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CY2366B1 - Process for the production of powdered pulmonary surfactant preparations. - Google Patents

Process for the production of powdered pulmonary surfactant preparations.

Info

Publication number
CY2366B1
CY2366B1 CY0300048A CY0300048A CY2366B1 CY 2366 B1 CY2366 B1 CY 2366B1 CY 0300048 A CY0300048 A CY 0300048A CY 0300048 A CY0300048 A CY 0300048A CY 2366 B1 CY2366 B1 CY 2366B1
Authority
CY
Cyprus
Prior art keywords
pulmonary surfactant
production
powdered
surfactant preparations
powdered pulmonary
Prior art date
Application number
CY0300048A
Other languages
English (en)
Inventor
Klaus Eistetter
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of CY2366B1 publication Critical patent/CY2366B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CY0300048A 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations. CY2366B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06

Publications (1)

Publication Number Publication Date
CY2366B1 true CY2366B1 (en) 2004-06-04

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300048A CY2366B1 (en) 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations.

Country Status (15)

Country Link
US (1) US6315983B1 (fr)
EP (1) EP0877602B1 (fr)
JP (1) JP3725166B2 (fr)
KR (1) KR100449789B1 (fr)
AT (1) ATE212220T1 (fr)
CA (1) CA2244767C (fr)
CY (1) CY2366B1 (fr)
CZ (1) CZ292186B6 (fr)
DE (1) DE59706180D1 (fr)
DK (1) DK0877602T3 (fr)
ES (1) ES2171883T3 (fr)
PT (1) PT877602E (fr)
TR (1) TR199801408T2 (fr)
UA (1) UA59358C2 (fr)
WO (1) WO1997026863A1 (fr)

