CY1111275T1 - Κρυσταλλικη μορφη μιας ενωσης κινολινονης-καρβοξαμιδιου - Google Patents
Κρυσταλλικη μορφη μιας ενωσης κινολινονης-καρβοξαμιδιουInfo
- Publication number
- CY1111275T1 CY1111275T1 CY20101101076T CY101101076T CY1111275T1 CY 1111275 T1 CY1111275 T1 CY 1111275T1 CY 20101101076 T CY20101101076 T CY 20101101076T CY 101101076 T CY101101076 T CY 101101076T CY 1111275 T1 CY1111275 T1 CY 1111275T1
- Authority
- CY
- Cyprus
- Prior art keywords
- quinolin
- crystalline form
- carboxamide compound
- crystalline
- crystalline salts
- Prior art date
Links
- -1 quinolin-carboxamide compound Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 108091005482 5-HT4 receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση παρέχει ένα κρυσταλλικό υδροχλωρικό άλας του {(1S,3R,5R)-8-[(R)-2-υδροξυ-3-(μεθανοσουλφονυλ-μεθυλ-αμινο)προπυλ]-8-αζαδικυκλο[3.2.1]οκτ-3-υλ} αμιδίου 1 -ισοπροπυλ-2-οξο-1,2-διϋδροκινολιν-3-καρβοξυλικού οξέος ή ενός διαλύτη αυτού. Η εφεύρεση παρέχει επίσης φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν τέτοιου είδους κρυσταλλικές μορφές άλατος, μεθόδους χρήσης τέτοιου είδους κρυσταλλικών μορφών άλατος για τη θεραπεία ασθενειών που σχετίζονται με την δράση του υποδοχέα 5 ΗΤ4, και διαδικασίες χρήσιμες για την παρασκευή τέτοιου είδους κρυσταλλικών μορφών άλατος.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66878005P | 2005-04-06 | 2005-04-06 | |
| EP06740692A EP1874766B1 (en) | 2005-04-06 | 2006-04-05 | Crystalline form of a quinolinone-carboxamide compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111275T1 true CY1111275T1 (el) | 2015-08-05 |
Family
ID=37074104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101101076T CY1111275T1 (el) | 2005-04-06 | 2010-11-25 | Κρυσταλλικη μορφη μιας ενωσης κινολινονης-καρβοξαμιδιου |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US7728004B2 (el) |
| EP (1) | EP1874766B1 (el) |
| JP (2) | JP5230407B2 (el) |
| KR (1) | KR101322873B1 (el) |
| CN (1) | CN101151264B (el) |
| AR (2) | AR053208A1 (el) |
| AT (1) | ATE479682T1 (el) |
| AU (1) | AU2006232129B2 (el) |
| BR (1) | BRPI0610657A2 (el) |
| CA (1) | CA2603654C (el) |
| CY (1) | CY1111275T1 (el) |
| DE (1) | DE602006016586D1 (el) |
| DK (1) | DK1874766T3 (el) |
| EA (1) | EA012115B1 (el) |
| ES (1) | ES2350495T3 (el) |
| HR (1) | HRP20100629T1 (el) |
| IL (1) | IL186023A (el) |
| MA (1) | MA29403B1 (el) |
| MX (1) | MX2007012438A (el) |
| MY (1) | MY151075A (el) |
| NO (1) | NO339699B1 (el) |
| NZ (1) | NZ561900A (el) |
| PE (1) | PE20061310A1 (el) |
| PL (1) | PL1874766T3 (el) |
| PT (1) | PT1874766E (el) |
| SI (1) | SI1874766T1 (el) |
| TW (1) | TWI377206B (el) |
| WO (1) | WO2006108127A2 (el) |
| ZA (1) | ZA200708071B (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7063671B2 (en) * | 2002-06-21 | 2006-06-20 | Boston Scientific Scimed, Inc. | Electronically activated capture device |
| TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| DE602005014566D1 (de) | 2004-11-05 | 2009-07-02 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
| EP1807422B1 (en) * | 2004-11-05 | 2009-09-02 | Theravance, Inc. | 5-ht4 receptor agonist compounds |
| TWI377206B (en) * | 2005-04-06 | 2012-11-21 | Theravance Inc | Crystalline form of a quinolinone-carboxamide compound |
| KR101331768B1 (ko) | 2005-11-08 | 2013-11-22 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제 |
| JP2010527357A (ja) * | 2007-05-17 | 2010-08-12 | セラヴァンス， インコーポレーテッド | 腸の前処置のための運動促進剤 |
| CH698729B1 (de) * | 2007-05-30 | 2009-10-15 | Cerbios Pharma Sa | Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure. |
| HRP20170241T2 (hr) | 2007-12-07 | 2023-03-17 | Vertex Pharmaceuticals Incorporated | Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| HRP20180018T1 (hr) | 2009-04-13 | 2018-02-09 | Theravance Biopharma R&D Ip, Llc | Kombinacija agonista receptora 5-ht 4 i inhibitora acetilkolinesteraze za liječenje kognitivnog poremećaja |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
| DK3150198T3 (da) | 2010-04-07 | 2021-11-01 | Vertex Pharma | Farmaceutiske sammensætninger af 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-yl)-cyclopropancarboxamido)-3-methylpyriodin-2-yl)benzoesyre og indgivelse deraf |
| RU2718044C2 (ru) | 2013-11-12 | 2020-03-30 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения фармацевтических композиций для лечения опосредованных cftr заболеваний |
