CY1107533T1 - Επιλεκτικοι συναγωνιστες και ανταγωνιστες της il-2 - Google Patents
Επιλεκτικοι συναγωνιστες και ανταγωνιστες της il-2Info
- Publication number
- CY1107533T1 CY1107533T1 CY20071100330T CY071100330T CY1107533T1 CY 1107533 T1 CY1107533 T1 CY 1107533T1 CY 20071100330 T CY20071100330 T CY 20071100330T CY 071100330 T CY071100330 T CY 071100330T CY 1107533 T1 CY1107533 T1 CY 1107533T1
- Authority
- CY
- Cyprus
- Prior art keywords
- mutein
- cells
- native
- human
- competitives
- Prior art date
Links
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 3
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102220622777 Sphingomyelin phosphodiesterase_N88G_mutation Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 102220273516 rs768267292 Human genes 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Η εφεύρεση αναφέρεται σε ένα πολυπεπτίδιο αποτελούμενο από μία ανθρώπινη μουτεΐνη της IL-2 αριθμημένη σύμφωνα με τη φυσική IL-2 όπου η εν λόγω ανθρώπινη IL-2 έχει υποκατασταθεί σε τουλάχιστον μία από τις θέσεις 20, 88 ή 126, όπου η εν λόγω μουτεΐνη πλεονεκτικά ενεργοποιεί τα κύτταρα Τ σε σχέση με τα κύτταρα ΝΚ. Οι D20H και I, N88G, I, και R, συγκεκριμένα έχουν μία σχετική διαφορική δράση κυττάρων Τ αρκετά μεγαλύτερη από τη φυσική IL-2, με προβλεπόμενη σχετιζόμενη μειωμένη in vivo τοξικότητα. Η εφεύρεση περιλαμβάνει επίσης πολυνουκλεοτίδια τα οποία κωδικοποιούν τις μουτεΐνες της εφευρέσεως, φορείς περιέχοντες τα πολυνουκλεοτίδια, μετασχηματισμένα κύτταρα ξενιστές, φαρμακευτικές συνθέσεις οι οποίες περιέχουν τις μουτεΐνες, και θεραπευτικές μεθόδους αγωγής.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8008098A | 1998-05-15 | 1998-05-15 | |
| EP99924232A EP1076704B1 (en) | 1998-05-15 | 1999-05-13 | Il-2 selective agonists and antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1107533T1 true CY1107533T1 (el) | 2013-03-13 |
Family
ID=22155135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100330T CY1107533T1 (el) | 1998-05-15 | 2007-03-09 | Επιλεκτικοι συναγωνιστες και ανταγωνιστες της il-2 |
Country Status (39)
| Country | Link |
|---|---|
| EP (1) | EP1076704B1 (el) |
| JP (1) | JP4276783B2 (el) |
| KR (1) | KR100607609B1 (el) |
| CN (2) | CN100366742C (el) |
| AR (1) | AR020322A1 (el) |
| AT (1) | ATE351907T1 (el) |
| AU (1) | AU759697B2 (el) |
| BG (1) | BG65139B1 (el) |
| BR (1) | BRPI9910504B1 (el) |
| CA (1) | CA2327349C (el) |
| CO (1) | CO5070701A1 (el) |
| CU (2) | CU23273B7 (el) |
| CY (1) | CY1107533T1 (el) |
| CZ (1) | CZ302071B6 (el) |
| DE (1) | DE69934881T2 (el) |
| DK (1) | DK1076704T3 (el) |
| DZ (1) | DZ2788A1 (el) |
| ES (1) | ES2281175T3 (el) |
| HK (1) | HK1039963B (el) |
| HN (1) | HN1999000075A (el) |
| HU (1) | HU226142B1 (el) |
| IL (2) | IL139136A0 (el) |
| MY (1) | MY130274A (el) |
| NO (1) | NO329235B1 (el) |
| NZ (1) | NZ508098A (el) |
| PA (1) | PA8472601A1 (el) |
| PE (1) | PE20000475A1 (el) |
| PL (1) | PL201675B1 (el) |
| PT (1) | PT1076704E (el) |
| RO (1) | RO122150B1 (el) |
| RU (1) | RU2235729C2 (el) |
| SI (1) | SI20643B (el) |
| SK (1) | SK288100B6 (el) |
| SV (1) | SV1999000061A (el) |
| TN (1) | TNSN99090A1 (el) |
| TR (1) | TR200003354T2 (el) |
| TW (1) | TWI223663B (el) |
| UA (1) | UA73719C2 (el) |
| WO (1) | WO1999060128A1 (el) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE267215T1 (de) | 1997-12-08 | 2004-06-15 | Lexigen Pharm Corp | Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung |
