[go: up one dir, main page]

CY1108104T1 - (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος - Google Patents

(4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος

Info

Publication number
CY1108104T1
CY1108104T1 CY20081100232T CY081100232T CY1108104T1 CY 1108104 T1 CY1108104 T1 CY 1108104T1 CY 20081100232 T CY20081100232 T CY 20081100232T CY 081100232 T CY081100232 T CY 081100232T CY 1108104 T1 CY1108104 T1 CY 1108104T1
Authority
CY
Cyprus
Prior art keywords
disease
morpholin
methoxy
amide
hydroxy
Prior art date
Application number
CY20081100232T
Other languages
English (en)
Inventor
Alexander Flohr
Jean-Luc Moreau
Sonia Maria Poli
Claus Riemer
Lucinda Steward
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34967309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108104(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CY1108104T1 publication Critical patent/CY1108104T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με την ένωση του τύπου (I): η οποία είναι το (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο)-αμίδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικού οξέος και με φαρμακευτικώς αποδεκτά άλατα προσθήκης οξέος αυτού. Έχει βρεθεί ότι η ένωση είναι χρήσιμη για την θεραπευτική αντιμετώπιση ή πρόληψη της νόσου Alzheimer, της νόσου Parkinson, της νόσου Huntington, της νευροπροστασίας, της σχιζοφρένειας, του άγχους, του πόνου, των προβλημάτων αναπνοής, της κατάθλιψης, της ADHD (διαταραχή ελλειμματικής προσοχής με υπερκινητικότητα), του εθισμού σε αμφεταμίνες, κοκαΐνη, οπιοειδή, αιθανόλη, νικοτίνη, κανναβινοειδή ή για την θεραπευτική αντιμετώπιση του άσθματος, αλλεργικών αντιδράσεων, υποξίας, ισχαιμίας, παροξυσμού, κατάχρησης ουσιών, ή για τη χρήση ως μυοχαλαρωτικών, αντιψυχωσικών, αντιεπιληπτικών, σπασμολυτικών και καρδιοπροστατευτικών παραγόντων.
CY20081100232T 2004-05-24 2008-02-28 (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος CY1108104T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04102262 2004-05-24
EP05741185A EP1753760B1 (en) 2004-05-24 2005-05-17 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Publications (1)

Publication Number Publication Date
CY1108104T1 true CY1108104T1 (el) 2014-02-12

Family

ID=34967309

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100232T CY1108104T1 (el) 2004-05-24 2008-02-28 (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος

Country Status (38)

