CY1122818T1 - Παραγωγα 3-((ετερο-)αρυλ)-αλκυλ-8-αμινο-2-οξο-1,3-διαζα- σπε1ρο-[4.5]-δεκανιου - Google Patents
Παραγωγα 3-((ετερο-)αρυλ)-αλκυλ-8-αμινο-2-οξο-1,3-διαζα- σπε1ρο-[4.5]-δεκανιουInfo
- Publication number
- CY1122818T1 CY1122818T1 CY20201100402T CY201100402T CY1122818T1 CY 1122818 T1 CY1122818 T1 CY 1122818T1 CY 20201100402 T CY20201100402 T CY 20201100402T CY 201100402 T CY201100402 T CY 201100402T CY 1122818 T1 CY1122818 T1 CY 1122818T1
- Authority
- CY
- Cyprus
- Prior art keywords
- diaza
- hetero
- oxo
- aryl
- amino
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αφορά παράγωγα 3-((ετερο-)αρυλ)-αλκυλ-8-αμινο-2-οξο-1,3-διαζα-σπειρο-[4.5]-δεκανίου, την παρασκευή και χρήση αυτών στην ιατρική, συγκεκριμένα στην αγωγή του πόνου.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151013 | 2016-01-13 | ||
| PCT/EP2017/025006 WO2017121648A1 (en) | 2016-01-13 | 2017-01-13 | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122818T1 true CY1122818T1 (el) | 2021-05-05 |
Family
ID=55129634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100402T CY1122818T1 (el) | 2016-01-13 | 2020-05-04 | Παραγωγα 3-((ετερο-)αρυλ)-αλκυλ-8-αμινο-2-οξο-1,3-διαζα- σπε1ρο-[4.5]-δεκανιου |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US20170197947A1 (el) |
| EP (1) | EP3402784B1 (el) |
| JP (1) | JP6893517B2 (el) |
| KR (1) | KR20180098369A (el) |
| CN (1) | CN108602777B (el) |
| AR (1) | AR107360A1 (el) |
| AU (1) | AU2017206909B2 (el) |
| BR (1) | BR112018014303B1 (el) |
| CA (1) | CA3011177A1 (el) |
| CL (1) | CL2018001912A1 (el) |
| CO (1) | CO2018008444A2 (el) |
| CY (1) | CY1122818T1 (el) |
| DK (1) | DK3402784T3 (el) |
| EA (1) | EA037481B1 (el) |
| EC (1) | ECSP18060848A (el) |
| ES (1) | ES2797904T3 (el) |
| HR (1) | HRP20200837T1 (el) |
| HU (1) | HUE049813T2 (el) |
| IL (1) | IL260491B (el) |
| LT (1) | LT3402784T (el) |
| MX (1) | MX378994B (el) |
| PE (1) | PE20181375A1 (el) |
| PL (1) | PL3402784T3 (el) |
| PT (1) | PT3402784T (el) |
| RS (1) | RS60315B1 (el) |
| SI (1) | SI3402784T1 (el) |
| TW (1) | TWI636048B (el) |
| WO (1) | WO2017121648A1 (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017121649A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| PE20221732A1 (es) * | 2016-01-13 | 2022-11-07 | Gruenenthal Chemie | Derivados de 3-((hetero)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| RS60223B1 (sr) | 2016-01-13 | 2020-06-30 | Gruenenthal Gmbh | Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| ES2797904T3 (es) | 2016-01-13 | 2020-12-04 | Gruenenthal Gmbh | Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano |
| BR112018014301B1 (pt) | 2016-01-13 | 2023-10-31 | Grünenthal GmbH | Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| KR102798145B1 (ko) | 2018-04-18 | 2025-04-22 | 콘스텔레이션 파마슈티칼스, 인크. | 메틸 변형 효소 조절제, 이의 조성물 및 용도 |
| CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP7446316B2 (ja) | 2019-01-11 | 2024-03-08 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換ピロリジンアミドｉｉｉ |
| GB201905721D0 (en) | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
| KR20250141712A (ko) * | 2022-12-28 | 2025-09-29 | 길가메쉬 파마슈티컬스, 인코포레이티드 | 2-페닐-2-아미노-시클로헥산-1-온 유도체의 합성 |
| US20240400537A1 (en) | 2023-04-25 | 2024-12-05 | Gruenenthal Gmbh | Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| AU2002303406B2 (en) | 2001-04-18 | 2006-03-30 | Euro-Celtique S.A. | Nociceptin analogs |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| DE60330456D1 (de) | 2002-07-05 | 2010-01-21 | Targacept Inc | N-aryl diazaspirozyklische verbindungen, deren verwendung und das verfahren zu ihren herstellung |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| US20080287478A1 (en) | 2003-05-23 | 2008-11-20 | Lars Bo Laurenborg Hansen | Nociceptin Analogues and Uses Thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| CA2666489C (en) | 2006-10-19 | 2012-10-02 | F. Hoffmann-La Roche Ag | Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes |
