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CY1110296T1 - Χρηση αμινων ή αμινοξεων ως τροποποιητες κινητης φασης στη χρωματογραφια - Google Patents

Χρηση αμινων ή αμινοξεων ως τροποποιητες κινητης φασης στη χρωματογραφια

Info

Publication number
CY1110296T1
CY1110296T1 CY20101100422T CY101100422T CY1110296T1 CY 1110296 T1 CY1110296 T1 CY 1110296T1 CY 20101100422 T CY20101100422 T CY 20101100422T CY 101100422 T CY101100422 T CY 101100422T CY 1110296 T1 CY1110296 T1 CY 1110296T1
Authority
CY
Cyprus
Prior art keywords
chromatography
aminoids
amines
mobile phase
phase modifiers
Prior art date
Application number
CY20101100422T
Other languages
English (en)
Inventor
Kent E Goklen
Joseph Nti-Gyabaah
Firoz D Antia
Mary Ellen Dahlgren
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of CY1110296T1 publication Critical patent/CY1110296T1/el

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/284—Porous sorbents based on alumina
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με τη χρήση τροποποιητών κινητής φάσης αμίνη, αμινοξύ ή αμινοξικό εστέρα, σε χρωματογραφία κανονικής φάσης για βελτίωση της ανάλυσης ή/και της παραγωγικότητας στον καθαρισμό πεπτιδίου και λιποπεπτιδίου. Αυτή η μέθοδος χρωματογραφίας μπορεί να χρησιμοποιηθεί για καθαρισμό είτε αναλυτικής είτε παρασκευαστικής κλίμακας.
CY20101100422T 2002-10-30 2010-05-14 Χρηση αμινων ή αμινοξεων ως τροποποιητες κινητης φασης στη χρωματογραφια CY1110296T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42235602P 2002-10-30 2002-10-30
EP03776553A EP1558354B1 (en) 2002-10-30 2003-10-24 Using amines, amino acids or amino acid esters as mobile phase modifiers in chromatography

Publications (1)

Publication Number Publication Date
CY1110296T1 true CY1110296T1 (el) 2015-01-14

Family

ID=32312493

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100422T CY1110296T1 (el) 2002-10-30 2010-05-14 Χρηση αμινων ή αμινοξεων ως τροποποιητες κινητης φασης στη χρωματογραφια

Country Status (12)

Country Link
US (1) US7241866B2 (el)
EP (1) EP1558354B1 (el)
JP (1) JP4549862B2 (el)
AT (1) ATE457798T1 (el)
AU (1) AU2003284163A1 (el)
CY (1) CY1110296T1 (el)
DE (1) DE60331338D1 (el)
DK (1) DK1558354T3 (el)
ES (1) ES2342772T3 (el)
PT (1) PT1558354E (el)
SI (1) SI1558354T1 (el)
WO (1) WO2004042350A2 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPS264302A0 (en) * 2002-05-29 2002-06-20 Neopraxis Pty Ltd Implantable bladder sensor
CN103936837B (zh) * 2014-02-14 2016-05-25 博瑞生物医药泰兴市有限公司 一种提纯纽莫康定b0的方法
US10383550B2 (en) * 2014-07-17 2019-08-20 Elwha Llc Monitoring body movement or condition according to motion regimen with conformal electronics
CN105001305A (zh) * 2015-04-29 2015-10-28 利穗科技(苏州)有限公司 利用层析技术提取高纯度达托霉素的方法
CN108250274A (zh) * 2016-12-28 2018-07-06 浙江华谱新创科技有限公司 米卡芬净高效分离纯化方法
IL294319A (en) * 2020-01-08 2022-08-01 Regeneron Pharma Using amino acids to improve signals in mass spectrometry tests
CN111925421B (zh) * 2020-07-02 2022-05-10 北大方正集团有限公司 一种从发酵液中提取纽莫康定b0的方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812442A (en) * 1984-05-29 1989-03-14 Merck & Co., Inc. Tripeptide renin inhibitors
IT1190433B (it) * 1985-12-11 1988-02-16 Prodotti Antibiotici Spa Peptidi correlati al lisozima
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US5194377A (en) 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
GB9508195D0 (en) * 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
US6130353A (en) * 1997-03-18 2000-10-10 Chiral Technologies, Inc. Chiral separations of amino acids
JP3780638B2 (ja) * 1997-06-27 2006-05-31 東ソー株式会社 分離法及びこれを用いた装置

Also Published As

Publication number Publication date
EP1558354B1 (en) 2010-02-17
ATE457798T1 (de) 2010-03-15
AU2003284163A1 (en) 2004-06-07
WO2004042350A3 (en) 2004-07-15
JP2006504786A (ja) 2006-02-09
US7241866B2 (en) 2007-07-10
PT1558354E (pt) 2010-04-20
AU2003284163A8 (en) 2004-06-07
EP1558354A2 (en) 2005-08-03
WO2004042350A2 (en) 2004-05-21
JP4549862B2 (ja) 2010-09-22
SI1558354T1 (sl) 2010-05-31
ES2342772T3 (es) 2010-07-14
US20060014933A1 (en) 2006-01-19
EP1558354A4 (en) 2008-07-02
DE60331338D1 (de) 2010-04-01
DK1558354T3 (da) 2010-05-25

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