CY1112848T1 - Αναστολεις του ιου της ηπατιτιδας c - Google Patents
Αναστολεις του ιου της ηπατιτιδας cInfo
- Publication number
- CY1112848T1 CY1112848T1 CY20121100523T CY121100523T CY1112848T1 CY 1112848 T1 CY1112848 T1 CY 1112848T1 CY 20121100523 T CY20121100523 T CY 20121100523T CY 121100523 T CY121100523 T CY 121100523T CY 1112848 T1 CY1112848 T1 CY 1112848T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitions
- virus
- suspension virus
- compounds
- treatment
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- 241000711549 Hepacivirus C Species 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 150000004074 biphenyls Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η παρούσα αποκάλυψη σχετίζεται με συνθέσεις (4-4'-διιμιδαζολυλ) διφαινυλίων και μεθόδους για την αγωγή της λοίμωξης από ιό της ηπατίτιδας C (ΗCV). Επίσης αποκαλύπτονται φαρμακευτικές συνθέσεις περιέχοντας τέτοιες ενώσεις και μέθοδοι για χρήση αυτών των ενώσεων στην αγωγή της λοίμωξης από ΗCV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08780411A EP2250163B1 (en) | 2008-02-12 | 2008-02-12 | Hepatitis c virus inhibitors |
| PCT/US2008/053638 WO2009102318A1 (en) | 2008-02-12 | 2008-02-12 | Hepatitis c virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112848T1 true CY1112848T1 (el) | 2016-02-10 |
Family
ID=39944252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100523T CY1112848T1 (el) | 2008-02-12 | 2012-06-08 | Αναστολεις του ιου της ηπατιτιδας c |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP2250163B1 (el) |
| JP (1) | JP5314053B2 (el) |
| KR (1) | KR101468765B1 (el) |
| CN (1) | CN101998952B (el) |
| AT (1) | ATE551337T1 (el) |
| AU (1) | AU2008350327B2 (el) |
| BR (1) | BRPI0822335A2 (el) |
| CA (1) | CA2715367C (el) |
| CY (1) | CY1112848T1 (el) |
| DK (1) | DK2250163T3 (el) |
| EA (1) | EA018782B1 (el) |
| ES (1) | ES2383388T3 (el) |
| HR (1) | HRP20120440T1 (el) |
| IL (1) | IL207468A (el) |
| MX (1) | MX2010008650A (el) |
| NZ (1) | NZ587323A (el) |
| PL (1) | PL2250163T3 (el) |
| PT (1) | PT2250163E (el) |
| SI (1) | SI2250163T1 (el) |
| WO (1) | WO2009102318A1 (el) |
| ZA (1) | ZA201005700B (el) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7906655B2 (en) | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8383094B2 (en) | 2008-10-01 | 2013-02-26 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| MX2011006332A (es) | 2008-12-23 | 2011-06-27 | Abbott Lab | Compuestos antivirales. |
| JP2012513410A (ja) | 2008-12-23 | 2012-06-14 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| TWI438200B (zh) | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | C型肝炎病毒抑制劑 |
| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| KR20130130875A (ko) | 2009-02-27 | 2013-12-02 | 이난타 파마슈티칼스, 인코포레이티드 | C형 간염 바이러스 억제제 |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8507522B2 (en) | 2009-03-06 | 2013-08-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2419404B1 (en) | 2009-04-15 | 2015-11-04 | AbbVie Inc. | Anti-viral compounds |
| MX363732B (es) | 2009-05-13 | 2019-04-01 | Gilead Pharmasset Llc Star | Compuestos antivirales. |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| DK2368890T3 (da) | 2009-06-11 | 2013-07-22 | Abbvie Bahamas Ltd | Hepatitis C-virusinhibitorer |
| US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| CN102656160A (zh) | 2009-07-16 | 2012-09-05 | 顶点制药公司 | 用于治疗或预防黄病毒感染的苯并咪唑类似物 |
| CN102625700A (zh) * | 2009-07-23 | 2012-08-01 | 夏尔有限责任公司 | 加兰他敏氨基酸和肽前药及其用途 |
| PE20120993A1 (es) | 2009-09-04 | 2012-08-22 | Janssen Pharmaceuticals Inc | Derivados bifenilicos como antivirales |
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| US8927709B2 (en) | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8822700B2 (en) | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8703938B2 (en) | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8759332B2 (en) | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP2512480A4 (en) | 2009-12-14 | 2013-05-15 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| US8377980B2 (en) * | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2011075607A1 (en) * | 2009-12-18 | 2011-06-23 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
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| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8178531B2 (en) | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| WO2011109037A1 (en) | 2010-03-04 | 2011-09-09 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as inhibitors of hcv replication |
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| EP2593565A4 (en) * | 2010-07-16 | 2013-12-04 | Bristol Myers Squibb Co | METHODS FOR IDENTIFYING COMBINATIONS OF NS5A TARGETING COMPOUNDS THAT SYNERGISTICALLY WORK TO INHIBIT THE REPLICATION OF HEPATITIS C VIRUS |
| US20120195857A1 (en) * | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8697704B2 (en) | 2010-08-12 | 2014-04-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
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| BR112013004520A2 (pt) | 2010-08-26 | 2016-06-07 | Univ Emory | inibidores potentes e seletivos do virus da hepatite c |
| WO2012040124A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
