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CY1111863T1 - Αντισωματα εναντιον υποδοχεα θανατου 4 (dr4) και χρησεις αυτων - Google Patents

Αντισωματα εναντιον υποδοχεα θανατου 4 (dr4) και χρησεις αυτων

Info

Publication number
CY1111863T1
CY1111863T1 CY20111100932T CY111100932T CY1111863T1 CY 1111863 T1 CY1111863 T1 CY 1111863T1 CY 20111100932 T CY20111100932 T CY 20111100932T CY 111100932 T CY111100932 T CY 111100932T CY 1111863 T1 CY1111863 T1 CY 1111863T1
Authority
CY
Cyprus
Prior art keywords
death receptor
against death
options against
antibodies
options
Prior art date
Application number
CY20111100932T
Other languages
English (en)
Inventor
Anan Chuntharapai
Kyung Jin Kim
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22107878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111863(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of CY1111863T1 publication Critical patent/CY1111863T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Παρέχονται αντισώματα Υποδοχέα Θανάτου 4 (DR4: Death Receptor 4). Τα αντισώματα DR4 μπορούν να συμπεριληφθούν σε φαρμακευτικές συνθέσεις, βιομηχανικά προϊόντα, ή κιτ. Παρέχονται επίσης μέθοδοι θεραπευτικής αγωγής και διάγνωσης χρησιμοποιώντας τα αντισώματα DR4.
CY20111100932T 1998-01-26 2011-09-27 Αντισωματα εναντιον υποδοχεα θανατου 4 (dr4) και χρησεις αυτων CY1111863T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7248198P 1998-01-26 1998-01-26
EP99903332A EP1053256B9 (en) 1998-01-26 1999-01-25 Antibodies to death receptor 4 (dr4) and uses thereof

Publications (1)

Publication Number Publication Date
CY1111863T1 true CY1111863T1 (el) 2015-11-04

Family

ID=22107878

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100932T CY1111863T1 (el) 1998-01-26 2011-09-27 Αντισωματα εναντιον υποδοχεα θανατου 4 (dr4) και χρησεις αυτων

Country Status (11)