| US6566500B1 (en) | 1999-03-30 | 2003-05-20 | Board Of Regents, The University Of Texas System | Compositions and methods for modifying toxic effects of proteinaceous compounds |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| ATE316982T1 (de) | 1999-08-09 | 2006-02-15 | Lexigen Pharm Corp | Mehrere zytokin-antikörper komplexen |
| JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
| AU4314801A (en) | 2000-02-11 | 2001-08-20 | Lexigen Pharm Corp | Enhancing the circulating half-life of antibody-based fusion proteins |
| EP1935431A3 (en) | 2000-05-15 | 2008-08-13 | Health Research, Inc. | Cancer treatments by using a combination of an antibody against her2 and interleukin-2 |
| US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| PL358582A1 (en) | 2000-06-29 | 2004-08-09 | Merck Patent Gmbh | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
| MY139948A (en) * | 2000-09-28 | 2009-11-30 | Bayer Corp | Enhanced transfection system |
| US7723102B2 (en) * | 2000-09-28 | 2010-05-25 | Bayer Corporation | Enhanced transfection system |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| MXPA03009924A (es) | 2001-05-03 | 2004-01-29 | Merck Patent Gmbh | Anticuerpo recombinante especifico de tumor y uso del mismo. |
| DK1454138T3 (da) | 2001-12-04 | 2012-02-13 | Merck Patent Gmbh | Immunocytokiner med moduleret selektivitet |
| EP1572748B1 (en) | 2002-12-17 | 2010-06-23 | MERCK PATENT GmbH | Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2 |
| US7569215B2 (en) | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| ES2356154T3 (es) | 2003-07-21 | 2011-04-05 | Transgene S.A. | Citoquinas multifuncionales. |
| DE602004031341D1 (de) * | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
| KR101403910B1 (ko) | 2003-11-04 | 2014-06-09 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 길항제 항-ｃｄ４０ 단클론성 항체 및 그것의 사용 방법 |
| EP1718670B1 (en) * | 2004-02-27 | 2011-07-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Il-15 binding site for il 15-ralpha and specific il-15 mutants having agonist/antagonist activity |
| KR20070003934A (ko) * | 2004-03-05 | 2007-01-05 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 치료제의 환자 내약성을 예측하기 위한 시험관 내 테스트시스템 |
| WO2009061853A2 (en) * | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Mutant interleukin-2 (il-2) polypeptides |
| CN101244261B (zh) * | 2008-03-10 | 2010-09-15 | 山东大学 | 一种含未复性重组蛋白的生物制剂及其制备方法与应用 |
| DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| CA2749539C (en) | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
| CN102101885B (zh) * | 2010-09-01 | 2013-06-05 | 南京发士达生物科技有限公司 | 低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途 |
| KR20200070407A (ko) | 2010-11-12 | 2020-06-17 | 넥타르 테라퓨틱스 | Ｉｌ-2 부분 및 중합체의 접합체 |
| CU23923B1 (es) * | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| CA2860170C (en) | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| ES2694564T3 (es) | 2011-02-10 | 2018-12-21 | Roche Glycart Ag | Polipéptidos de interleucina-2 mutantes |
| WO2012119093A1 (en) * | 2011-03-03 | 2012-09-07 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| CA2925421C (en) | 2013-09-24 | 2023-08-29 | Medicenna Therapeutics, Inc. | Interleukin-2 fusion proteins and uses thereof |
| EA201992609A1 (ru) | 2014-02-06 | 2020-03-04 | Ф.Хоффманн-Ля Рош Аг | Слитые белки, содержащие интерлейкин-2, и их применения |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| CN113234138A (zh) | 2014-08-11 | 2021-08-10 | 德里尼亚公司 | 选择性地活化调节性t细胞用于治疗自身免疫病的修饰的il-2变体 |
| JP7407511B2 (ja) | 2015-10-08 | 2024-01-04 | ネクター セラピューティクス | ＩＬ－２Ｒβ選択的作動薬と長時間作用型ＩＬ－１５作動薬との併用 |
