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CU20090209A7 - MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION - Google Patents

MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Info

Publication number
CU20090209A7
CU20090209A7 CU20090209A CU20090209A CU20090209A7 CU 20090209 A7 CU20090209 A7 CU 20090209A7 CU 20090209 A CU20090209 A CU 20090209A CU 20090209 A CU20090209 A CU 20090209A CU 20090209 A7 CU20090209 A7 CU 20090209A7
Authority
CU
Cuba
Prior art keywords
formula
methods
compound
inhibitors
viral replication
Prior art date
Application number
CU20090209A
Other languages
Spanish (es)
Other versions
CU23787B7 (en
Inventor
Benjamin Woodard
George Andrew Doherty
Machender R Madduru
Peter John Stengel
John Anthony Josey
Kevin Ronald Condroski
April Layne Kennedy
Yutong Jiang
Steven Wade Andrews
Steven Mark Wenglowsky
Lawrence M Blatt
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of CU20090209A7 publication Critical patent/CU20090209A7/en
Publication of CU23787B7 publication Critical patent/CU23787B7/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proveen compuestos de fórmula general I, así como sus composiciones , entre las que se incluyen composiciones farmacéuticas , que comprenden un compuesto de fórmula I.Las realizaciones proveen además, métodos de tratamiento, que incluyen métodos de tratamiento de infecciones flavirales, que incluyen la infección por el virus de hepatitis C y métodos de tratar la fibrosis hepática. Los métodos consisten en general en la administración a un individuo que lo necesita una cantidad eficaz de un compuesto de fórmula I, o una composición que comprende un compuesto de fórmula I. ESPACIO PARA LA FÓRMULACompounds of general formula I are provided, as well as their compositions, including pharmaceutical compositions, which comprise a compound of formula I. The embodiments further provide methods of treatment, including methods of treating flaviral infections, including hepatitis C virus infection and methods of treating liver fibrosis. The methods generally consist of administering to an individual in need an effective amount of a compound of formula I, or a composition comprising a compound of formula I. SPACE FOR FORMULA

CU20090209A 2004-03-30 2009-12-08 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION CU23787B7 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30
US56241804P 2004-04-14 2004-04-14
US61238104P 2004-09-22 2004-09-22
US61246004P 2004-09-22 2004-09-22

Publications (2)

Publication Number Publication Date
CU20090209A7 true CU20090209A7 (en) 2011-04-26
CU23787B7 CU23787B7 (en) 2012-03-15

Family

ID=35005653

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20090209A CU23787B7 (en) 2004-03-30 2009-12-08 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Country Status (16)

Country Link
EP (1) EP1749007A2 (en)
JP (1) JP4950026B2 (en)
AP (1) AP2006003763A0 (en)
AR (1) AR050321A1 (en)
AU (1) AU2005228894B9 (en)
BR (1) BRPI0509467A (en)
CA (1) CA2560897C (en)
CU (1) CU23787B7 (en)
EA (1) EA012389B1 (en)
EC (1) ECSP066959A (en)
GE (1) GEP20104926B (en)
IL (1) IL177917A0 (en)
MA (1) MA28548B1 (en)
NO (1) NO20064933L (en)
NZ (1) NZ549697A (en)
WO (1) WO2005095403A2 (en)

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Also Published As

Publication number Publication date
WO2005095403A3 (en) 2005-12-01
NO20064933L (en) 2006-12-15
ECSP066959A (en) 2006-12-20
AP2006003763A0 (en) 2006-10-31
EA012389B1 (en) 2009-10-30
JP4950026B2 (en) 2012-06-13
CU23787B7 (en) 2012-03-15
GEP20104926B (en) 2010-03-25
EP1749007A2 (en) 2007-02-07
WO2005095403A2 (en) 2005-10-13
CA2560897C (en) 2012-06-12
AU2005228894B9 (en) 2011-10-13
IL177917A0 (en) 2006-12-31
AR050321A1 (en) 2006-10-18
NZ549697A (en) 2009-12-24
AU2005228894A1 (en) 2005-10-13
AU2005228894B2 (en) 2011-08-25
MA28548B1 (en) 2007-04-03
CA2560897A1 (en) 2005-10-13
EA200601467A1 (en) 2007-06-29
JP2007531749A (en) 2007-11-08
BRPI0509467A (en) 2007-09-11

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