CO6311000A2 - Polipeptidos modificados del factor ix con uno o mas sitios de glicosilacion introducidos - Google Patents
Polipeptidos modificados del factor ix con uno o mas sitios de glicosilacion introducidosInfo
- Publication number
- CO6311000A2 CO6311000A2 CO10128682A CO10128682A CO6311000A2 CO 6311000 A2 CO6311000 A2 CO 6311000A2 CO 10128682 A CO10128682 A CO 10128682A CO 10128682 A CO10128682 A CO 10128682A CO 6311000 A2 CO6311000 A2 CO 6311000A2
- Authority
- CO
- Colombia
- Prior art keywords
- factor
- polypeptides
- sites introduced
- modified polypeptides
- modified factor
- Prior art date
Links
- 229960004222 factor ix Drugs 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102100022641 Coagulation factor IX Human genes 0.000 abstract 6
- 108010076282 Factor IX Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 208000009429 hemophilia B Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12456708P | 2008-04-16 | 2008-04-16 | |
| US4596108P | 2008-04-17 | 2008-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6311000A2 true CO6311000A2 (es) | 2011-08-22 |
Family
ID=41265284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10128682A CO6311000A2 (es) | 2008-04-16 | 2010-10-15 | Polipeptidos modificados del factor ix con uno o mas sitios de glicosilacion introducidos |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP2288622A4 (fr) |
| JP (1) | JP2011517951A (fr) |
| KR (1) | KR20110005862A (fr) |
| CN (1) | CN102083856A (fr) |
| AU (1) | AU2009244633A1 (fr) |
| BR (1) | BRPI0910702A2 (fr) |
| CA (1) | CA2721683A1 (fr) |
| CO (1) | CO6311000A2 (fr) |
| CR (1) | CR11737A (fr) |
| DO (1) | DOP2010000311A (fr) |
| EC (1) | ECSP10010551A (fr) |
| IL (1) | IL208718A0 (fr) |
| MX (1) | MX2010011345A (fr) |
| RU (1) | RU2010146387A (fr) |
| SG (1) | SG189790A1 (fr) |
| SV (1) | SV2010003704A (fr) |
| WO (1) | WO2009137254A2 (fr) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8383388B2 (en) * | 2006-06-19 | 2013-02-26 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| US20110154516A1 (en) * | 2007-10-15 | 2011-06-23 | Stafford Darrel W | Human factor ix variants with an extended half life |
| US9249405B2 (en) | 2008-09-15 | 2016-02-02 | Paolo Simioni | Factor IX polypeptide mutant, its uses and a method for its production |
| NZ605348A (en) | 2010-07-09 | 2015-01-30 | Biogen Idec Hemophilia Inc | Factor ix polypeptides and methods of use thereof |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| AU2013204511B2 (en) * | 2010-11-03 | 2016-03-17 | Gc Biopharma Corp. | Modified factor ix polypeptides and uses thereof |
| PT2717898T (pt) | 2011-06-10 | 2019-05-20 | Bioverativ Therapeutics Inc | Compostos pró-coagulantes e processos para a sua utilização |
| US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
| EP2842966B1 (fr) * | 2012-04-27 | 2018-08-15 | Nihon University | Agent thérapeutique pour les lésions épithéliales et endothéliales |
| EP3970738A1 (fr) | 2012-07-25 | 2022-03-23 | Bioverativ Therapeutics Inc. | Essai de surveillance de facteur sanguin et utilisations de celui-ci |
| TWI810729B (zh) | 2012-09-25 | 2023-08-01 | 美商百歐維拉提夫治療公司 | Ｆｉｘ多肽的應用 |
| CA2888806A1 (fr) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Procedes d'utilisation d'une dose fixe d'un facteur de coagulation |
| US10717965B2 (en) | 2013-01-10 | 2020-07-21 | Gloriana Therapeutics, Inc. | Mammalian cell culture-produced neublastin antibodies |