Country Link
US (1) US7368446B2 (el)
EP (1) EP1753760B1 (el)
JP (1) JP4668265B2 (el)
CN (1) CN1956983B (el)
AR (1) AR048973A1 (el)
AT (1) ATE382619T1 (el)
AU (1) AU2005247567B2 (el)
BR (1) BRPI0511543B1 (el)
CA (1) CA2567703C (el)
CR (1) CR8703A (el)
CY (1) CY1108104T1 (el)
DE (1) DE602005004142T2 (el)
DK (1) DK1753760T3 (el)
DO (1) DOP2005000091A (el)
EA (1) EA011279B1 (el)
EC (1) ECSP067018A (el)
ES (1) ES2297710T3 (el)
GT (1) GT200500124A (el)
HN (1) HN2005000238A (el)
HR (1) HRP20080027T3 (el)
IL (1) IL179364A (el)
MA (1) MA28601B1 (el)
MX (1) MXPA06013417A (el)
MY (1) MY140011A (el)
NO (1) NO336939B1 (el)
NZ (1) NZ550763A (el)
PA (1) PA8633901A1 (el)
PE (1) PE20060274A1 (el)
PL (1) PL1753760T3 (el)
PT (1) PT1753760E (el)
RS (1) RS50574B (el)
SI (1) SI1753760T1 (el)
SV (1) SV2006002125A (el)
TN (1) TNSN06371A1 (el)
TW (1) TWI358297B (el)
UA (1) UA87142C2 (el)
WO (1) WO2005116026A1 (el)
ZA (1) ZA200609136B (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521512C2 (sv) * 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
ES2708552T3 (es) * 2002-12-20 2019-04-10 Niconovum Ab Método para la preparación de un material particulado que contiene nicotina con una celulosa cristalina (en particular MCC)
WO2007104573A2 (en) 2006-03-16 2007-09-20 Niconovum Ab Improved snuff composition
US20090082341A1 (en) * 2007-07-23 2009-03-26 Synosia Therapeutics 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide FOR THE TREATMENT OF POST-TRAUMATIC STRESS DISORDER
GEP20135992B (en) 2009-01-12 2013-12-25 Icagen Inc Sulfonamide derivatives
US8168785B2 (en) 2009-06-17 2012-05-01 Biotie Therapies, Inc. Benzothiazole derivatives
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
ES2532356T3 (es) 2010-07-09 2015-03-26 Pfizer Limited N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje
WO2012060844A1 (en) * 2010-11-05 2012-05-10 Biotie Therapies, Inc A2a antagonists as cognition and motor function enhancers
AU2013251079B2 (en) * 2012-04-20 2017-03-23 Ucb Pharma S.A. Methods for treating Parkinson's disease
EP3310344A1 (en) 2015-06-19 2018-04-25 Biotie Therapies, Inc. Controlled-release tozadenant formulations
WO2018059531A1 (zh) * 2016-09-30 2018-04-05 苏州晶云药物科技有限公司 一种腺苷a2a受体拮抗剂药物的晶型及其制备方法和用途
JP7287952B2 (ja) * 2017-08-21 2023-06-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング アデノシン受容体アンタゴニストとしてのベンズイミダゾール誘導体
WO2019038214A1 (en) * 2017-08-21 2019-02-28 Merck Patent Gmbh QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS
WO2019141096A1 (zh) * 2018-01-19 2019-07-25 四川科伦博泰生物医药股份有限公司 取代脲类化合物及其制备方法和用途
EP3897653A1 (en) 2018-12-20 2021-10-27 Biotie Therapies, Inc. Methods for treating cancer using tozadenant
DE102019110904B4 (de) 2019-04-26 2022-01-20 Helmholtz-Zentrum Dresden - Rossendorf E. V. N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung
CN116407539B (zh) * 2021-12-30 2025-01-10 上海现代药物制剂工程研究中心有限公司 依匹哌唑甲基脂肪酸酯的用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505543A (de) * 1968-11-01 1971-04-15 Ciba Geigy Ag Schädlingsbekämpfungsmittel
NL7109150A (el) 1970-07-06 1972-01-10
US4028374A (en) * 1975-11-03 1977-06-07 Morton-Norwich Products, Inc. Antibacterial thiocyanatobenzothiazoles
DE2656468A1 (de) 1976-12-14 1978-06-15 Boehringer Mannheim Gmbh N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung
KR930005004B1 (ko) 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
FI91859C (fi) 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
IL90337A0 (en) 1988-05-24 1989-12-15 Pfizer Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
WO1990015801A1 (en) 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases
DE59005183D1 (de) * 1989-11-10 1994-05-05 Agrolinz Agrarchemikalien Verfahren zur Herstellung reiner, unsymmetrisch disubstituierter Harnstoffe.
KR0185225B1 (ko) 1992-05-21 1999-05-15 오오쓰까 아끼히꼬 포스폰산 디에스테르 유도체
FR2753970B1 (fr) 1996-10-01 1998-10-30 Synthelabo Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
JPH11130761A (ja) 1997-10-24 1999-05-18 Otsuka Pharmaceut Co Ltd ベンゾチアゾール誘導体
ES2256969T3 (es) 1997-11-10 2006-07-16 Bristol-Myers Squibb Company Compuestos de benzotiazol inhibidores de proteina tirosina qauinasa.
CN1288462A (zh) 1998-01-23 2001-03-21 法玛西雅厄普约翰美国公司 噁唑烷酮组合库、组合物和制备方法
HK1038749A1 (zh) 1998-09-30 2002-03-28 纽罗根公司 2-哌嗪烷基氨苯并吡咯衍生物:多巴胺受体亚型特异配体
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
UA71587C2 (uk) 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
WO2001087786A1 (en) 2000-05-12 2001-11-22 Corning Incorporated Method for manufacturing an optical fiber preform with a protective coating
KR100526487B1 (ko) * 2000-06-21 2005-11-08 에프. 호프만-라 로슈 아게 벤조티아졸 유도체
US6727247B2 (en) * 2001-12-10 2004-04-27 Hoffman-La Roche Inc. Substituted benzothiazole amide derivatives
US6713499B2 (en) * 2001-12-12 2004-03-30 Hoffman-La Roche Inc. 7-Amino-benzothiazole derivatives

