[go: up one dir, main page]

CY1118267T1 - Μεθοδοι εστιασης και οπτικα συστηματα και διαταξεις που χρησιμοποιουν τα ιδια - Google Patents

Μεθοδοι εστιασης και οπτικα συστηματα και διαταξεις που χρησιμοποιουν τα ιδια

Info

Publication number
CY1118267T1
CY1118267T1 CY20161101111T CY161101111T CY1118267T1 CY 1118267 T1 CY1118267 T1 CY 1118267T1 CY 20161101111 T CY20161101111 T CY 20161101111T CY 161101111 T CY161101111 T CY 161101111T CY 1118267 T1 CY1118267 T1 CY 1118267T1
Authority
CY
Cyprus
Prior art keywords
light beams
catering
provisions
methods
same
Prior art date
Application number
CY20161101111T
Other languages
English (en)
Inventor
Dale Buermann
Alexander P Kindwall
Original Assignee
Illumina, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina, Inc. filed Critical Illumina, Inc.
Publication of CY1118267T1 publication Critical patent/CY1118267T1/el

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/245—Devices for focusing using auxiliary sources, detectors
    • G02B21/247—Differential detectors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/245—Devices for focusing using auxiliary sources, detectors

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Automatic Focus Adjustment (AREA)

Abstract

Μέθοδος για τον έλεγχο της εστίασης ενός οπτικού συστήματος. Η μέθοδος περιλαμβάνει παροχή ζεύγους προσπιπτουσών φωτεινών δεσμών σε συνδεδεμένο φακό. Οι προσπίπτουσες φωτεινές δέσμες κατευθύνονται από το φακό ώστε να συγκλίνουν προς μια εστιακή περιοχή. Η μέθοδος επίσης περιλαμβάνει ανάκλαση των προσπιπτουσών φωτεινών δεσμών με ένα αντικείμενο που τοποθετείται κοντά στην εστιακή περιοχή. Οι ανακλώμενες φωτεινές δέσμες επιστρέφουν στο φακό και διαδίδονται μέσω αυτού. Η μέθοδος επίσης περιλαμβάνει τον καθορισμό του σχετικού διαχωρισμού που μετριέται μεταξύ των ανακλώμενων φωτεινών δεσμών και τον καθορισμό του βαθμού εστίασης του οπτικού συστήματος σε σχέση με το δείγμα με βάση το σχετικό διαχωρισμό.
CY20161101111T 2010-02-01 2016-11-03 Μεθοδοι εστιασης και οπτικα συστηματα και διαταξεις που χρησιμοποιουν τα ιδια CY1118267T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30030010P 2010-02-01 2010-02-01
PCT/US2010/056844 WO2011093939A1 (en) 2010-02-01 2010-11-16 Focusing methods and optical systems and assemblies using the same

Publications (1)

Publication Number Publication Date
CY1118267T1 true CY1118267T1 (el) 2017-06-28

Family

ID=43432176

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101111T CY1118267T1 (el) 2010-02-01 2016-11-03 Μεθοδοι εστιασης και οπτικα συστηματα και διαταξεις που χρησιμοποιουν τα ιδια

Country Status (8)

