CZ156795A3 - Mouth preparation containing agents against formation of microbial plaque, tartar, gingivitis and foetor ex ore - Google Patents

Mouth preparation containing agents against formation of microbial plaque, tartar, gingivitis and foetor ex ore Download PDF

Info

Publication number: CZ156795A3
Authority: CZ; Czechia
Prior art keywords: oral; tartar; gingivitis; zinc; composition
Prior art date: 1992-12-18

Application number

CZ951567A

Other languages

Czech (cs)

English (en)

Inventor

Ronald Earl Montgomery

Joseph Wasyl Pyrz

Margaret Mary Coyle-Rees

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-18

Filing date

1993-12-06

Publication date

1996-01-17

1993-12-06 Application filed by Procter & Gamble filed Critical Procter & Gamble

1996-01-17 Publication of CZ156795A3 publication Critical patent/CZ156795A3/cs

Links

208000006558 Dental Calculus Diseases 0.000 title claims abstract description 28
208000007565 gingivitis Diseases 0.000 title claims abstract description 18
230000000813 microbial effect Effects 0.000 title description 30
230000015572 biosynthetic process Effects 0.000 title description 5
238000002360 preparation method Methods 0.000 title description 5
206010006326 Breath odour Diseases 0.000 title 1
239000000203 mixture Substances 0.000 claims abstract description 89
-1 citrate ions Chemical class 0.000 claims abstract description 27
239000003795 chemical substances by application Substances 0.000 claims abstract description 25
235000011180 diphosphates Nutrition 0.000 claims abstract description 16
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 15
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 14
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims abstract description 11
230000000699 topical effect Effects 0.000 claims abstract description 10
229920000388 Polyphosphate Polymers 0.000 claims abstract description 9
239000001205 polyphosphate Substances 0.000 claims abstract description 9
235000011176 polyphosphates Nutrition 0.000 claims abstract description 9
XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 claims abstract description 5
UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims abstract description 5
239000011248 coating agent Substances 0.000 claims description 22
238000000576 coating method Methods 0.000 claims description 21
239000002324 mouth wash Substances 0.000 claims description 20
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
239000004599 antimicrobial Substances 0.000 claims description 12
230000000845 anti-microbial effect Effects 0.000 claims description 10
229940051866 mouthwash Drugs 0.000 claims description 6
229910019142 PO4 Inorganic materials 0.000 claims description 5
238000009472 formulation Methods 0.000 claims description 5
235000021317 phosphate Nutrition 0.000 claims description 5
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 4
150000002500 ions Chemical class 0.000 claims description 3
BYOBJKVGOIXVED-UHFFFAOYSA-N (2-phosphonoazepan-2-yl)phosphonic acid Chemical compound OP(O)(=O)C1(P(O)(O)=O)CCCCCN1 BYOBJKVGOIXVED-UHFFFAOYSA-N 0.000 claims description 2
230000008901 benefit Effects 0.000 claims description 2
229940124378 dental agent Drugs 0.000 claims description 2
150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
239000004575 stone Substances 0.000 claims 4
206010061218 Inflammation Diseases 0.000 claims 2
239000003153 chemical reaction reagent Substances 0.000 claims 2
230000004054 inflammatory process Effects 0.000 claims 2
229940048084 pyrophosphate Drugs 0.000 claims 2
WKVZMKDXJFCMMD-UVWUDEKDSA-L (5ar,8ar,9r)-5-[[(2r,4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one;azanide;n,3-bis(2-chloroethyl)-2-ox Chemical compound [NH2-].[NH2-].Cl[Pt+2]Cl.ClCCNP1(=O)OCCCN1CCCl.COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3C(O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 WKVZMKDXJFCMMD-UVWUDEKDSA-L 0.000 claims 1
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235000015250 liver sausages Nutrition 0.000 claims 1
239000002736 nonionic surfactant Substances 0.000 claims 1
XYSQXZCMOLNHOI-UHFFFAOYSA-N s-[2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]phenyl] 5-pyridin-1-ium-1-ylpentanethioate;bromide Chemical compound [Br-].C1=CC(S(=O)(=O)NC(=O)C)=CC=C1NC(=O)C1=CC=CC=C1SC(=O)CCCC[N+]1=CC=CC=C1 XYSQXZCMOLNHOI-UHFFFAOYSA-N 0.000 claims 1
239000011701 zinc Substances 0.000 abstract description 36
229910052725 zinc Inorganic materials 0.000 abstract description 32
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 30
210000000214 mouth Anatomy 0.000 abstract description 28
238000000034 method Methods 0.000 abstract description 8
208000002064 Dental Plaque Diseases 0.000 abstract description 6
WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 abstract description 3
