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CY1118061T1 - Δικυκλικα παραγωγα heterocyclyl σαν καταστολεις κινασης (kinase) fgfr για θεραπευτικη χρηση - Google Patents

Δικυκλικα παραγωγα heterocyclyl σαν καταστολεις κινασης (kinase) fgfr για θεραπευτικη χρηση

Info

Publication number
CY1118061T1
CY1118061T1 CY20161100619T CY161100619T CY1118061T1 CY 1118061 T1 CY1118061 T1 CY 1118061T1 CY 20161100619 T CY20161100619 T CY 20161100619T CY 161100619 T CY161100619 T CY 161100619T CY 1118061 T1 CY1118061 T1 CY 1118061T1
Authority
CY
Cyprus
Prior art keywords
heterocyclyl
therapeutic use
derivatives
fgfr
kinase
Prior art date
Application number
CY20161100619T
Other languages
English (en)
Inventor
Gordon Saxty
Valerio Berdini
Eddy Jean Edgard Freyne
Alexandra Papanikos
Pascal Benderitter
Werner Constant Johan Embrechts
Berthold Wroblowski
Rhalid Akkari
Original Assignee
Astex Therapeutics Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd. filed Critical Astex Therapeutics Ltd.
Publication of CY1118061T1 publication Critical patent/CY1118061T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση σχετίζεται με νέα δικυκλικά παράγωγα heterocyclyl του τύπου (I), με φαρμακευτικές συνθέσεις που περιέχουν τις εν λόγω ενώσεις και την χρήση των εν λόγω ενώσεων στην θεραπεία ασθενειών, π.χ. καρκίνου.
CY20161100619T 2009-04-15 2016-07-05 Δικυκλικα παραγωγα heterocyclyl σαν καταστολεις κινασης (kinase) fgfr για θεραπευτικη χρηση CY1118061T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16948709P 2009-04-15 2009-04-15
GBGB0906472.6A GB0906472D0 (en) 2009-04-15 2009-04-15 New compounds
PCT/GB2010/050617 WO2010119284A1 (en) 2009-04-15 2010-04-15 Bicyclic heterocyclyl derivatives as fgfr kinase inhibitors for therapeutic use

Publications (1)

Publication Number Publication Date
CY1118061T1 true CY1118061T1 (el) 2017-06-28

Family

ID=40750627

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100619T CY1118061T1 (el) 2009-04-15 2016-07-05 Δικυκλικα παραγωγα heterocyclyl σαν καταστολεις κινασης (kinase) fgfr για θεραπευτικη χρηση

Country Status (18)

Country Link
US (1) US8481531B2 (el)
EP (1) EP2419427B1 (el)
JP (1) JP5718897B2 (el)
AU (1) AU2010238289B2 (el)
CA (1) CA2757592C (el)
CY (1) CY1118061T1 (el)
DK (1) DK2419427T3 (el)
ES (1) ES2580781T3 (el)
GB (1) GB0906472D0 (el)
HR (1) HRP20160725T1 (el)
HU (1) HUE028138T2 (el)
ME (1) ME02463B (el)
PL (1) PL2419427T3 (el)
PT (1) PT2419427T (el)
RS (1) RS55038B1 (el)
SI (1) SI2419427T1 (el)
SM (1) SMT201600220B (el)
WO (1) WO2010119284A1 (el)

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EP2419427B1 (en) 2016-04-06
WO2010119284A1 (en) 2010-10-21
PT2419427T (pt) 2016-07-13
GB0906472D0 (en) 2009-05-20
US20120035171A1 (en) 2012-02-09
JP2012524055A (ja) 2012-10-11
US8481531B2 (en) 2013-07-09
PL2419427T3 (pl) 2016-12-30
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CA2757592C (en) 2018-08-21
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CA2757592A1 (en) 2010-10-21
HRP20160725T1 (hr) 2016-09-23
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AU2010238289A1 (en) 2011-12-08
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