| US20170204154A1 (en) * | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CN115073581A (zh) * | 2016-05-04 | 2022-09-20 | 美国安进公司 | 用于扩增t调节性细胞的白细胞介素-2突变蛋白 |
| EP3458485B1 (en) | 2016-05-19 | 2021-12-29 | The General Hospital Corporation | Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| AU2017281469B2 (en) | 2016-06-22 | 2023-08-31 | David Klatzmann | Genetically modified T lymphocytes |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| EA201991142A1 (ru) | 2016-11-08 | 2019-10-31 | Варианты il-2 для лечения аутоиммунных заболеваний | |
| US10472405B2 (en) * | 2016-12-13 | 2019-11-12 | Delinia, Inc. | Multivalent regulatory T cell modulators |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| MX2019014023A (es) | 2017-05-24 | 2020-02-17 | Novartis Ag | Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer. |
| CN111107868A (zh) * | 2017-05-24 | 2020-05-05 | 诺华股份有限公司 | 抗体细胞因子移植蛋白及使用方法 |
| JOP20190271A1 (ar) * | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| CN111010866A (zh) | 2017-05-24 | 2020-04-14 | 潘迪恩治疗公司 | 靶向免疫耐受性 |
| US11542312B2 (en) | 2017-06-19 | 2023-01-03 | Medicenna Therapeutics, Inc. | IL-2 superagonists in combination with anti-PD-1 antibodies |
| SG11202000939PA (en) * | 2017-08-03 | 2020-02-27 | Synthorx Inc | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| PH12020550661A1 (en) * | 2017-11-21 | 2021-04-19 | Univ Leland Stanford Junior | Partial agonists of interleukin-2 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| KR102722731B1 (ko) | 2017-12-19 | 2024-10-25 | 젠코어 인코포레이티드 | 조작된 il-2 fc 융합 단백질 |
| US11534479B2 (en) | 2018-02-16 | 2022-12-27 | Iltoo Pharma | Use of interleukin 2 for treating Sjögren's syndrome |
| CN120590539A (zh) | 2018-03-28 | 2025-09-05 | 百时美施贵宝公司 | 白介素-2/白介素-2受体α融合蛋白以及使用方法 |
| MA52662A (fr) | 2018-03-28 | 2021-02-17 | Ascendis Pharma Oncology Div A/S | Conjugués d'il-2 |
| WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
| KR20210038549A (ko) * | 2018-07-24 | 2021-04-07 | 비온테크 알엔에이 파마슈티컬스 게엠베하 | Il2 작용제 |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| KR102201086B1 (ko) * | 2018-09-17 | 2021-01-11 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 이의 용도 |
| AU2019343251B2 (en) | 2018-09-21 | 2022-06-09 | Innovent Biologics (Suzhou) Co., Ltd. | Novel interleukin 2 and use thereof |
| TW202034945A (zh) | 2018-12-21 | 2020-10-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種人白細胞介素２變體或其衍生物 |
| US11739146B2 (en) | 2019-05-20 | 2023-08-29 | Pandion Operations, Inc. | MAdCAM targeted immunotolerance |
| TW202115105A (zh) * | 2019-06-24 | 2021-04-16 | 德商拜恩迪克Ｒｎａ製藥有限公司 | Ｉｌ２激動劑 |
| MX2022001061A (es) | 2019-07-26 | 2022-02-14 | Visterra Inc | Agentes de interleuquina-2 y usos de los mismos. |
| UY38836A (es) * | 2019-08-13 | 2021-02-26 | Amgen Inc | Muteínas de interleucina-2 para la expansión de células t reguladoras |
| US20230036793A1 (en) | 2019-12-12 | 2023-02-02 | Iltoo Pharma | Interleukin 2 chimeric constructs |
| BR112022011949A2 (pt) | 2019-12-17 | 2022-11-22 | Amgen Inc | Dupla de interleucina-2/agonista do receptor tnf para uso em terapia |
| AU2021206449A1 (en) | 2020-01-10 | 2022-07-21 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
| JP7303391B2 (ja) | 2020-01-14 | 2023-07-04 | シンセカイン インコーポレイテッド | バイアス型ｉｌ２ムテイン、方法、および組成物 |
| IL294070A (en) * | 2020-01-14 | 2022-08-01 | Synthekine Inc | Il2 muteins |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| CN115698052A (zh) | 2020-03-19 | 2023-02-03 | 信达生物制药(苏州)有限公司 | 白介素2突变体及其用途 |