241001465754 Metazoa Species 0.000 abstract description 2
230000002272 anti-calculus Effects 0.000 abstract description 2
206010044029 Tooth deposit Diseases 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
239000000606 toothpaste Substances 0.000 description 18
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
239000000377 silicon dioxide Substances 0.000 description 11
239000004094 surface-active agent Substances 0.000 description 11
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 10
239000003082 abrasive agent Substances 0.000 description 10
239000000796 flavoring agent Substances 0.000 description 10
235000013355 food flavoring agent Nutrition 0.000 description 9
239000003906 humectant Substances 0.000 description 9
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
239000004480 active ingredient Substances 0.000 description 8
239000000243 solution Substances 0.000 description 8
229940034610 toothpaste Drugs 0.000 description 8
241000894006 Bacteria Species 0.000 description 7
239000004354 Hydroxyethyl cellulose Substances 0.000 description 7
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239000011230 binding agent Substances 0.000 description 7
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239000004615 ingredient Substances 0.000 description 7
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239000000463 material Substances 0.000 description 6
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PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
239000003765 sweetening agent Substances 0.000 description 6
239000007864 aqueous solution Substances 0.000 description 5
239000000551 dentifrice Substances 0.000 description 5
239000000668 oral spray Substances 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
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239000002562 thickening agent Substances 0.000 description 5
239000011787 zinc oxide Substances 0.000 description 5
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MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
229910052783 alkali metal Inorganic materials 0.000 description 4
239000000969 carrier Substances 0.000 description 4
235000011187 glycerol Nutrition 0.000 description 4
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239000000047 product Substances 0.000 description 4
239000001509 sodium citrate Substances 0.000 description 4
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 4
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000007844 bleaching agent Substances 0.000 description 3
230000001680 brushing effect Effects 0.000 description 3
239000001768 carboxy methyl cellulose Substances 0.000 description 3
239000003086 colorant Substances 0.000 description 3
210000003298 dental enamel Anatomy 0.000 description 3
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NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
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239000011734 sodium Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
239000011775 sodium fluoride Substances 0.000 description 3
235000013024 sodium fluoride Nutrition 0.000 description 3
ILJOYZVVZZFIKA-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;hydrate Chemical compound O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 ILJOYZVVZZFIKA-UHFFFAOYSA-M 0.000 description 3
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GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
YFVBASFBIJFBAI-UHFFFAOYSA-M 1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=CC=C1 YFVBASFBIJFBAI-UHFFFAOYSA-M 0.000 description 2
ANAAMBRRWOGKGU-UHFFFAOYSA-M 4-ethyl-1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=C(CC)C=C1 ANAAMBRRWOGKGU-UHFFFAOYSA-M 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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238000007796 conventional method Methods 0.000 description 2
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DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 description 1
229960005164 acesulfame Drugs 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000002313 adhesive film Substances 0.000 description 1
241001148470 aerobic bacillus Species 0.000 description 1
LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
229950010221 alexidine Drugs 0.000 description 1
150000004973 alkali metal peroxides Chemical class 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
229960003022 amoxicillin Drugs 0.000 description 1
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000003610 anti-gingivitis Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
229940050390 benzoate Drugs 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
UDEWPOVQBGFNGE-UHFFFAOYSA-N benzoic acid n-propyl ester Natural products CCCOC(=O)C1=CC=CC=C1 UDEWPOVQBGFNGE-UHFFFAOYSA-N 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