| PL2956477T5 (pl) | 2013-02-15 | 2024-05-27 | Bioverativ Therapeutics Inc. | Zoptymalizowany gen czynnika viii |
| WO2014144549A1 (fr) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Préparations contenant un polypeptide du facteur ix |
| WO2015048330A2 (fr) | 2013-09-25 | 2015-04-02 | Biogen Idec Ma Inc. | Procédés d'inactivation de virus sur colonne |
| US10584147B2 (en) | 2013-11-08 | 2020-03-10 | Biovertiv Therapeutics Inc. | Procoagulant fusion compound |
| ES2967617T3 (es) | 2013-12-06 | 2024-05-03 | Bioverativ Therapeutics Inc | Herramientas de farmacocinética poblacional y sus usos |
| EP3083933A1 (fr) | 2013-12-20 | 2016-10-26 | Biogen MA Inc. | Utilisation de cultures de semences sous perfusion pour améliorer la capacité de production en alimentation programmée de produits biopharmaceutiques et la qualité des produits |
| SG10201913735SA (en) | 2014-03-24 | 2020-03-30 | Bioverativ Therapeutics Inc | Lyophilized factor ix formulations |
| WO2016004113A1 (fr) | 2014-06-30 | 2016-01-07 | Biogen Ma Inc. | Gène du facteur ix optimisé |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| CA2994547A1 (fr) | 2015-08-03 | 2017-02-09 | Bioverativ Therapeutics Inc. | Proteines de fusion du facteur xi et leurs methodes de production et d'utilisation |
| PT3411478T (pt) | 2016-02-01 | 2022-09-13 | Bioverativ Therapeutics Inc | Genes do fator viii otimizados |
| CN105695616A (zh) * | 2016-04-22 | 2016-06-22 | 王冬国 | 诊断甲状腺癌的分析标志物及其应用 |
| US12161696B2 (en) | 2016-12-02 | 2024-12-10 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| CR20190389A (es) | 2017-01-31 | 2019-11-26 | Bioverativ Therapeutics Inc | Proteínas de fusión del factor ix y procedimientos de preparación y utilización de las mismas |
| FR3069540B1 (fr) | 2017-07-28 | 2019-09-13 | Universite Claude Bernard Lyon 1 | Proteine modifiee avec demi-vie amelioree |
| WO2019032898A1 (fr) | 2017-08-09 | 2019-02-14 | Bioverativ Therapeutics Inc. | Molécules d'acide nucléique et leurs utilisations |
| US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
| WO2019067766A1 (fr) | 2017-09-27 | 2019-04-04 | Sigilon Therapeutics, Inc. | Procédés, compositions et éléments implantables comprenant des cellules actives |
| WO2019195056A1 (fr) | 2018-04-04 | 2019-10-10 | Sigilon Therapeutics, Inc. | Procédés, compositions et éléments implantables comprenant des cellules souches |
| UY38160A (es) | 2018-04-04 | 2019-11-29 | Sigilon Therapeutics Inc | Partículas implantables y métodos relacionados |
| TW202015723A (zh) | 2018-05-18 | 2020-05-01 | 美商百歐維拉提夫治療公司 | 治療ａ型血友病的方法 |
| SG11202101157VA (en) | 2018-08-09 | 2021-03-30 | Bioverativ Therapeutics Inc | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| WO2020086408A1 (fr) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bioprocédé d'expression génique transitoire basé sur une perfusion à haut rendement |
| BR112021020668A2 (pt) | 2019-04-17 | 2022-01-11 | Codiak Biosciences Inc | Composições de exossomos e aav |
| WO2021067389A1 (fr) | 2019-09-30 | 2021-04-08 | Bioverativ Therapeutics Inc. | Formulations de vecteur lentiviral |
| WO2021154414A2 (fr) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Thérapie génique pour l'hémophilie b avec un vecteur de capside d'aav chimérique codant pour des polypeptides du facteur ix modifiés |
