CY1123999T1 - Φαρμακευτικη συνθεση που περιεχει νικοτινικο οξυ ή/και νικοτιναμιδιο ή/και τρυπτοφανη για να επηρεαστει θετικα η εντερικη μικροβιοκοινοτητα - Google Patents
Φαρμακευτικη συνθεση που περιεχει νικοτινικο οξυ ή/και νικοτιναμιδιο ή/και τρυπτοφανη για να επηρεαστει θετικα η εντερικη μικροβιοκοινοτηταInfo
- Publication number
- CY1123999T1 CY1123999T1 CY20211100172T CY211100172T CY1123999T1 CY 1123999 T1 CY1123999 T1 CY 1123999T1 CY 20211100172 T CY20211100172 T CY 20211100172T CY 211100172 T CY211100172 T CY 211100172T CY 1123999 T1 CY1123999 T1 CY 1123999T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical composition
- nicotinamide
- composition containing
- nicotinic acid
- intestinal
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αφορά νέα φαρμακευτική σύνθεση που περιέχει νικοτινικό οξύ, νικοτιναμίδιο, τρυπτοφάνη ή σχετικές ενώσεις νια να επηρεαστεί θετικά η εντερική μικροβιοκοινότητα. Σε ορισμένες εφαρμογές, η φαρμακευτική σύνθεση αποδεσμεύεται εν μέρει ή εξ ολοκλήρου εντός του λεπτού εντέρου ή του παχέος εντέρου.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012011890 | 2012-06-15 | ||
| PCT/EP2013/062363 WO2013186355A1 (en) | 2012-06-15 | 2013-06-14 | A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123999T1 true CY1123999T1 (el) | 2022-05-27 |
Family
ID=47002494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100172T CY1123999T1 (el) | 2012-06-15 | 2021-03-02 | Φαρμακευτικη συνθεση που περιεχει νικοτινικο οξυ ή/και νικοτιναμιδιο ή/και τρυπτοφανη για να επηρεαστει θετικα η εντερικη μικροβιοκοινοτητα |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10426765B2 (el) |
| EP (2) | EP3831379B1 (el) |
| JP (3) | JP6855165B2 (el) |
| KR (2) | KR20150021071A (el) |
| CN (2) | CN108273064A (el) |
| AR (1) | AR091465A1 (el) |
| AU (1) | AU2013276451B2 (el) |
| BR (1) | BR112014030835B1 (el) |
| CA (1) | CA2876540C (el) |
| CY (1) | CY1123999T1 (el) |
| DK (1) | DK2861229T3 (el) |
| ES (1) | ES2859758T3 (el) |
| HR (1) | HRP20210090T1 (el) |
| HU (1) | HUE053359T2 (el) |
| IL (1) | IL236205B (el) |
| IN (1) | IN2014DN10260A (el) |
| JO (1) | JO3578B1 (el) |
| LT (1) | LT2861229T (el) |
| MX (1) | MX370795B (el) |
| NZ (1) | NZ702297A (el) |
| PH (1) | PH12014502744A1 (el) |
| PL (1) | PL2861229T3 (el) |
| PT (1) | PT2861229T (el) |
| RS (1) | RS61288B1 (el) |
| RU (1) | RU2657797C2 (el) |
| SA (1) | SA113340643B1 (el) |
| SG (1) | SG11201408251SA (el) |
| SI (1) | SI2861229T1 (el) |
| SM (1) | SMT202100248T1 (el) |
| TW (1) | TWI624260B (el) |
| WO (1) | WO2013186355A1 (el) |
| ZA (1) | ZA201408922B (el) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2859758T3 (es) | 2012-06-15 | 2021-10-04 | Conaris Res Institute Ag | Una composición farmacéutica que contiene ácido nicotínico y/o nicotinamida y/o triptófano para influir positivamente en la microbiota intestinal |
| RU2726416C2 (ru) | 2013-06-05 | 2020-07-14 | Ти Юниверсити Оф Бритиш Коламбиа | Антифиброгенные соединения, способы и их применение |
| EP3007680B1 (en) | 2013-06-14 | 2020-02-19 | CONARIS research institute AG | Extended release nicotinamide formulation |
| HUE048488T2 (hu) | 2013-12-13 | 2020-07-28 | Conaris Res Institute Ag | Nikotinsavat és/vagy nikotinamidot tartalmazó gyógyászati készítmény a vérlipid szint jótékony hatású befolyására történõ alkalmazásra a bélrendszeri mikrobióta módosításával |
