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CU20190096A7 - Compuestos derivados de 3-metil-3-hidroxi-4-[(n,n-dimetil)amino]-9-[2-(benciloxi)bencil]-1-oxa-9-azaspiro[5,5]undecano substituidos como inhibidores de la función mitocondrial y composiciones farmacéuticas que los contienen - Google Patents

Compuestos derivados de 3-metil-3-hidroxi-4-[(n,n-dimetil)amino]-9-[2-(benciloxi)bencil]-1-oxa-9-azaspiro[5,5]undecano substituidos como inhibidores de la función mitocondrial y composiciones farmacéuticas que los contienen

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Publication number
CU20190096A7
CU20190096A7 CU2019000096A CU20190096A CU20190096A7 CU 20190096 A7 CU20190096 A7 CU 20190096A7 CU 2019000096 A CU2019000096 A CU 2019000096A CU 20190096 A CU20190096 A CU 20190096A CU 20190096 A7 CU20190096 A7 CU 20190096A7
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CU
Cuba
Prior art keywords
inhibitors
pharmaceutical compositions
mitochondrial function
undecan
azaspiro
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Application number
CU2019000096A
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English (en)
Inventor
Michael P Lisanti
Federica Sotgia
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Lunella Biotech Inc
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Publication date
Application filed by Lunella Biotech Inc filed Critical Lunella Biotech Inc
Publication of CU20190096A7 publication Critical patent/CU20190096A7/es

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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

<p>La presente descripción se refiere a compuestos de mitoribosporinas de fórmula</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>, composiciones farmacéuticas que los contienen como inhibidores de la función mitocondrial. Tales compuestos tienen propiedades anti-cáncer y antibióticas, para proporcionar beneficios anti-edad, así como anticonceptivo masculino, agente espermistático y agente inmovilizador del esperma.</p>
CU2019000096A 2017-03-15 2018-03-14 Compuestos derivados de 3-metil-3-hidroxi-4-[(n,n-dimetil)amino]-9-[2-(benciloxi)bencil]-1-oxa-9-azaspiro[5,5]undecano substituidos como inhibidores de la función mitocondrial y composiciones farmacéuticas que los contienen CU20190096A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762471688P 2017-03-15 2017-03-15
PCT/US2018/022403 WO2018170109A1 (en) 2017-03-15 2018-03-14 Mitoriboscins: mitochondrial-based therapeutics targeting cancer cells, bacteria, and pathogenic yeast

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CU20190096A7 true CU20190096A7 (es) 2020-10-20

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CU2019000096A CU20190096A7 (es) 2017-03-15 2018-03-14 Compuestos derivados de 3-metil-3-hidroxi-4-[(n,n-dimetil)amino]-9-[2-(benciloxi)bencil]-1-oxa-9-azaspiro[5,5]undecano substituidos como inhibidores de la función mitocondrial y composiciones farmacéuticas que los contienen
CU2019000079A CU20190079A7 (es) 2017-03-15 2018-03-14 Compuestos derivados de 3-([2-fenoxi]fenoxi)-2-hidroxi-n-bencyl-ciclohexilamina substituidos como inhibidores de la función mitocondrial y composiciones farmacéuticas que los contienen
CU2019000097A CU20190097A7 (es) 2017-03-15 2018-03-14 Compuestos derivados de 2-(benciloxi)-anilina n-substituidos como inhibidores de la función mitocondrial y composiciones farmacéuticas que los contienen

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