Country Link
US (2) US8422031B2 (el)
EP (2) EP3151052B1 (el)
CY (1) CY1118267T1 (el)
DK (1) DK2531880T3 (el)
ES (1) ES2596655T3 (el)
PL (1) PL2531880T3 (el)
PT (1) PT2531880T (el)
WO (1) WO2011093939A1 (el)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011003807A1 (de) * 2011-02-08 2012-08-09 Leica Microsystems Cms Gmbh Mikroskop mit Autofokuseinrichtung und Verfahren zur Autofokussierung bei Mikroskopen
EP2825313B1 (en) * 2012-03-16 2018-05-16 Life Technologies Corporation Systems and methods for assessing of biological samples
US20140168402A1 (en) * 2012-12-13 2014-06-19 Vala Sciences, Inc. Continuous-Scanning Image Acquisition in Automated Microscopy Using Reflective Autofocus
JP2014178357A (ja) * 2013-03-13 2014-09-25 Sony Corp デジタル顕微鏡装置、その撮像方法およびプログラム
CN104122237B (zh) * 2014-07-16 2017-06-27 大族激光科技产业集团股份有限公司 基因测序光学系统
TWI688789B (zh) * 2014-11-20 2020-03-21 美商英特爾股份有限公司 虛擬影像產生器及投影虛擬影像的方法
TWI588535B (zh) * 2014-11-20 2017-06-21 英特爾股份有限公司 可調式焦距平面光學系統
US10379047B2 (en) 2016-11-30 2019-08-13 Scientific Industries, Inc. Apparatus for detecting pH and dissolved oxygen
US11402200B2 (en) * 2016-03-09 2022-08-02 Hamamatsu Photonics K.K. Measuring device, observing device and measuring method
KR102414312B1 (ko) * 2017-02-10 2022-06-28 나노트로닉스 이미징, 인코포레이티드 현미경 검사에서 대 영역 이미징을 용이하게 하는 카메라 및 표본 정렬
NL2018854B1 (en) 2017-05-05 2018-11-14 Illumina Inc Systems and methodes for improved focus tracking using blocking structures
NL2018853B1 (en) 2017-05-05 2018-11-14 Illumina Inc Systems and methods for improved focus tracking using a hybrid mode light source
NL2018857B1 (en) 2017-05-05 2018-11-09 Illumina Inc Systems and methods for improved focus tracking using a light source configuration
JP2019113329A (ja) * 2017-12-21 2019-07-11 株式会社ニューフレアテクノロジー 変位計測装置及び電子ビーム検査装置
NL2020618B1 (en) 2018-01-12 2019-07-18 Illumina Inc Real time controller switching
JP7226825B2 (ja) * 2018-02-14 2023-02-21 国立研究開発法人理化学研究所 オートフォーカス装置ならびにそれを備える光学装置および顕微鏡
KR20220118301A (ko) * 2019-12-31 2022-08-25 일루미나, 인코포레이티드 광학 샘플 분석에서의 오토포커스 기능
US20220008913A1 (en) * 2020-06-27 2022-01-13 Jeffrey G. Manni Optically actuated fluid control for microfluidic structures
US11965731B2 (en) * 2020-11-03 2024-04-23 Taiwan Semiconductor Manufacturing Company Ltd. Package structure and measurement method for the package structure
US20230088338A1 (en) 2021-09-10 2023-03-23 Illumina, Inc. Sequencer focus quality metrics and focus tracking for periodically patterned surfaces
US20230228984A1 (en) * 2022-01-18 2023-07-20 Illumina, Inc. Dynamic detilt focus tracking
JP2025526537A (ja) * 2022-06-09 2025-08-15 イルミナ インコーポレイテッド フローセル傾斜に対する塩基コーリングの依存性
TW202431213A (zh) * 2022-09-28 2024-08-01 美商伊路米納有限公司 用於焦點追蹤的光點誤差處置
US20250004244A1 (en) * 2023-06-30 2025-01-02 Illumina, Inc. Detilt focus tracking
US12452530B2 (en) * 2023-12-20 2025-10-21 Illumina, Inc. Intelligent sample tilt adjustment with zones having variable size

