CY1107974T1 - Παραγωγα κινολινης και κιναζολινης εχοντα συναφεια προς τους υποδοχεις τυπου 5ht1 - Google Patents
Παραγωγα κινολινης και κιναζολινης εχοντα συναφεια προς τους υποδοχεις τυπου 5ht1Info
- Publication number
- CY1107974T1 CY1107974T1 CY20081100555T CY081100555T CY1107974T1 CY 1107974 T1 CY1107974 T1 CY 1107974T1 CY 20081100555 T CY20081100555 T CY 20081100555T CY 081100555 T CY081100555 T CY 081100555T CY 1107974 T1 CY1107974 T1 CY 1107974T1
- Authority
- CY
- Cyprus
- Prior art keywords
- kinazolin
- kinolin
- receptors
- derivatives related
- derivatives
- Prior art date
Links
- 102000035038 5-HT1 receptors Human genes 0.000 title 1
- 108091005478 5-HT1 receptors Proteins 0.000 title 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Manufacturing & Machinery (AREA)
- Ceramic Engineering (AREA)
- Structural Engineering (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Παρέχονται ενώσεις τύπου (Ι) και φαρμακευτικά αποδεκτά άλατά τους: όπου τα R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 και q έχουν τις έννοιες που ορίζονται στην περιγραφή. Αποκαλυπτονται επίσης μέθοδοι παρασκευής και χρήσεις τους στη θεραπεία, ιδιαίτερα για διαταραχές του ΚΝΣ.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316915.8A GB0316915D0 (en) | 2003-07-18 | 2003-07-18 | Compounds |
| EP04763307A EP1646613B1 (en) | 2003-07-18 | 2004-07-15 | Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1107974T1 true CY1107974T1 (el) | 2013-09-04 |
Family
ID=27764115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081100555T CY1107974T1 (el) | 2003-07-18 | 2008-05-29 | Παραγωγα κινολινης και κιναζολινης εχοντα συναφεια προς τους υποδοχεις τυπου 5ht1 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US7279481B2 (el) |
| EP (3) | EP1876174B1 (el) |
| JP (1) | JP2006528146A (el) |
| KR (1) | KR20060041242A (el) |
| CN (1) | CN100441571C (el) |
| AR (1) | AR046394A1 (el) |
| AT (2) | ATE389637T1 (el) |
| AU (1) | AU2004263268B2 (el) |
| BR (1) | BRPI0412695A (el) |
| CA (1) | CA2532452A1 (el) |
| CY (1) | CY1107974T1 (el) |
| DE (2) | DE602004012564T2 (el) |
| DK (1) | DK1646613T3 (el) |
| ES (2) | ES2336148T3 (el) |
| GB (1) | GB0316915D0 (el) |
| HR (1) | HRP20080226T3 (el) |
| IL (1) | IL173036A0 (el) |
| IS (1) | IS2744B (el) |
| MA (1) | MA27926A1 (el) |
| MX (1) | MXPA06000716A (el) |
| NO (1) | NO20060774L (el) |
| NZ (1) | NZ544586A (el) |
| PL (1) | PL1646613T3 (el) |
| PT (1) | PT1646613E (el) |
| RU (1) | RU2402533C2 (el) |
| SI (1) | SI1646613T1 (el) |
| TW (1) | TW200521115A (el) |
| WO (1) | WO2005014552A1 (el) |
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| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| US7507735B2 (en) * | 2004-06-17 | 2009-03-24 | Cytokinetics, Inc. | Compounds, compositions and methods |
| KR100817538B1 (ko) * | 2006-07-05 | 2008-03-27 | 한국화학연구원 | 신규 치환된―１ｈ―퀴나졸린―２,４―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물 |
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| EP2016943B1 (en) | 2007-07-19 | 2011-02-23 | Laboratorios del Dr. Esteve S.A. | Substituted tetrahydro-quinoline-sulfonamide compounds, their preparation and use as medicaments |
| CA2697990A1 (en) * | 2007-08-27 | 2009-03-05 | University Of Virginia Patent Foundation | Medication combinations for the treatment of alcoholism and drug addiction |
| EP2255184B1 (en) * | 2008-02-28 | 2013-04-24 | University Of Virginia Patent Foundation | Serotonin transporter gene and treatment of alcoholism |
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| EP2801625B1 (en) | 2010-07-02 | 2017-11-01 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
| UA114406C2 (uk) * | 2011-08-09 | 2017-06-12 | Такеда Фармасьютікал Компані Лімітед | Похідні циклопропанаміну як інгібітори lsd1 |
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| BR112016023382B1 (pt) | 2014-04-11 | 2023-01-10 | Takeda Pharmaceutical Company Limited | Composto, medicamento, e, uso de um composto |
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| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
