CU20070114A7 - RECEPTORS DERIVED FROM 3-PHENYL-PIRAZOL AS MODULATORS OF 5-HT2A SEROTONIN USEFUL IN THE TREATMENT OF DISORDERS RELATED TO THEM - Google Patents
RECEPTORS DERIVED FROM 3-PHENYL-PIRAZOL AS MODULATORS OF 5-HT2A SEROTONIN USEFUL IN THE TREATMENT OF DISORDERS RELATED TO THEMInfo
- Publication number
- CU20070114A7 CU20070114A7 CU20070114A CU20070114A CU20070114A7 CU 20070114 A7 CU20070114 A7 CU 20070114A7 CU 20070114 A CU20070114 A CU 20070114A CU 20070114 A CU20070114 A CU 20070114A CU 20070114 A7 CU20070114 A7 CU 20070114A7
- Authority
- CU
- Cuba
- Prior art keywords
- psychosis
- disorders
- treatment
- phenyl
- pharmaceutical compositions
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 5
- 229940076279 serotonin Drugs 0.000 title abstract 2
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 title 1
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 abstract 2
- 108010072564 5-HT2A Serotonin Receptor Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 201000000980 schizophrenia Diseases 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- OEDUIFSDODUDRK-UHFFFAOYSA-N 5-phenyl-1h-pyrazole Chemical class N1N=CC=C1C1=CC=CC=C1 OEDUIFSDODUDRK-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010003658 Atrial Fibrillation Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 abstract 1
- 208000034800 Leukoencephalopathies Diseases 0.000 abstract 1
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000003542 behavioural effect Effects 0.000 abstract 1
- 230000035602 clotting Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002964 excitative effect Effects 0.000 abstract 1
- 210000002816 gill Anatomy 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención está relacionada con ciertos derivados de 3-fenil-pirazol de fórmula (Ia) y sus composiciones farmacéuticas que modulan la actividad del receptor 5-HT2A de la serotonina. ESPACIO PARA FÓRMULA Los compuestos y sus composiciones farmacéuticas están dirigidos hacia métodos útiles en el tratamiento de la agregación plaquetaria, arteriopatía coronaria, infarto d emiocardio, accidente esquémico transitorio, angina, accidente cerebrovascular, fibrilación auricular, reducción del riesgo de formación de coágulos sanguíneos, asma o sus síntomas, agitación o un síntoma, trastornos de la conducta, psicosis farmacógena, psicosis excitativa, síndrome de Gilles d ela Tourette, trastorno maníaco, psicosis orgánica o sin especificación, trastorno psicótico, psicosis, ezquizofrenia aguda, esquizofrenia crónica, esquizofrenia sin especificación y trastornos relacionados, y trastornos del sueno, Trastornos relacionados con la diabetes, leucoencefalopatíamultifocal prograsiva y semejantes. La presente invención también esta relacionadacon los métodos para el tratamiento de trastornos originados por el receptor 5-HT2A de la seretoninaen combinación con otros agentes farmacéuticos administrados juntos o por separado.The present invention is related to certain 3-phenyl-pyrazole derivatives of formula (Ia) and their pharmaceutical compositions that modulate the activity of the serotonin 5-HT2A receptor. FORMULA SPACE The compounds and their pharmaceutical compositions are directed towards useful methods in the treatment of platelet aggregation, coronary artery disease, heart attack, transient eschemic accident, angina, stroke, atrial fibrillation, reduced risk of blood clot formation, asthma or its symptoms, agitation or a symptom, behavioral disorders, pharmacogenic psychosis, excitative psychosis, Gilles d ela Tourette syndrome, manic disorder, organic or unspecified psychosis, psychotic disorder, psychosis, acute ezchizophrenia, chronic schizophrenia, schizophrenia without specification and related disorders, and sleep disorders, diabetes-related disorders, programmable multifocal leukoencephalopathy and the like. The present invention is also related to methods for the treatment of disorders caused by the 5-HT2A receptor of seretonin in combination with other pharmaceutical agents administered together or separately.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070114A CU20070114A7 (en) | 2007-05-18 | 2007-05-18 | RECEPTORS DERIVED FROM 3-PHENYL-PIRAZOL AS MODULATORS OF 5-HT2A SEROTONIN USEFUL IN THE TREATMENT OF DISORDERS RELATED TO THEM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20070114A CU20070114A7 (en) | 2007-05-18 | 2007-05-18 | RECEPTORS DERIVED FROM 3-PHENYL-PIRAZOL AS MODULATORS OF 5-HT2A SEROTONIN USEFUL IN THE TREATMENT OF DISORDERS RELATED TO THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20070114A7 true CU20070114A7 (en) | 2009-01-20 |
