CY2510B1 - N- (1-nbutyl-4-piperidyl)methyl -3,4-dihydro-2h 1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof - Google Patents

N- (1-nbutyl-4-piperidyl)methyl -3,4-dihydro-2h 1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof

Info

Publication number: CY2510B1
Authority: CY; Cyprus
Prior art keywords: oxazino; nbutyl; piperidyl; carboxamide; indole
Prior art date: 1992-03-12

Application number

CY0500021A

Other languages

English (en)

Inventor

Laramie Mary Gaster

Paul Adrian Wyman

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-12

Filing date

2005-04-12

Publication date

2005-12-23

1992-03-12 Priority claimed from GB929205428A external-priority patent/GB9205428D0/en

1992-09-05 Priority claimed from GB929218846A external-priority patent/GB9218846D0/en

1992-12-29 Priority claimed from GB929227045A external-priority patent/GB9227045D0/en

2005-04-12 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2005-12-23 Publication of CY2510B1 publication Critical patent/CY2510B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CY0500021A 1992-03-12 2005-04-12 N- (1-nbutyl-4-piperidyl)methyl -3,4-dihydro-2h 1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof CY2510B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB929205428A GB9205428D0 (en)	1992-03-12	1992-03-12	Pharmaceuticals
GB929218846A GB9218846D0 (en)	1992-09-05	1992-09-05	Pharmaceuticals
GB929227045A GB9227045D0 (en)	1992-12-29	1992-12-29	Pharmaceuticals

Publications (1)

Publication Number	Publication Date
CY2510B1 true CY2510B1 (en)	2005-12-23

Family

ID=27266092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0500021A CY2510B1 (en)	1992-03-12	2005-04-12	N- (1-nbutyl-4-piperidyl)methyl -3,4-dihydro-2h 1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof

Country Status (29)

Country	Link
EP (2)	EP0884319B1 (xx)
JP (1)	JP2831467B2 (xx)
KR (1)	KR100282730B1 (xx)
CN (2)	CN1043893C (xx)
AP (1)	AP401A (xx)
AT (2)	ATE266033T1 (xx)
AU (1)	AU671102B2 (xx)
CA (1)	CA2131797C (xx)
CY (1)	CY2510B1 (xx)
CZ (1)	CZ286194B6 (xx)
DE (2)	DE69333504T2 (xx)
DK (2)	DK0630376T3 (xx)
ES (2)	ES2132223T3 (xx)
FI (1)	FI107158B (xx)
GR (1)	GR3030668T3 (xx)
HU (1)	HU219121B (xx)
IL (1)	IL105003A (xx)
MA (1)	MA22819A1 (xx)
MX (1)	MX9301348A (xx)
MY (1)	MY110110A (xx)
NO (1)	NO303638B1 (xx)
NZ (1)	NZ249565A (xx)
PT (1)	PT884319E (xx)
RU (1)	RU2104279C1 (xx)
SG (1)	SG50693A1 (xx)
SI (1)	SI9300114B (xx)
SK (1)	SK281423B6 (xx)
UA (1)	UA41311C2 (xx)
WO (1)	WO1993018036A1 (xx)

