CY1110157T1 - Χιμαιρικα ανασυνδυασμενα αντιγονα του toxoplasma gondii - Google Patents
Χιμαιρικα ανασυνδυασμενα αντιγονα του toxoplasma gondiiInfo
- Publication number
- CY1110157T1 CY1110157T1 CY20101100583T CY101100583T CY1110157T1 CY 1110157 T1 CY1110157 T1 CY 1110157T1 CY 20101100583 T CY20101100583 T CY 20101100583T CY 101100583 T CY101100583 T CY 101100583T CY 1110157 T1 CY1110157 T1 CY 1110157T1
- Authority
- CY
- Cyprus
- Prior art keywords
- toxoplasma gondii
- antigens
- chemical recovery
- recovery
- chemical
- Prior art date
Links
- 241000223997 Toxoplasma gondii Species 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 238000011084 recovery Methods 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/45—Toxoplasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Η εφεύρεση που περιγράφεται στο κείμενο σχετίζεται με μέθοδο συνδυασμού αντιγονοθραυσμάτων από πρωτεΐνες του Toxoplasma gondii, στη μορφή χιμαιρικών προϊόντων σύντηξης, και με τη χρήση τους ως διαγνωστικά και ανοσογόνα μέσα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05005065 | 2005-03-08 | ||
| EP06723123A EP1856159B1 (en) | 2005-03-08 | 2006-02-27 | Chimeric recombinant antigens of toxoplasma gondii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110157T1 true CY1110157T1 (el) | 2015-01-14 |
Family
ID=34934134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100583T CY1110157T1 (el) | 2005-03-08 | 2010-06-25 | Χιμαιρικα ανασυνδυασμενα αντιγονα του toxoplasma gondii |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7790187B2 (el) |
| EP (1) | EP1856159B1 (el) |
| JP (1) | JP2008535481A (el) |
| KR (1) | KR20080003330A (el) |
| CN (1) | CN101137674A (el) |
| AT (1) | ATE463515T1 (el) |
| AU (1) | AU2006222315A1 (el) |
| BR (1) | BRPI0608342A2 (el) |
| CA (1) | CA2599620A1 (el) |
| CY (1) | CY1110157T1 (el) |
| DE (1) | DE602006013428D1 (el) |
| DK (1) | DK1856159T3 (el) |
| EA (1) | EA013349B1 (el) |
| ES (1) | ES2342971T3 (el) |
| HR (1) | HRP20100370T1 (el) |
| IL (1) | IL184845A (el) |
| MX (1) | MX2007009524A (el) |
| PL (1) | PL1856159T3 (el) |
| PT (1) | PT1856159E (el) |
| RS (1) | RS51327B (el) |
| SI (1) | SI1856159T1 (el) |
| WO (1) | WO2006094665A1 (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2160608A1 (en) * | 2007-06-29 | 2010-03-10 | Prionics AG | Diagnostic composition and method for the detection of a trichinella infection |
| US20140004141A1 (en) * | 2010-12-23 | 2014-01-02 | Immport Therapeutics, Inc. | Methods And Compositions Of Protein Antigens For The Diagnosis And Treatment Of Toxoplasma Gondii Infections And Toxoplasmosis |
| CN102288768A (zh) * | 2011-09-19 | 2011-12-21 | 厦门市湖里区妇幼保健院 | 弓形虫IgG抗体免疫印迹试剂盒及其制备方法 |
| CN102492696B (zh) * | 2011-12-13 | 2014-01-29 | 北京英诺特生物技术有限公司 | 一种重组弓形虫蛋白及其应用 |
| CN103235119B (zh) * | 2013-04-11 | 2015-09-16 | 南京农业大学 | 一种用于弓形虫感染的诊断抗原的应用 |
| CN103251960B (zh) * | 2013-05-27 | 2014-08-13 | 山东大学 | 用于预防人或动物慢性弓形虫病的dna疫苗 |
| CN104152466A (zh) * | 2014-04-04 | 2014-11-19 | 中国农业科学院兰州兽医研究所 | 一种用于弓形虫感染预防的疫苗和制备方法及其应用 |
| WO2016046321A1 (en) * | 2014-09-25 | 2016-03-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating cancer and infectious diseases |
| CN105759030B (zh) * | 2016-03-15 | 2018-01-02 | 中国农业大学 | 一种检测弓形虫抗体的胶体金试纸条 |
| CN106153894A (zh) * | 2016-08-12 | 2016-11-23 | 江苏泽成生物技术有限公司 | 一种测定弓形虫IgM抗体的检测试剂盒及其检测方法 |
