CZ19225U1 - Hydrophilic cream for treating hands - Google Patents

Description

Hydrophilic hand cream

Technical field 1

The object of the present invention is to provide a hydrophilic cream composition for hand treatment at various types of work. .3 ti

BACKGROUND OF THE INVENTION j

Hand creams for various types of workstations are known in the art ^. their performance for a long time. According to the state of the art, there is a growing demand for the safety and efficacy of cosmetics, which also include this "working cosmetics".

ío. Due to the development of the synthesis of new macromolecules and surfactants, the possibilities for the selection of excipients enabling the preparation of ointments and creams have increased in recent decades. Their selection should aim at enhancing the effect without adversely affecting the physiological functions of the skin.

Hydrophobic and hydrophilic ointments hitherto used, which contain paraffins, syn15 tetriacylglycerols, waxes as vehicles, may contain very small amounts of water, have moisturizing and emollient effects on the skin in the short term. In these vehicles, hygroscopicity and osmotic activity cause water to be removed from the skin, which is disadvantageous because the release of substances from the vehicles and their transfer to the skin requires a balance between vehicle and water taken from epidermal cells, as reported in Mandak M et al .: "Pharmaceutical Forms Π" scriptum, FaF UK Bratislava, 1990; Muller R.H., Hildebrand G.: "Modeme Arzneiformen", Wissenschaft odd Verlagsgesellschaft mbH, Stuttgart, 1998; Milan Chalabala et al .: "Technology of Drugs", Galén 1997.

Hydrophilic creams are a complex of systems that contain several different surfactants, have a continuous aqueous phase, contain O / W emulsifiers, and these vehicles can serve to “release” the ingredients for a longer lasting effect on the skin.

(Katzung B.G .: "Basic and Clinical Pharmacology", H&H, 1994, p.

520)

The essence of the technical solution

The present invention relates to a hydrophilic hand cream containing as main ingredients water, glycerol, olive oil, sodium lactate and sodium pyroglutamic acid.

The composition of the cream according to this invention is increasingly in compliance with the safety and efficacy requirements of cosmetics.

In particular, this cream composition complies with the criteria for testing skin tolerance according to the Cosmetic Product Test Guidelines for Human Skin Compatibility Assessment, COLIPA,

Bruxelles, 1995. Tests were conducted in 2008 at an accredited workplace at the National Institute of Public Health in Prague. Zero irritation was subsequently confirmed by epicutaneous irritation tests in the laboratory of toxicological sereening at the Slovak Medical University in Bratislava.

The effectiveness of the new skin composition was evaluated by the degree of “high hydration” according to the Guideline for the Evaluation of Effectiveness of Cosmetic Products, Bruxelles, 1997 at the accredited workplace of the EAA in Prague.

This high hydration will largely prevent the harmful effects of a number of chemical compounds, but also the effects of detergents or household detergents.

The combination of two hydrates of sodium lactate and sodium pyroglutamic acid (PCA) in combination with glycerine and vegetable olive oil has been shown to be important for achieving the desired effects.

-1 CZ 19225 Ul

The vegetable olive oil is preferably Olea Europaea oil.

Further, the selection of a suitable surfactant and perfume so that they do not contribute to irritability is important for safety and efficacy.

The resulting emulsion then permits the penetration of nutrients and preservatives below the skin surface also due to a suitably selected emollient, preferably octyldodecanol.

The hand cream according to the present invention also contains a high amount of water. The amount of water exceeds 50% by weight, the content of glycerol and olive oil in the emulsion is up to 5% by weight, of sodium salts, i.e. sodium lactate and sodium salt of PCA is less than 1% by weight, based on the total weight of the cream.

Preferably, the hydrophilic cream comprises 61.8 to 78.4 wt. % water, 1 to 5 wt. % glycerol, 1 to 5 wt. % olive oil, 0.2 to 1 wt. % sodium lactate and 0.2 to 1 wt. % sodium PCA, the remainder being up to 100 wt. For example, stearic acid, PEG-5 glyceryl stearate, liquid paraffin, cetyl alcohol, a preservative and perfume, or an emolent, preferably octyldodecanol, are included in the cream composition.

In a particularly preferred embodiment, the composition of the hydrophilic cream is by weight. % following:

Water 61.8 to 78.4 Glycerol 85% 1.0 to 5.0 Stearic acid 5.0 PEG-5 glyceryl stearate 3.0 to 8.0 Octyldodecanol 3.0 to 5.0 Liquid paraffin 6.0 Sodium lactate 0.2 to 1.0 Pyroglutamic acid sodium salt 0.2 to 1.0 Cetyl alcohol 1.0 Olea Europaea oil 1.0 to 5.0 Preservative 1.0 Perfume 0.2

The hydrophilic hand cream can be prepared by a known process for the manufacture of creams, i.e. by emulsifying the oil and aqueous phases at a temperature of 70 to 75 ° C and subsequently homogenizing the resulting emulsion at the same temperature. This is followed by slow cooling of the emulsion under high vacuum and stirring. At a temperature of 30 to 35 ° C, the thermolabile components are mixed into the emulsion and the emulsion is cooled in a deep vacuum with stirring.

The specific composition of the hydrophilic cream according to this invention is shown in the following example.

Examples

Name g in 100 g of the preparation Water 72,00 Glycerol 3.80 Kemaben 2 * 1.00 Stearic acid 5.00 PEG-5 glyceryl stearate 6.00 Octyldodecanol 3.00 Liquid paraffin 6.00 Lactil ** 1.00 Cetyl alcohol 1.00 Olea Europaea oil 1.00 Perfume 0.20

-2EN 19225 UL * Kemaben 2: propylene glycol + diazolidinylurea + methylparaben + propylparaben. j ** Lactil: sodium lactate + sodium pyroglutamic acid + fructose + glycine + inositol + | lactic acid + urea + niacinamide + sodium benzoate. $

The hydrophilic hand cream was made by hot-emulsifying the oil and water phases. After thorough homogenization and partial cooling, the other heat-sensitive ingredients were mixed into the emulsion and the finished cream was further cooled. The cooled homogeneous cream was filled into tubes.

Claims (6)

Hydrophilic hand cream, comprising as main ingredients: water, glycerol, olive oil, sodium lactate and sodium pyroglutamic acid. ío 2. A hydrophilic cream according to claim 1, further comprising an emollient. d 3. The hydrophilic cream of claim 2 wherein the emollient is octyldodecanol. A hydrophilic cream according to any one of the preceding claims 1 to 3, further comprising stearic acid, PEG-5 giyceryl stearate, liquid paraffin, cetyl alcohol, and the like. Preservative and perfume. $ Hydrophilic cream according to any one of the preceding claims 1 to 4, characterized in that it contains by weight: 61.8 to 78.4% water; 1.0 to 5.0% glycerol 85%; 20 5.0% stearic acid; _λ 3.0 to 8.0% PEG-5 glyceryl stearate; 3.0 to 5.0% octyldodecanol; 6.0% liquid paraffin; 0.2 to 1.0% sodium lactate; 25, 0.2 to 1.0% pyroglutamic acid sodium salt; 1.0% cetyl alcohol; 1.0 to 5.0% Olea Europaea; 1.0% preservative; 0.2% perfume.