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483618A (en) * 1982-05-24 1984-11-20 Hamar M R Laser measurement system, virtual detector probe and carriage yaw compensator
NL8603108A (nl) * 1986-12-08 1988-07-01 Philips Nv Mikroskoop.
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
JPH0769162B2 (ja) * 1990-04-23 1995-07-26 大日本スクリーン製造株式会社 光学的検査システムのための自動焦点合わせ装置
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
JPH05142462A (ja) * 1991-11-18 1993-06-11 Olympus Optical Co Ltd 合焦装置
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
AU675054B2 (en) 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5311288A (en) * 1992-07-06 1994-05-10 Opal Technologies Ltd. Method and apparatus for detecting surface deviations from a reference plane
US5298976A (en) * 1992-11-16 1994-03-29 Arie Shahar Method and apparatus for measuring surface distances from a reference plane
US5400093A (en) * 1992-12-28 1995-03-21 U.S. Philips Corporation Image projection system with autofocusing
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6090555A (en) 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
DE69503126T2 (de) 1994-05-05 1998-11-12 Beckman Instruments Inc Repetitive oligonukleotide matrix
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
EP0770219B1 (en) * 1994-07-08 1999-10-20 Forskningscenter Riso An optical measurement method and apparatus
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
EP0750891A1 (en) * 1995-06-30 1997-01-02 Laser Industries Limited Laser microscope adaptor apparatus with auto-focus
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
JP2000512744A (ja) 1996-05-16 2000-09-26 アフィメトリックス，インコーポレイテッド 標識材料を検出するシステムおよび方法
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
ATE234674T1 (de) 1996-11-14 2003-04-15 Affymetrix Inc Chemische amplifizierung zur synthese von musterordnungen
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
WO1998051993A1 (fr) * 1997-05-16 1998-11-19 Olympus Optical Co., Ltd. Dispositif servant a mesurer une hauteur
WO1998059066A1 (en) 1997-06-25 1998-12-30 Orchid Biocomputer, Inc. Methods for the detection of multiple single nucleotide polymorphisms in a single reaction
DK1801214T3 (da) 1997-07-07 2011-01-24 Medical Res Council In vitro sorteringsfremgangsmåde
DE69829402T2 (de) 1997-10-31 2006-04-13 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Expressionsprofile in adulten und fötalen organen
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
AU2586799A (en) 1998-02-06 1999-08-23 Affymetrix, Inc. Method of quality control in manufacturing processes
US6388788B1 (en) * 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US6677565B1 (en) * 1998-08-18 2004-01-13 Veeco Tucson Inc. High speed autofocus and tilt for an optical imaging system
US20030207295A1 (en) 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20030108867A1 (en) 1999-04-20 2003-06-12 Chee Mark S Nucleic acid sequencing using microsphere arrays
HK1046156B (en) 1999-04-20 2009-01-23 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
WO2001001112A1 (en) * 1999-06-26 2001-01-04 Packard Instrument Company, Inc. Microplate reader
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
JP4519987B2 (ja) * 2000-04-13 2010-08-04 オリンパス株式会社 焦点検出装置
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
JP2004513619A (ja) 2000-07-07 2004-05-13 ヴィジゲン　バイオテクノロジーズ　インコーポレイテッド リアルタイム配列決定
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
DE10204367B4 (de) * 2002-02-02 2006-05-11 Leica Microsystems Cms Gmbh Autofokusmodul für mikroskopbasierte Systeme und Autofokusverfahren für ein mikroskopbasiertes System
DE10312682B4 (de) * 2002-03-22 2015-07-16 Carl Zeiss Meditec Ag Mikroskopieanordnung mit Autofokus und astigmatisch geformtem Analyselichtstrahl
US6995847B2 (en) * 2002-05-24 2006-02-07 Honeywell International Inc. Methods and systems for substrate surface evaluation
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US20050227252A1 (en) 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
SI3363809T1 (sl) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modificirani nukleotidi za polinukleotidno sekvenciranje
WO2004024328A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US7339148B2 (en) * 2002-12-16 2008-03-04 Olympus America Inc. Confocal microscope
CA2513535C (en) 2003-01-29 2012-06-12 454 Corporation Bead emulsion nucleic acid amplification
US20050181394A1 (en) 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005010145A2 (en) 2003-07-05 2005-02-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
EP1673614A1 (en) 2003-10-01 2006-06-28 CiDra Corporation Optical reader for diffraction grating-based encoded optical identification elements
US7813579B2 (en) * 2004-05-24 2010-10-12 Hamamatsu Photonics K.K. Microscope system
JP4729269B2 (ja) * 2004-06-01 2011-07-20 オリンパス株式会社 レーザ走査型顕微鏡
US7435927B2 (en) * 2004-06-18 2008-10-14 Electron Scientific Industries, Inc. Semiconductor link processing using multiple laterally spaced laser beam spots with on-axis offset
WO2006044078A2 (en) 2004-09-17 2006-04-27 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
SG170802A1 (en) 2006-03-31 2011-05-30 Solexa Inc Systems and devices for sequence by synthesis analysis
DE102006040636B3 (de) * 2006-05-15 2007-12-20 Leica Microsystems (Schweiz) Ag Autofokus-System und Verfahren zum Autofokussieren
WO2008032096A2 (en) * 2006-09-14 2008-03-20 Oxford Gene Technology Ip Limited Apparatus for imaging single molecules
US7498551B2 (en) * 2006-10-06 2009-03-03 Los Alamos National Security, Llc Apparatus and method for tracking a molecule or particle in three dimensions
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
TWI369508B (en) * 2006-12-12 2012-08-01 Nat Applied Res Laboratories Automatic focus device and method thereof
EP2091062A1 (en) * 2008-02-13 2009-08-19 FEI Company TEM with aberration corrector and phase plate
EP2110696B1 (en) * 2008-04-15 2013-10-16 Sensovation AG Method and apparatus for autofocus

