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CY1114426T1 - Microrna (mirna) mir-21 για διαγνωστικους και θεραπευτικους σκοπους - Google Patents

Microrna (mirna) mir-21 για διαγνωστικους και θεραπευτικους σκοπους

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Publication number
CY1114426T1
CY1114426T1 CY20131100690T CY131100690T CY1114426T1 CY 1114426 T1 CY1114426 T1 CY 1114426T1 CY 20131100690 T CY20131100690 T CY 20131100690T CY 131100690 T CY131100690 T CY 131100690T CY 1114426 T1 CY1114426 T1 CY 1114426T1
Authority
CY
Cyprus
Prior art keywords
fibrosis
mir
treatment
prevention
microrna
Prior art date
Application number
CY20131100690T
Other languages
English (en)
Inventor
Thomas Thum
Johann Bauersachs
Stefan Engelhardt
Carina Gross
Original Assignee
Julius-Maximilians-Universität Würzburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julius-Maximilians-Universität Würzburg filed Critical Julius-Maximilians-Universität Würzburg
Publication of CY1114426T1 publication Critical patent/CY1114426T1/el

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Abstract

Η παρούσα αποκάλυψη αφορά μια περιοχή υποκινητή ενός microRNA, τη χρήση ενός microRNA, συγκεκριμένα miR-21, και σχετικά στοιχεία για τη διάγνωση και για την κατασκευή ενός φαρμάκου για τη θεραπευτική αγωγή ή/και πρόληψη ίνωσης ή/και σχετιζόμενων με ίνωση ασθενειών. Επιπροσθέτως, η αποκάλυψη αφορά διάφορα αντινοηματικά ολιγονουκλεοτίδια έναντι στόχων miR-21. Ένα κύτταρο ανεπαρκές για miR-21, η περιοχή υποκινητή και στόχοι του miR-21 και ένας knock-out οργανισμός αυτών περικλείονται επίσης. Τελικώς, η αποκάλυψη κατευθύνεται σε μια μέθοδο για τη διάγνωση ίνωσης ή/και σχετιζόμενων με ίνωση ασθενειών και σε μια μέθοδο για τη διαλογή μιας φαρμακευτικώς δραστικής ένωσης για τη θεραπευτική αγωγή ίνωσης ή/και σχετιζόμενων με ίνωση ασθενειών. Η παρούσα εφεύρεση περαιτέρω αφορά συνθέσεις για χρήση στη θεραπευτική αγωγή, βελτίωση, ή/και πρόληψη ίνωσης. Σε ορισμένες υλοποιήσεις, οι συνθέσεις ρυθμίζουν τη δραστικότητα ενός miRNA για τη θεραπευτική αγωγή, βελτίωση, ή/και πρόληψη ίνωσης. Σε ορισμένες υλοποιήσεις, οι συνθέσεις αναστέλλουν τη δραστικότητα του miR-21 για τη θεραπευτική αγωγή, βελτίωση, ή/και πρόληψη ίνωσης.
CY20131100690T 2008-02-27 2013-08-13 Microrna (mirna) mir-21 για διαγνωστικους και θεραπευτικους σκοπους CY1114426T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3183508P 2008-02-27 2008-02-27
EP20080003570 EP2096171A1 (en) 2008-02-27 2008-02-27 MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
US3334008P 2008-03-03 2008-03-03
EP09714079.2A EP2260101B1 (en) 2008-02-27 2009-02-26 Microrna (mirna) mir-21 for diagnostic and therapeutic purposes

Publications (1)

Publication Number Publication Date
CY1114426T1 true CY1114426T1 (el) 2016-08-31

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US (10) US8236777B2 (el)
EP (3) EP2096171A1 (el)
JP (2) JP6033527B2 (el)
KR (1) KR101697482B1 (el)
CN (1) CN102027113B (el)
AU (1) AU2009218704C1 (el)
BR (1) BRPI0907565B1 (el)
CA (2) CA3123067A1 (el)
CY (1) CY1114426T1 (el)
DK (1) DK2260101T3 (el)
EA (1) EA020335B1 (el)
ES (1) ES2436885T3 (el)
HR (1) HRP20130766T1 (el)
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SI (1) SI2260101T1 (el)
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