| US12173307B2 (en) | 2020-06-24 | 2024-12-24 | Bioverativ Therapeutics Inc. | Methods for the purification of viral vectors |
| US11670855B2 (en) | 2021-02-24 | 2023-06-06 | Bluehalo, Llc | System and method for a digitally beamformed phased array feed |
| EP4602155A1 (fr) | 2022-10-11 | 2025-08-20 | Sigilon Therapeutics, Inc. | Cellules modifiées et éléments implantables pour le traitement d'une maladie |
| CN120659872A (zh) | 2022-10-11 | 2025-09-16 | 西吉隆医疗股份有限公司 | 用于治疗疾病的经工程化的细胞和可植入元件 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2638643B1 (fr) * | 1988-11-09 | 1991-04-12 | Transgene Sa | Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees, procede de preparation du facteur ix et produits obtenus correspondants |
| WO1999003496A1 (fr) * | 1997-07-21 | 1999-01-28 | The University Of North Carolina At Chapel Hill | Facteur ix antihemophilique presentant une activite de coagulation augmentee |
| MXPA04001982A (es) * | 2001-09-04 | 2004-06-07 | Merck Patent Gmbh | Factor ix modificado. |
| US20050008580A1 (en) * | 2003-04-09 | 2005-01-13 | Wyeth | Hemophilia treatment by inhalation of coagulation factors |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| CA2549413A1 (fr) * | 2003-12-03 | 2005-06-23 | Neose Technologies, Inc. | Facteur ix glycopegyle |
| US8383388B2 (en) * | 2006-06-19 | 2013-02-26 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| US7700734B2 (en) * | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
-
2009
- 2009-04-16 KR KR1020107025567A patent/KR20110005862A/ko not_active Ceased
- 2009-04-16 CA CA2721683A patent/CA2721683A1/fr not_active Abandoned
- 2009-04-16 WO PCT/US2009/040813 patent/WO2009137254A2/fr not_active Ceased
- 2009-04-16 RU RU2010146387/10A patent/RU2010146387A/ru not_active Application Discontinuation
- 2009-04-16 AU AU2009244633A patent/AU2009244633A1/en not_active Abandoned
- 2009-04-16 CN CN2009801227842A patent/CN102083856A/zh active Pending
- 2009-04-16 JP JP2011505204A patent/JP2011517951A/ja active Pending
- 2009-04-16 SG SG2013028790A patent/SG189790A1/en unknown
- 2009-04-16 MX MX2010011345A patent/MX2010011345A/es not_active Application Discontinuation
- 2009-04-16 BR BRPI0910702A patent/BRPI0910702A2/pt not_active IP Right Cessation
- 2009-04-16 EP EP09743241A patent/EP2288622A4/fr not_active Withdrawn
-
2010
- 2010-10-14 IL IL208718A patent/IL208718A0/en unknown
- 2010-10-15 DO DO2010000311A patent/DOP2010000311A/es unknown
- 2010-10-15 CR CR11737A patent/CR11737A/es not_active Application Discontinuation
- 2010-10-15 CO CO10128682A patent/CO6311000A2/es active IP Right Grant
- 2010-10-15 SV SV2010003704A patent/SV2010003704A/es unknown
- 2010-10-15 EC EC2010010551A patent/ECSP10010551A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR11737A (es) | 2011-02-07 |
| JP2011517951A (ja) | 2011-06-23 |
| AU2009244633A1 (en) | 2009-11-12 |
| DOP2010000311A (es) | 2011-02-28 |
| WO2009137254A2 (fr) | 2009-11-12 |
| EP2288622A2 (fr) | 2011-03-02 |
| WO2009137254A3 (fr) | 2010-01-14 |
| KR20110005862A (ko) | 2011-01-19 |
| ECSP10010551A (es) | 2010-11-30 |
| MX2010011345A (es) | 2011-02-23 |
| IL208718A0 (en) | 2010-12-30 |
| RU2010146387A (ru) | 2012-05-27 |
| EP2288622A4 (fr) | 2012-04-18 |
| BRPI0910702A2 (pt) | 2016-07-05 |
| SG189790A1 (en) | 2013-05-31 |
| CN102083856A (zh) | 2011-06-01 |
| SV2010003704A (es) | 2011-02-21 |
| CA2721683A1 (fr) | 2009-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |