CY1110264T1 - Φαρμακευτικες συνθεσεις που περιλαμβανουν ευαισθητα σε ρη συμπολυμερη τυπου μπλοκ και υδροφοβο φαρμακο - Google Patents
Φαρμακευτικες συνθεσεις που περιλαμβανουν ευαισθητα σε ρη συμπολυμερη τυπου μπλοκ και υδροφοβο φαρμακοInfo
- Publication number
- CY1110264T1 CY1110264T1 CY20091100371T CY091100371T CY1110264T1 CY 1110264 T1 CY1110264 T1 CY 1110264T1 CY 20091100371 T CY20091100371 T CY 20091100371T CY 091100371 T CY091100371 T CY 091100371T CY 1110264 T1 CY1110264 T1 CY 1110264T1
- Authority
- CY
- Cyprus
- Prior art keywords
- block copolymer
- pharmaceutical compositions
- compositions including
- poly
- alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229920001400 block copolymer Polymers 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 230000000712 assembly Effects 0.000 abstract 2
- 238000000429 assembly Methods 0.000 abstract 2
- 239000000693 micelle Substances 0.000 abstract 2
- -1 poly(ethylene oxide) Polymers 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μια φαρμακευτική σύνθεση ενός βιολογικώς δραστικού παράγοντα και ενός συμπολυμερούς τύπου μπλοκ που αποτελείται από πολυ(αιθυλενοξείδιο) που σχηματίζει υδρόφιλο τμήμα και πολυ(βουτυλ(αλκυλ)ακρυλικό-συν-(αλκυλ)ακρυλικό οξύ που είναι ικανό σχηματισμού υπερμοριακών συκγροτημάτων ή μικκυλίων κάτω από ευνοϊκές συνθήκες. Τα υπερμοριακά συγκροτήματα ή μικκύλια που σχηματίζονται από τα αναφερθέντα πολυμερή συνδέονται ή αποσυνδέονται αντίστροφα κατά τις αλλαγές στο περιβαλλοντικό pH. Οι φαρμακευτικές συνθέσεις της παρούσας εφεύρεσης περιέχουν υδρόφοβα φάρμακα, κατίοντα ή πολυκατιονικές ενώσεις που μπορούν να απελευθερωθούν στο σώμα με από του στόματος τρόπο χορήγησης ή άλλους τρόπους χορήγησης.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/607,446 US7094810B2 (en) | 2001-06-08 | 2003-06-25 | pH-sensitive block copolymers for pharmaceutical compositions |
| EP04727195A EP1638539B1 (en) | 2003-06-25 | 2004-04-14 | Pharmaceutical compositions comprising ph-sensitive block copolymers and a hydrophobic drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110264T1 true CY1110264T1 (el) | 2015-01-14 |
Family
ID=33540273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100371T CY1110264T1 (el) | 2003-06-25 | 2009-03-31 | Φαρμακευτικες συνθεσεις που περιλαμβανουν ευαισθητα σε ρη συμπολυμερη τυπου μπλοκ και υδροφοβο φαρμακο |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7094810B2 (el) |
| EP (1) | EP1638539B1 (el) |
| JP (1) | JP4619357B2 (el) |
| AT (1) | ATE418970T1 (el) |
| AU (1) | AU2004248863B2 (el) |
| BR (1) | BRPI0411872A (el) |
| CA (1) | CA2530736C (el) |
| CY (1) | CY1110264T1 (el) |
| DE (1) | DE602004018772D1 (el) |
| DK (1) | DK1638539T3 (el) |
| ES (1) | ES2323701T3 (el) |
| MX (1) | MXPA05014017A (el) |
| PL (1) | PL1638539T3 (el) |
| PT (1) | PT1638539E (el) |
| SI (1) | SI1638539T1 (el) |
| WO (1) | WO2004112757A1 (el) |
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| JP2003523544A (ja) * | 2000-02-17 | 2003-08-05 | レックスマーク・インターナショナル・インコーポレーテツド | 導電性駆動ハブを備えたトナーカートリッジ |
| US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
| WO2005079856A1 (en) * | 2004-02-23 | 2005-09-01 | The University Of British Columbia | Drug delivery compositions comprising hydrophobic polymers and amphipathic molecules |
| US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| US20090074872A1 (en) * | 2006-06-26 | 2009-03-19 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
| RU2009102262A (ru) * | 2006-06-26 | 2010-08-10 | Мьючуал Фармасьютикал Компани, Инк. (Us) | Композиции активного агента, способы их получения и способы применения |
| AU2007298674A1 (en) * | 2006-09-22 | 2008-03-27 | Labopharm (Barbados) Limited | Compositions and methods for pH targeted drug delivery |
| EP2097140B1 (en) * | 2006-12-20 | 2012-09-26 | Arkema Inc. | Polymer encapsulation and/or binding |
| JP2010524860A (ja) * | 2007-04-20 | 2010-07-22 | ユニバーシティー オブ サウス オーストラリア | 薬剤の皮膚送達用ナノ粒子コーティングカプセル製剤 |
| WO2009036368A2 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| FR2922452B1 (fr) * | 2007-10-19 | 2010-01-22 | Coatex Sas | Formulations de composes organoplatiniques en presence de polymeres associatifs, produits obtenus et leurs utilisations |
| TWI388591B (zh) * | 2008-03-28 | 2013-03-11 | Ind Tech Res Inst | 溫度敏感性材料 |
| US8778400B2 (en) * | 2008-04-21 | 2014-07-15 | University Of South Australia | Nanoparticle-stabilized capsule formulation for treatment of inflammation |
| CN102066444A (zh) | 2008-05-13 | 2011-05-18 | 华盛顿大学 | 胶束装配体 |