| KR102545250B1 (ko) * | 2020-03-31 | 2023-06-21 | 한미약품 주식회사 | 신규한 면역 활성 인터루킨 2 아날로그 |
| JP2023527919A (ja) | 2020-06-03 | 2023-06-30 | アセンディス ファーマ オンコロジー ディヴィジョン エー／エス | Ｉｌ－２配列及びその使用 |
| EP4236962A1 (en) | 2020-10-29 | 2023-09-06 | Bristol-Myers Squibb Company | Fusion proteins for the treatment of disease |
| CN114507643A (zh) * | 2020-10-29 | 2022-05-17 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-2的多能干细胞衍生物及应用 |
| AU2021391924A1 (en) | 2020-12-04 | 2023-06-22 | The General Hospital Corporation | Methods of using interleukin-2 agents |
| CN113308477A (zh) * | 2021-04-08 | 2021-08-27 | 华南农业大学 | 一种鸭il-2基因真核表达重组质粒及其制备方法 |
| MX2024003535A (es) | 2021-09-22 | 2024-05-07 | Fortvita Biologics Singapore Pte Ltd | Proteina mutante de interleucina-2 y fusion de la misma. |
| JP2024533848A (ja) | 2021-10-06 | 2024-09-12 | イルトゥー・ファルマ | 炎症組織へのターゲティング特異性を備えるインターロイキン２キメラコンストラクト |
| CN114875069B (zh) * | 2022-04-22 | 2023-09-15 | 四川大学 | 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途 |
| AU2023295521A1 (en) * | 2022-06-16 | 2025-01-02 | Cephalon Llc | Anti-pd-1 antibody-attenuated il-2 immunoconjugates and uses thereof |
| WO2024056154A1 (en) | 2022-09-12 | 2024-03-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukin-2 for use in treating autism spectrum disorder |
| FR3140287B1 (fr) | 2022-10-03 | 2025-11-21 | Arkema France | Procede de granulation de composes azoiques et granules obtenus |
| EP4631972A1 (en) | 2022-11-18 | 2025-10-15 | Nanjing Novoacine Biotechnology Co., Ltd. | Site-specific coupled pegylated interleukin-2 mutant with receptor affinity preference and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2003334C1 (ru) * | 1988-07-26 | 1993-11-30 | Хем Рисерч, Инк, (US) | Способ лечени больных с опухол ми |
| FR2684878B1 (fr) * | 1991-12-12 | 1994-02-11 | Roussel Uclaf | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
| US5696234A (en) * | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
-
1999
- 1999-05-12 DZ DZ990088A patent/DZ2788A1/xx active
- 1999-05-13 PE PE1999000399A patent/PE20000475A1/es not_active Application Discontinuation
- 1999-05-13 JP JP2000549735A patent/JP4276783B2/ja not_active Expired - Lifetime
- 1999-05-13 EP EP99924232A patent/EP1076704B1/en not_active Expired - Lifetime
- 1999-05-13 PL PL344407A patent/PL201675B1/pl unknown
- 1999-05-13 UA UA2000127206A patent/UA73719C2/uk unknown
- 1999-05-13 AU AU40784/99A patent/AU759697B2/en not_active Expired
- 1999-05-13 TN TNTNSN99090A patent/TNSN99090A1/fr unknown
- 1999-05-13 DK DK99924232T patent/DK1076704T3/da active
- 1999-05-13 NZ NZ508098A patent/NZ508098A/en not_active IP Right Cessation
- 1999-05-13 CA CA2327349A patent/CA2327349C/en not_active Expired - Lifetime
- 1999-05-13 BR BRPI9910504A patent/BRPI9910504B1/pt not_active IP Right Cessation
- 1999-05-13 RU RU2000131593/04A patent/RU2235729C2/ru active
- 1999-05-13 PA PA19998472601A patent/PA8472601A1/es unknown
- 1999-05-13 PT PT99924232T patent/PT1076704E/pt unknown
- 1999-05-13 HK HK02101283.2A patent/HK1039963B/zh not_active IP Right Cessation
- 1999-05-13 KR KR1020007012747A patent/KR100607609B1/ko not_active Expired - Lifetime
- 1999-05-13 AR ARP990102269A patent/AR020322A1/es active IP Right Grant
- 1999-05-13 CN CNB998086509A patent/CN100366742C/zh not_active Expired - Lifetime
- 1999-05-13 RO ROA200001123A patent/RO122150B1/ro unknown
- 1999-05-13 SI SI9920034A patent/SI20643B/sl active Search and Examination
- 1999-05-13 IL IL13913699A patent/IL139136A0/xx unknown
