CY1112469T1 - Μια il-2 μουτεϊνη για θεραπεια ή για προφυλαξη απο ενα αυτοανοσο νοσημα - Google Patents
Μια il-2 μουτεϊνη για θεραπεια ή για προφυλαξη απο ενα αυτοανοσο νοσημαInfo
- Publication number
- CY1112469T1 CY1112469T1 CY20121100236T CY121100236T CY1112469T1 CY 1112469 T1 CY1112469 T1 CY 1112469T1 CY 20121100236 T CY20121100236 T CY 20121100236T CY 121100236 T CY121100236 T CY 121100236T CY 1112469 T1 CY1112469 T1 CY 1112469T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- mutein
- protection
- automatic disease
- disease
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A61K38/20—Interleukins [IL]
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- C12N2501/2302—Interleukin-2 (IL-2)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
Abstract
Η παρούσα εφεύρεση αφορά ένα μέσο για θεραπεία και/ή για προφύλαξη από ένα αυτοάνοσο νόσημα, ένα μέσο για τη δημιουργία ρυθμιστικών Τ-κυττάρων (ΤReg) σε έναν ζώντα οργανισμό, καθώς και διάφορες μεθόδους, στις οποίες χρησιμοποιούνται τα σύμφωνα με την εφεύρεση μέσα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008023820A DE102008023820A1 (de) | 2008-05-08 | 2008-05-08 | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| EP09741834A EP2288372B1 (de) | 2008-05-08 | 2009-04-28 | Ein il-2 mutein zur behandlung oder prophylaxe einer autoimmunerkrankung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112469T1 true CY1112469T1 (el) | 2015-12-09 |
Family
ID=41152787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100236T CY1112469T1 (el) | 2008-05-08 | 2012-03-08 | Μια il-2 μουτεϊνη για θεραπεια ή για προφυλαξη απο ενα αυτοανοσο νοσημα |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US20110150826A1 (el) |
| EP (1) | EP2288372B1 (el) |
| JP (2) | JP5651583B2 (el) |
| KR (3) | KR20160092048A (el) |
| CN (2) | CN110935025A (el) |
| AR (1) | AR071756A1 (el) |
| AT (1) | ATE544465T1 (el) |
| AU (1) | AU2009244039B2 (el) |
| BR (1) | BRPI0912411B8 (el) |
| CA (1) | CA2723761C (el) |
| CL (1) | CL2009001099A1 (el) |
| CY (1) | CY1112469T1 (el) |
| DE (1) | DE102008023820A1 (el) |
| DK (1) | DK2288372T3 (el) |
| ES (1) | ES2378957T3 (el) |
| HR (1) | HRP20120296T1 (el) |
| IL (3) | IL209128A (el) |
| MX (1) | MX2010012214A (el) |
| PE (1) | PE20091967A1 (el) |
| PL (1) | PL2288372T3 (el) |
| PT (1) | PT2288372E (el) |
| RU (1) | RU2531936C2 (el) |
| SI (1) | SI2288372T1 (el) |
| TW (1) | TWI510622B (el) |
| UA (1) | UA102099C2 (el) |
| UY (1) | UY31816A (el) |
| WO (1) | WO2009135615A2 (el) |
| ZA (1) | ZA201008129B (el) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| CA2749539C (en) | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
| WO2011006029A1 (en) | 2009-07-10 | 2011-01-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Artificial cell constructs for inducing immunological tolerance |
| US11090363B2 (en) | 2009-07-10 | 2021-08-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Vasoactive intestinal peptide release from microparticles |
| CU23734A1 (es) * | 2009-11-27 | 2011-11-15 | Centro Inmunologia Molecular | Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas |
| US9018006B2 (en) * | 2010-07-23 | 2015-04-28 | The University Of Toledo | Stable Tregs and related materials and methods |
| CU23923B1 (es) * | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| KR102220006B1 (ko) | 2011-03-11 | 2021-02-24 | 아시스땅스 퍼블리끄-오삐또 드 빠리 | 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 il2 의 용도 |
| US9669071B2 (en) | 2011-03-11 | 2017-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for stimulating T lymphocytes with IL-2 |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| BR112015013557B1 (pt) | 2012-12-11 | 2021-12-14 | Albert Einstein College Of Medicine | Sistema, método, método para determinar o efeito de um resíduo de aminoácido predeterminado de uma primeira proteína sobre a ligação da primeira proteína a uma segunda proteína e polipeptídeo pd-l1 mutante |
| EA201992609A1 (ru) | 2014-02-06 | 2020-03-04 | Ф.Хоффманн-Ля Рош Аг | Слитые белки, содержащие интерлейкин-2, и их применения |
| CN113234138A (zh) | 2014-08-11 | 2021-08-10 | 德里尼亚公司 | 选择性地活化调节性t细胞用于治疗自身免疫病的修饰的il-2变体 |
| IL304950A (en) | 2015-04-10 | 2023-10-01 | Amgen Inc | Interleukin for the expansion of myotonic control T-2 cells |
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