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CY1110228T1 - Η χρηση του εισπνεομενου νο ως αντιφλεγμονωδους παραγοντα - Google Patents

Η χρηση του εισπνεομενου νο ως αντιφλεγμονωδους παραγοντα

Info

Publication number
CY1110228T1
CY1110228T1 CY20091100436T CY091100436T CY1110228T1 CY 1110228 T1 CY1110228 T1 CY 1110228T1 CY 20091100436 T CY20091100436 T CY 20091100436T CY 091100436 T CY091100436 T CY 091100436T CY 1110228 T1 CY1110228 T1 CY 1110228T1
Authority
CY
Cyprus
Prior art keywords
ischemia
mammal
reperfusion
pulmonary
inflammation
Prior art date
Application number
CY20091100436T
Other languages
English (en)
Inventor
Warren M Zapol
Kenneth D Bloch
Anthony Rosenzweig
Original Assignee
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26742873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110228(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The General Hospital Corporation filed Critical The General Hospital Corporation
Publication of CY1110228T1 publication Critical patent/CY1110228T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)

Abstract

Μια μέθοδος για την ελάττωση ή την πρόληψη του μη-πνευμονικού τραυματισμού ισχαιμίας-επαναδιάχυσης ή της φλεγμονής σε ένα θηλαστικό με τον προσδιορισμό ενός θηλαστικού που έχει ισχαιμία-επαναδιάχυση ή διατρέχει τον κίνδυνο για να αναπτύξει ισχαιμία-επαναδιάχυση σε έναν μη-πνευμονικό ιστό· και την πρόκληση του θηλαστικού στο να εισπνεύσει μια θεραπευτικά αποτελεσματική ποσότητα αέριου μονοξειδίου αζώτου επαρκή για να ελαττώσει την ικανότητα των λευκοκυττάρων ή των αιμοπεταλίων να ενεργοποιηθούν με έναν τρόπο που συμβάλλει σε μια φλεγμονώδη διαδικασία στην τοποθεσία της ισχαιμίας-επαναδιάχυσης ή της φλεγμονής στον μη-πνευμονικό ιστό, ελαττώνοντας ή προλαμβάνοντας με αυτόν τον τρόπο τον μη-πνευμονικό τραυματισμό ισχαιμίας-επαναδιάχυσης στο θηλαστικό.
CY20091100436T 1997-10-21 2009-04-13 Η χρηση του εισπνεομενου νο ως αντιφλεγμονωδους παραγοντα CY1110228T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6292697P 1997-10-21 1997-10-21
US08/971,003 US6656452B1 (en) 1997-10-21 1997-11-14 Use of inhaled NO as anti-inflammatory agent
EP98953702A EP1073416B1 (en) 1997-10-21 1998-10-19 Use of inhaled no as anti-inflammatory agent

Publications (1)

Publication Number Publication Date
CY1110228T1 true CY1110228T1 (el) 2015-01-14

Family

ID=26742873

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100436T CY1110228T1 (el) 1997-10-21 2009-04-13 Η χρηση του εισπνεομενου νο ως αντιφλεγμονωδους παραγοντα

Country Status (13)