| PT3661518T (pt) * | 2017-07-31 | 2024-11-04 | Alfasigma Spa | Métodos de tratamento dos sintomas da gastroparesia usando velusetrag |
| US10570127B1 (en) | 2018-11-05 | 2020-02-25 | Renexxion, Llc | Material and methods for the treatment of gastro-intestinal disorders |
| IL319356A (en) | 2022-09-20 | 2025-05-01 | Alfasigma Spa | Velostrag for use in the treatment of chronic pseudointestinal obstruction (CIPO) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3122671B2 (ja) | 1990-05-23 | 2001-01-09 | 協和醗酵工業株式会社 | 複素環式化合物 |
| DE69113284T2 (de) * | 1990-12-28 | 1996-02-22 | Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo | Chinolinderivat. |
| EP0670319A4 (en) | 1992-11-20 | 1996-01-17 | Thaisho Pharmaceutical Co Ltd | HETEROCYCLIC COMPOUNDS. |
| JP3829879B2 (ja) | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
| TW402591B (en) * | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| US7105195B2 (en) * | 2003-07-25 | 2006-09-12 | General Mills, Inc. | Reduced trans fat product |
| ES2338882T3 (es) | 2003-11-24 | 2010-05-13 | Pfizer, Inc. | Compuestos de acido quinolona-carboxilico que tienen actividad agonista del receptor 5-ht4. |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US7728006B2 (en) | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| DE602005014566D1 (de) | 2004-11-05 | 2009-07-02 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
| EP1807422B1 (en) | 2004-11-05 | 2009-09-02 | Theravance, Inc. | 5-ht4 receptor agonist compounds |
| US20060183901A1 (en) | 2005-02-17 | 2006-08-17 | Theravance, Inc. | Crystalline form of an indazole-carboxamide compound |
| AU2006218603A1 (en) | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-HT4 receptor agonists |
| TWI377206B (en) * | 2005-04-06 | 2012-11-21 | Theravance Inc | Crystalline form of a quinolinone-carboxamide compound |
-
2006
- 2006-03-27 TW TW095110607A patent/TWI377206B/zh not_active IP Right Cessation
- 2006-04-03 PE PE2006000360A patent/PE20061310A1/es not_active Application Discontinuation
- 2006-04-03 MY MYPI20061482 patent/MY151075A/en unknown
- 2006-04-05 HR HR20100629T patent/HRP20100629T1/hr unknown
- 2006-04-05 US US11/398,119 patent/US7728004B2/en active Active
- 2006-04-05 EP EP06740692A patent/EP1874766B1/en active Active
- 2006-04-05 PL PL06740692T patent/PL1874766T3/pl unknown
- 2006-04-05 BR BRPI0610657-9A patent/BRPI0610657A2/pt not_active Application Discontinuation
- 2006-04-05 EA EA200702161A patent/EA012115B1/ru not_active IP Right Cessation
- 2006-04-05 NZ NZ561900A patent/NZ561900A/en unknown
- 2006-04-05 SI SI200630833T patent/SI1874766T1/sl unknown
- 2006-04-05 CA CA2603654A patent/CA2603654C/en active Active
- 2006-04-05 ES ES06740692T patent/ES2350495T3/es active Active
- 2006-04-05 WO PCT/US2006/012978 patent/WO2006108127A2/en not_active Ceased
- 2006-04-05 MX MX2007012438A patent/MX2007012438A/es active IP Right Grant
- 2006-04-05 CN CN2006800107676A patent/CN101151264B/zh active Active
- 2006-04-05 JP JP2008505559A patent/JP5230407B2/ja active Active
- 2006-04-05 DK DK06740692.6T patent/DK1874766T3/da active
- 2006-04-05 AT AT06740692T patent/ATE479682T1/de active
- 2006-04-05 PT PT06740692T patent/PT1874766E/pt unknown
- 2006-04-05 DE DE602006016586T patent/DE602006016586D1/de active Active
- 2006-04-05 AU AU2006232129A patent/AU2006232129B2/en active Active
- 2006-04-05 KR KR1020077025632A patent/KR101322873B1/ko active Active
- 2006-04-06 AR ARP060101375A patent/AR053208A1/es not_active Application Discontinuation
-
2007
- 2007-09-18 IL IL186023A patent/IL186023A/en active IP Right Grant
- 2007-09-19 ZA ZA200708071A patent/ZA200708071B/xx unknown
- 2007-10-25 MA MA30317A patent/MA29403B1/fr unknown
- 2007-11-02 NO NO20075574A patent/NO339699B1/no not_active IP Right Cessation
-
2010
- 2010-04-13 US US12/759,080 patent/US8658671B2/en active Active
- 2010-11-25 CY CY20101101076T patent/CY1111275T1/el unknown
-
2012
- 2012-05-17 JP JP2012113464A patent/JP2012153725A/ja not_active Withdrawn
-
2014
- 2014-01-08 US US14/150,059 patent/US9126994B2/en active Active
-
2015
- 2015-08-03 US US14/816,237 patent/US9402840B2/en active Active
-
2017
- 2017-11-01 AR ARP170103029A patent/AR110019A2/es unknown
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