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US5852014A (en) *	1992-03-12	1998-12-22	Smithkline Beecham P.L.C.	Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) *	1992-03-12	1999-12-07	Smithkline Beecham Plc	Condensed indole derivatives as 5HT4 -receptor antagonists
GB9316195D0 (en) *	1993-08-05	1993-09-22	Smithkline Beecham Plc	Pharmaceuticals
MX9305947A (es) *	1992-09-29	1994-06-30	Smithkline Beecham Plc	Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
EP0664794A1 (en) *	1992-10-16	1995-08-02	Smithkline Beecham Plc	N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
NZ257545A (en) *	1992-11-05	1997-01-29	Smithkline Beecham Plc	Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
FR2699921B1 (fr) *	1992-12-30	1995-02-10	Synthelabo	Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) *	1993-02-19	1993-04-07	Smithkline Beecham Plc	Pharmaceuticals
GB9310582D0 (en) *	1993-05-22	1993-07-07	Smithkline Beecham Plc	Pharmaceuticals
GB9312348D0 (en) *	1993-06-16	1993-07-28	Smithkline Beecham Plc	Pharmaceuticals
KR100219922B1 (ko) *	1996-05-16	1999-09-01	이서봉	신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US6013666A (en) *	1996-07-02	2000-01-11	Sang Sup Jew	Oxirane carboxylic acid derivative and its manufacturing method
ATE197588T1 (de) *	1996-08-16	2000-12-15	Smithkline Beecham Plc	Verfahren zur herstellung von n- (1-n-butyl-4- piperidinyl)methyl) -3,4-dihydro -2h-(1, 3)oxazino(3,2-a)indol-10-carboxamid und salze sowie zwischenprodukte in dem verfahren
US6100397A (en) *	1996-08-16	2000-08-08	Smithkline Beecham Plc	Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
GB9618967D0 (en) *	1996-09-11	1996-10-23	Smithkline Beecham Plc	Pharmaceuticals
GB9725933D0 (en) *	1997-12-05	1998-02-04	Smithkline Beecham Plc	Pharmaceuticals
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US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US20020091271A1 (en)	1998-07-16	2002-07-11	Smithkline Beecham Plc	Process for the preparation of an indole derivative
GB9819035D0 (en) *	1998-09-01	1998-10-28	Cerebrus Res Ltd	Chemical compounds VII
AU758807B2 (en) *	1998-09-10	2003-03-27	F. Hoffmann-La Roche Ag	Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT4 receptor antagonists
GB9820294D0 (en) *	1998-09-17	1998-11-11	Smithkline Beecham Plc	Pharmaceuticals
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
AU2005203196B9 (en) *	2000-08-07	2009-04-09	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782863C (en) *	2000-08-07	2006-08-31	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
MXPA03001210A (es) *	2000-08-07	2004-08-12	Smithkline Beecham Corp	Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial.
AU782870C (en) *	2000-08-07	2007-03-15	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
NZ535261A (en) *	2000-08-08	2004-12-24	Smithkline Beecham P	A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
WO2002011733A1 (en) *	2000-08-08	2002-02-14	Smithkline Beecham P.L.C.	Pharmaceutical composition comprising condensed indole compound
KR100967782B1 (ko) *	2002-02-14	2010-07-05	글락소 그룹 리미티드	Ｎ-((1-Ｎ-부틸-4-피페리디닐)메틸)-3,4-디하이드로-2Ｈ-(1,3)옥사지노(3,2-ａ)인돌-10-카복스아미드 또는 그의 염을포함하는 제약 조성물, 및 건식 과립화를 포함하는 그의제조 방법
JP2005529076A (ja)	2002-02-15	2005-09-29	サイトキネティクス・インコーポレーテッド	キナゾリノンの合成
CA2485148A1 (en)	2002-05-09	2003-11-20	Cytokinetics, Inc.	Pyrimidinone compounds, compositions and methods
JP2005530785A (ja)	2002-05-09	2005-10-13	サイトキネティクス・インコーポレーテッド	化合物、組成物、及び方法
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
US7038048B2 (en)	2002-05-23	2006-05-02	Cytokinetics, Inc.	3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
JP2005538062A (ja)	2002-06-14	2005-12-15	サイトキネティクス・インコーポレーテッド	化合物、組成物、および方法
EP1537089A4 (en)	2002-07-23	2008-04-16	Cytokinetics Inc	CONNECTIONS, COMPOSITIONS AND PROCEDURES
US7557115B2 (en)	2002-09-30	2009-07-07	Cytokinetics, Inc.	Compounds, compositions, and methods
ITMI20031467A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco attivo nel dolore neuropatico
ITMI20031468A1 (it)	2003-07-18	2005-01-19	Acraf	Farmaco ativo nel dolore neuropatico
WO2005061460A1 (en)	2003-12-08	2005-07-07	Cytokinetics, Inc.	Compounds, compositions, and methods
AU2004303722B2 (en)	2003-12-23	2010-02-18	Serodus As	Modulators of peripheral 5-HT receptors
JP4612301B2 (ja) *	2003-12-26	2011-01-12	広栄化学工業株式会社	１−アルキル−４−アミノメチルピペリジンの製造法
AU2005313325C1 (en) *	2004-12-07	2011-11-10	Janssen Pharmaceutica N.V.	Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
RU2320662C1 (ru) *	2006-08-24	2008-03-27	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ ПИРРОЛО[4,3-b]ИНДОЛЫ, КОМБИНАТОРНАЯ И ФОКУСИРОВАННАЯ БИБЛИОТЕКИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
CN101801937A (zh)	2007-06-22	2010-08-11	艾科尔公司	喹唑啉酮化合物及其使用方法
GB0905641D0 (en) *	2009-04-01	2009-05-13	Serodus As	Compounds
WO2021116487A1 (en)	2019-12-13	2021-06-17	Som Innovation Biotech, S.A.	Compounds for use in the treatment of niemann-pick c disease
WO2025077825A1 (en) *	2023-10-13	2025-04-17	Fauna Bio Incorporated	Methods and compositions for treating cardio-pulmonary disorders