235000019827 calcium polyphosphate Nutrition 0.000 description 1
229940043256 calcium pyrophosphate Drugs 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920003086 cellulose ether Polymers 0.000 description 1
229960001927 cetylpyridinium chloride Drugs 0.000 description 1
230000008859 change Effects 0.000 description 1
230000002925 chemical effect Effects 0.000 description 1
229960003260 chlorhexidine Drugs 0.000 description 1
239000010634 clove oil Substances 0.000 description 1
238000011970 concomitant therapy Methods 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
239000007859 condensation product Substances 0.000 description 1
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical class OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
230000006378 damage Effects 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
229940023487 dental product Drugs 0.000 description 1
210000004268 dentin Anatomy 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
235000019821 dicalcium diphosphate Nutrition 0.000 description 1
230000029087 digestion Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
238000009826 distribution Methods 0.000 description 1
229960001859 domiphen bromide Drugs 0.000 description 1
229960003722 doxycycline Drugs 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
229960004756 ethanol Drugs 0.000 description 1
210000002744 extracellular matrix Anatomy 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
238000005187 foaming Methods 0.000 description 1
229940014144 folate Drugs 0.000 description 1
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
235000019152 folic acid Nutrition 0.000 description 1
239000011724 folic acid Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
229960002737 fructose Drugs 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
238000000227 grinding Methods 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
229960004867 hexetidine Drugs 0.000 description 1
239000012535 impurity Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000003993 interaction Effects 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
229940001447 lactate Drugs 0.000 description 1
230000003902 lesion Effects 0.000 description 1
239000001645 levisticum officinale Substances 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
244000005700 microbiome Species 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
229940074371 monofluorophosphate Drugs 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
229950002404 octapinol Drugs 0.000 description 1
229960001774 octenidine Drugs 0.000 description 1
SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
239000003921 oil Substances 0.000 description 1
150000001451 organic peroxides Chemical class 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
210000003254 palate Anatomy 0.000 description 1
239000002245 particle Substances 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000002491 polymer binding agent Substances 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000012487 rinsing solution Substances 0.000 description 1
229940084560 sanguinarine Drugs 0.000 description 1
YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
239000010672 sassafras oil Substances 0.000 description 1
230000035807 sensation Effects 0.000 description 1
235000019615 sensations Nutrition 0.000 description 1
239000000344 soap Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
235000019983 sodium metaphosphate Nutrition 0.000 description 1
235000019832 sodium triphosphate Nutrition 0.000 description 1
YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
239000000271 synthetic detergent Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
239000000892 thaumatin Substances 0.000 description 1
235000010436 thaumatin Nutrition 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
229960003500 triclosan Drugs 0.000 description 1
VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
239000003643 water by type Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1
229940006486 zinc cation Drugs 0.000 description 1
229940085658 zinc citrate trihydrate Drugs 0.000 description 1
229940077935 zinc phosphate Drugs 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
239000011686 zinc sulphate Substances 0.000 description 1
235000009529 zinc sulphate Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Birds (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Emergency Medicine (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CZ951567A 1992-12-18 1993-12-06 Mouth preparation containing agents against formation of microbial plaque, tartar, gingivitis and foetor ex ore CZ156795A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US99333692A	1992-12-18	1992-12-18
US14877693A	1993-11-16	1993-11-16

