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CO6321280A2 - NEW ESPIRO PIPERIDINAS CLASS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES - Google Patents

NEW ESPIRO PIPERIDINAS CLASS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Info

Publication number
CO6321280A2
CO6321280A2 CO10141834A CO10141834A CO6321280A2 CO 6321280 A2 CO6321280 A2 CO 6321280A2 CO 10141834 A CO10141834 A CO 10141834A CO 10141834 A CO10141834 A CO 10141834A CO 6321280 A2 CO6321280 A2 CO 6321280A2
Authority
CO
Colombia
Prior art keywords
treatment
piperidinas
espiro
class
new
Prior art date
Application number
CO10141834A
Other languages
Spanish (es)
Inventor
Michael Aaron Brodney
Christopher John Helal
Brian Thomas Oneill
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO6321280A2 publication Critical patent/CO6321280A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se desvelan compuestos y sales farmacéuticamente aceptables de los compuestos, teniendo los compuestos la estructura de Fórmula Icomo se define en la memoria descriptiva. También se desvelan composiciones farmacéuticas, procedimientos de tratamiento, procedimientos de síntesis e intermedios correspondientes.Compounds and pharmaceutically acceptable salts of the compounds are disclosed, the compounds having the structure of Formula I as defined in the specification. Pharmaceutical compositions, treatment procedures, synthesis procedures and corresponding intermediates are also disclosed.

CO10141834A 2008-05-05 2010-11-11 NEW ESPIRO PIPERIDINAS CLASS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CO6321280A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5042308P 2008-05-05 2008-05-05

Publications (1)

Publication Number Publication Date
CO6321280A2 true CO6321280A2 (en) 2011-09-20

Family

ID=40902870

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10141834A CO6321280A2 (en) 2008-05-05 2010-11-11 NEW ESPIRO PIPERIDINAS CLASS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Country Status (22)

Country Link
US (1) US20110046160A1 (en)
EP (1) EP2300484B1 (en)
JP (1) JP2011519913A (en)
KR (1) KR20110000749A (en)
CN (1) CN102083841A (en)
AP (1) AP2010005456A0 (en)
AT (1) ATE537178T1 (en)
AU (1) AU2009245322B2 (en)
BR (1) BRPI0912433A2 (en)
CA (1) CA2721786A1 (en)
CO (1) CO6321280A2 (en)
CR (1) CR11759A (en)
DO (1) DOP2010000317A (en)
EA (1) EA201001566A1 (en)
EC (1) ECSP10010597A (en)
ES (1) ES2375913T3 (en)
IL (1) IL208793A0 (en)
MA (1) MA32290B1 (en)
MX (1) MX2010012066A (en)
NZ (1) NZ588589A (en)
SV (1) SV2010003725A (en)
WO (1) WO2009136350A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
UA108363C2 (en) 2009-10-08 2015-04-27 IMINOTIADIASIADIOXIDE OXIDES AS BACE INHIBITORS, COMPOSITIONS THEREOF AND THEIR APPLICATIONS
US20130150376A1 (en) * 2010-04-09 2013-06-13 Pfizer Inc. Novel Sultam Compounds
US9145426B2 (en) 2011-04-07 2015-09-29 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
US9221839B2 (en) 2011-04-07 2015-12-29 Merck Sharp & Dohme Corp. C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
EP2747769B1 (en) 2011-08-22 2017-08-02 Merck Sharp & Dohme Corp. 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068463A1 (en) * 2004-01-08 2005-07-28 F. Hoffmann-La Roche Ag Diaza-spiropiperidine derivatives
JP2006044497A (en) * 2004-08-05 2006-02-16 Toyota Motor Corp Wheel information processing device
CA2583342A1 (en) * 2004-10-13 2006-04-27 Merck And Co., Inc. Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease
ATE550338T1 (en) * 2005-07-18 2012-04-15 Merck Sharp & Dohme SPIROPIPERIDINE INHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
US20100298342A1 (en) * 2006-09-07 2010-11-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease
US8377954B2 (en) * 2007-01-04 2013-02-19 Merck, Sharp & Dohme, Corp Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease

Also Published As

Publication number Publication date
ATE537178T1 (en) 2011-12-15
KR20110000749A (en) 2011-01-05
EA201001566A1 (en) 2011-04-29
ECSP10010597A (en) 2010-12-30
MX2010012066A (en) 2010-12-06
ES2375913T3 (en) 2012-03-07
CN102083841A (en) 2011-06-01
EP2300484A1 (en) 2011-03-30
MA32290B1 (en) 2011-05-02
SV2010003725A (en) 2011-07-05
WO2009136350A1 (en) 2009-11-12
EP2300484B1 (en) 2011-12-14
CA2721786A1 (en) 2009-11-12
NZ588589A (en) 2012-07-27
BRPI0912433A2 (en) 2015-12-22
IL208793A0 (en) 2010-12-30
AU2009245322A1 (en) 2009-11-12
CR11759A (en) 2010-11-22
DOP2010000317A (en) 2010-11-15
AU2009245322B2 (en) 2011-07-14
US20110046160A1 (en) 2011-02-24
AP2010005456A0 (en) 2010-12-31
JP2011519913A (en) 2011-07-14

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Legal Events

Date Code Title Description
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