Family
ID=44280823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20070114A CU20070114A7 (en) | 2007-05-18 | 2007-05-18 | RECEPTORS DERIVED FROM 3-PHENYL-PIRAZOL AS MODULATORS OF 5-HT2A SEROTONIN USEFUL IN THE TREATMENT OF DISORDERS RELATED TO THEM |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU20070114A7 (en) |
-
2007
- 2007-05-18 CU CU20070114A patent/CU20070114A7/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NI200700127A (en) | DERIVATIVES OF 3-PHENYL-PIRAZOL AS MODULATORS OF THE SEROTONINE 5-HT2A RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED TO THIS. | |
| ECSP066269A (en) | DERIVATIVES OF DIARIL AND ARILHETEROARIL UREA AS MODULATORS OF THE 5-HT2A SEROTONINE RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED TO THE SAME | |
| CL2014002541A1 (en) | Compounds derived from heterocyclic fused imidazole, such as diacylglycerol acyltransferase 2 inhibitors; pharmaceutical composition that includes them, useful for the treatment of type I and II diabetes, coronary heart disease, arthritis, thrombosis, Alzheimer's, among other diseases. | |
| BR112013021236A8 (en) | compound, composition, and method of treating a disorder, condition, or disease | |
| HN2010001563A (en) | COMPOUNDS | |
| DOP2009000149A (en) | AGONIST AND ANTAGONIST COMPOUNDS OF THE SPHINGOSINE-1-PHOSPHATE RECEPTOR | |
| CL2008002351A1 (en) | Compounds derived from 6-triazolopyridazine-sulfanyl benzothiazole and benzimidazole; preparation procedure; intermediate compounds; pharmaceutical composition comprising said compounds; and its use in the treatment of cancer. | |
| CL2007001887A1 (en) | COMPOUNDS DERIVED FROM BIFENSUSTUIDAS BY TETRAZOL; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF DISEASES ASSOCIATED WITH P2X PURINERGIC RECEPTORS, SUCH AS GASTROINT DISORDERS | |
| BR112015015468B8 (en) | COMPOUND AND PHARMACEUTICAL COMPOSITION | |
| CO6430427A2 (en) | BENZOFURANILO DERIVATIVES | |
| UY32094A (en) | HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION, DRUGS THAT INCLUDE SUCH COMPOUNDS AND THEIR USE. | |
| UY35156A (en) | DERIVATIVES OF ACETIC INDANILOXI DIHIDROBENZOFURANIL ACID AS AGONISTS OF THE GPR40 | |
| UY31612A1 (en) | DERIVATIVES OF INCOL 2-CARBOXAMIDS AND AZAINDOL 2-CARBOXAMIDS REPLACED WITH A SILANILO GROUP, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS | |
| NI201000032A (en) | 2-ANILINOPURIN-8-ONAS AS INHIBITORS OF TTK / MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS. | |
| BR112015012555A2 (en) | benzimidazole derivatives as ep4 antagonists | |
| UY32923A (en) | POLYCHYCLICAL COMPOUNDS AS ANTAGONISTS OF THE LISOPHOSPHATIDIC ACID RECEPTOR | |
| CO6771417A2 (en) | Lysophosphatidic acid receptor antagonists and their use in the treatment of fibrosis | |
| ECSP088620A (en) | 1H-INDOLES REPLACED BY SULFONYL AS LIGANDOS FOR 5-HYDROXITRIPTAMINE RECEPTORS | |
| EA201190207A1 (en) | CONNECTIONS FOR THE TREATMENT OF METABOLIC DISORDERS | |
| CL2008000438A1 (en) | COMPOUNDS DERIVED FROM REPLACED HETEROCICLES, ALFA 2C ADRENORECEPTORS AGONISTS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT ALLERGIC RHINITIS, GLAUCOMA, CONGESTIVE CARDIAC INSUFFICIENCY, ENT SCHIZOPHRENIA | |
| NI201000035A (en) | DERIVATIVES OF AZACYCLILISOQUINOLINONE AND ISOINDOLINONE AS HISTAMINE-3 ANTAGONISTS | |
| PE20141944A1 (en) | N- (6 - ((2R, 3S) -3,4-DIHYDROXIBUTAN-2-ILOXI) -2- (4-FLUOROBENZYLTIO) PYRIMIDIN-4-IL) -3-METHYLACETIDINE-1-SULPHONAMIDE AS CHEMOKIN RECEPTOR MODULATORS | |
| CL2008002506A1 (en) | Compounds derived from substituted benzimidazole, preparation process, pharmaceutical composition, useful in the treatment of diseases modulated with antagonists of the fxr receptor, in particular for the treatment of increased levels of lipids and / or cholesterol, atherosclerotic disease, diabetes, cancer, parkinson's , Alzheimer's. | |
| UY30330A1 (en) | NEW POLYMORPH FORMS OF (2S) - (4E) -N-METIL-5- (3- (5-ISOPROPOXIPIRIDIN) IL) -4-PENTEN-2-AMINA | |
| CL2012002570A1 (en) | Compounds derived from 2- (3-heteroaryl-amino-1,2,3,4-tetrahydro-9h-carbazole) -acetic acid, pharmaceutical composition that comprises them, and their use as medicines, in the prophylaxis and / or treatment of pathologies mediated by modulation of prostaglandin d2 receptors, such as allergic or immune disorders. |