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CY1119466T1 - Παραγωγα ιμιδαζοθειαδιαζολης και ιμιδαζοπυραζινης ως αναστολεις του ενεργοποιουμενου απο πρωτεαση υποδοχεα 4 (par 4) για αγωγη συσσωματωσης αιμοπεταλιων - Google Patents

Παραγωγα ιμιδαζοθειαδιαζολης και ιμιδαζοπυραζινης ως αναστολεις του ενεργοποιουμενου απο πρωτεαση υποδοχεα 4 (par 4) για αγωγη συσσωματωσης αιμοπεταλιων

Info

Publication number
CY1119466T1
CY1119466T1 CY20171101023T CY171101023T CY1119466T1 CY 1119466 T1 CY1119466 T1 CY 1119466T1 CY 20171101023 T CY20171101023 T CY 20171101023T CY 171101023 T CY171101023 T CY 171101023T CY 1119466 T1 CY1119466 T1 CY 1119466T1
Authority
CY
Cyprus
Prior art keywords
inhibitors
imidazothiadiazole
par
action
activated protease
Prior art date
Application number
CY20171101023T
Other languages
English (en)
Inventor
Jacques Banville
Roger RÉMILLARD
Edward H. Ruediger
Daniel H. Deon
Marc Gagnon
Laurence DUBÉ
Julia GUY
Eldon Scott Priestley
Shoshana L. POSY
Brad D. MAXWELL
Pancras C. Wong
Michael R. Lawrence
Michael M. Miller
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1119466T1 publication Critical patent/CY1119466T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
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Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις θειαζόλης του Χημικού Τύπου I όπου τα W, Υ, R0, R2, R4, R5, R6, R7, Χ1, Χ2, Χ3 και Χ4 είναι όπως καθορίζεται εις το παρόν, ή ένα στερεοϊσομερές, ταυτομερές, φαρμακευτικώς αποδεκτό άλας, εστέρα προφαρμάκου ή μορφή επιδιαλυτωμένου άλατος εξ' αυτών, όπου όλες οι μεταβλητές είναι όπως καθορίζεται εις το παρόν. Αυτές οι ενώσεις είναι αναστολείς της συσσωμάτωσης αιμοπεταλίων και τοιουτοτρόπως μπορούν να χρησιμοποιηθούν ως φάρμακα για αγωγή ή πρόληψη θρομβοεμβολικών διαταραχών.
CY20171101023T 2012-04-26 2017-09-29 Παραγωγα ιμιδαζοθειαδιαζολης και ιμιδαζοπυραζινης ως αναστολεις του ενεργοποιουμενου απο πρωτεαση υποδοχεα 4 (par 4) για αγωγη συσσωματωσης αιμοπεταλιων CY1119466T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261638577P 2012-04-26 2012-04-26
US201361787680P 2013-03-15 2013-03-15
PCT/US2013/037956 WO2013163279A1 (en) 2012-04-26 2013-04-24 Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation

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CY1119466T1 true CY1119466T1 (el) 2018-03-07

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CY20171101023T CY1119466T1 (el) 2012-04-26 2017-09-29 Παραγωγα ιμιδαζοθειαδιαζολης και ιμιδαζοπυραζινης ως αναστολεις του ενεργοποιουμενου απο πρωτεαση υποδοχεα 4 (par 4) για αγωγη συσσωματωσης αιμοπεταλιων
CY20201100069T CY1122625T1 (el) 2012-04-26 2020-01-24 Παραγωγα ιμιδαζοθειαδιαζολης και ιμιδαζοπυραζινης ως αναστολεις του ενεργοποιουμενου απο πρωτεαση υποδοχεα 4 (par4) για αγωγη συσσωματωσης αιμοπεταλιων

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JP6101343B2 (ja) 2012-04-26 2017-03-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 血小板凝集を治療するためのプロテアーゼ活性化受容体４（ｐａｒ４）阻害剤としてのイミダゾチアジアゾールおよびイミダゾピリダジン誘導体
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