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CY1116878T1 - sGC ΔΙΕΓΕΡΤΕΣ Ή sGC ΕΝΕΡΓΟΠΟΙΗΤΕΣ ΜΟΝΟΙ ΚΑΙ ΣΕ ΣΥΝΔΥΑΣΜΟ ME PDE5 ΑΝΑΣΤΟΛΕΙΣ ΓΙΑ ΤΗΝ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΤΗΣ ΚΥΣΤΙΚΗΣ ΙΝΩΣΗΣ - Google Patents

sGC ΔΙΕΓΕΡΤΕΣ Ή sGC ΕΝΕΡΓΟΠΟΙΗΤΕΣ ΜΟΝΟΙ ΚΑΙ ΣΕ ΣΥΝΔΥΑΣΜΟ ME PDE5 ΑΝΑΣΤΟΛΕΙΣ ΓΙΑ ΤΗΝ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΤΗΣ ΚΥΣΤΙΚΗΣ ΙΝΩΣΗΣ

Info

Publication number
CY1116878T1
CY1116878T1 CY20151100972T CY151100972T CY1116878T1 CY 1116878 T1 CY1116878 T1 CY 1116878T1 CY 20151100972 T CY20151100972 T CY 20151100972T CY 151100972 T CY151100972 T CY 151100972T CY 1116878 T1 CY1116878 T1 CY 1116878T1
Authority
CY
Cyprus
Prior art keywords
sgc
combination
pde5 inhibitors
cystic fibrosis
therapeutic treatment
Prior art date
Application number
CY20151100972T
Other languages
English (en)
Inventor
Peter Sandner
Degenfeld Georges Von
Johannes-Peter Stasch
Original Assignee
Adverio Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43759663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116878(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adverio Pharma Gmbh filed Critical Adverio Pharma Gmbh
Publication of CY1116878T1 publication Critical patent/CY1116878T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με διαλυτή γουανυλική κυκλάση (sGC) και με φωσφοδιεστεράσες (PDEs) και με την φαρμακολογία των sGC διεγερτών, sGC ενεργοποιητών και PDE5 αναστολέων. Ειδικότερα, η εφεύρεση σχετίζεται με τη χρήση των sGC διεγερτών και sGC ενεργοποιητών σε συνδυασμό με PDE5 αναστολείς για την παρασκευή φαρμάκων για την θεραπευτική αγωγή της Κυστικής Ίνωσης (CF).
CY20151100972T 2010-02-05 2015-10-30 sGC ΔΙΕΓΕΡΤΕΣ Ή sGC ΕΝΕΡΓΟΠΟΙΗΤΕΣ ΜΟΝΟΙ ΚΑΙ ΣΕ ΣΥΝΔΥΑΣΜΟ ME PDE5 ΑΝΑΣΤΟΛΕΙΣ ΓΙΑ ΤΗΝ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΤΗΣ ΚΥΣΤΙΚΗΣ ΙΝΩΣΗΣ CY1116878T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10152727 2010-02-05
EP11701683.2A EP2531187B1 (en) 2010-02-05 2011-02-03 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS

Publications (1)

Publication Number Publication Date
CY1116878T1 true CY1116878T1 (el) 2017-04-05

Family

ID=43759663

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100972T CY1116878T1 (el) 2010-02-05 2015-10-30 sGC ΔΙΕΓΕΡΤΕΣ Ή sGC ΕΝΕΡΓΟΠΟΙΗΤΕΣ ΜΟΝΟΙ ΚΑΙ ΣΕ ΣΥΝΔΥΑΣΜΟ ME PDE5 ΑΝΑΣΤΟΛΕΙΣ ΓΙΑ ΤΗΝ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΤΗΣ ΚΥΣΤΙΚΗΣ ΙΝΩΣΗΣ

Country Status (33)

Country Link
US (1) US20130035340A1 (el)
EP (1) EP2531187B1 (el)
JP (2) JP6143461B2 (el)
KR (1) KR101793304B1 (el)
CN (3) CN102770133A (el)
AU (1) AU2011212521B2 (el)
BR (1) BR112012019666A2 (el)
CA (1) CA2788969C (el)
CL (1) CL2012002173A1 (el)
CR (1) CR20120408A (el)
CY (1) CY1116878T1 (el)
DK (1) DK2531187T3 (el)
EA (1) EA025177B1 (el)
ES (1) ES2548394T3 (el)
HK (1) HK1212892A1 (el)
HR (1) HRP20151187T1 (el)
HU (1) HUE028008T2 (el)
IL (1) IL221012B (el)
MA (1) MA33984B1 (el)
MX (1) MX342944B (el)
MY (2) MY159697A (el)
NZ (1) NZ601612A (el)
PH (1) PH12012501587A1 (el)
PL (1) PL2531187T3 (el)
PT (1) PT2531187E (el)
RS (1) RS54336B1 (el)
SG (1) SG182819A1 (el)
SI (1) SI2531187T1 (el)
SM (1) SMT201500286B (el)
TN (1) TN2012000397A1 (el)
UA (1) UA112962C2 (el)
WO (1) WO2011095534A1 (el)
ZA (1) ZA201205532B (el)