Country Link
EP (1) EP1053256B9 (el)
JP (1) JP2002500877A (el)
AT (1) ATE517125T1 (el)
AU (1) AU2338299A (el)
CA (1) CA2318405C (el)
CY (1) CY1111863T1 (el)
DK (1) DK1053256T3 (el)
ES (1) ES2368823T3 (el)
IL (1) IL137176A0 (el)
PT (1) PT1053256E (el)
WO (1) WO1999037684A1 (el)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1012274E (pt) 1997-01-28 2007-08-14 Craig A Rosen Receptor 4 contendo um domínio de morte (dm4; receptor de morte 4), membro da super-família do ftn e ligação a liart (ap02)
US6433147B1 (en) 1997-01-28 2002-08-13 Human Genome Sciences, Inc. Death domain containing receptor-4
US7452538B2 (en) 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US8329179B2 (en) 1997-01-28 2012-12-11 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
EP1178828A4 (en) * 1999-05-06 2004-10-13 Human Genome Sciences Inc RECEPTOR CONTAINING "DEATH DOMAIN"
PT1181319E (pt) * 1999-05-28 2009-07-14 Genentech Inc Anticorpos quiméricos contra dr4 e suas utilizações
IL146491A0 (en) * 1999-06-09 2002-07-25 Genentech Inc APo-2L RECEPTOR AGONIST AND CPT-11 SYNERGISM
EP1658859A1 (en) * 1999-06-09 2006-05-24 Genentech, Inc. APO-2L receptor agonist and CPT-11 synergism
PT2857516T (pt) 2000-04-11 2017-08-28 Genentech Inc Anticorpos multivalentes e utilizações dos mesmos
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
ES2317924T3 (es) * 2000-07-27 2009-05-01 Genentech, Inc. Administracion secuencial de cpt-11 y polipeptido apo-2l.
AU2001297702A1 (en) * 2000-11-08 2002-10-15 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
CA2447602C (en) 2001-05-18 2011-11-01 Kirin Beer Kabushiki Kaisha Anti-trail-r antibodies
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
MXPA03010747A (es) 2001-05-25 2004-03-02 Human Genome Sciences Inc Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral.
WO2004016753A2 (en) * 2002-08-15 2004-02-26 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US7252994B2 (en) * 2001-07-03 2007-08-07 Genentech, Inc. Human DR4 antibodies and uses thereof
ES2357225T3 (es) * 2001-11-01 2011-04-20 Uab Research Foundation Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos.
EP2500032A1 (en) 2002-06-24 2012-09-19 Genentech, Inc. APO-2 ligand/trail variants and uses thereof
RS20150135A1 (sr) 2003-05-30 2015-08-31 Genentech Inc. Tretman sa anti-vegf antitelima
MX2007001469A (es) 2004-08-06 2007-03-26 Genentech Inc Ensayos y metodos que utilizan biomarcadores.
ZA200701657B (en) 2004-08-06 2008-09-25 Genentech Inc Assays and methods using biomarkers
AU2005282397A1 (en) * 2004-09-08 2006-03-16 Genentech, Inc. Methods of using death receptor ligands and CD20 antibodies
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
US8129124B2 (en) 2005-02-02 2012-03-06 The Uab Research Foundation Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
PT1915626E (pt) 2005-08-16 2012-02-03 Genentech Inc Sensibilidade da apoptose a apo2l/trail por ensaio de expressão de galnac-t14 em células/tecidos
CN101074261A (zh) * 2006-04-30 2007-11-21 北京同为时代生物技术有限公司 Trail受体1和/或trail受体2特异性抗体及其应用
WO2008066854A2 (en) * 2006-11-28 2008-06-05 Novartis Ag Methods and compositions for inducing apoptosis in cancer cells
CA2739663A1 (en) 2008-10-10 2010-05-15 Anaphore, Inc. Polypeptides that bind trail-r1 and trail-r2
WO2012117336A2 (en) 2011-02-28 2012-09-07 Istituto Di Ricovero E Cura A Carattere Scientifico Materno-Infantile Burlo Garofolo - Ospedale Di Alta Specializzazione E Di Rilievo Nazionale Per La Salute Della Donna E Del Bambino Apoptosis-inducing molecules and uses therefor
CA2834776A1 (en) 2011-05-03 2012-11-08 Genentech, Inc. Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies
EP3323428A1 (en) 2016-11-17 2018-05-23 CNRS Centre National de la Recherche Scientifique Selective c-flip inhibitors as anticancer agents
BR112022010757A2 (pt) 2019-12-03 2022-08-16 Shanghai Jiao Tong Univ School Of Medicine Região de anticorpo fc com afinidade de ligação aumentada para fc-gama-riib.
EP3910331A1 (en) 2020-05-15 2021-11-17 iOmx Therapeutics AG Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof
EP4257132A1 (en) 2022-04-08 2023-10-11 iOmx Therapeutics AG Sik3 inhibitors for treating diseases resistant to death receptor signalling
WO2024175554A1 (en) 2023-02-21 2024-08-29 Institut Curie Trail agonists for use in the treatment of cancer in patients having an activating alteration of fgfr3

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1368292A (en) * 1991-03-11 1992-10-06 Sheila Drover Murine monoclonal antibodies recognizing polymorphic determinants of hla
US6030945A (en) 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
SE9600820D0 (sv) * 1996-03-01 1996-03-01 Pharmacia Ab Antibodies and their use
ATE465257T1 (de) * 1996-07-03 2010-05-15 Genentech Inc Agonisten für den rezeptor des hepatozyten- wachstumsfaktors und deren anwendungen
EP0912734B1 (en) * 1996-07-12 2010-11-03 Genentech, Inc. Chimeric heteromultimer adhesins
PT1012274E (pt) * 1997-01-28 2007-08-14 Craig A Rosen Receptor 4 contendo um domínio de morte (dm4; receptor de morte 4), membro da super-família do ftn e ligação a liart (ap02)

Also Published As

Publication number Publication date
PT1053256E (pt) 2011-09-28
ATE517125T1 (de) 2011-08-15
CA2318405C (en) 2014-01-07
DK1053256T3 (da) 2011-10-03
EP1053256A1 (en) 2000-11-22
EP1053256B1 (en) 2011-07-20
WO1999037684A1 (en) 1999-07-29
JP2002500877A (ja) 2002-01-15
EP1053256B9 (en) 2012-01-18
AU2338299A (en) 1999-08-09
CA2318405A1 (en) 1999-07-29
IL137176A0 (en) 2001-07-24
ES2368823T3 (es) 2011-11-22
HK1033582A1 (en) 2001-09-07

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