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CY1113551T1 - Υποκατεστημενες ενωσεις νικοτιναμιδιου και η χρησιμοποιηση τους σε φαρμακα - Google Patents

Υποκατεστημενες ενωσεις νικοτιναμιδιου και η χρησιμοποιηση τους σε φαρμακα

Info

Publication number
CY1113551T1
CY1113551T1 CY20131100043T CY131100043T CY1113551T1 CY 1113551 T1 CY1113551 T1 CY 1113551T1 CY 20131100043 T CY20131100043 T CY 20131100043T CY 131100043 T CY131100043 T CY 131100043T CY 1113551 T1 CY1113551 T1 CY 1113551T1
Authority
CY
Cyprus
Prior art keywords
medicinal products
substituted nicotinamide
nicotinamide compounds
compounds
substituted
Prior art date
Application number
CY20131100043T
Other languages
English (en)
Inventor
Beatrix Merla
Sven Kühnert
Robert Frank
Dagmar Kaulartz
Wolfgang Schröder
Gregor Bahrenberg
Klaus Schiene
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1113551T1 publication Critical patent/CY1113551T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφεύρεση αφορά σε υποκατεστημένες ενώσεις νικοτιναμιδίου, μεθόδους για την παρασκευή τους, φάρμακα που περιέχουν τις ενώσεις αυτές καθώς και στη χρησιμοποίηση των ενώσεων αυτών για την παρασκευή φαρμάκων.
CY20131100043T 2007-09-17 2013-01-15 Υποκατεστημενες ενωσεις νικοτιναμιδιου και η χρησιμοποιηση τους σε φαρμακα CY1113551T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007044277A DE102007044277A1 (de) 2007-09-17 2007-09-17 Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln
EP08802179A EP2188258B1 (de) 2007-09-17 2008-09-15 Substituierte nicotinamid-verbindungen und deren verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
CY1113551T1 true CY1113551T1 (el) 2016-06-22

Family

ID=40347805

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100043T CY1113551T1 (el) 2007-09-17 2013-01-15 Υποκατεστημενες ενωσεις νικοτιναμιδιου και η χρησιμοποιηση τους σε φαρμακα

Country Status (23)

Country Link
US (1) US8084470B2 (el)
EP (1) EP2188258B1 (el)
JP (1) JP5539205B2 (el)
KR (1) KR20100068453A (el)
CN (1) CN101801932A (el)
AR (1) AR068467A1 (el)
BR (1) BRPI0817044A2 (el)
CA (1) CA2699689C (el)
CO (1) CO6260092A2 (el)
CY (1) CY1113551T1 (el)
DE (1) DE102007044277A1 (el)
DK (1) DK2188258T3 (el)
ES (1) ES2400407T3 (el)
HR (1) HRP20130166T1 (el)
IL (1) IL204496A (el)
MX (1) MX2010002506A (el)
NZ (1) NZ583684A (el)
PE (1) PE20090652A1 (el)
PL (1) PL2188258T3 (el)
PT (1) PT2188258E (el)
RU (1) RU2489425C2 (el)
SI (1) SI2188258T1 (el)
WO (1) WO2009036938A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI475020B (zh) * 2009-03-12 2015-03-01 The substituted nicotine amide as a KCNQ2 / 3 modifier
BR112013004562A2 (pt) * 2010-08-27 2016-09-06 Gruenenthal Gmbh 2-óxi-quinolina-3-carboxamidas substituídas como moduladores kcnq2/3
NZ610689A (en) * 2010-10-20 2014-08-29 Gruenenthal Chemie Substituted 6-amino-nicotinamides as kcnq2/3 modulators
FR2968661B1 (fr) * 2010-12-14 2016-01-01 Oreal Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones
MX2015004511A (es) 2012-10-11 2015-07-06 Grünenthal GmbH Tratamiento y/o profilaxis de enfermedades y/o trastornos provocados por tspo.
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
MX2015006689A (es) 2012-11-28 2015-08-20 Grünenthal GmbH Carboxamidas especificas como moduladores de kcnq2/3.
WO2018110669A1 (en) 2016-12-15 2018-06-21 Ono Pharmaceutical Co., Ltd. Activator of trek (twik related k+ channels) channels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
GB9919588D0 (en) * 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
MXPA03007397A (es) 2001-02-20 2003-12-04 Bristol Myers Squibb Co Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas.
GB0319793D0 (en) * 2003-08-22 2003-09-24 Lilly Co Eli Pyridinylmorpholine derivatives

Also Published As

Publication number Publication date
JP5539205B2 (ja) 2014-07-02
PE20090652A1 (es) 2009-05-28
NZ583684A (en) 2011-04-29
US8084470B2 (en) 2011-12-27
RU2010115184A (ru) 2011-10-27
KR20100068453A (ko) 2010-06-23
HK1144422A1 (en) 2011-02-18
JP2010539124A (ja) 2010-12-16
US20090076086A1 (en) 2009-03-19
EP2188258A1 (de) 2010-05-26
WO2009036938A1 (de) 2009-03-26
CO6260092A2 (es) 2011-03-22
AR068467A1 (es) 2009-11-18
CA2699689C (en) 2015-03-24
PT2188258E (pt) 2013-01-23
SI2188258T1 (sl) 2013-01-31
MX2010002506A (es) 2010-03-26
CN101801932A (zh) 2010-08-11
DE102007044277A1 (de) 2009-03-19
EP2188258B1 (de) 2012-11-28
CA2699689A1 (en) 2009-03-26
BRPI0817044A2 (pt) 2015-03-24
PL2188258T3 (pl) 2013-04-30
ES2400407T3 (es) 2013-04-09
IL204496A (en) 2013-02-28
RU2489425C2 (ru) 2013-08-10
AU2008300945A1 (en) 2009-03-26
DK2188258T3 (da) 2013-01-14
HRP20130166T1 (hr) 2013-03-31

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