| CN108265070B (zh) * | 2016-12-30 | 2022-07-26 | 中国农业科学院上海兽医研究所 | 一种特异性的检测弓形虫的方法 |
| CN107253983A (zh) * | 2017-06-28 | 2017-10-17 | 潍坊汉唐生物工程有限公司 | 一种检测弓形虫抗体的重组蛋白组合物及其制备方法 |
| CN108165569A (zh) * | 2017-11-10 | 2018-06-15 | 江苏省血吸虫病防治研究所 | 一种快速检测弓形虫的重组蛋白及其制备方法和应用 |
| WO2020056229A1 (en) * | 2018-09-14 | 2020-03-19 | Prommune, Inc. | Anti-parasitic immunological compositions |
| CN109369796A (zh) * | 2018-09-27 | 2019-02-22 | 华中农业大学 | 一种检测羊弓形虫IgG抗体的酶联免疫方法 |
| CN110540602B (zh) * | 2019-08-28 | 2023-02-14 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 一种弓形虫表面抗原gra1和gra7重组蛋白胶体金试纸条 |
| CN110818787B (zh) * | 2019-12-04 | 2023-08-04 | 南京医科大学 | 一种增加Ly6C+巨噬细胞的抗原及其应用 |
| CN111116726A (zh) * | 2020-01-14 | 2020-05-08 | 中国农业科学院北京畜牧兽医研究所 | 用于检测弓形虫的重组蛋白及其编码基因 |
| EP4560316A1 (en) * | 2023-11-23 | 2025-05-28 | Biokit Research & Development S.L.U. | Antigenic regions for the detection of anti-toxoplasma gondii igm antibodies |
| CN118459612B (zh) * | 2024-07-12 | 2024-09-24 | 北京纳百生物科技有限公司 | 一种刚地弓形虫融合抗原及其应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2226468A1 (en) | 1973-04-18 | 1974-11-15 | Merieux Bd | Toxoplasma antigens - as agents for detecting toxoplasmosis by direct agglutination |
| SU533376A1 (ru) | 1973-08-31 | 1976-10-30 | Научно-исследовательский ветеринарный институт | Способ получени токсоплазменного антигена |
| JPS5444016A (en) | 1977-09-13 | 1979-04-07 | Nippon Touketsu Kansou Kenkiyu | Latex coagulation and reaction reagent for detecting toxoplasma antibody and production thereof |
| DE3940598A1 (de) | 1989-12-08 | 1991-06-13 | Behringwerke Ag | Toxoplasma gondii-antigene, ihre herstellung und ihre verwendung |
| FR2518407A1 (fr) | 1981-12-17 | 1983-06-24 | Merieux Inst | Nouvel antigene pour la recherche de l'immunite toxoplasmique et son procede de preparation |
| US6265176B1 (en) * | 1985-10-29 | 2001-07-24 | Cordis Corporation | Dot immunoassay on plastic sheets |
| IT1196817B (it) | 1986-12-03 | 1988-11-25 | Consiglio Nazionale Ricerche | Procedimento per l'ottenimento di una preparazione di antigene toxoplasmico insolubile corredo diagnostico comprendente tale preparazione e saggio diagnostico che la utilizza |
| FR2618680B1 (fr) | 1987-07-31 | 1990-05-11 | Pasteur Institut | Antigenes d'excretion-secretion specifiques de toxoplasma gondii, leurs produits d'expression, leur procede d'obtention et leurs applications diagnostiques et prophylactiques |
| FR2625099B1 (fr) | 1987-12-24 | 1991-06-14 | Transgene Sa | Proteines et leur procede de preparation, sequences d'adn, anticorps et leur application, poxvirus, cellules transformees ou infectees et compositions pharmaceutiques utiles dans la prevention de la toxoplasmose |
| US4877726A (en) * | 1988-03-02 | 1989-10-31 | Research Institute Of Palo Alto Medical Foundation | Method for the detection of acute-phase toxoplasma infection |
| JPH02503633A (ja) | 1988-03-09 | 1990-11-01 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | トキソプラスマ症のための診断上の遺伝子 |
| FR2633309B1 (fr) | 1988-06-24 | 1992-04-24 | Pasteur Institut | Sequence d'adn codant pour la proteine p30 de toxoplasma gondii, produits d'expression de cette sequence, leurs procedes d'obtention et leurs applications |