| EP2884282A1 (en) | 2013-12-13 | 2015-06-17 | CONARIS research institute AG | Use of tryptophan as a biomarker for patient selection, dosing and therapy monitoring for pharmaceutical compositions targeting the intestinal microbiota in diseases featuring tryptophan deficiency |
| EP3079704B1 (en) | 2013-12-13 | 2019-01-02 | CONARIS research institute AG | A pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation |
| WO2015124637A1 (en) * | 2014-02-18 | 2015-08-27 | Conaris Research Institute Ag | Methods and compositions for intestinal microenvironment transfer |
| EA031758B1 (ru) * | 2014-05-12 | 2019-02-28 | Юнилевер Н.В. | Ниацинамид для стимуляции продуцирования антимикробных пептидов |
| CN105287561A (zh) * | 2015-11-25 | 2016-02-03 | 上海交通大学医学院附属瑞金医院 | 一种治疗溃疡性结肠炎的药物组合物 |
| US10857172B2 (en) * | 2016-04-14 | 2020-12-08 | Chromadex, Inc. | Use of nicotinamide riboside, nicotinic acid riboside, and nicotinamide mononucleotide, reduced nicotinyl compounds, and nicotinoyl compound derivatives in infant formula for healthy development |
| TW201740932A (zh) | 2016-04-19 | 2017-12-01 | 菲林公司 | 美沙拉 的口服醫藥組成物 |
| BR112018071363A2 (pt) * | 2016-04-19 | 2019-02-05 | Ferring Bv | composições farmacêuticas orais de nicotinamida |
| CN109718234A (zh) * | 2017-10-31 | 2019-05-07 | 中国农业大学 | L-色氨酸在缓解肠道炎症反应和屏障功能紊乱中的应用 |
| CN108935981A (zh) * | 2018-06-05 | 2018-12-07 | 西北农林科技大学 | 围产期奶山羊添加烟酰胺对羔羊糖脂代谢的影响及其机制 |
| CN113438896B (zh) * | 2019-02-12 | 2024-10-29 | 田中惠 | 婴幼儿食品或饮料、用于改善婴幼儿肠道环境的方法和用于增强婴幼儿免疫力的方法 |
| CN113573777A (zh) * | 2019-03-28 | 2021-10-29 | 国立大学法人东北大学 | 癌的预防或治疗剂 |
| CN113398130A (zh) * | 2020-03-16 | 2021-09-17 | 广州市妇女儿童医疗中心（广州市妇幼保健院、广州市儿童医院、广州市妇婴医院、广州市妇幼保健计划生育服务中心） | 烟酰胺用于预防和治疗胃肠道功能紊乱的用途 |
| EP4251157A1 (en) * | 2020-11-27 | 2023-10-04 | CONARIS research institute AG | Nicotinamide, nicotinamide precursors and nicotinamide metabolites and compositions thereof for reducing the time to resolution of symptoms in patients with covid-19 and other viral infections |
| CN116635025A (zh) * | 2020-11-27 | 2023-08-22 | 康纳里斯研究院股份公司 | 用于缩短covid-19和其他病毒感染患者的症状消退时间的烟酰胺、烟酰胺前体和烟酰胺代谢物及其组合物 |
| TW202308605A (zh) * | 2021-07-19 | 2023-03-01 | 日商明治控股股份有限公司 | 用於炎症性腸疾病之預防或改善之組合物、以及用於腸內細菌叢調節之組合物 |
| EP4499059A1 (en) * | 2022-03-30 | 2025-02-05 | CONARIS research institute AG | Composition comprising nicotinamide, nicotinamide precursors, nicotinamide metabolites or combinations thereof for preventing or reducing one or more post-acute symptoms of infectious diseases |
| KR102789810B1 (ko) | 2023-02-06 | 2025-03-31 | 한림대학교 산학협력단 | 아토피 피부염 진단용 바이오마커 |
| CN117837697A (zh) * | 2023-12-22 | 2024-04-09 | 汕头大学 | 一种烟酰胺的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| DE19524928A1 (de) * | 1995-07-08 | 1997-01-09 | Basf Ag | Verfahren zur Rektifikation von Gemischen hochsiedender luft- und/oder temperaturempfindlicher Substanzen, die eine hohe Trennleistung erfordern, im Feinvakuum, sowie für dieses Verfahren geeignete Kolonnen |
| US5846983A (en) * | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5736532A (en) * | 1996-02-14 | 1998-04-07 | Furda; Ivan | Multifunctional fat absorption and blood cholesterol reducing formulation comprising chitosan |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| CZ20012343A3 (cs) * | 1998-12-23 | 2001-12-12 | G. D. Searle Llc | Kombinace inhibitorů transportu ľlučové kyseliny v ileu a derivátů kyseliny nikotinové pro kardiovaskulární indikace |
| US6713057B1 (en) | 1999-02-24 | 2004-03-30 | The Johns Hopkins University | Compositions and methods for modulating serum cholesterol |
| GB0015242D0 (en) | 2000-06-22 | 2000-08-16 | Nycomed Amersham Plc | Stabiliser for radiopharmaceuticals |
| AU2001278699A1 (en) | 2000-08-08 | 2002-02-18 | Shionogi And Co., Ltd. | Inflammatory cytokine production inhibitors |
| US20040185097A1 (en) | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| EP1722630A4 (en) | 2004-01-20 | 2009-05-27 | Richard F Harty | COMPOSITIONS AND METHOD FOR THE TREATMENT OF INFLAMMATORY DISEASES |
| US20060264409A1 (en) | 2004-01-20 | 2006-11-23 | Harty Richard F | Compositions and methods of treatment for inflammatory diseases |
| CA2565993C (en) | 2004-05-27 | 2011-08-16 | Antibe Therapeutics Inc. | Salt of 4-or 5- aminosalicylic acid |
| DE602005010899D1 (de) * | 2004-09-27 | 2008-12-18 | Sigmoid Pharma Ltd | Mikrokapseln mit einem methylxanthin und einem kortikosteroid |
| WO2007004613A1 (ja) * | 2005-07-01 | 2007-01-11 | Ajinomoto Co., Inc. | 炎症性腸疾患治療薬及びＴＮＦ－α産生抑制剤 |
| CA2657606A1 (en) * | 2006-03-08 | 2007-09-13 | Cortria Corporation | Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries |
| ITMI20061932A1 (it) * | 2006-10-09 | 2008-04-10 | Carlo Ghisalberti | Complessi a trasferimento di carica per uso medicale |
| EP1935422A1 (en) * | 2006-12-20 | 2008-06-25 | PEJO Iserlohn Heilmittel-und Diät-GmbH & Co.KG | Pharmaceutical composition comprising nicotinamide or nicotinic acid |
| US20090104171A1 (en) * | 2007-10-19 | 2009-04-23 | Pardee Joel D | Metabolic Enhancement Therapy |
| WO2009131537A1 (en) * | 2008-04-25 | 2009-10-29 | Karolinska Institutet Innovations Ab | New therapy of treatment of the irritable bowel syndrome. |
| WO2009142731A2 (en) * | 2008-05-20 | 2009-11-26 | Cerenis Therapeutics S.A. | Niacin and nsaid combination therapy |
| BRPI0913425A2 (pt) * | 2008-06-02 | 2015-11-24 | Reddys Lab Ltd Dr | formulações de niacina com liberação modificada |
| CN102238868A (zh) | 2008-10-03 | 2011-11-09 | 福尔克博士药物有限责任公司 | 使用颗粒状5-氨基水杨酸治疗肠病的组合物和方法 |
| JP2011121889A (ja) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用アミノ酸組成物 |
| JP2012102054A (ja) * | 2010-11-11 | 2012-05-31 | Kyodo Milk Industry Co Ltd | 腸内ポリアミン増強剤 |
| WO2012090224A1 (en) | 2010-12-29 | 2012-07-05 | Nutracryst Therapeutics Private Limited | Novel cocrystals / molecular salts of mesalamine to be used as improved anti-inflammatory drug |
| ES2859758T3 (es) | 2012-06-15 | 2021-10-04 | Conaris Res Institute Ag | Una composición farmacéutica que contiene ácido nicotínico y/o nicotinamida y/o triptófano para influir positivamente en la microbiota intestinal |
| EP3007680B1 (en) | 2013-06-14 | 2020-02-19 | CONARIS research institute AG | Extended release nicotinamide formulation |
| BR112018071363A2 (pt) | 2016-04-19 | 2019-02-05 | Ferring Bv | composições farmacêuticas orais de nicotinamida |
| EP4251157A1 (en) * | 2020-11-27 | 2023-10-04 | CONARIS research institute AG | Nicotinamide, nicotinamide precursors and nicotinamide metabolites and compositions thereof for reducing the time to resolution of symptoms in patients with covid-19 and other viral infections |
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