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CY1110550T1 - Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους - Google Patents

Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους

Info

Publication number
CY1110550T1
CY1110550T1 CY20091101187T CY091101187T CY1110550T1 CY 1110550 T1 CY1110550 T1 CY 1110550T1 CY 20091101187 T CY20091101187 T CY 20091101187T CY 091101187 T CY091101187 T CY 091101187T CY 1110550 T1 CY1110550 T1 CY 1110550T1
Authority
CY
Cyprus
Prior art keywords
bicalutamide
crystal
production
vicalutamide
crystals
Prior art date
Application number
CY20091101187T
Other languages
English (en)
Inventor
Tetsuya Shintaku
Tadashi Katsura
Nobushige Itaya
Original Assignee
Sumitomo Chemical Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Company, Limited filed Critical Sumitomo Chemical Company, Limited
Publication of CY1110550T1 publication Critical patent/CY1110550T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Meat, Egg Or Seafood Products (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με ένα κρύσταλλο βικαλουταμίδης η οποία έχει μια ορισμένη μορφή, καθώς επίσης και με οικονομικές και βιομηχανικώς πρακτικές μεθόδους παραγωγής βικαλουταμίδης και ενός κρυστάλλου αυτής, οι οποίες είναι ανώτερες ως προς την ηπιότητα έναντι του περιβάλλοντος και την ασφάλεια.
CY20091101187T 2001-12-13 2009-11-12 Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους CY1110550T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001380686 2001-12-13
JP2002166213 2002-06-06
EP02788815A EP1462442B1 (en) 2001-12-13 2002-12-13 Crystals of bicalutamide and process for their production

Publications (1)

Publication Number Publication Date
CY1110550T1 true CY1110550T1 (el) 2015-04-29

Family

ID=26625048

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101187T CY1110550T1 (el) 2001-12-13 2009-11-12 Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους

Country Status (20)

Country Link
US (2) US6740770B2 (el)
EP (1) EP1462442B1 (el)
JP (2) JP4255381B2 (el)
KR (1) KR100938188B1 (el)
CN (1) CN1602299A (el)
AT (1) ATE440817T1 (el)
AU (2) AU2002354475B2 (el)
BR (1) BR0214933A (el)
CA (1) CA2469594C (el)
CY (1) CY1110550T1 (el)
DE (1) DE60233526D1 (el)
DK (1) DK1462442T3 (el)
ES (1) ES2331178T3 (el)
IL (3) IL162398A0 (el)
IS (1) IS2737B (el)
NZ (1) NZ533943A (el)
PT (1) PT1462442E (el)
SI (1) SI1462442T1 (el)
WO (1) WO2003053920A1 (el)
ZA (1) ZA200404891B (el)

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HU223950B1 (hu) * 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
WO2003053920A1 (en) * 2001-12-13 2003-07-03 Sumika Fine Chemicals Co., Ltd. Crystals of bicalutamide and process for their production
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
WO2004074350A2 (en) * 2003-02-21 2004-09-02 Hetero Drugs Limited Bicalutamide polymorphs
AU2003247740A1 (en) * 2003-06-25 2005-02-14 Teva Gyogyszergyar Reszventarsasag Process for purifying and isolating rac-bicalutamide
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
WO2005089511A2 (en) * 2004-03-19 2005-09-29 Transform Pharmaceuticals, Inc. Novel pharmaceutical forms, and methods of making and using the same
AU2005260816B2 (en) * 2004-07-14 2010-12-16 Sumitomo Chemical Company, Limited Method of crystallizing bicalutamide
AU2005329762A1 (en) * 2005-03-29 2006-10-05 Usv Limited Process for preparation of bicalutamide
CA2513356A1 (en) * 2005-07-26 2007-01-26 Apotex Pharmachem Inc. Process for production of bicalutamide
AU2006329551A1 (en) * 2005-12-27 2007-07-05 Dabur Pharma Limited An improved process for preparation of Bicalutamide
JP2009067710A (ja) * 2007-09-12 2009-04-02 Sumitomo Chemical Co Ltd Ｎ−メタクリロイル−４−シアノ−３−トリフルオロメチルアニリンの製造方法
WO2009087666A2 (en) * 2008-01-04 2009-07-16 Kekule Pharma An improved process for production of bicalutamide useful in the treatment of prostate cancer
CN101987086B (zh) * 2009-08-03 2012-07-18 北京化工大学 一种超细比卡鲁胺口服片剂及其制备方法
US9033993B2 (en) 2009-11-03 2015-05-19 Howmedica Osteonics Corp. Intervertebral implant with integrated fixation
CN101891663A (zh) * 2010-07-21 2010-11-24 杭州民生药业有限公司 一种比卡鲁胺中间体的制备方法
JP2013544768A (ja) 2010-09-29 2013-12-19 シルパ メディケア リミテッド ビカルタミドの調製方法
CN102321000A (zh) * 2011-07-21 2012-01-18 宁波人健药业集团有限公司 氧化制备比卡鲁胺的方法
US9650382B2 (en) 2012-01-13 2017-05-16 Aranda Pharma Ltd Heteroarylamide derivatives having antiandrogenic properties
CN105541680B (zh) * 2016-02-16 2017-12-22 重庆硕奥科技有限公司 一种比卡鲁胺的合成方法
CN105949095A (zh) * 2016-05-27 2016-09-21 山西振东制药股份有限公司 一种比卡鲁胺i晶型的制备方法
CN106748884B (zh) * 2016-12-13 2021-08-20 山西振东制药股份有限公司 一种比卡鲁胺中间体的制备方法
CN106905265A (zh) * 2017-03-09 2017-06-30 常州沃腾化工科技有限公司 N‑[4‑氰基‑3‑（三氟甲基）苯基]‑2,3‑环氧‑2‑甲基丙酰胺的制备方法
CN109336798B (zh) * 2018-11-19 2021-11-16 常州新星联生物科技有限公司 一种比卡鲁胺硫醚中间体的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE225694C (el)
US4191775A (en) 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
EP0100172B1 (en) * 1982-07-23 1987-08-12 Imperial Chemical Industries Plc Amide derivatives
DD225694A1 (de) * 1984-06-14 1985-08-07 Univ Leipzig Verfahren zur darstellung substituierter 9-oxabicyclo/6.1.0/-nonane
HU223950B1 (hu) * 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
IL149056A0 (en) 1999-10-19 2002-11-10 Nobex Corp Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof
NZ518552A (en) 1999-10-27 2003-10-31 Nobex Corp Resolution of intermediates in the synthesis of substantially pure bicalutamide
PL361705A1 (en) 2000-09-21 2004-10-04 Bristol-Myers Squibb Company Process for the preparation of n-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
US6479692B1 (en) 2001-05-02 2002-11-12 Nobex Corporation Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
AU2002312431A1 (en) 2001-06-13 2002-12-23 Biogal Gyogyszergyar Rt. Novel process for preparing rac-bicalutamide and its intermediates
WO2003053920A1 (en) * 2001-12-13 2003-07-03 Sumika Fine Chemicals Co., Ltd. Crystals of bicalutamide and process for their production
US20040063782A1 (en) 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof

Also Published As

Publication number Publication date
BR0214933A (pt) 2004-12-14
CA2469594A1 (en) 2003-07-03
EP1462442A4 (en) 2005-12-07
US6740770B2 (en) 2004-05-25
IL189180A (en) 2010-12-30
JPWO2003053920A1 (ja) 2005-04-28
ATE440817T1 (de) 2009-09-15
SI1462442T1 (sl) 2010-01-29
IL189180A0 (en) 2009-02-11
IL162398A0 (en) 2005-11-20
AU2002354475B2 (en) 2008-08-14
US20030191337A1 (en) 2003-10-09
IS2737B (is) 2011-06-15
EP1462442B1 (en) 2009-08-26
JP4255381B2 (ja) 2009-04-15
AU2002354475A1 (en) 2003-07-09
US7132560B2 (en) 2006-11-07
JP4907634B2 (ja) 2012-04-04
EP1462442A1 (en) 2004-09-29
DE60233526D1 (de) 2009-10-08
ZA200404891B (en) 2005-06-21
CA2469594C (en) 2011-01-25
IS7302A (is) 2004-06-08
IL162398A (en) 2009-08-03
KR100938188B1 (ko) 2010-01-21
AU2008203026A1 (en) 2008-07-31
ES2331178T3 (es) 2009-12-23
AU2008203026B2 (en) 2011-05-12
JP2009108081A (ja) 2009-05-21
PT1462442E (pt) 2009-10-09
KR20040063947A (ko) 2004-07-14
NZ533943A (en) 2006-06-30
DK1462442T3 (da) 2009-12-14
CN1602299A (zh) 2005-03-30
WO2003053920A1 (en) 2003-07-03
US20040133031A1 (en) 2004-07-08

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