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DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung
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1993
- 1993-03-10 DK DK93905561T patent/DK0630376T3/da active
- 1993-03-10 KR KR1019940703167A patent/KR100282730B1/ko not_active Expired - Fee Related
- 1993-03-10 DE DE69333504T patent/DE69333504T2/de not_active Expired - Lifetime
- 1993-03-10 CA CA2131797A patent/CA2131797C/en not_active Expired - Fee Related
- 1993-03-10 AT AT98114130T patent/ATE266033T1/de active
- 1993-03-10 AU AU36448/93A patent/AU671102B2/en not_active Expired
- 1993-03-10 DE DE69325167T patent/DE69325167T2/de not_active Expired - Lifetime
- 1993-03-10 HU HU9402601A patent/HU219121B/hu unknown
- 1993-03-10 UA UA94095780A patent/UA41311C2/uk unknown
- 1993-03-10 RU RU94040864A patent/RU2104279C1/ru not_active IP Right Cessation
- 1993-03-10 WO PCT/GB1993/000506 patent/WO1993018036A1/en active IP Right Grant
- 1993-03-10 DK DK98114130T patent/DK0884319T3/da active
- 1993-03-10 SK SK1078-94A patent/SK281423B6/sk not_active IP Right Cessation
- 1993-03-10 PT PT98114130T patent/PT884319E/pt unknown
- 1993-03-10 JP JP5515490A patent/JP2831467B2/ja not_active Expired - Lifetime
- 1993-03-10 IL IL10500393A patent/IL105003A/en not_active IP Right Cessation
- 1993-03-10 AP APAP/P/1993/000494A patent/AP401A/en active
- 1993-03-10 ES ES93905561T patent/ES2132223T3/es not_active Expired - Lifetime
- 1993-03-10 MA MA23113A patent/MA22819A1/fr unknown
- 1993-03-10 ES ES98114130T patent/ES2219813T3/es not_active Expired - Lifetime
- 1993-03-10 SI SI9300114A patent/SI9300114B/sl active Search and Examination
- 1993-03-10 CZ CZ19942210A patent/CZ286194B6/cs not_active IP Right Cessation
- 1993-03-10 AT AT93905561T patent/ATE180785T1/de active
- 1993-03-10 MY MYPI93000436A patent/MY110110A/en unknown
- 1993-03-10 EP EP98114130A patent/EP0884319B1/en not_active Expired - Lifetime
- 1993-03-10 SG SG1996008846A patent/SG50693A1/en unknown
- 1993-03-10 EP EP93905561A patent/EP0630376B1/en not_active Expired - Lifetime
- 1993-03-10 NZ NZ249565A patent/NZ249565A/en not_active IP Right Cessation
- 1993-03-11 MX MX9301348A patent/MX9301348A/es not_active IP Right Cessation
- 1993-03-11 CN CN93102648A patent/CN1043893C/zh not_active Expired - Fee Related
- 1993-05-22 CN CN93107234A patent/CN1085083A/zh active Pending
1994
- 1994-09-09 NO NO943348A patent/NO303638B1/no not_active IP Right Cessation
- 1994-09-12 FI FI944204A patent/FI107158B/fi not_active IP Right Cessation
1999
- 1999-06-30 GR GR990401755T patent/GR3030668T3/el unknown
2005
- 2005-04-12 CY CY0500021A patent/CY2510B1/xx unknown