Also Published As

Publication number Publication date
AR048973A1 (es) 2006-06-14
EP1753760B1 (en) 2008-01-02
RS50574B (sr) 2010-05-07
ECSP067018A (es) 2006-12-29
PT1753760E (pt) 2008-02-12
MXPA06013417A (es) 2007-01-23
PA8633901A1 (es) 2006-05-16
AU2005247567B2 (en) 2010-09-02
IL179364A (en) 2013-01-31
HK1105199A1 (en) 2008-02-06
NO20065732L (no) 2006-12-22
IL179364A0 (en) 2007-03-08
BRPI0511543B1 (pt) 2022-05-10
GT200500124A (es) 2005-12-26
JP4668265B2 (ja) 2011-04-13
HN2005000238A (es) 2008-07-14
CN1956983B (zh) 2010-05-26
CN1956983A (zh) 2007-05-02
SV2006002125A (es) 2006-02-15
HRP20080027T3 (hr) 2008-05-31
BRPI0511543A (pt) 2008-01-02
MA28601B1 (fr) 2007-05-02
PL1753760T3 (pl) 2008-06-30
JP2008500295A (ja) 2008-01-10
ATE382619T1 (de) 2008-01-15
CR8703A (es) 2007-10-04
PE20060274A1 (es) 2006-04-14
DK1753760T3 (da) 2008-04-14
TNSN06371A1 (fr) 2008-02-22
ZA200609136B (en) 2008-07-30
UA87142C2 (en) 2009-06-25
TW200612937A (en) 2006-05-01
EA011279B1 (ru) 2009-02-27
CA2567703A1 (en) 2005-12-08
AU2005247567A1 (en) 2005-12-08
ES2297710T3 (es) 2008-05-01
WO2005116026A1 (en) 2005-12-08
MY140011A (en) 2009-11-30
DE602005004142T2 (de) 2009-01-02
SI1753760T1 (sl) 2008-04-30
NO336939B1 (no) 2015-11-30
TWI358297B (en) 2012-02-21
DOP2005000091A (es) 2005-06-29
CA2567703C (en) 2013-03-05
NZ550763A (en) 2010-07-30
US20050261289A1 (en) 2005-11-24
US7368446B2 (en) 2008-05-06
EA200602048A1 (ru) 2007-06-29
DE602005004142D1 (de) 2008-02-14
EP1753760A1 (en) 2007-02-21

Similar Documents

Publication Publication Date Title
CY1108104T1 (el) (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος
ATE438632T1 (de) Aryl-4-ethinylisoxazolderivate
NO20062303L (no) Pyrazinderivater og farmasoytisk anvendelse derav
MX2010005717A (es) Derivados de isoxazolo-piridina.
ATE521348T1 (de) Kombination aus glycopyrrolat und einem beta2- adrenoceptor-agonist
BRPI0510515A (pt) compostos de morfolina
ATE414703T1 (de) Isoxazolderivate als inverse gaba a alpha5 agonisten
BR0214221A (pt) Derivados de benzotiazol como ligantes de receptores de adenosina
ATE466858T1 (de) 3-arylisoxazol-4-carbonylbenzofuranderivative
ATE414516T1 (de) Morphinanderivate als mittel gegen juckreiz
BRPI0513511A (pt) derivados de benzotiazol
DE602004025935D1 (de) Histondeacetylaseinhibitor und verfahren zu dessen herstellung
BRPI0514820A (pt) antagonistas de receptor de histamina-3 amina azabicìclicos
MY140167A (en) Substituted benzothiazoles
JO2502B1 (en) 4-Hydroxy-4-methyl-piperidine-1-carboxylic acid-4) methoxy-7-morpholine-4-yl-benzothiazole-2-yl) -amide
MXPA05011059A (es) Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.
DE602005014365D1 (de) Verfahren zur gewinnung von 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazolen
ATE417039T1 (de) 3,4-dihydro-2-naphthoesäureamidderivate und deren therapeutische anwendungen
ATE440826T1 (de) Benzoxazolonderivate, verfahren zu deren herstellung und deren anwendungen
TH87428A (th) สารประกอบชนิดใหม่
DE602008005014D1 (de) Prolinamidtetrazolderivate als nk3-rezeptorantagonisten
ATE485820T1 (de) Verwendung von n-(dibenz (b,f)oxepin-10-ylmethyl)-n-methyl-n-prop-2-inyl min (omigapil) zur prophylaxe und/oder behandlung von muskeldystrophie
TH98482B (th) เกลือซินาโฟเอตของสารประกอบ5-ออกซาโซล-2-อิล-ควิโนลีนที่ถูกแทนที่
TH77075A (th) ซัลฟามิคซิดอามีด
DE602006018149D1 (de) Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors