CY1119537T1 - Ρυθμιστες υποδοχεα cxcr 7 - Google Patents
Ρυθμιστες υποδοχεα cxcr 7Info
- Publication number
- CY1119537T1 CY1119537T1 CY20171101149T CY171101149T CY1119537T1 CY 1119537 T1 CY1119537 T1 CY 1119537T1 CY 20171101149 T CY20171101149 T CY 20171101149T CY 171101149 T CY171101149 T CY 171101149T CY 1119537 T1 CY1119537 T1 CY 1119537T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cxcr
- regulators
- receiver
- formula
- pharmaceuticals
- Prior art date
Links
- 102100022716 Atypical chemokine receptor 3 Human genes 0.000 abstract 1
- 101000678890 Homo sapiens Atypical chemokine receptor 3 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με παράγωγα του Χημικού τύπου (I) όπου τα (R1)n, R2a, R2b, R3a, R3b, R4, L1, L2, Χ, Υ και Ar1 είναι όπως περιγράφονται στην περιγραφή, με την παρασκευή τους, με φαρμακευτικά αποδεκτά άλατα αυτών, και με τη χρήση τους ως φαρμακευτικές ουσίες, με φαρμακευτικές συνθέσεις που περιέχουν μια ή περισσότερες ενώσεις του χημικού τύπου (I), και ιδίως με τη χρήση τους ως ρυθμιστές του υποδοχέα CXCR7.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013054478 | 2013-05-30 | ||
| PCT/IB2014/061774 WO2014191929A1 (en) | 2013-05-30 | 2014-05-28 | Cxcr7 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119537T1 true CY1119537T1 (el) | 2018-03-07 |
Family
ID=50943357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171101149T CY1119537T1 (el) | 2013-05-30 | 2017-11-02 | Ρυθμιστες υποδοχεα cxcr 7 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9920010B2 (el) |
| EP (1) | EP3004082B1 (el) |
| JP (1) | JP6393749B2 (el) |
| KR (1) | KR102302580B1 (el) |
| CN (1) | CN105263924B (el) |
| AR (1) | AR096490A1 (el) |
| AU (1) | AU2014272718B2 (el) |
| BR (1) | BR112015030095B1 (el) |
| CA (1) | CA2912133C (el) |
| CL (1) | CL2015003470A1 (el) |
| CY (1) | CY1119537T1 (el) |
| DK (1) | DK3004082T3 (el) |
| EA (1) | EA028604B1 (el) |
| ES (1) | ES2645470T3 (el) |
| HR (1) | HRP20171597T1 (el) |
| HU (1) | HUE036649T2 (el) |
| IL (1) | IL242782B (el) |
| LT (1) | LT3004082T (el) |
| MA (1) | MA38679B1 (el) |
| MX (1) | MX364104B (el) |
| MY (1) | MY173564A (el) |
| NO (1) | NO3004082T3 (el) |
| PH (1) | PH12015502632A1 (el) |
| PL (1) | PL3004082T3 (el) |
| PT (1) | PT3004082T (el) |
| SG (1) | SG11201509057UA (el) |
| SI (1) | SI3004082T1 (el) |
| TW (1) | TWI640510B (el) |
| UA (1) | UA118562C2 (el) |
| WO (1) | WO2014191929A1 (el) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR091516A1 (es) | 2012-06-22 | 2015-02-11 | Actelion Pharmaceuticals Ltd | Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida |
| CA2963447A1 (en) | 2014-12-01 | 2016-06-09 | Actelion Pharmaceuticals Ltd | Cxcr7 receptor modulators |
| US20170112831A1 (en) * | 2015-10-23 | 2017-04-27 | James MERRITT | Use of ccr1 antagonists as a treatment for tumors of the central nervous system |
| SI3798217T1 (sl) * | 2016-07-28 | 2023-05-31 | Idorsia Pharmaceuticals Ltd | Piperidinski modulatorji cxcr7 receptorja |
| PE20191811A1 (es) | 2017-05-18 | 2019-12-26 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| PE20191814A1 (es) | 2017-05-18 | 2019-12-27 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| RS65594B1 (sr) | 2018-01-26 | 2024-06-28 | Idorsia Pharmaceuticals Ltd | Kristalni oblici antagonista cxcr7 receptora (1-pirimidin-2-il-ciklopropil)-amida (3s,4s)-1-ciklopropilmetil-4-{[5-(2,4-difluoro-fenil)-izoksazol-3-karbonil]-amino}-piperidin-3-karboksilne kiseline |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896170A (en) | 1969-02-26 | 1975-07-22 | American Home Prod | Intermediates for the preparation of 1,3-dihydro-2h-1, -benzodiazepin-2-ones |
| IL137720A0 (en) | 1998-02-18 | 2001-10-31 | Neurosearch As | Compounds and their use as positive ampa receptor modulators |
| GB9816984D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
| JP2004515494A (ja) | 2000-12-07 | 2004-05-27 | アストラゼネカ・アクチエボラーグ | 治療剤 |
| DE60327106D1 (de) * | 2002-12-20 | 2009-05-20 | Chemocentryx Inc | Inhibitoren der bindungder chemokine i-tac bzw. sdf-1 an den ccxckr2-rezeptor |
| DK1954274T3 (da) * | 2005-11-10 | 2011-01-31 | Chemocentryx Inc | Substituerede quinoloner og fremgangsmåder til anvendelse |