Also Published As

Publication number	Publication date
SI9300114B (sl)	2006-08-31
ATE266033T1 (de)	2004-05-15
NZ249565A (en)	1997-07-27
HUT71121A (en)	1995-11-28
DE69325167D1 (de)	1999-07-08
KR100282730B1 (ko)	2001-02-15
MY110110A (en)	1998-01-27
AP401A (en)	1995-08-29
NO943348D0 (no)	1994-09-09
EP0884319B1 (en)	2004-05-06
HU219121B (hu)	2001-02-28
EP0630376A1 (en)	1994-12-28
CN1085083A (zh)	1994-04-13
JPH07504433A (ja)	1995-05-18
MX9301348A (es)	1993-09-01
CA2131797C (en)	2010-05-18
AU671102B2 (en)	1996-08-15
DE69333504T2 (de)	2005-05-12
CZ221094A3 (en)	1995-09-13
CZ286194B6 (cs)	2000-02-16
AP9300494A0 (en)	1993-04-30
NO943348L (no)	1994-11-09
SI9300114A (sl)	1993-12-31
FI944204A0 (fi)	1994-09-12
RU94040864A (ru)	1996-07-20
ES2132223T3 (es)	1999-08-16
UA41311C2 (uk)	2001-09-17
FI107158B (fi)	2001-06-15
GR3030668T3 (en)	1999-10-29
EP0630376B1 (en)	1999-06-02
RU2104279C1 (ru)	1998-02-10
CN1043893C (zh)	1999-06-30
DK0630376T3 (da)	1999-06-23
NO303638B1 (no)	1998-08-10
CA2131797A1 (en)	1993-09-16
DK0884319T3 (da)	2004-08-30
CN1078471A (zh)	1993-11-17
KR950700304A (ko)	1995-01-16
FI944204L (fi)	1994-09-12
SK281423B6 (sk)	2001-03-12
HU9402601D0 (en)	1994-12-28
AU3644893A (en)	1993-10-05
IL105003A (en)	1996-09-12
IL105003A0 (en)	1993-07-08
EP0884319A3 (en)	1999-02-10
ES2219813T3 (es)	2004-12-01
EP0884319A2 (en)	1998-12-16
PT884319E (pt)	2004-09-30
SG50693A1 (en)	1998-07-20
WO1993018036A1 (en)	1993-09-16
DE69325167T2 (de)	2000-01-20
DE69333504D1 (de)	2004-06-09
SK107894A3 (en)	1995-04-12
JP2831467B2 (ja)	1998-12-02
MA22819A1 (fr)	1993-10-01
HK1012352A1 (en)	1999-07-30
ATE180785T1 (de)	1999-06-15

Publication	Publication Date	Title
CY2510B1 (en)	2005-12-23	N- (1-nbutyl-4-piperidyl)methyl -3,4-dihydro-2h 1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof
EP0650356A4 (en)	1995-06-14	RAPAMYCIN DERIVATIVES.
EP0650489A4 (en)	1995-06-14	RAPAMYCINE DERIVATIVES.
AP9300478A0 (en)	1993-01-31	1,5 benzodiazepine derivatives
ZA942571B (en)	1994-11-11	1,5 benzodiazepine derivatives
EG20523A (en)	1999-06-30	Benzoylisoxazole derivatives used herbicides
IL106138A0 (en)	1993-10-20	Rotary sprinklers
HU9403451D0 (en)	1995-02-28	Imidazopyridine derivatives
EP0650357A4 (en)	1995-06-14	RAPAMYCINE DERIVATIVES.
AP9400657A0 (en)	1994-07-31	1,5 benzodiazepine derivatives
ZA938349B (en)	1994-08-01	Rapamycin derivatives.
HU9301651D0 (en)	1993-09-28	Pyridyl-1,2,5-oxadiazole-carbonamide-2-oxide derivatives
ZA9811642B (en)	1999-06-24	Pyrido 1,2,4-thiadiazine derivatives their preparation and use
ZA957309B (en)	1996-04-01	New thiazolo[3,2-a]quinoline and -naphthyridine derivatives
EP0683787A1 (en)	1995-11-29	4'-O-SULFONYL-ANTHRACYCLINE DERIVATIVES.
HU9402902D0 (en)	1995-02-28	1,2-dihydro-2-oxo-3-methyl-sulfonyl-aminomethyl-pyridine derivatives
IL100999A0 (en)	1992-11-15	Immunosuppressive drug
GB2313058B (en)	1998-01-21	Pharmaceutically useful thiopheneyl derivatives
IE901122L (en)	1990-09-28	1,8-naphthyridine derivatives
GB9201836D0 (en)	1992-03-11	Heterotricyclic derivatives
GB9224012D0 (en)	1993-01-06	Heterotricyclic derivatives
HU9501251D0 (en)	1995-06-28	17,20-epoxy-20-substituted-pregnane derivatives
HU9204124D0 (en)	1993-04-28	1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrholo/2,3-b/-indole-tetrahydro-isoquinoline-urea derivatives
ZA921317B (en)	1992-11-25	Immunosuppressive drug
GB9100256D0 (en)	1991-02-20	Cyclosporin derivatives