02-10	2004-12-08	화이자 프로덕츠 인코포레이티드	2-아미노-6-(2-치환된-4-페녹시)-치환된-피리딘
HN1998000118A (es) *	1997-08-27	1999-02-09	Pfizer Prod Inc	2 - aminopiridinas que contienen sustituyentes de anillos condensados.
HN1998000125A (es) *	1997-08-28	1999-02-09	Pfizer Prod Inc	2-aminopiridinas con sustituyentes alcoxi ramificados
SE9703693D0 (sv) *	1997-10-10	1997-10-10	Astra Pharma Prod	Novel combination

1999
- 1999-08-05 OA OA1200100036A patent/OA11595A/en unknown
- 1999-08-05 CZ CZ2001486A patent/CZ2001486A3/cs unknown
- 1999-08-05 GE GEAP19995742A patent/GEP20043252B/en unknown
- 1999-08-05 HU HU0103113A patent/HUP0103113A3/hu unknown
- 1999-08-05 AU AU49248/99A patent/AU749439B2/en not_active Ceased
- 1999-08-05 CA CA002340200A patent/CA2340200A1/en not_active Abandoned
- 1999-08-05 IL IL14103199A patent/IL141031A0/xx unknown
- 1999-08-05 JP JP2000564633A patent/JP2002522498A/ja active Pending
- 1999-08-05 KR KR1020017001788A patent/KR20010085364A/ko not_active Ceased
- 1999-08-05 AP APAP/P/2001/002067A patent/AP2001002067A0/en unknown
- 1999-08-05 ID IDW20010317A patent/ID28227A/id unknown
- 1999-08-05 EE EEP200100084A patent/EE200100084A/xx unknown
- 1999-08-05 HR HR20010099A patent/HRP20010099A2/hr not_active Application Discontinuation
- 1999-08-05 BR BR9912906-0A patent/BR9912906A/pt not_active IP Right Cessation
- 1999-08-05 WO PCT/IB1999/001389 patent/WO2000009130A2/en not_active Ceased
- 1999-08-05 EA EA200100125A patent/EA200100125A1/ru unknown
- 1999-08-05 EP EP99933077A patent/EP1109556A2/en not_active Withdrawn
- 1999-08-05 TR TR2004/01803T patent/TR200401803T2/xx unknown
- 1999-08-05 SK SK170-2001A patent/SK1702001A3/sk unknown
- 1999-08-05 CN CN99811907A patent/CN1323211A/zh active Pending
- 1999-08-05 YU YU9601A patent/YU9601A/sh unknown
- 1999-08-05 NZ NZ509298A patent/NZ509298A/en unknown
- 1999-08-05 HK HK02103597.9A patent/HK1041819A1/zh unknown
- 1999-08-05 PL PL99346842A patent/PL346842A1/xx not_active Application Discontinuation
- 1999-08-05 TR TR2001/00434T patent/TR200100434T2/xx unknown
- 1999-08-05 TR TR2001/03661T patent/TR200103661T2/xx unknown
- 1999-08-06 PA PA19998479801A patent/PA8479801A1/es unknown
- 1999-08-09 GT GT199900127A patent/GT199900127A/es unknown
- 1999-08-09 PE PE1999000801A patent/PE20001025A1/es not_active Application Discontinuation
- 1999-08-10 DZ DZ990167A patent/DZ2867A1/xx active
- 1999-08-10 MA MA25724A patent/MA26670A1/fr unknown
- 1999-08-10 SV SV1999000121A patent/SV1999000121A/es not_active Application Discontinuation
- 1999-08-10 AR ARP990103995A patent/AR020009A1/es unknown
- 1999-08-10 TN TNTNSN99154A patent/TNSN99154A1/fr unknown
- 1999-08-11 US US09/372,352 patent/US20020151572A1/en not_active Abandoned
- 1999-08-11 CO CO99051077A patent/CO5130011A1/es unknown