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US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
WO1998029098A1 (fr) * 1996-12-31 1998-07-09 Inhale Therapeutic Systems, Inc. Procedes permettant de secher par pulverisation de suspensions aqueuses de medicaments hydrophobes avec des excipients hydrophiles et compositions preparees selon ces procedes
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
EP1107743B1 (fr) * 1998-08-25 2007-06-27 Advanced Inhalation Research, Inc. Formulations proteiques atomisees stables
EP1767195A3 (fr) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Formulations de protéines stables séchées par pulvérisation
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
JP2002529394A (ja) * 1998-11-10 2002-09-10 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 肺サーファクタント組成物を含有する治療セット
EP1189625A1 (fr) * 1999-06-11 2002-03-27 Byk Gulden Lomberg Chemische Fabrik GmbH Preparation pharmaceutique contenant des modifications de la proteine b du surfactant (sp-b) et de la proteine c du surfactant (sp-c)
US6749835B1 (en) * 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
ATE285755T1 (de) * 1999-08-25 2005-01-15 Advanced Inhalation Res Inc Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
EP1216052A1 (fr) 1999-09-16 2002-06-26 Byk Gulden Lomberg Chemische Fabrik GmbH Combinaison de c1-inh et d'un agent tensioactif pulmonaire pour le traitement des troubles respiratoires
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
CA2382133C (fr) † 2000-05-10 2010-11-23 Alliance Pharmaceutical Corporation Poudres a base de phospholipides permettant de distribuer un medicament
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
JP4559731B2 (ja) 2001-10-11 2010-10-13 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタントの新規使用
AU2002346472A1 (en) * 2001-11-20 2003-06-10 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
CA2465675C (fr) 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Compositions particulaires ameliorees destinees a etre administrees par voie pulmonaire
WO2003053411A1 (fr) 2001-12-19 2003-07-03 Nektar Therapeutics Administration pulmonaire d'aminoglycosides
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
EP1486204A1 (fr) * 2002-03-18 2004-12-15 Yamanouchi Pharmaceutical Co. Ltd. Compositions medicales en poudre pour inhalation et procede de production de celles-ci
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
EP1755720A1 (fr) * 2004-05-20 2007-02-28 Discovery Laboratories, Inc. Procedes, systemes et dispositifs destines a une administration pulmonaire non invasive
EP1781323B1 (fr) * 2004-08-06 2010-02-17 Nycomed GmbH Composition comprenant un tensioactif pulmonaire et un peptide derive de tnf
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
CN101094651B (zh) * 2004-12-30 2011-03-09 多贝尔有限公司 含有胶原凝集素家族蛋白质或者其变体的喷雾干燥的组合物和其制备方法
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (fr) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Nouveaux peptides et leur utilisation pour le traitement de l'oedème
RU2463084C2 (ru) 2008-03-17 2012-10-10 Дискавери Лабораториз, Инк. Адаптер дыхательного контура и система проксимальной доставки аэрозоля
EP2179760B1 (fr) 2008-10-22 2013-02-27 Trudell Medical International Système modulaire d'administration d'un aérosol
EP2370068A4 (fr) 2008-12-10 2015-09-23 Paka Pulmonary Pharmaceuticals Inc Procédés et compositions pour la délivrance de médicaments aux poumons
PT2410981T (pt) * 2009-03-26 2017-05-25 Pulmatrix Inc Formulações em pó seco e métodos para tratar doenças pulmonares
EP2308489B1 (fr) 2009-10-05 2014-01-01 Nutri-Fit GmbH & Co. KG Compositions pour une utilisation dans le traitement ou la prévention des maladies pulmonaires induites par le stress métabolique et procédés pour augmenter la capacité physique du bétail mammifère
EA201300255A1 (ru) 2010-08-23 2013-06-28 Такеда Гмбх Увлажненные частицы, содержащие терапевтически активное вещество
EP2837377A1 (fr) 2012-03-28 2015-02-18 Discovery Laboratories, Inc. Lyophilisation de tensioactif pulmonaire liposomale synthétique
BR112016020519B1 (pt) 2014-03-05 2021-11-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Dispositivo para fornecer um aerossol a partir de um material aerossolizável e sistema de controle
CN106163600B (zh) 2014-03-05 2019-03-22 弗劳恩霍夫应用研究促进协会 用于对气溶胶进行加湿的加湿器
JP6397984B2 (ja) * 2014-03-18 2018-09-26 アペプティコ・フォルシュング・ウント・エントヴィックルング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＡｐｅｐｔｉｃｏ Ｆｏｒｓｃｈｕｎｇ Ｕｎｄ Ｅｎｔｗｉｃｋｌｕｎｇ Ｇｍｂｈ 乾燥粉末ペプチド医薬
AU2017281931B2 (en) * 2016-06-24 2023-02-02 Merz Pharmaceuticals, Llc Surfactant formulations for inhalation
AU2018392458B2 (en) * 2017-12-21 2025-06-26 Merz Pharmaceuticals, Llc Surfactant formulations for inhalation
EP3727353A4 (fr) * 2017-12-21 2021-10-13 Civitas Therapeutics, Inc. Formulations de tensioactifs pour l'inhalation

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JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) * 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
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KR0181309B1 (ko) 1990-10-17 1999-03-20 알렌 불룸 합성 폐 계면활성제
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0655237A1 (fr) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Composition d'aerosol medicinal
ATE264096T1 (de) 1994-03-07 2004-04-15 Nektar Therapeutics Verfahren und mittel zur verabreichung von insulin über die lunge
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
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US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
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GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
EP1107743B1 (fr) 1998-08-25 2007-06-27 Advanced Inhalation Research, Inc. Formulations proteiques atomisees stables

Also Published As

Publication number Publication date
EP0877602A1 (fr) 1998-11-18
DK0877602T3 (da) 2002-05-06
PT877602E (pt) 2002-07-31
CA2244767C (fr) 2005-11-22
UA59358C2 (uk) 2003-09-15
US6315983B1 (en) 2001-11-13
DE59706180D1 (de) 2002-03-14
JP2000503976A (ja) 2000-04-04
ES2171883T3 (es) 2002-09-16
TR199801408T2 (xx) 1998-10-21
CZ233898A3 (cs) 1999-02-17
JP3725166B2 (ja) 2005-12-07
WO1997026863A1 (fr) 1997-07-31
EP0877602B1 (fr) 2002-01-23
KR19990081886A (ko) 1999-11-15
CZ292186B6 (cs) 2003-08-13
CA2244767A1 (fr) 1997-07-31
KR100449789B1 (ko) 2005-02-03
ATE212220T1 (de) 2002-02-15

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