| WO2009140421A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Polymeric carrier |
| CN103342789B (zh) * | 2008-05-13 | 2016-11-23 | 华盛顿大学 | 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物 |
| WO2009140423A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Targeted polymer bioconjugates |
| KR20110020804A (ko) * | 2008-05-13 | 2011-03-03 | 유니버시티 오브 워싱톤 | 치료제의 세포내 전달을 위한 미셀 |
| KR101638201B1 (ko) * | 2008-05-16 | 2016-07-08 | 유니버시티 오브 시드니 | 투여 가능한 조성물 |
| CA2635187A1 (en) * | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
| KR101650907B1 (ko) * | 2008-06-24 | 2016-08-24 | 나노캐리어 가부시키가이샤 | 시스플라틴 배위 화합물의 액체 조성물 |
| WO2010021770A1 (en) | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
| US8822213B2 (en) | 2008-11-06 | 2014-09-02 | University Of Washington | Bispecific intracellular delivery vehicles |
| MX2011004242A (es) | 2008-11-06 | 2011-07-20 | Univ Washington | Copolimeros multibloque. |
| WO2010077678A2 (en) | 2008-12-08 | 2010-07-08 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
| US20100159010A1 (en) * | 2008-12-24 | 2010-06-24 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
| TWI374903B (en) * | 2008-12-31 | 2012-10-21 | Ind Tech Res Inst | Biodegradable copolymer hydrogel materials |
| WO2011062965A2 (en) | 2009-11-18 | 2011-05-26 | University Of Washington Through Its Center For Commercialization | Targeting monomers and polymers having targeting blocks |
| AU2014296278C1 (en) | 2013-07-30 | 2023-02-02 | Genevant Sciences Gmbh | Block copolymers and their conjugates or complexes with oligonucleotides |
| WO2016118697A1 (en) | 2015-01-21 | 2016-07-28 | Phaserx, Inc. | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
| EP3426301A4 (en) | 2016-03-08 | 2019-11-06 | Los Gatos Pharmaceuticals, Inc. | VERBUNDNANOPARTICLES AND USES THEREOF |
| EP3426352A4 (en) | 2016-03-08 | 2019-11-13 | Los Gatos Pharmaceuticals, Inc. | CAMPTOTHECIN DERIVATIVES AND USES THEREOF |
| CN106432647B (zh) * | 2016-09-26 | 2018-10-30 | 华南理工大学 | 基于叔氨基的pH响应嵌段聚合物及其混合胶束与应用 |
| US11684584B2 (en) | 2016-12-30 | 2023-06-27 | Genevant Sciences Gmbh | Branched peg molecules and related compositions and methods |
| WO2019032975A1 (en) * | 2017-08-10 | 2019-02-14 | Mec Device Pharma International Llc | ANTI-ABUSE MEDICINAL FORMULATIONS |
| CN114377144B (zh) * | 2022-01-28 | 2024-10-29 | 南通大学 | pH/活性氧双重响应性超分子聚肽前药纳米粒子 |
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| KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
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-
2003
- 2003-06-25 US US10/607,446 patent/US7094810B2/en not_active Expired - Lifetime
-
2004
- 2004-04-14 BR BRPI0411872-3A patent/BRPI0411872A/pt not_active IP Right Cessation
- 2004-04-14 PL PL04727195T patent/PL1638539T3/pl unknown
- 2004-04-14 EP EP04727195A patent/EP1638539B1/en not_active Expired - Lifetime
- 2004-04-14 SI SI200431088T patent/SI1638539T1/sl unknown
- 2004-04-14 ES ES04727195T patent/ES2323701T3/es not_active Expired - Lifetime
- 2004-04-14 DE DE602004018772T patent/DE602004018772D1/de not_active Expired - Lifetime
- 2004-04-14 WO PCT/CA2004/000561 patent/WO2004112757A1/en not_active Ceased
- 2004-04-14 DK DK04727195T patent/DK1638539T3/da active
- 2004-04-14 AT AT04727195T patent/ATE418970T1/de active
- 2004-04-14 PT PT04727195T patent/PT1638539E/pt unknown
- 2004-04-14 CA CA2530736A patent/CA2530736C/en not_active Expired - Lifetime
- 2004-04-14 JP JP2006515571A patent/JP4619357B2/ja not_active Expired - Lifetime
- 2004-04-14 AU AU2004248863A patent/AU2004248863B2/en not_active Ceased
- 2004-04-14 MX MXPA05014017A patent/MXPA05014017A/es active IP Right Grant
-
2009
- 2009-03-31 CY CY20091100371T patent/CY1110264T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007505029A (ja) | 2007-03-08 |
| CA2530736A1 (en) | 2004-12-29 |
| EP1638539B1 (en) | 2008-12-31 |
| DE602004018772D1 (de) | 2009-02-12 |
| EP1638539A1 (en) | 2006-03-29 |
| US7094810B2 (en) | 2006-08-22 |
| BRPI0411872A (pt) | 2006-08-08 |
| PT1638539E (pt) | 2009-04-09 |
| WO2004112757A1 (en) | 2004-12-29 |
| CA2530736C (en) | 2013-07-02 |
| AU2004248863B2 (en) | 2009-03-12 |
| PL1638539T3 (pl) | 2009-10-30 |
| ES2323701T3 (es) | 2009-07-23 |
| AU2004248863A1 (en) | 2004-12-29 |
| SI1638539T1 (sl) | 2009-10-31 |
| MXPA05014017A (es) | 2007-01-31 |
| JP4619357B2 (ja) | 2011-01-26 |
| DK1638539T3 (da) | 2009-05-04 |
| ATE418970T1 (de) | 2009-01-15 |
| US20040072784A1 (en) | 2004-04-15 |
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