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CO5690548A2 - N-ARILHETEROCICLOS REPLACED, PROCEDURES FOR THEIR PREPARATION AND ITS EMPLOYMENT AS MEDICINES - Google Patents

N-ARILHETEROCICLOS REPLACED, PROCEDURES FOR THEIR PREPARATION AND ITS EMPLOYMENT AS MEDICINES

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Publication number
CO5690548A2
CO5690548A2 CO05079788A CO05079788A CO5690548A2 CO 5690548 A2 CO5690548 A2 CO 5690548A2 CO 05079788 A CO05079788 A CO 05079788A CO 05079788 A CO05079788 A CO 05079788A CO 5690548 A2 CO5690548 A2 CO 5690548A2
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Colombia
Prior art keywords
alkyl
independently
mean
nitrogen
worth
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CO05079788A
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Spanish (es)
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Lothar Schwink
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Sanofi Aventis Deutschland
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Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of CO5690548A2 publication Critical patent/CO5690548A2/en

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- Compuestos de fórmula I,en la cualR1, R2 significan, de manera independiente entre sí, H, alquilo C1-C8, -(CR78R79)o-R12, (alcoxi C1-C4)-(alquilo C1-C4), ariloxi-(alquilo C1-C4), alquenilo C3-C8, alquinilo C3-C8, CO-(alquilo C1-C8), -CO-(CH2)o-R12, CO-ariloxi-(alquilo C1-C4), CO-(alquenilo C2-C8), CO-(alquinilo C2-C8), COCH=CH(R13), COCC(R14), CO-(alquil C1-C4)-S(O)p-(alquilo C1-C4), CO(C(R15)(R16)qN(R17)(R18), CO(C(R19)(R20)rCON(R21)(R22), CO(C(R23)(R24))sO(R25); o bien R1 y R2 forman, junto con el átomo de nitrógeno al cual están unidos, un anillo mono-, bi- o espirocíclico de 4 a 10 eslabones que, además del átomo de nitrógeno, puede contener 0 a 4 heteroátomos adicionales seleccionados del grupo de oxígeno, nitrógeno y azufre, pudiendo el sistema anular heterocíclico estar sustituido adicionalmente con F, CI, Br, CF3, NO2, CN, alquilo C1-C6, O-(alquilo C1-C8), (alcoxi C1-C4)-(alquilo C1-C4), hidroxi-(alquilo C1-C4), (alquilen C0-C8)-arilo, oxo, CO(R26), CON(R27)(R28), hidroxi, COO(R29), N(R30)CO(alquilo C1-C6), N(R31)(R32) ó SO2CH3;o vale 0, 1, 2, 3, 4, 5, 6;p vale 0, 1, 2;q, r, s valen, de manera independiente entre sí, 0, 1, 2, 3, 4;R13, R14 significan, de manera independiente entre sí, un sistema anular aromático de 5-10 eslabones, que puede contener 0-2 heteroátomos adicionales del grupo de nitrógeno, oxígeno y azufre entalten y que puede estar sustituido con F, Cl, Br, CF3, NO2, CN, alquilo C1-C6, O-(alquilo C1-C8);R15, R16, R17, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32 significan, de manera independiente entre sí, H, alquilo C1-C6;R18 significa H, alquilo C1-C6, CO(alquilo C1-C6), CO(R33);o bien R17 y R18, R21 y R22, R27 y R28, R31 y R32 significan, de manera independiente entre sí y opcionalmente junto con el átomo de nitrógeno al cual están unidos, ...1.- Compounds of formula I, in which R1, R2 independently mean each other, H, C1-C8 alkyl, - (CR78R79) or-R12, (C1-C4 alkoxy) - (C1-C4 alkyl), aryloxy- (C1-C4 alkyl), C3-C8 alkenyl, C3-C8 alkynyl, CO- (C1-C8 alkyl), -CO- (CH2) or-R12, CO-aryloxy- (C1-C4 alkyl), CO - (C2-C8 alkenyl), CO- (C2-C8 alkynyl), COCH = CH (R13), COCC (R14), CO- (C1-C4 alkyl) -S (O) p- (C1-C4 alkyl) , CO (C (R15) (R16) qN (R17) (R18), CO (C (R19) (R20) rCON (R21) (R22), CO (C (R23) (R24)) sO (R25); or R1 and R2 together with the nitrogen atom to which they are attached, a mono-, bi- or spirocyclic ring of 4 to 10 links which, in addition to the nitrogen atom, can contain 0 to 4 additional heteroatoms selected from the group of oxygen, nitrogen and sulfur, the heterocyclic ring system being able to be additionally substituted with F, CI, Br, CF3, NO2, CN, C1-C6 alkyl, O- (C1-C8 alkyl), (C1-C4 alkoxy) - ( C1-C4 alkyl), hydroxy- (C1-C4 alkyl), (C0-C8 alkylene) -aryl, oxo, CO (R26), CON (R27) (R2 8), hydroxy, COO (R29), N (R30) CO (C1-C6 alkyl), N (R31) (R32) or SO2CH3; or is worth 0, 1, 2, 3, 4, 5, 6; p is worth 0, 1, 2; q, r, s are worth, independently of each other, 0, 1, 2, 3, 4; R13, R14 mean, independently of each other, an aromatic ring system of 5-10 links, which may contain 0-2 additional heteroatoms of the nitrogen, oxygen and sulfur group enthalten and which may be substituted with F, Cl, Br, CF3, NO2, CN, C1-C6 alkyl, O- (C1-C8 alkyl); R15 , R16, R17, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32 mean, independently of each other, H, C1-C6 alkyl; R18 means H , C1-C6 alkyl, CO (C1-C6 alkyl), CO (R33); or R17 and R18, R21 and R22, R27 and R28, R31 and R32 mean, independently of each other and optionally together with the atom of nitrogen to which they are attached, ...

CO05079788A 2003-02-14 2005-08-11 N-ARILHETEROCICLOS REPLACED, PROCEDURES FOR THEIR PREPARATION AND ITS EMPLOYMENT AS MEDICINES CO5690548A2 (en)

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DE10306250A DE10306250A1 (en) 2003-02-14 2003-02-14 Substituted N-aryl heterocycles, processes for their preparation and their use as pharmaceuticals

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AU2004212145B2 (en) 2010-06-17
KR20050101215A (en) 2005-10-20
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MA27735A1 (en) 2006-02-01
UA86760C2 (en) 2009-05-25
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RU2005128551A (en) 2006-02-10
PE20040952A1 (en) 2005-02-08
AR044496A1 (en) 2005-09-14
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MXPA05008449A (en) 2006-05-25
HRP20050710A2 (en) 2006-07-31
BRPI0407504A (en) 2006-02-14
CN100506792C (en) 2009-07-01
AU2004212145A1 (en) 2004-08-26
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WO2004072025A2 (en) 2004-08-26

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