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RS54336B1 (sr) * 2010-02-05 2016-02-29 Adverio Pharma Gmbh Sgc stimulatori ili sgc aktivatori, sami za sebe i kombinovani sa pde5 inhibitorima za tretman cistične fibroze
ES2549979T3 (es) 2010-05-26 2015-11-03 Adverio Pharma Gmbh El uso de estimuladores de la sGC, activadores de la sGC, solos y en combinaciones con inhibidores de la PDE5 para el tratamiento de esclerosis sistémica (EcS)
EP2585055A1 (de) * 2010-06-25 2013-05-01 Bayer Intellectual Property GmbH Verwendung von stimulatoren und aktivatoren der löslichen guanylatzyklase zur behandlung von sichelzellanämie und konservierung von blutersatzstoffen
EP2594270A3 (en) * 2011-11-18 2013-07-31 BIP Patents The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc)
DK2892891T3 (da) 2012-09-07 2019-10-14 Boehringer Ingelheim Int Alkoxypyrazoler som opløselige guanylatcyklaseaktivatorer
EP3024455A1 (en) * 2013-07-25 2016-06-01 Bayer Pharma Aktiengesellschaft Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
US20160311826A1 (en) 2013-12-11 2016-10-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
TW201625584A (zh) 2014-07-02 2016-07-16 諾華公司 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
EA032972B1 (ru) 2014-07-22 2019-08-30 Бёрингер Ингельхайм Интернациональ Гмбх Гетероциклические карбоновые кислоты в качестве активаторов растворимой гуанилатциклазы
US10844064B2 (en) 2014-09-17 2020-11-24 Cyclerion Therapeutics, Inc. sGC stimulators
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Also Published As

Publication number Publication date
HUE028008T2 (en) 2016-11-28
CA2788969C (en) 2017-11-21
UA112962C2 (uk) 2016-11-25
WO2011095534A1 (en) 2011-08-11
IL221012B (en) 2018-01-31
CR20120408A (es) 2013-02-12
MX2012009011A (es) 2012-09-07
JP2013518851A (ja) 2013-05-23
HRP20151187T1 (hr) 2015-12-04
EA201290702A1 (ru) 2013-02-28
KR20120125276A (ko) 2012-11-14
SMT201500286B (it) 2016-01-08
AU2011212521A1 (en) 2012-08-16
RS54336B1 (sr) 2016-02-29
IL221012A0 (en) 2012-09-24
TN2012000397A1 (en) 2014-01-30
KR101793304B1 (ko) 2017-11-02
SI2531187T1 (sl) 2016-01-29
MX342944B (es) 2016-10-18
US20130035340A1 (en) 2013-02-07
PL2531187T3 (pl) 2016-01-29
JP6143461B2 (ja) 2017-06-07
HK1212892A1 (zh) 2016-06-24
MA33984B1 (fr) 2013-02-01
EP2531187B1 (en) 2015-08-12
JP2016155857A (ja) 2016-09-01
NZ601612A (en) 2014-08-29
MY160856A (en) 2017-03-31
CN104800219A (zh) 2015-07-29
CA2788969A1 (en) 2011-08-11
JP6270907B2 (ja) 2018-01-31
DK2531187T3 (en) 2015-11-09
EP2531187A1 (en) 2012-12-12
ES2548394T3 (es) 2015-10-16
ZA201205532B (en) 2014-12-23
SG182819A1 (en) 2012-09-27
PT2531187E (pt) 2015-10-20
PH12012501587A1 (en) 2020-10-19
CN102770133A (zh) 2012-11-07
CL2012002173A1 (es) 2013-05-17
AU2011212521B2 (en) 2015-11-19
CN107929271A (zh) 2018-04-20
MY159697A (en) 2017-01-13
EA025177B1 (ru) 2016-11-30
BR112012019666A2 (pt) 2017-06-20

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