CR20190401A - Dropropizina en combinación con ambroxol en la forma farmacéutica de jarabe y tabletas - Google Patents
Dropropizina en combinación con ambroxol en la forma farmacéutica de jarabe y tabletasInfo
- Publication number
- CR20190401A CR20190401A CR20190401A CR20190401A CR20190401A CR 20190401 A CR20190401 A CR 20190401A CR 20190401 A CR20190401 A CR 20190401A CR 20190401 A CR20190401 A CR 20190401A CR 20190401 A CR20190401 A CR 20190401A
- Authority
- CR
- Costa Rica
- Prior art keywords
- dropropizine
- ambroxol
- combination
- relates
- pharmaceutically acceptable
- Prior art date
Links
- PTVWPYVOOKLBCG-UHFFFAOYSA-N 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Chemical compound C1CN(CC(O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-UHFFFAOYSA-N 0.000 title abstract 3
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 title abstract 3
- 229960005174 ambroxol Drugs 0.000 title abstract 3
- 229960004722 dropropizine Drugs 0.000 title abstract 3
- 239000002552 dosage form Substances 0.000 title 1
- 239000006188 syrup Substances 0.000 title 1
- 235000020357 syrup Nutrition 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una combinación farmacéutica de ambroxol o una sal farmacéuticamente aceptable del mismo y dropropizina. Asimismo, se refiere a una composición farmacéutica, preferentemente en una forma de administración oral, que contiene dichos ingredientes activos, junto con uno o más aditivos farmacéuticamente aceptables. La invención también se refiere a los procesos de preparación y los procesos de uso de la combinación farmacéutica o la composición farmacéutica de la presente invención.The present invention relates to a pharmaceutical combination of ambroxol, or a pharmaceutically acceptable salt of same, and dropropizine. The invention also relates to a pharmaceutical composition, preferably in an oral administration form, which contains said active ingredients together with one or more pharmaceutically acceptable additives. The invention further relates to methods for preparing and using the pharmaceutical combination or the pharmaceutical composition of the present invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2017014725A MX2017014725A (es) | 2017-11-16 | 2017-11-16 | Dropropizina en combinacion con ambroxol en la forma farmaceutica de jarabe y tabletas. |
| PCT/IB2018/052699 WO2019097309A1 (es) | 2017-11-16 | 2018-04-19 | Dropropizina en combinación con ambroxol en la forma farmacéutica de jarabe y tabletas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20190401A true CR20190401A (es) | 2019-11-18 |
Family
ID=66538528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20190401A CR20190401A (es) | 2017-11-16 | 2018-04-19 | Dropropizina en combinación con ambroxol en la forma farmacéutica de jarabe y tabletas |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20210128496A1 (es) |
| CL (1) | CL2019002446A1 (es) |
| CO (1) | CO2019013645A2 (es) |
| CR (1) | CR20190401A (es) |
| DO (1) | DOP2019000233A (es) |
| MX (1) | MX2017014725A (es) |
| NI (1) | NI201900084A (es) |
| PE (1) | PE20191820A1 (es) |
| WO (1) | WO2019097309A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1203721B (it) * | 1983-12-29 | 1989-02-23 | Dompe Farmaceutici Spa | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
| DE19933148A1 (de) * | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim Int | Ambroxolhaltige Lutschtablette |
| KR101915056B1 (ko) * | 2012-04-10 | 2018-11-07 | 한미약품 주식회사 | 암브록솔, 레보드로프로피진 및 완충제를 포함하는 경구용 액상 제제 및 이의 제조방법 |
-
2017
- 2017-11-16 MX MX2017014725A patent/MX2017014725A/es unknown
-
2018
- 2018-04-19 PE PE2019002014A patent/PE20191820A1/es unknown
- 2018-04-19 WO PCT/IB2018/052699 patent/WO2019097309A1/es not_active Ceased
- 2018-04-19 CR CR20190401A patent/CR20190401A/es unknown
- 2018-04-19 US US16/497,269 patent/US20210128496A1/en not_active Abandoned
-
2019
- 2019-07-31 NI NI201900084A patent/NI201900084A/es unknown
- 2019-08-26 CL CL2019002446A patent/CL2019002446A1/es unknown
- 2019-09-12 DO DO2019000233A patent/DOP2019000233A/es unknown
- 2019-12-03 CO CONC2019/0013645A patent/CO2019013645A2/es unknown
-
2023
- 2023-11-17 US US18/512,349 patent/US20240082176A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2019000233A (es) | 2019-12-15 |
| NI201900084A (es) | 2020-04-02 |
| CO2019013645A2 (es) | 2020-01-17 |
| MX2017014725A (es) | 2019-05-17 |
| CL2019002446A1 (es) | 2019-12-13 |
| WO2019097309A1 (es) | 2019-05-23 |
| PE20191820A1 (es) | 2019-12-27 |
| US20240082176A1 (en) | 2024-03-14 |
| US20210128496A1 (en) | 2021-05-06 |
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