Also Published As

Publication number Publication date
PT2531880T (pt) 2016-10-31
PL2531880T3 (pl) 2017-09-29
DK2531880T3 (da) 2016-11-07
US20110188053A1 (en) 2011-08-04
ES2596655T3 (es) 2017-01-11
US8446573B1 (en) 2013-05-21
WO2011093939A1 (en) 2011-08-04
US8422031B2 (en) 2013-04-16
EP2531880A1 (en) 2012-12-12
EP3151052B1 (en) 2025-03-26
EP3151052C0 (en) 2025-03-26
EP3151052A1 (en) 2017-04-05
EP2531880B1 (en) 2016-08-03

Similar Documents

Publication Publication Date Title
CY1118267T1 (el) Μεθοδοι εστιασης και οπτικα συστηματα και διαταξεις που χρησιμοποιουν τα ιδια
MX2021015750A (es) Aparato y metodos de seguimiento ocular a partir de la obtencion de imagenes oculares mediante un elemento optico de guia de luz.
EP4306036A3 (en) Confocal laser eye surgery system
WO2012117353A3 (en) Method and apparatus for measuring the thickness of a transparent object in an automatic production line
SG138557A1 (en) A method of characterising the transmission losses of an optical system
ATE554416T1 (de) Kalibriervorrichtung und laser-scanning-mikroskop mit einer derartigen kalibriervorrichtung
WO2016018478A3 (en) Athermalized optics for laser wind sensing
EA201291288A1 (ru) Способ и устройство измерения оптических характеристик оптически изменяемой маркировки, нанесенной на объект
WO2012096847A3 (en) Apparatus for euv imaging and methods of using same
WO2010078070A3 (en) Systems and methods for measuring the shape and location of an object
WO2014205256A3 (en) Apparatus, devices and methods for obtaining omnidirectional viewing by a catheter
PH12017501062A1 (en) High efficiency optical combiner for multiple non-coherent light sources
WO2016175395A3 (ko) 미러 회전 방식의 다채널 라이더 스캐너 광학계
FR2989294B1 (fr) Dispositif et methode de nano-usinage par laser
WO2012141544A3 (ko) Ｔｓｖ 측정용 간섭계 및 이를 이용한 측정방법
MY205985A (en) Systems and methods for improved focus tracking using a light source configuration
IN2015DN01424A (el)
JP2016024009A5 (el)
SG152162A1 (en) An optical focus sensor, an inspection apparatus and a lithographic apparatus
WO2012110837A8 (en) Method and device for detecting an object with background suppression
WO2012018674A3 (en) Optics symmetrization for metrology
JP2021501657A5 (el)
WO2015095724A3 (en) Digital shearography ndt system for speckless objects
JP2014503842A5 (ja) 共焦点レーザー走査顕微鏡
TW201614386A (en) Illumination system