| WO2009076404A1 (en) | 2007-12-10 | 2009-06-18 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
| AR091516A1 (es) | 2012-06-22 | 2015-02-11 | Actelion Pharmaceuticals Ltd | Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida |
| CA2963447A1 (en) | 2014-12-01 | 2016-06-09 | Actelion Pharmaceuticals Ltd | Cxcr7 receptor modulators |
-
2014
- 2014-05-28 MY MYPI2015704311A patent/MY173564A/en unknown
- 2014-05-28 NO NO14730591A patent/NO3004082T3/no unknown
- 2014-05-28 UA UAA201512741A patent/UA118562C2/uk unknown
- 2014-05-28 EA EA201501163A patent/EA028604B1/ru not_active IP Right Cessation
- 2014-05-28 LT LTEP14730591.6T patent/LT3004082T/lt unknown
- 2014-05-28 JP JP2016516287A patent/JP6393749B2/ja not_active Expired - Fee Related
- 2014-05-28 ES ES14730591.6T patent/ES2645470T3/es active Active
- 2014-05-28 SI SI201430415T patent/SI3004082T1/sl unknown
- 2014-05-28 HU HUE14730591A patent/HUE036649T2/hu unknown
- 2014-05-28 EP EP14730591.6A patent/EP3004082B1/en active Active
- 2014-05-28 BR BR112015030095-2A patent/BR112015030095B1/pt not_active IP Right Cessation
- 2014-05-28 WO PCT/IB2014/061774 patent/WO2014191929A1/en not_active Ceased
- 2014-05-28 CN CN201480030766.2A patent/CN105263924B/zh not_active Expired - Fee Related
- 2014-05-28 MX MX2015016429A patent/MX364104B/es active IP Right Grant
- 2014-05-28 KR KR1020157036801A patent/KR102302580B1/ko not_active Expired - Fee Related
- 2014-05-28 AU AU2014272718A patent/AU2014272718B2/en not_active Ceased
- 2014-05-28 SG SG11201509057UA patent/SG11201509057UA/en unknown
- 2014-05-28 PT PT147305916T patent/PT3004082T/pt unknown
- 2014-05-28 DK DK14730591.6T patent/DK3004082T3/en active
- 2014-05-28 PL PL14730591T patent/PL3004082T3/pl unknown
- 2014-05-28 CA CA2912133A patent/CA2912133C/en active Active
- 2014-05-28 US US14/892,959 patent/US9920010B2/en active Active
- 2014-05-28 MA MA38679A patent/MA38679B1/fr unknown
- 2014-05-28 HR HRP20171597TT patent/HRP20171597T1/hr unknown
- 2014-05-29 TW TW103118884A patent/TWI640510B/zh not_active IP Right Cessation
- 2014-05-29 AR ARP140102121A patent/AR096490A1/es active IP Right Grant
-
2015
- 2015-11-25 IL IL242782A patent/IL242782B/en active IP Right Grant
- 2015-11-26 PH PH12015502632A patent/PH12015502632A1/en unknown
- 2015-11-27 CL CL2015003470A patent/CL2015003470A1/es unknown
-
2017
- 2017-11-02 CY CY20171101149T patent/CY1119537T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1119537T1 (el) | Ρυθμιστες υποδοχεα cxcr 7 | |
| CY1125016T1 (el) | Διαμορφωτες υποδοχεα πιπεριδινης cxcr7 | |
| CY1118735T1 (el) | Παραγωγα βενζιμιδαζολο-προλινης | |
| CY1121867T1 (el) | Αναστολεις jak2 και alk2 και μεθοδοι για τη χρηση τους | |
| NI201700096A (es) | Derivados de 4h-pirrol[3, 2-c]piridin-4-ona | |
| CY1119953T1 (el) | Yποκατεστημενες πυριδοπυραζινες ως προτυποι syk ανοστολεις | |
| CY1119387T1 (el) | Τριαζολοπυραζινες ως αναστολεις brd4 για χρηση στην αντιμετωπιση καρκινου | |
| CY1118379T1 (el) | Αναστολεις ιου ηπατιτιδας c | |
| JO3674B1 (ar) | مشتقات ثنائية الحلقة جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها | |
| CY1117638T1 (el) | Παραγωγα του 2-(1,2,3-τριαζολ-2-υλο)βενζαμιδιου και του 3-(1,2,3-τριαζολ-2-υλο)πικολιναμιδιου ως ανταγωνιστες του υποδοχεα της ορεξινης | |
| CY1121137T1 (el) | Φαρμακευτικα σκευασματα που περιλαμβανουν ανταγωνιστες ccr3 | |
| MX373716B (es) | Compuesto de pirazol-amida y sus usos farmaceuticos. | |
| CY1121361T1 (el) | Παραγωγα υδροξυαλκυλ πιπεραζινης ως ρυθμιστες υποδοχεα cxcr3 | |
| CY1120008T1 (el) | Βενζαμιδια | |
| ECSP18074962A (es) | Derivados de aminotiazol útiles como agentes antivíricos | |
| CY1116004T1 (el) | Παραγωγα οξαζολυλ-μεθυλαιθερα ως αγωνιστες υποδοχεα alx | |
| CY1122496T1 (el) | Παραγωγα αιμινης με αντιβακτηριακη και αντιιικη δραστικοτητα | |
| CY1117210T1 (el) | Παραγωγα 2-οξο-1-ιμιδαζολιδινυλ ιμιδαζοθειαδιαζολης | |
| TR201901977T4 (tr) | Cxcr3 reseptörü modülatörleri olarak (r)-2-metil-piperazin türevleri. | |
| CY1120101T1 (el) | Παραγωγο πυριδονης και φαρμακο που το περιεχει | |
| TH158992A (th) | อนุพันธ์เบนซิมิดาโซล-โปรลีน | |
| UA112586C2 (uk) | Похідні бензімідазолпроліну |