| JPH02261382A (ja) | 1989-04-03 | 1990-10-24 | Mochida Pharmaceut Co Ltd | トキソプラズマ由来新規dna配列およびそれによってコードされる蛋白質 |
| US5665542A (en) * | 1989-11-03 | 1997-09-09 | Research Institute Of Palo Alto Medical Foundation | Toxoplasma gondii P28 gene and methods for its use |
| US5215917A (en) * | 1989-11-03 | 1993-06-01 | Research Institute Of Palo Alto Medical Foundation | Nucleotide sequence encoding the Toxoplasma gondii P22 gene |
| FR2664290B1 (fr) | 1990-07-05 | 1993-01-29 | Centre Nat Rech Scient | Sondes genetiques specifiques de toxoplasma gondii, et leur utilisation pour la detection in vitro de toxoplasma gondii et pour le typage des souches toxoplasmiques. |
| EP0542843A4 (en) | 1990-08-10 | 1994-07-06 | Univ Southern Australia | Cloning and expression of toxoplasma antigens and use of recombinant antigens |
| GB9027728D0 (en) | 1990-12-20 | 1991-02-13 | Smithkline Beecham Biolog | Novel protein |
| FR2692282B1 (fr) * | 1992-06-15 | 1995-07-13 | Pasteur Institut | Clonage du gene codant pour la proteine gp28.5 de t. gondii; fragments peptidiques issus de ladite proteine et leurs applications. |
| WO1994017813A1 (en) | 1993-02-08 | 1994-08-18 | Paravax, Inc. | Defective sindbis virus vectors that express toxoplasma gondii p30 antigens |
| FR2702491B1 (fr) | 1993-03-12 | 1995-04-28 | Pasteur Institut | Clonage de gènes codant pour des antigènes d'excrétion-sécrétion P21 et P32 de toxoplasme, préparations de tels antigènes, fragments de ceux-ci et leurs applications. |
| US5976553A (en) * | 1993-11-04 | 1999-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Transfection and genetic manipulations in obligate intracellular parasites |
| FR2722508B1 (fr) | 1994-07-13 | 1996-10-04 | Transgene Sa | Cassette d'expression d'une proteine p30 de toxoplasma gondii |
| EP0710724A2 (en) | 1994-10-06 | 1996-05-08 | Akzo Nobel N.V. | Toxoplasma gondii antigens |
| FR2729960A1 (fr) | 1995-01-30 | 1996-08-02 | Bio Merieux | Polypeptides mimotopes de toxoplasma gondii et applications |
| CA2242200A1 (en) | 1996-01-26 | 1997-07-31 | Innogenetics N.V. | Toxoplasma gondii antigen tg20 |
| SE505631C2 (sv) | 1996-08-30 | 1997-09-22 | Scania Cv Ab | Buss med tvärställt bakre drivaggregat |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| JP3336275B2 (ja) | 1997-10-23 | 2002-10-21 | 明彦 矢野 | トキソプラズマ・ゴンディ抗原、該抗原に対する抗体及び該抗原又は抗体を用いた免疫測定方法 |
| JP3831754B2 (ja) | 1997-10-23 | 2006-10-11 | 青才 文江 | トキソプラズマ・ゴンディ抗原、これをコードする核酸並びに該抗原に対する抗体 |
| US6514694B2 (en) | 1997-12-19 | 2003-02-04 | Heska Corporation | Methods for the detection of encysted parasites |
| US5962654A (en) * | 1998-01-30 | 1999-10-05 | International Business Machines Operation | Alkoxyalkoxides and use to form films |
| UA73718C2 (en) | 1998-05-01 | 2005-09-15 | Schering Plough Ltd | Therapeutic vector expressing foreign dna, coding cat's cd80, cat's cd86, cat's cd28 or cat's ctla-4 and use thereof |
| CA2333598C (en) | 1998-05-28 | 2009-10-13 | Abbott Laboratories | Toxoplasma gondii antigens, p35, and uses thereof |
| US6329157B1 (en) * | 1998-05-28 | 2001-12-11 | Abbott Laboratories | Antigen cocktails and uses thereof |
| WO1999066043A1 (en) | 1998-06-12 | 1999-12-23 | Smithkline Beecham Biologicals S.A. | Recombinant production of toxoplasma sag1 antigen |
| JP4545869B2 (ja) | 2000-02-23 | 2010-09-15 | 日本ケミファ株式会社 | 多孔性フィルタを用いる生理活性試料物質の測定方法 |
