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CY1112009T1 - Παρασκευη συζυγων ινσουλινης - Google Patents

Παρασκευη συζυγων ινσουλινης

Info

Publication number
CY1112009T1
CY1112009T1 CY20111100398T CY111100398T CY1112009T1 CY 1112009 T1 CY1112009 T1 CY 1112009T1 CY 20111100398 T CY20111100398 T CY 20111100398T CY 111100398 T CY111100398 T CY 111100398T CY 1112009 T1 CY1112009 T1 CY 1112009T1
Authority
CY
Cyprus
Prior art keywords
insulin
wife
preparation
conjugation
oligomer
Prior art date
Application number
CY20111100398T
Other languages
English (en)
Inventor
Nitesh Dave
Gautam Krishnan
Shrikumar Suryanarayan
Partha Hazra
Hs Manjunath
Anand Khedkar
Harish Iyer
Original Assignee
Biocon Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Limited filed Critical Biocon Limited
Publication of CY1112009T1 publication Critical patent/CY1112009T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση αποκαλύπτει μια μέθοδο παραγωγής ενός συζυγούς ινσουλίνης-ολιγομερούς ως αντίδρασης ενός δοχείου με σύζευξη εστέρα ινσουλίνης με ενεργοποιημένο ολιγομερές όπου διεξάγεται το ταυτόχρονο απομπλοκάρισμα και η σύζευξη.
CY20111100398T 2005-07-08 2011-04-18 Παρασκευη συζυγων ινσουλινης CY1112009T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IN2005/000234 WO2007007345A1 (en) 2005-07-08 2005-07-08 Preparation of insulin conjugates
EP05784019A EP1907419B1 (en) 2005-07-08 2005-07-08 Preparation of insulin conjugates

Publications (1)

Publication Number Publication Date
CY1112009T1 true CY1112009T1 (el) 2015-11-04

Family

ID=37636774

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100398T CY1112009T1 (el) 2005-07-08 2011-04-18 Παρασκευη συζυγων ινσουλινης

Country Status (16)

Country Link
US (1) US7977454B2 (el)
EP (1) EP1907419B1 (el)
JP (1) JP4818361B2 (el)
KR (1) KR101225679B1 (el)
CN (1) CN101223190B (el)
AT (1) ATE496941T1 (el)
BR (1) BRPI0520362B1 (el)
CY (1) CY1112009T1 (el)
DE (1) DE602005026182D1 (el)
DK (1) DK1907419T3 (el)
ES (1) ES2361166T3 (el)
IL (1) IL188603A (el)
PL (1) PL1907419T3 (el)
PT (1) PT1907419E (el)
SI (1) SI1907419T1 (el)
WO (1) WO2007007345A1 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007043059A1 (en) * 2005-10-13 2007-04-19 Biocon Limited Process for the preparation of insulin conjugates.
WO2008049711A1 (en) 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
US20120123089A1 (en) * 2009-07-09 2012-05-17 Biocon Limited Preparative non-linear gradient based chromatographic method and purified products thereof
AR080884A1 (es) 2010-04-14 2012-05-16 Sanofi Aventis Conjugados de insulina-sirna
CN102675452B (zh) * 2011-03-17 2015-09-16 重庆富进生物医药有限公司 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物
TWI565714B (zh) * 2011-06-02 2017-01-11 韓美科學股份有限公司 非肽基聚合物－胰島素集合體及其製造方法
US9457096B2 (en) 2012-07-06 2016-10-04 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery
CN102816819B (zh) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
GB2567646B8 (en) 2017-10-18 2020-07-08 Leonardo Mw Ltd Apparatus and method for reducing distortion of an optical signal

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
JP2002217457A (ja) * 2001-01-12 2002-08-02 Nec Corp 携帯電話機、それに備えられた拡散体及び照明装置
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same

Also Published As

Publication number Publication date
PL1907419T3 (pl) 2011-08-31
EP1907419A4 (en) 2008-07-23
BRPI0520362A2 (pt) 2009-05-05
ATE496941T1 (de) 2011-02-15
WO2007007345A1 (en) 2007-01-18
CN101223190A (zh) 2008-07-16
EP1907419B1 (en) 2011-01-26
CN101223190B (zh) 2012-06-20
EP1907419A1 (en) 2008-04-09
JP2009500396A (ja) 2009-01-08
US7977454B2 (en) 2011-07-12
DE602005026182D1 (de) 2011-03-10
US20080139784A1 (en) 2008-06-12
IL188603A (en) 2012-12-31
PT1907419E (pt) 2011-04-06
BRPI0520362B1 (pt) 2017-10-17
KR101225679B1 (ko) 2013-01-23
IL188603A0 (en) 2008-04-13
DK1907419T3 (da) 2011-04-26
JP4818361B2 (ja) 2011-11-16
ES2361166T3 (es) 2011-06-14
KR20080033334A (ko) 2008-04-16
SI1907419T1 (sl) 2011-06-30

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