CU20090035A7 - BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES - Google Patents
BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASESInfo
- Publication number
- CU20090035A7 CU20090035A7 CU20090035A CU20090035A CU20090035A7 CU 20090035 A7 CU20090035 A7 CU 20090035A7 CU 20090035 A CU20090035 A CU 20090035A CU 20090035 A CU20090035 A CU 20090035A CU 20090035 A7 CU20090035 A7 CU 20090035A7
- Authority
- CU
- Cuba
- Prior art keywords
- treatment
- disease
- compounds
- formula
- oxazolopiridins
- Prior art date
Links
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- 102000015617 Janus Kinases Human genes 0.000 title 1
- 108010024121 Janus Kinases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000011282 treatment Methods 0.000 abstract 6
- 201000010099 disease Diseases 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- -1 2,7-disubstituted benzoxazole Chemical class 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 abstract 1
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 229940100514 Syk tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 abstract 1
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de benzoxazol 2,7-disustituido y oxazolo-[5,4-c]-piridina 2,4-disustituida de la fórmula I que se da más adelante, así como a sales de los mismos, a procesos para su preparación, a la aplicación de los mismos en un proceso para el tratamiento del cuerpo humano o animal, estos compuestos para utilizarse en el tratamiento (incluyendo profilaxis) del cuerpo del animal, en especial humano (especialmente con respecto a una enfermedad proliferativa), el uso de los mismos- solos o en combinación con uno o más compuestos farmacéuticamente activos diferentes- para el tratamiento en especial de una enfermedad mediada por la cinasa de proteína tirosina (tal como una enfermedad tumoral) o para la fabricación de una preparación farmacéutica para utilizarse en el tratamiento de esta enfermedad, un método para el tratamiento de esta enfermedad y una preparación farmacéutica para el tratamiento de una enfermedad como se menciona. Los compuestos son de la fórmula I: ESPACIO PARA FÓRMULA en donde los símbolos son como se definen en la descripción. Los compuestos inhiben, por ejemplo, JAK2 y JAK3.The invention relates to 2,7-disubstituted benzoxazole and 2,4-disubstituted oxazolo- [5,4-c] -pyridine compounds of the formula I given below, as well as salts thereof, to processes for their preparation, to the application thereof in a process for the treatment of the human or animal body, these compounds for use in the treatment (including prophylaxis) of the animal's body, especially human (especially with respect to a proliferative disease) , the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment in particular of a tyrosine protein kinase mediated disease (such as a tumor disease) or for the manufacture of a pharmaceutical preparation to be used in the treatment of this disease, a method for the treatment of this disease and a pharmaceutical preparation for the treatment of a disease as mentioned. The compounds are of the formula I: FORMULA SPACE where the symbols are as defined in the description. The compounds inhibit, for example, JAK2 and JAK3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20090035A CU20090035A7 (en) | 2009-03-11 | 2009-03-11 | BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20090035A CU20090035A7 (en) | 2009-03-11 | 2009-03-11 | BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20090035A7 true CU20090035A7 (en) | 2011-03-21 |
Family
ID=44280884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20090035A CU20090035A7 (en) | 2009-03-11 | 2009-03-11 | BENZOXAZOLES AND OXAZOLOPIRIDINS THAT ARE USEFUL AS INHIBITORS OF JANUS KINASES |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU20090035A7 (en) |
-
2009
- 2009-03-11 CU CU20090035A patent/CU20090035A7/en unknown
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