| FR2805466A1 (fr) | 2000-02-25 | 2001-08-31 | Virsol | Utilisation de la proteine mic3 de toxoplasma gondii ou d'un de ses derives en tant qu'agent immunogene ou en tant qu'antigene de vaccination |
| WO2003080839A2 (en) | 2002-03-21 | 2003-10-02 | Kenton S.R.L. | Antigen fragments for the diagnosis of toxoplasma gondii |
| US7094879B2 (en) | 2002-10-02 | 2006-08-22 | Abbott Laboratories | Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof |
| CN1194991C (zh) | 2003-05-09 | 2005-03-30 | 李越希 | 重组弓形虫融合蛋白抗原及其制备方法、应用 |
-
2006
- 2006-02-27 US US11/885,951 patent/US7790187B2/en not_active Expired - Fee Related
- 2006-02-27 MX MX2007009524A patent/MX2007009524A/es active IP Right Grant
- 2006-02-27 PT PT06723123T patent/PT1856159E/pt unknown
- 2006-02-27 CA CA002599620A patent/CA2599620A1/en not_active Abandoned
- 2006-02-27 SI SI200630701T patent/SI1856159T1/sl unknown
- 2006-02-27 AT AT06723123T patent/ATE463515T1/de active
- 2006-02-27 HR HR20100370T patent/HRP20100370T1/hr unknown
- 2006-02-27 WO PCT/EP2006/001760 patent/WO2006094665A1/en not_active Ceased
- 2006-02-27 EA EA200701911A patent/EA013349B1/ru not_active IP Right Cessation
- 2006-02-27 DK DK06723123.3T patent/DK1856159T3/da active
- 2006-02-27 DE DE602006013428T patent/DE602006013428D1/de active Active
- 2006-02-27 BR BRPI0608342-0A patent/BRPI0608342A2/pt not_active IP Right Cessation
- 2006-02-27 JP JP2008500081A patent/JP2008535481A/ja active Pending
- 2006-02-27 RS RSP-2010/0283A patent/RS51327B/sr unknown
- 2006-02-27 PL PL06723123T patent/PL1856159T3/pl unknown
- 2006-02-27 EP EP06723123A patent/EP1856159B1/en active Active
- 2006-02-27 ES ES06723123T patent/ES2342971T3/es active Active
- 2006-02-27 AU AU2006222315A patent/AU2006222315A1/en not_active Abandoned
- 2006-02-27 CN CNA2006800068629A patent/CN101137674A/zh active Pending
- 2006-02-27 KR KR1020077022864A patent/KR20080003330A/ko not_active Ceased
-
2007
- 2007-07-26 IL IL184845A patent/IL184845A/en not_active IP Right Cessation
- 2007-09-06 US US11/899,754 patent/US7867503B2/en not_active Expired - Fee Related
-
2010
- 2010-06-25 CY CY20101100583T patent/CY1110157T1/el unknown
- 2010-07-01 US US12/829,367 patent/US20110027810A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2342971T3 (es) | 2010-07-20 |
| AU2006222315A1 (en) | 2006-09-14 |
| EP1856159A1 (en) | 2007-11-21 |
| DK1856159T3 (da) | 2010-07-05 |
| US20080280307A1 (en) | 2008-11-13 |
| EP1856159B1 (en) | 2010-04-07 |
| US20090092630A1 (en) | 2009-04-09 |
| RS51327B (sr) | 2011-02-28 |
| US20110027810A1 (en) | 2011-02-03 |
| CA2599620A1 (en) | 2006-09-14 |
| US7867503B2 (en) | 2011-01-11 |
| JP2008535481A (ja) | 2008-09-04 |
| KR20080003330A (ko) | 2008-01-07 |
| ATE463515T1 (de) | 2010-04-15 |
| PT1856159E (pt) | 2010-06-22 |
| CN101137674A (zh) | 2008-03-05 |
| MX2007009524A (es) | 2008-03-04 |
| IL184845A0 (en) | 2007-12-03 |
| PL1856159T3 (pl) | 2010-09-30 |
| WO2006094665A1 (en) | 2006-09-14 |
| HRP20100370T1 (hr) | 2010-08-31 |
| EA013349B1 (ru) | 2010-04-30 |
| DE602006013428D1 (de) | 2010-05-20 |
| EA200701911A1 (ru) | 2008-02-28 |
| US7790187B2 (en) | 2010-09-07 |
| IL184845A (en) | 2011-06-30 |
| SI1856159T1 (sl) | 2010-08-31 |
| BRPI0608342A2 (pt) | 2009-12-01 |
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