CY1116523T1 - PHOSPHONE NUCLEOTIDE ANALYSIS PRODUCTS AND METHODS FOR SELECTION AND MANUFACTURE - Google Patents
PHOSPHONE NUCLEOTIDE ANALYSIS PRODUCTS AND METHODS FOR SELECTION AND MANUFACTUREInfo
- Publication number
- CY1116523T1 CY1116523T1 CY20151100413T CY151100413T CY1116523T1 CY 1116523 T1 CY1116523 T1 CY 1116523T1 CY 20151100413 T CY20151100413 T CY 20151100413T CY 151100413 T CY151100413 T CY 151100413T CY 1116523 T1 CY1116523 T1 CY 1116523T1
- Authority
- CY
- Cyprus
- Prior art keywords
- novel
- compounds
- phosphone
- selection
- manufacture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- -1 magnesium alkoxide Chemical class 0.000 abstract 1
- CAAULPUQFIIOTL-UHFFFAOYSA-N methyl dihydrogen phosphate Chemical class COP(O)(O)=O CAAULPUQFIIOTL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Παρέχεται νέα μέθοδος για συστηματική εξέταση προφαρμάκων αναλόγων μεθοξυφωσφονικού νουκλεοτιδίου για να πιστοποιούνται προφάρμακα που στοχεύουν εκλεκτικώς επιθυμητούς ιστούς με αντι-ιική ή κατά του όγκου δραστικότητα. Η μέθοδος αυτή έχει οδηγήσει στην πιστοποίηση νέων δεικτών εστέρα-αμιδικών του ΡΜΡΑ για ρετροϊική ή ηπατοτροφικής-dna μόλυνσης θεραπεία, συμπεριλαμβανομένων ενώσεων της σύνταξης (5a) που έχουν ομάδες υποκαταστάτη όπως ορίζεται στο παρόν. Παρέχονται συνθέσεις αυτών των νέων ενώσεων σε φαρμακευτικώς αποδεκτά έκδοχα και χρήση αυτών στην θεραπεία και προφύλαξη. Επίσης, παρέχεται βελτιωμένη μέθοδος για την χρήση αλκοξειδίου μαγνησίου για την παρασκευή υλικών έναρξης και ενώσεων για χρήση στο παρόν.A novel method is provided for screening prodrug analogs of methoxyphosphonate nucleotide to identify prodrugs that target selectively desirable tissues with antiviral or antitumor activity. This method has led to the identification of novel PMPA ester-amide markers for retroviral or hepatotrophic-dna infection treatment, including compounds of the structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. Also provided is an improved method for the use of magnesium alkoxide for the preparation of starting materials and compounds for use herein.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22002100A | 2000-07-21 | 2000-07-21 | |
| EP01961695.2A EP1301519B2 (en) | 2000-07-21 | 2001-07-20 | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116523T1 true CY1116523T1 (en) | 2016-12-14 |
Family
ID=58464055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100413T CY1116523T1 (en) | 2000-07-21 | 2015-05-11 | PHOSPHONE NUCLEOTIDE ANALYSIS PRODUCTS AND METHODS FOR SELECTION AND MANUFACTURE |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1116523T1 (en) |
-
2015
- 2015-05-11 CY CY20151100413T patent/CY1116523T1/en unknown
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