- 1999-05-13 AT AT99924232T patent/ATE351907T1/de active
- 1999-05-13 TR TR2000/03354T patent/TR200003354T2/xx unknown
- 1999-05-13 ES ES99924232T patent/ES2281175T3/es not_active Expired - Lifetime
- 1999-05-13 DE DE69934881T patent/DE69934881T2/de not_active Expired - Lifetime
- 1999-05-13 CZ CZ20004213A patent/CZ302071B6/cs not_active IP Right Cessation
- 1999-05-13 CN CN2007101609093A patent/CN101319247B/zh not_active Expired - Lifetime
- 1999-05-13 SK SK1724-2000A patent/SK288100B6/sk not_active IP Right Cessation
- 1999-05-13 HU HU0101948A patent/HU226142B1/hu unknown
- 1999-05-13 WO PCT/US1999/010643 patent/WO1999060128A1/en not_active Ceased
- 1999-05-14 CO CO99030158A patent/CO5070701A1/es unknown
- 1999-05-14 SV SV1999000061A patent/SV1999000061A/es active IP Right Grant
- 1999-05-14 TW TW088107812A patent/TWI223663B/zh not_active IP Right Cessation
- 1999-05-14 HN HN1999000075A patent/HN1999000075A/es unknown
- 1999-05-14 MY MYPI99001912A patent/MY130274A/en unknown
-
2000
- 2000-10-18 IL IL139136A patent/IL139136A/en not_active IP Right Cessation
- 2000-11-08 BG BG104929A patent/BG65139B1/bg unknown
- 2000-11-14 NO NO20005762A patent/NO329235B1/no not_active IP Right Cessation
- 2000-11-15 CU CU20000257A patent/CU23273B7/es not_active IP Right Cessation
-
2002
- 2002-06-19 CU CU20020125A patent/CU23272A1/es not_active IP Right Cessation
-
2007
- 2007-03-09 CY CY20071100330T patent/CY1107533T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1107533T1 (el) | Επιλεκτικοι συναγωνιστες και ανταγωνιστες της il-2 | |
| DE68929551D1 (de) | Menschliche DNase | |
| LTC2599503I2 (lt) | Interferono beta-1A polimero konjugatai ir jų panaudojimas | |
| DK1025124T3 (da) | Human interferon-alfa-analoge med lav toksicitet | |
| CY1108610T1 (el) | Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| BR9301944A (pt) | Derivado de proteina c,molecula de dna recombinante,celula hospedeira e formulacao farmaceutica | |
| NZ226005A (en) | Covalent conjugates of a human cytokine and a human immunoglobulin, processes for their manufacture and pharmaceutical compositions thereof | |
| NO952744D0 (no) | Cytokinbegrensende midler | |
| BR0111182A (pt) | Peptìdeos neuroprotetores | |
| ATE88898T1 (de) | Cd4-polypeptidderivate. | |
| BR9507189A (pt) | Combinaçoes de proteinas tromboliticamente ativas e anticoagulantes e usos dos mesmos | |
| ATE199167T1 (de) | Nichtglykosyliertes fgf-4 und dieses enthaltende präparate | |
| DE3875108D1 (de) | Physiologisch aktives polypeptid und pharmazeutische komposition. | |
| DE69534165D1 (de) | Adenovirus mit glutathion peroxydate gene | |
| DK465488A (da) | Farmaceutisk praeparat indeholdende en triazol-forbindelse | |
| FI893681A0 (fi) | N-2,3-butadienyltri- och tetra-aminoalkanderivat. | |
| ATE76579T1 (de) | Interferon-zusammensetzungen. | |
| ATE90359T1 (de) | Peptide. | |
| GR3032224T3 (en) | Therapeutic agent for threatened abortion. | |
| AU3902489A (en) | Non-glycosylated, recombinant human IL2 in the reduced form, the process for obtaining it and its use as a medicament | |
| DK0821969T3 (da) | Medicinsk sammensætning omfattende TCF-II | |
| KR100488038B1 (ko) | 기관 보호 활성을 지닌 신규한 신체 보호 화합물 펩티드염, 이의 제조 방법 및 치료에서의 이의 용도 | |
| DE3767175D1 (de) | Therapeutische zusammenstellungen auf basis von 3-alkoxyflavonen und derivate von 3-alkoxyflavonen. | |
| DE69836278D1 (de) | Allele formen von menschlichem stat3 | |
| ES8704903A1 (es) | Un metodo para preparar 6-cloro-2-metil-1h-2,3,4,5-tetrahidro-3-benzazepen-n-oxido. |