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| EP3600363B1 (en) | 2017-06-14 | 2020-12-02 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
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| PL3814347T3 (pl) | 2018-06-27 | 2023-07-24 | Bristol-Myers Squibb Company | Związki naftyrydynonu użyteczne jako aktywatory komórek t |
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| US20050124625A1 (en) | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
| WO2005087742A1 (en) | 2004-03-08 | 2005-09-22 | Exelixis, Inc. | Metabolic kinase modulators and methods of use as pesticides |
| EP1725534A1 (en) | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| PE20060653A1 (es) | 2004-08-31 | 2006-09-27 | Glaxo Group Ltd | Derivados triciclicos condensados como moduladores del receptor 5-ht1 |
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2003
- 2003-07-18 GB GBGB0316915.8A patent/GB0316915D0/en not_active Ceased
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2004
- 2004-07-15 KR KR1020067001103A patent/KR20060041242A/ko not_active Ceased
- 2004-07-15 BR BRPI0412695-5A patent/BRPI0412695A/pt not_active IP Right Cessation
- 2004-07-15 HR HR20080226T patent/HRP20080226T3/xx unknown
- 2004-07-15 JP JP2006520756A patent/JP2006528146A/ja not_active Ceased
- 2004-07-15 AU AU2004263268A patent/AU2004263268B2/en not_active Ceased
- 2004-07-15 DE DE602004012564T patent/DE602004012564T2/de not_active Expired - Lifetime
- 2004-07-15 PL PL04763307T patent/PL1646613T3/pl unknown
- 2004-07-15 AT AT04763307T patent/ATE389637T1/de active
- 2004-07-15 SI SI200430699T patent/SI1646613T1/sl unknown
- 2004-07-15 DK DK04763307T patent/DK1646613T3/da active
- 2004-07-15 NZ NZ544586A patent/NZ544586A/en unknown
- 2004-07-15 EP EP07118193A patent/EP1876174B1/en not_active Expired - Lifetime
- 2004-07-15 CA CA002532452A patent/CA2532452A1/en not_active Abandoned
- 2004-07-15 PT PT04763307T patent/PT1646613E/pt unknown
- 2004-07-15 ES ES07118193T patent/ES2336148T3/es not_active Expired - Lifetime
- 2004-07-15 EP EP09175186A patent/EP2145622A1/en not_active Withdrawn
- 2004-07-15 DE DE602004024141T patent/DE602004024141D1/de not_active Expired - Lifetime
- 2004-07-15 CN CNB2004800270575A patent/CN100441571C/zh not_active Expired - Fee Related
- 2004-07-15 AT AT07118193T patent/ATE448205T1/de not_active IP Right Cessation
- 2004-07-15 WO PCT/EP2004/008000 patent/WO2005014552A1/en not_active Ceased
- 2004-07-15 MX MXPA06000716A patent/MXPA06000716A/es active IP Right Grant
- 2004-07-15 ES ES04763307T patent/ES2302543T3/es not_active Expired - Lifetime
- 2004-07-15 US US10/565,066 patent/US7279481B2/en not_active Expired - Fee Related
- 2004-07-15 RU RU2006104993/04A patent/RU2402533C2/ru not_active IP Right Cessation
- 2004-07-15 EP EP04763307A patent/EP1646613B1/en not_active Expired - Lifetime
- 2004-07-16 TW TW093121227A patent/TW200521115A/zh unknown
- 2004-07-16 AR ARP040102527A patent/AR046394A1/es not_active Application Discontinuation
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2006
- 2006-01-09 IL IL173036A patent/IL173036A0/en unknown
- 2006-01-18 MA MA28738A patent/MA27926A1/fr unknown
- 2006-02-15 IS IS8304A patent/IS2744B/is unknown
- 2006-02-17 NO NO20060774A patent/NO20060774L/no not_active Application Discontinuation
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2007
- 2007-03-16 US US11/687,098 patent/US7459456B2/en not_active Expired - Fee Related
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2008
- 2008-05-29 CY CY20081100555T patent/CY1107974T1/el unknown
- 2008-07-02 US US12/166,547 patent/US7592346B2/en not_active Expired - Fee Related
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2009
- 2009-08-13 US US12/540,452 patent/US7732600B2/en not_active Expired - Fee Related
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2010
- 2010-04-23 US US12/766,053 patent/US20100204273A1/en not_active Abandoned
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