Country Link
US (2) US6656452B1 (el)
EP (1) EP1073416B1 (el)
JP (1) JP2003532615A (el)
AR (1) AR015973A1 (el)
AT (1) ATE421874T1 (el)
AU (1) AU751853B2 (el)
CA (1) CA2309038C (el)
CY (1) CY1110228T1 (el)
DE (1) DE69840526D1 (el)
DK (1) DK1073416T3 (el)
ES (1) ES2319240T3 (el)
PT (1) PT1073416E (el)
WO (1) WO1999020251A1 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
US20030070674A1 (en) * 2001-10-12 2003-04-17 Bryan Perry Use of aerosolized compounds in the treatment of exercise induced pulmonary hemorrhage in an equine
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US7086397B2 (en) * 2002-02-16 2006-08-08 Graham Lindley Spruiell Patient usable emergency medical kit
US7091207B2 (en) * 2002-05-22 2006-08-15 Virginia Commonwealth University Method of treating myocardial infarction with PDE-5 inhibitors
WO2003105872A1 (de) * 2002-06-12 2003-12-24 Messer Griesheim Gmbh Xenonhaltiges spasmolytikum
CA2490392A1 (en) * 2002-06-21 2003-12-31 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
AU2004255268B2 (en) 2003-07-09 2010-04-01 Loma Linda University Use of nitrite salts for the treatment of cardiovascular conditions
WO2005077005A2 (en) * 2004-02-04 2005-08-25 The General Hospital Corporation Enhancing the effectiveness of an inhaled therapeutic gas
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
WO2006125123A2 (en) * 2005-05-19 2006-11-23 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
WO2007130725A2 (en) * 2006-02-06 2007-11-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of hmgb1 for protection against ischemia reperfusion injury
CL2007003193A1 (es) * 2006-11-07 2008-07-04 Gen Hospital Corp Metodo para evitar o reducir la vasoconstriccion a continuacion de la administracion de un portador de oxigeno vasoactivo, que comprende oxido nitrico gaseoso y otro agente activo; composicion farmaceutica que comprende un inhibidor de fosfodiesteras
WO2008132239A1 (en) 2007-04-30 2008-11-06 Nnoxe Pharmaceutiques Inc Pharmaceutical composition comprising at least one thrombolytic agent (a) and at least one gas (b) selected from the group consisting of nitrous oxide, argon, xenon, helium, neon
WO2010049423A1 (en) * 2008-10-27 2010-05-06 Life Sciences Research Partners Vzw Effects of nitric oxide inhalation on long-term myocardial reperfusion injury
PL2440239T3 (pl) 2009-06-09 2018-01-31 Prolong Pharmaceuticals Llc Kompozycje hemoglobiny
JP5581500B2 (ja) 2010-03-10 2014-09-03 学校法人北里研究所 虚血再灌流障害軽減用治療剤および治療装置
WO2012075420A1 (en) * 2010-12-03 2012-06-07 Geno Llc Nitric oxide treatments
EP3650408A1 (en) 2011-10-03 2020-05-13 NitricGen, Inc. Apparatus and method for generating nitric oxide in controlled and accurate amounts
JP6389125B2 (ja) 2011-11-07 2018-09-12 ザ ジェネラル ホスピタル コーポレイション 赤血球の処理法
JP2014141536A (ja) * 2014-05-16 2014-08-07 Kitasato Institute 虚血再灌流障害軽減用治療剤および治療装置
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
JPWO2023190532A1 (el) * 2022-03-29 2023-10-05

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5570683A (en) * 1990-12-05 1996-11-05 The General Hospital Corporation Methods and devices for treating pulmonary vasoconstriction and asthma
DE10299002I1 (de) * 1990-12-05 2012-07-05 Gen Hospital Corp Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion
US5536241A (en) 1990-12-05 1996-07-16 The General Hospital Corporation Methods and devices for relaxing smooth muscle contractions
US5396882A (en) 1992-03-11 1995-03-14 The General Hospital Corporation Generation of nitric oxide from air for medical uses
US5427797A (en) * 1993-04-06 1995-06-27 Brigham And Women's Hospital Systemic effects of nitric oxide inhalation
GB9320978D0 (en) 1993-10-12 1993-12-01 Higenbottam Timohy W Nitric oxide treatment
AU704173B2 (en) 1993-11-02 1999-04-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The Use of nitric oxide releasing compounds as protective agents in ischemia reperfusion injury
US5521191A (en) 1994-10-17 1996-05-28 Washington University Method for treatment of arterial stenosis
US6063407A (en) 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US5823180A (en) 1995-04-03 1998-10-20 The General Hospital Corporation Methods for treating pulmonary vasoconstriction and asthma
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5725492A (en) * 1996-03-04 1998-03-10 Cormedics Corp Extracorporeal circulation apparatus and method
ATE331505T1 (de) 1996-04-05 2006-07-15 Gen Hospital Corp Behandlung einer hämoglobinstörung
US6601580B1 (en) 2000-06-28 2003-08-05 The General Hospital Corporation Enhancing therapeutic effectiveness of nitric oxide inhalation

Also Published As

Publication number Publication date
DK1073416T3 (da) 2009-03-09
AR015973A1 (es) 2001-05-30
US6656452B1 (en) 2003-12-02
CA2309038C (en) 2009-04-21
CA2309038A1 (en) 1999-04-29
ES2319240T3 (es) 2009-05-05
EP1073416A1 (en) 2001-02-07
PT1073416E (pt) 2009-03-17
DE69840526D1 (de) 2009-03-19
US20040096523A1 (en) 2004-05-20
ATE421874T1 (de) 2009-02-15
AU1101299A (en) 1999-05-10
EP1073416A4 (en) 2004-07-07
EP1073416B1 (en) 2009-01-28
JP2003532615A (ja) 2003-11-05
WO1999020251A1 (en) 1999-04-29
AU751853B2 (en) 2002-08-29
US6811768B2 (en) 2004-11-02

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