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| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CN103687489A (zh) | 2011-05-18 | 2014-03-26 | 埃南塔制药公司 | 制备5-氮杂螺[2.4]庚烷-6-甲酸及其衍生物的方法 |
| WO2013016499A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Methods for preparation of thiophene compounds |
| TW201317223A (zh) | 2011-07-26 | 2013-05-01 | Vertex Pharma | 噻吩化合物 |
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| CA2840242C (en) | 2011-09-16 | 2019-03-26 | Gilead Sciences, Inc. | Methods for treating hcv |
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| US9012427B2 (en) | 2012-03-22 | 2015-04-21 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
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| KR20200060782A (ko) | 2013-01-31 | 2020-06-01 | 길리애드 파마셋 엘엘씨 | 두 항바이러스 화합물의 병용 제형물 |
| TW201526899A (zh) | 2013-02-28 | 2015-07-16 | Alios Biopharma Inc | 醫藥組成物 |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP3019196B1 (en) * | 2013-07-09 | 2018-06-06 | Bristol-Myers Squibb Company | Combinations of hepatitis c virus inhibitors |
| EP3650014B1 (en) | 2013-08-27 | 2021-10-06 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
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| TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
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| US9790207B2 (en) * | 2015-09-04 | 2017-10-17 | Alexandre Vasilievich Ivachtchenko | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods |
| US20220099637A1 (en) | 2018-12-04 | 2022-03-31 | Bristol-Myers Squibb Company | Methods of analysis using in-sample calibration curve by multiple isotopologue reaction monitoring |
| CN109456375B (zh) * | 2018-12-11 | 2019-10-22 | 枣庄学院 | 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法 |
| CA3220903A1 (en) | 2021-05-21 | 2022-11-24 | Gilead Sciences, Inc. | Pentacyclic derivatives as zika virus inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003264038A1 (en) | 2002-08-12 | 2004-02-25 | Bristol-Myers Squibb Company | Combination pharmaceutical agents as inhibitors of hcv replication |
| DE102004036971B4 (de) | 2004-07-30 | 2009-07-30 | Advanced Micro Devices, Inc., Sunnyvale | Technik zur Bewertung lokaler elektrischer Eigenschaften in Halbleiterbauelementen |
| US8143288B2 (en) * | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US8329159B2 (en) * | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7759495B2 (en) * | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7741347B2 (en) * | 2007-05-17 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
-
2008
- 2008-02-12 NZ NZ587323A patent/NZ587323A/en not_active IP Right Cessation
- 2008-02-12 PL PL08780411T patent/PL2250163T3/pl unknown
- 2008-02-12 JP JP2010546737A patent/JP5314053B2/ja not_active Expired - Fee Related
- 2008-02-12 WO PCT/US2008/053638 patent/WO2009102318A1/en not_active Ceased
- 2008-02-12 MX MX2010008650A patent/MX2010008650A/es active IP Right Grant
- 2008-02-12 CA CA2715367A patent/CA2715367C/en not_active Expired - Fee Related
- 2008-02-12 AT AT08780411T patent/ATE551337T1/de active
- 2008-02-12 BR BRPI0822335A patent/BRPI0822335A2/pt not_active IP Right Cessation
- 2008-02-12 PT PT08780411T patent/PT2250163E/pt unknown
- 2008-02-12 HR HRP20120440AT patent/HRP20120440T1/hr unknown
- 2008-02-12 SI SI200830675T patent/SI2250163T1/sl unknown
- 2008-02-12 KR KR1020107020257A patent/KR101468765B1/ko not_active Expired - Fee Related
- 2008-02-12 ES ES08780411T patent/ES2383388T3/es active Active
- 2008-02-12 DK DK08780411.8T patent/DK2250163T3/da active
- 2008-02-12 CN CN200880128704.XA patent/CN101998952B/zh not_active Expired - Fee Related
- 2008-02-12 EA EA201001276A patent/EA018782B1/ru not_active IP Right Cessation
- 2008-02-12 EP EP08780411A patent/EP2250163B1/en not_active Not-in-force
- 2008-02-12 AU AU2008350327A patent/AU2008350327B2/en not_active Ceased
-
2010
- 2010-08-08 IL IL207468A patent/IL207468A/en not_active IP Right Cessation
- 2010-08-10 ZA ZA2010/05700A patent/ZA201005700B/en unknown
-
2012
- 2012-06-08 CY CY20121100523T patent/CY1112848T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2250163T3 (pl) | 2012-10-31 |
| AU2008350327B2 (en) | 2013-09-12 |
| CA2715367C (en) | 2015-05-05 |
| EP2250163A1 (en) | 2010-11-17 |
| IL207468A (en) | 2015-11-30 |
| WO2009102318A1 (en) | 2009-08-20 |
| BRPI0822335A2 (pt) | 2019-09-24 |
| CN101998952B (zh) | 2014-10-08 |
| KR20100114924A (ko) | 2010-10-26 |
| AU2008350327A1 (en) | 2009-08-20 |
| MX2010008650A (es) | 2010-08-30 |
| KR101468765B1 (ko) | 2014-12-04 |
| NZ587323A (en) | 2012-02-24 |
| DK2250163T3 (da) | 2012-07-16 |
| ZA201005700B (en) | 2012-01-25 |
| EA018782B1 (ru) | 2013-10-30 |
| HK1144935A1 (en) | 2011-03-18 |
| PT2250163E (pt) | 2012-06-01 |
| ES2383388T3 (es) | 2012-06-20 |
| IL207468A0 (en) | 2010-12-30 |
| EP2250163B1 (en) | 2012-03-28 |
| HRP20120440T1 (hr) | 2012-06-30 |
| JP5314053B2 (ja) | 2013-10-16 |
| SI2250163T1 (sl) | 2012-08-31 |
| JP2011511832A (ja) | 2011-04-14 |
| EA201001276A1 (ru) | 2011-04-29 |
| CN101998952A (zh) | 2011-03-30 |
| CA2715367A1 (en) | 2009-08-20 |
| ATE551337T1 (de) | 2012-04-15 |
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