2001
- 2001-01-16 IS IS5814A patent/IS5814A/is unknown
- 2001-02-06 CR CR6302A patent/CR6302A/es not_active Application Discontinuation
- 2001-02-09 NO NO20010685A patent/NO20010685L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
YU9601A (sh)	2003-12-31
SK1702001A3 (en)	2003-02-04
IS5814A (is)	2001-01-16
TR200100434T2 (tr)	2001-07-23
CO5130011A1 (es)	2002-02-27
TR200103661T2 (tr)	2002-06-21
OA11595A (en)	2004-08-19
DZ2867A1 (fr)	2003-12-15
HRP20010099A2 (en)	2002-02-28
HK1041819A1 (zh)	2002-07-26
EP1109556A2 (en)	2001-06-27
MA26670A1 (fr)	2004-12-20
IL141031A0 (en)	2002-02-10
HUP0103113A3 (en)	2002-02-28
TNSN99154A1 (fr)	2005-11-10
PA8479801A1 (es)	2000-09-29
EE200100084A (xx)	2002-08-15
SV1999000121A (es)	2000-07-06
NO20010685L (no)	2001-04-09
NO20010685D0 (no)	2001-02-09
HUP0103113A2 (hu)	2002-01-28
WO2000009130A3 (en)	2000-05-18
CR6302A (es)	2004-03-24
PE20001025A1 (es)	2000-10-11
EA200100125A1 (ru)	2001-08-27
ID28227A (id)	2001-05-10
TR200401803T2 (tr)	2004-11-22
WO2000009130A2 (en)	2000-02-24
BR9912906A (pt)	2001-05-08
AP2001002067A0 (en)	2001-03-31
AR020009A1 (es)	2002-03-27
US20020151572A1 (en)	2002-10-17
KR20010085364A (ko)	2001-09-07
GT199900127A (es)	2001-01-30
CN1323211A (zh)	2001-11-21
PL346842A1 (en)	2002-02-25
CA2340200A1 (en)	2000-02-24
AU4924899A (en)	2000-03-06
NZ509298A (en)	2005-02-25
JP2002522498A (ja)	2002-07-23
AU749439B2 (en)	2002-06-27
GEP20043252B (en)	2004-06-25

Publication	Publication Date	Title
JP3411271B2 (ja)	2003-05-26	Ｎｏｓ阻害剤であり縮合環置換基を含む２−アミノピリジン類
EP0946512B1 (en)	2003-10-08	6-phenylpyridyl-2-amine derivatives useful as nos inhibitors
SK113998A3 (en)	2001-05-10	6-phenylpyridyl-2-amine derivatives
JP2011513334A (ja)	2011-04-28	ピラゾロ［１，５−ａ］ピリミジンの架橋二環式複素環式またはスピロ二環式複素環式誘導体、その調製方法および使用
JP2021105002A (ja)	2021-07-26	イミダゾピリダジン化合物
KR20020079730A (ko)	2002-10-19	노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도
SK16602001A3 (sk)	2003-03-04	Nové farmaceutické kombinácie inhibítorov NOS
EP1007512B1 (en)	2002-04-03	Branched alkoxy-subsituted 2-aminopyridines as nos inhibitors
CZ2001486A3 (cs)	2002-06-12	Nové farmaceutické pouľití inhibitorů NOS
US20040229911A1 (en)	2004-11-18	New pharmaceutical combinations for NOS inhibitors
SK12022001A3 (sk)	2002-07-02	2-aminopyridíny obsahujúce ako substituenty kondenzované kruhové skupiny
NZ508057A (en)	2003-07-25	2-aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors
MXPA01001548A (es)	2001-09-07	Nuevos usos farmaceuticos para inhibidores de oxido nitrico sintetasa
CN119730850A (zh)	2025-03-28	取代的稠合二环化合物以及相关的治疗方法
JP2025514034A (ja)	2025-05-02	チロシンキナーゼ阻害剤
HK1153477A (en)	2012-03-30	Bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-a]pyrimidines, methods for preparation and uses thereof