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CY1119356T1 - Πυριδινυλ και συντηγμενα παραγωγα πυριδινυλ τριαζολονης - Google Patents

Πυριδινυλ και συντηγμενα παραγωγα πυριδινυλ τριαζολονης

Info

Publication number
CY1119356T1
CY1119356T1 CY20171100458T CY171100458T CY1119356T1 CY 1119356 T1 CY1119356 T1 CY 1119356T1 CY 20171100458 T CY20171100458 T CY 20171100458T CY 171100458 T CY171100458 T CY 171100458T CY 1119356 T1 CY1119356 T1 CY 1119356T1
Authority
CY
Cyprus
Prior art keywords
pyridinyl
producers
synthesis
triazolone
malignancies
Prior art date
Application number
CY20171100458T
Other languages
English (en)
Inventor
John David Lawson
Mark Sabat
Nicholas Scorah
Christopher Smith
Phong H Vu
Haixia Wang
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of CY1119356T1 publication Critical patent/CY1119356T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Αποκαλύπτονται ενώσεις του τύπου 1, ή φαρμακευτικώς αποδεκτά άλατα αυτών, όπου τα R1, R2, R3, και R4 ορίζονται στην προδιαγραφή. Αυτή η αποκάλυψη αφορά επίσης υλικά και μεθόδους για την παρασκευή ενώσεων του τύπου 1, φαρμακευτικές συνθέσεις οι οποίες τα περιέχουν, και τη χρήση αυτών για τη θεραπευτική αγωγή αντιδράσεων υπερευαισθησίας Τύπου I, αυτοάνοσων ασθενειών, φλεγμονωδών διαταραχών, καρκίνου, μη κακοηθών πολλαπλασιαστικών διαταραχών, και άλλων καταστάσεων που συνδέονται με ΒΤΚ.
CY20171100458T 2013-03-11 2017-04-25 Πυριδινυλ και συντηγμενα παραγωγα πυριδινυλ τριαζολονης CY1119356T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776445P 2013-03-11 2013-03-11
PCT/US2014/022801 WO2014164558A1 (en) 2013-03-11 2014-03-10 Pyridinyl and fused pyridinyl triazolone derivatives

Publications (1)

Publication Number Publication Date
CY1119356T1 true CY1119356T1 (el) 2018-02-14

Family

ID=50543655

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100458T CY1119356T1 (el) 2013-03-11 2017-04-25 Πυριδινυλ και συντηγμενα παραγωγα πυριδινυλ τριαζολονης

Country Status (43)

Country Link
US (4) US9402841B2 (el)
EP (2) EP3235814B1 (el)
JP (2) JP6271700B2 (el)
KR (1) KR102300612B1 (el)
CN (1) CN105121427B (el)
AP (1) AP2015008646A0 (el)
AR (1) AR095198A1 (el)
AU (1) AU2014249248B2 (el)
BR (1) BR112015020264B1 (el)
CA (1) CA2899948C (el)
CL (1) CL2015002370A1 (el)
CR (1) CR20150470A (el)
CY (1) CY1119356T1 (el)
DK (1) DK2970202T3 (el)
DO (1) DOP2015000184A (el)
EA (1) EA028584B1 (el)
EC (1) ECSP15042779A (el)
ES (2) ES2624439T3 (el)
GE (1) GEP201706778B (el)
HK (1) HK1245256B (el)
HR (1) HRP20170622T1 (el)
HU (1) HUE032720T2 (el)
IL (1) IL240353B (el)
JO (1) JO3377B1 (el)
LT (1) LT2970202T (el)
MA (1) MA38391B1 (el)
ME (1) ME02693B (el)
MX (1) MX364527B (el)
MY (1) MY183927A (el)
PE (1) PE20151889A1 (el)
PH (1) PH12015502046B1 (el)
PL (1) PL2970202T3 (el)
PT (1) PT2970202T (el)
RS (1) RS55879B1 (el)
SG (1) SG11201506112QA (el)
SI (1) SI2970202T1 (el)
SM (1) SMT201700218T1 (el)
TN (1) TN2015000342A1 (el)
TW (1) TWI637950B (el)
UA (1) UA114944C2 (el)
UY (1) UY35376A (el)
WO (1) WO2014164558A1 (el)
ZA (1) ZA201505996B (el)

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Also Published As

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ECSP15042779A (es) 2017-08-31
TWI637950B (zh) 2018-10-11
PH12015502046A1 (en) 2016-01-18
UY35376A (es) 2014-10-31
US20140256734A1 (en) 2014-09-11
ME02693B (me) 2017-10-20
MA38391A1 (fr) 2018-01-31
SI2970202T1 (sl) 2017-07-31
IL240353A0 (en) 2015-09-24
US10307414B2 (en) 2019-06-04
EP2970202A1 (en) 2016-01-20
BR112015020264A2 (pt) 2017-07-18
MA38391B1 (fr) 2018-09-28
PL2970202T3 (pl) 2017-08-31
DK2970202T3 (en) 2017-05-08
GEP201706778B (en) 2017-11-27
JP2018076357A (ja) 2018-05-17
EA201591686A1 (ru) 2015-12-30
WO2014164558A1 (en) 2014-10-09
PE20151889A1 (es) 2015-12-26
CN105121427B (zh) 2018-04-10
CA2899948C (en) 2021-11-16
AU2014249248A1 (en) 2015-08-20
MX2015011533A (es) 2016-02-03
HK1245256B (en) 2019-09-27
CN105121427A (zh) 2015-12-02
PT2970202T (pt) 2017-05-03
AR095198A1 (es) 2015-09-30
CR20150470A (es) 2016-01-11
TN2015000342A1 (en) 2017-01-03
UA114944C2 (uk) 2017-08-28
HUE032720T2 (en) 2017-10-30
MX364527B (es) 2019-04-30
CA2899948A1 (en) 2014-10-09
JO3377B1 (ar) 2019-03-13
EP3235814A1 (en) 2017-10-25
HK1220183A1 (en) 2017-04-28
EP3235814B1 (en) 2018-12-12
EP2970202B1 (en) 2017-02-01
RS55879B1 (sr) 2017-08-31
AU2014249248B2 (en) 2017-08-17
KR20150126687A (ko) 2015-11-12
US9402841B2 (en) 2016-08-02
JP2016512515A (ja) 2016-04-28
AP2015008646A0 (en) 2015-08-31
US20160310483A1 (en) 2016-10-27
MY183927A (en) 2021-03-17
NZ710852A (en) 2020-12-18
ES2714166T3 (es) 2019-05-27
US20180015083A1 (en) 2018-01-18
HRP20170622T1 (hr) 2017-06-30
PH12015502046B1 (en) 2019-01-23
IL240353B (en) 2018-11-29
US20190224190A1 (en) 2019-07-25
TW201522328A (zh) 2015-06-16
KR102300612B1 (ko) 2021-09-09
US9801872B2 (en) 2017-10-31
SG11201506112QA (en) 2015-09-29
ES2624439T3 (es) 2017-07-14
JP6271700B2 (ja) 2018-01-31
EA028584B1 (ru) 2017-12-29
LT2970202T (lt) 2017-06-12
JP6462842B2 (ja) 2019-01-30
DOP2015000184A (es) 2015-11-30
CL2015002370A1 (es) 2016-03-11
SMT201700218T1 (it) 2017-07-18
ZA201505996B (en) 2016-11-30
BR112015020264B1 (pt) 2021-03-02

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