Publications (1)

Publication Number	Publication Date
CZ156795A3 true CZ156795A3 (en)	1996-01-17

Family

ID=26846152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ951567A CZ156795A3 (en)	1992-12-18	1993-12-06	Mouth preparation containing agents against formation of microbial plaque, tartar, gingivitis and foetor ex ore

Country Status (10)

Country	Link
EP (1)	EP0675706A1 (fr)
JP (1)	JPH08505843A (fr)
CN (1)	CN1095263A (fr)
AU (1)	AU5740094A (fr)
BR (1)	BR9307688A (fr)
CA (1)	CA2151913A1 (fr)
CZ (1)	CZ156795A3 (fr)
HU (1)	HUT72041A (fr)
MX (1)	MX9400053A (fr)
WO (1)	WO1994014407A1 (fr)

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US5302373A (en) *	1993-06-10	1994-04-12	Church & Dwight Co., Inc.	Liquid mouthwash containing a particulate bicarbonate suspension
HU219711B (hu) *	1993-12-22	2001-06-28	Smithkline Beecham Corporation	Fogfehérítő készítmény és eljárás alkalmazására
US5599527A (en) *	1994-11-14	1997-02-04	Colgate-Palmolive Company	Dentifrice compositions having improved anticalculus properties
US5833955A (en) *	1996-11-14	1998-11-10	The Research Foundation Of State University Of New York	Diagnostic tests to assess a persons oral malodor capacity and potential for developing periodontitis
US5939052A (en) *	1996-11-21	1999-08-17	The Procter & Gamble Company	Dentifrice compositions containing polyphosphate and fluoride
US6350436B1 (en)	1996-11-21	2002-02-26	The Procter & Gamble Company	Method of reducing staining of stannous in dentifrice compositions
US6190644B1 (en) *	1996-11-21	2001-02-20	The Procter & Gamble Company	Dentifrice compositions containing polyphosphate and monofluorophosphate
US6713049B1 (en)	1999-11-12	2004-03-30	The Procter & Gamble Company	Oral compositions providing optimal surface conditioning
DK176196B1 (da)	1997-10-07	2007-01-08	Ejvind Jersie Pedersen	Mundhygejnepræparat til behandling af halitosis samt anvendelse af et chelat omfattende en metaliondel og en aminosyredel som en komponent i præparatet
US6846478B1 (en) *	1998-02-27	2005-01-25	The Procter & Gamble Company	Promoting whole body health
US6350438B1 (en) *	1998-02-27	2002-02-26	The Procter & Gamble Company	Oral care compositions comprising chlorite and methods
JPH11246376A (ja) *	1998-02-27	1999-09-14	Sunstar Inc	口腔用組成物
AU1479501A (en)	1999-11-12	2001-06-06	Procter & Gamble Company, The	Improved dual phase stannous oral compositions
US10470985B2 (en)	1999-11-12	2019-11-12	The Procter & Gamble Company	Method of protecting teeth against erosion
US20040146466A1 (en)	1999-11-12	2004-07-29	The Procter & Gamble Company	Method of protecting teeth against erosion
AU1479301A (en)	1999-11-12	2001-06-06	Procter & Gamble Company, The	Improved stannous oral compositions
JP2001151651A (ja) *	1999-11-26	2001-06-05	Earth Chem Corp Ltd	口腔用組成物
MXPA03000041A (es) *	2000-06-30	2003-10-15	Procter & Gamble	Composiciones orales que comprenden agentes microbianos.
WO2002092037A1 (fr) *	2001-05-15	2002-11-21	The Procter & Gamble Company	Compositions de confiseries pour les soins de la bouche
AU2002308717A1 (en) *	2001-05-15	2002-11-25	The Procter And Gamble Company	Confectionery compositions
MXPA03010455A (es) *	2001-05-15	2004-03-09	Procter & Gamble	Composiciones para el cuidado bucal.
JP3957293B2 (ja) *	2003-01-27	2007-08-15	花王株式会社	口腔用組成物
DE10311171A1 (de) *	2003-03-12	2004-09-23	Henkel Kgaa	Mund- und Zahnpflegemittel
GB0319566D0 (en) *	2003-08-20	2003-09-24	Unilever Plc	Use of oral care composition
CN101330900A (zh) *	2005-12-20	2008-12-24	宝洁公司	包含锌和肌醇六磷酸的口腔护理组合物
TWI531379B (zh) *	2005-12-21	2016-05-01	美國棕欖公司	包含檸檬酸鋅及／或生育醇試劑之改良口用組成物
ATE431128T1 (de)	2006-03-22	2009-05-15	Procter & Gamble	Zink enthaltende mundzusammensetzungen
RU2448680C2 (ru)	2007-11-09	2012-04-27	Дзе Проктер Энд Гэмбл Компани	Композиции для полости рта, содержащие олово
PH12012500857A1 (en)	2009-10-29	2012-11-26	Colgate Palmolive Co	Dentrifice comprising stannous fluoride plus zinc citrate and low levels of water
US10123953B2 (en)	2012-06-21	2018-11-13	The Procter & Gamble Company	Reduction of tooth staining derived from cationic antimicrobials
JP2018002660A (ja) *	2016-07-01	2018-01-11	Ｎｓファーファ・ジャパン株式会社	口腔用組成物
CN113747948B (zh)	2019-04-26	2023-12-15	宝洁公司	减少来源于阳离子抗微生物剂的牙齿变色
JP2022099625A (ja) *	2020-12-23	2022-07-05	小林製薬株式会社	口腔用組成物

