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CO5700755A2 - Derivados de ester y amida del acido 2-cianopropanoico y metodos de su uso - Google Patents

Derivados de ester y amida del acido 2-cianopropanoico y metodos de su uso

Info

Publication number
CO5700755A2
CO5700755A2 CO05109228A CO05109228A CO5700755A2 CO 5700755 A2 CO5700755 A2 CO 5700755A2 CO 05109228 A CO05109228 A CO 05109228A CO 05109228 A CO05109228 A CO 05109228A CO 5700755 A2 CO5700755 A2 CO 5700755A2
Authority
CO
Colombia
Prior art keywords
carbon atoms
alkyl
ester
methods
nr5r6
Prior art date
Application number
CO05109228A
Other languages
English (en)
Inventor
Thomas J Caggiano
Antony A Brazzale
William Jay Moore
Callain Younghee Kim
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5700755A2 publication Critical patent/CO5700755A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07C2601/14—The ring being saturated

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Abstract

1.- Un compuesto de fórmula I que tiene la estructura en donde B y D son independientemente CH o N, con la condición de que B y D no sean ambos N;R1, R1a, R2 son cada uno, independientemente, hidrógeno, halógeno, alquilo de 1-6 átomos de carbono, alcoxi de 1-6 átomos de carbono, nitro, ciano, tioalquilo de 1-6 átomos de carbono, arilo, alquiltio de 1-6 átomos de carbono, CF3 , -OCF3, -NR5R6, o hidroxi;o R1 y R2 junto con los átomos de carbono a los cuales están unidos forman un anillo de benceno fusionado, estando el anillo de naftaleno así formado opcionalmente sustituido con halógeno, alquilo de 1-6 átomos de carbono, alcoxi de 1-6 átomos de carbono, nitro, ciano, tioalquilo de 1-6 átomos de carbono, arilo, alquiltio de 1-6 átomos de carbono, CF3, -OCF3, -NR5R6, o hidroxi;R3 es hidrógeno, alquilo de 1-6 átomos de carbono, arilalquilo con 1-6 átomos de carbono en la porción alquilo, alquenilo de 2-7 átomos de carbono, cicloalquilmetilo de 3-8 átomos de carbono en la porción cicloalquilo, arilalcoxialquil, alcoxialquilo, dialquilaminoalquilo con 1-6 átomos de carbono en las porciones alquilo, o Het-alquilo con 1-6 átomos de carbono en la porción alquilo; o A, en donde todo anillo de fenilo en R4 está opcionalmente sustituido con R7; ...
CO05109228A 2003-04-30 2005-10-26 Derivados de ester y amida del acido 2-cianopropanoico y metodos de su uso CO5700755A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46656703P 2003-04-30 2003-04-30
US10/833,678 US20050004164A1 (en) 2003-04-30 2004-04-28 2-Cyanopropanoic acid amide and ester derivatives and methods of their use

Publications (1)

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CO5700755A2 true CO5700755A2 (es) 2006-11-30

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US (2) US20050004164A1 (es)
EP (1) EP1620102B1 (es)
JP (1) JP2006526630A (es)
KR (1) KR20060015556A (es)
AR (1) AR044762A1 (es)
AT (1) ATE418335T1 (es)
AU (1) AU2004236216A1 (es)
BR (1) BRPI0409921A (es)
CA (1) CA2523235A1 (es)
CO (1) CO5700755A2 (es)
CR (1) CR8041A (es)
DE (1) DE602004018629D1 (es)
MX (1) MXPA05011581A (es)
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WO2004099150A3 (en) 2004-12-23
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AR044762A1 (es) 2005-10-05
DE602004018629D1 (de) 2009-02-05
NO20054969L (no) 2005-11-22
BRPI0409921A (pt) 2006-04-25
KR20060015556A (ko) 2006-02-17
AU2004236216A1 (en) 2004-11-18
CR8041A (es) 2006-05-30
EP1620102A2 (en) 2006-02-01
JP2006526630A (ja) 2006-11-24
TW200508217A (en) 2005-03-01
RU2005137175A (ru) 2006-05-27
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NO20054969D0 (no) 2005-10-26
US20050004164A1 (en) 2005-01-06
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US20070299105A1 (en) 2007-12-27
WO2004099150A2 (en) 2004-11-18

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