| US8741916B2 (en) | 2007-04-09 | 2014-06-03 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor |
| EP2502907B1 (de) * | 2008-03-27 | 2018-08-29 | Grünenthal GmbH | Substituierte 4-Aminocyclohexan-Derivate |
| WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| EP2938341B1 (en) * | 2012-12-31 | 2018-09-05 | Sunovion Pharmaceuticals Inc. | Heterocyclic compounds and methods of use thereof |
| US10131666B2 (en) | 2014-06-13 | 2018-11-20 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| RS60223B1 (sr) | 2016-01-13 | 2020-06-30 | Gruenenthal Gmbh | Derivati 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| ES2797904T3 (es) | 2016-01-13 | 2020-12-04 | Gruenenthal Gmbh | Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano |
| BR112018014301B1 (pt) | 2016-01-13 | 2023-10-31 | Grünenthal GmbH | Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| RS63298B1 (sr) | 2016-01-13 | 2022-07-29 | Novo Nordisk As | Egf(a) analozi sa supstituentima masnih kiselina |
| PE20221732A1 (es) | 2016-01-13 | 2022-11-07 | Gruenenthal Chemie | Derivados de 3-((hetero)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| WO2017121649A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
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2017
- 2017-01-13 ES ES17701638T patent/ES2797904T3/es active Active
- 2017-01-13 TW TW106101125A patent/TWI636048B/zh active
- 2017-01-13 EP EP17701638.3A patent/EP3402784B1/en active Active
- 2017-01-13 HU HUE17701638A patent/HUE049813T2/hu unknown
- 2017-01-13 CN CN201780006494.6A patent/CN108602777B/zh active Active
- 2017-01-13 KR KR1020187021562A patent/KR20180098369A/ko active Pending
- 2017-01-13 AU AU2017206909A patent/AU2017206909B2/en not_active Ceased
- 2017-01-13 HR HRP20200837TT patent/HRP20200837T1/hr unknown
- 2017-01-13 US US15/405,896 patent/US20170197947A1/en not_active Abandoned
- 2017-01-13 PL PL17701638T patent/PL3402784T3/pl unknown
- 2017-01-13 JP JP2018536484A patent/JP6893517B2/ja active Active
- 2017-01-13 AR ARP170100095A patent/AR107360A1/es unknown
- 2017-01-13 SI SI201730268T patent/SI3402784T1/sl unknown
- 2017-01-13 EA EA201891609A patent/EA037481B1/ru unknown
- 2017-01-13 RS RS20200585A patent/RS60315B1/sr unknown
- 2017-01-13 WO PCT/EP2017/025006 patent/WO2017121648A1/en not_active Ceased
- 2017-01-13 PE PE2018001302A patent/PE20181375A1/es unknown
- 2017-01-13 LT LTEP17701638.3T patent/LT3402784T/lt unknown
- 2017-01-13 MX MX2018008644A patent/MX378994B/es unknown
- 2017-01-13 BR BR112018014303-0A patent/BR112018014303B1/pt not_active IP Right Cessation
- 2017-01-13 CA CA3011177A patent/CA3011177A1/en active Pending
- 2017-01-13 DK DK17701638.3T patent/DK3402784T3/da active
- 2017-01-13 PT PT177016383T patent/PT3402784T/pt unknown
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2018
- 2018-05-21 US US15/984,919 patent/US20180327392A1/en not_active Abandoned
- 2018-07-09 IL IL260491A patent/IL260491B/en unknown
- 2018-07-13 CL CL2018001912A patent/CL2018001912A1/es unknown
- 2018-08-13 CO CONC2018/0008444A patent/CO2018008444A2/es unknown
- 2018-08-13 EC ECSENADI201860848A patent/ECSP18060848A/es unknown
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2019
- 2019-02-01 US US16/265,080 patent/US10829480B2/en active Active
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2020
- 2020-05-04 CY CY20201100402T patent/CY1122818T1/el unknown
- 2020-08-31 US US17/007,258 patent/US20200399252A1/en not_active Abandoned
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2021
- 2021-03-01 US US17/188,743 patent/US20210179592A1/en not_active Abandoned
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2023
- 2023-01-30 US US18/103,180 patent/US20230174520A1/en not_active Abandoned
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