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JPH0747531B2 (ja) *	1986-06-27	1995-05-24	ライオン株式会社	口腔用組成物
AU1746088A (en) *	1987-06-12	1988-12-15	Unilever Plc	Oral compositions
AU2090488A (en) *	1987-08-28	1989-03-02	Avantgarde S.P.A.	Chewing gum having antitartar activity
US4869898A (en) *	1988-01-25	1989-09-26	Colgate-Palmolive Co.	Anticalculus oral composition
GB8804817D0 (en) *	1988-03-01	1988-03-30	Unilever Plc	Anticalculas oral compositions
GB8922434D0 (en) *	1989-10-05	1989-11-22	Unilever Plc	Oral compositions
AU9160791A (en) *	1990-12-18	1992-07-22	Procter & Gamble Company, The	Oral compositions effective against plaque and gingivitis
US5240697A (en) *	1991-10-17	1993-08-31	Colgate-Palmolive Company	Desensitizing anti-tartar dentifrice

1993
- 1993-12-06 BR BR9307688-6A patent/BR9307688A/pt not_active Application Discontinuation
- 1993-12-06 HU HU9501784A patent/HUT72041A/hu unknown
- 1993-12-06 JP JP6515185A patent/JPH08505843A/ja active Pending
- 1993-12-06 CZ CZ951567A patent/CZ156795A3/cs unknown
- 1993-12-06 AU AU57400/94A patent/AU5740094A/en not_active Abandoned
- 1993-12-06 WO PCT/US1993/011787 patent/WO1994014407A1/fr not_active Ceased
- 1993-12-06 EP EP94903459A patent/EP0675706A1/fr not_active Withdrawn
- 1993-12-06 CA CA 2151913 patent/CA2151913A1/fr not_active Abandoned
- 1993-12-18 CN CN 93119922 patent/CN1095263A/zh active Pending
1994
- 1994-01-03 MX MX9400053A patent/MX9400053A/es unknown

Also Published As

Publication number	Publication date
HU9501784D0 (en)	1995-08-28
BR9307688A (pt)	1999-09-08
AU5740094A (en)	1994-07-19
EP0675706A1 (fr)	1995-10-11
JPH08505843A (ja)	1996-06-25
WO1994014407A1 (fr)	1994-07-07
MX9400053A (es)	1994-07-29
CA2151913A1 (fr)	1994-07-07
CN1095263A (zh)	1994-11-23
HUT72041A (en)	1996-03-28

Publication	Publication Date	Title
CZ156795A3 (en)	1996-01-17	Mouth preparation containing agents against formation of microbial plaque, tartar, gingivitis and foetor ex ore
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CZ156895A3 (en)	1996-01-17	Mouth preparation containing agents against formation of microbial plaque and tartar
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JP2001172146A (ja)	2001-06-26	口腔用組成物
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