CO5670350A2 - Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoico - Google Patents
Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoicoInfo
- Publication number
- CO5670350A2 CO5670350A2 CO05004558A CO05004558A CO5670350A2 CO 5670350 A2 CO5670350 A2 CO 5670350A2 CO 05004558 A CO05004558 A CO 05004558A CO 05004558 A CO05004558 A CO 05004558A CO 5670350 A2 CO5670350 A2 CO 5670350A2
- Authority
- CO
- Colombia
- Prior art keywords
- sub
- oxazol
- benzoic
- acid derivatives
- prepare acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 150000002916 oxazoles Chemical class 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Abstract
1.- Un proceso para preparar un compuesto de la fórmula En donde:R1 es alcoxi C1-C6 o OH;R2 y R3 son independientemente H, fenilo, o alquilo C1-C4; oR2 y R3 y los átomos a los cuales ellos están adheridos forman un anillo benzo, que está opcionalmente sustituido con alquilo C1-C4, alcoxi C1-C4, o dialquilamino; yR6 es alcoxi C1-C6, o NR4R5; en dondeR4 y R5 son independientemente alquilo C1-C6;Que comprende:Formar una mezcla de reacción que comprende un compuesto de fórmula I: X es Br, I, Otf, o Oms;Un compuesto de la fórmula II: Un catalizador, un aditivo opcional, y al menos un solvente.2.- Un proceso de acuerdo con la reivindicación 1, en donde el catalizador es un catalizador de metal de transición.3.- Un proceso de acuerdo con la reivindicación 2 en donde el catalizador de metal de transición es Pd(PPh3)4, PdCI2(PPh3)2, PdCI2, PdCI2 y PPh3, o Pd(OCOCh3)2.4.- Un proceso de acuerdo con la reivindicación 3 en donde el catalizador es Pd(PPh3)4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39028502P | 2002-06-20 | 2002-06-20 | |
| US45047803P | 2003-02-27 | 2003-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5670350A2 true CO5670350A2 (es) | 2006-08-31 |
Family
ID=30003150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05004558A CO5670350A2 (es) | 2002-06-20 | 2005-01-20 | Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoico |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7115747B2 (es) |
| EP (1) | EP1532123B1 (es) |
| JP (1) | JP2005533811A (es) |
| CN (1) | CN1324017C (es) |
| AT (1) | ATE370131T1 (es) |
| AU (1) | AU2003249344A1 (es) |
| BR (1) | BR0312439A (es) |
| CA (1) | CA2489988A1 (es) |
| CO (1) | CO5670350A2 (es) |
| DE (1) | DE60315664D1 (es) |
| EA (1) | EA008389B1 (es) |
| IL (1) | IL165763A0 (es) |
| MX (1) | MXPA04012630A (es) |
| NO (1) | NO20045497L (es) |
| NZ (1) | NZ537390A (es) |
| PL (1) | PL374999A1 (es) |
| WO (1) | WO2004000821A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050609A1 (en) * | 2002-11-27 | 2004-06-17 | Elan Pharmaceutical, Inc. | Substituted ureas and carbamates |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| WO2007061670A1 (en) | 2005-11-21 | 2007-05-31 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7745484B2 (en) * | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7838676B2 (en) | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7872009B2 (en) * | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
| US20080277393A1 (en) * | 2007-05-07 | 2008-11-13 | True Charles W | Collapsible, stackable, semi-rigid universal cotainer for hazardous and non-hazardous goods |
| TW200901991A (en) | 2007-05-25 | 2009-01-16 | Amgen Inc | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| CA2687608C (en) * | 2007-05-25 | 2013-07-02 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| US7803809B2 (en) | 2008-11-12 | 2010-09-28 | Amgen Inc. | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use |
| MX2011002705A (es) | 2008-09-11 | 2011-09-09 | Amgen Inc | Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso. |
| US9296698B2 (en) | 2009-11-23 | 2016-03-29 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| EP2504330A1 (en) | 2009-11-23 | 2012-10-03 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| CA2788363A1 (en) | 2010-01-19 | 2011-07-28 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| MX2012010658A (es) | 2010-03-15 | 2012-12-05 | Amgen Inc | Compuestos de anillo espiro tetraciclico como moduladores de beta-secretasa. |
| ES2450568T3 (es) | 2010-03-15 | 2014-03-25 | Amgen Inc. | Compuestos espiero de amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso médico |
| WO2012109165A1 (en) | 2011-02-07 | 2012-08-16 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use |
| WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9725469B2 (en) | 2012-11-15 | 2017-08-08 | Amgen, Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9462841B1 (en) | 2016-03-01 | 2016-10-11 | William Popejoy | Protective headgear and shoulder pad apparatus and methods |
| US11272751B2 (en) | 2016-03-01 | 2022-03-15 | Nicholas Popejoy | Protective headgear, impact diffusing systems and methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| MXPA04003245A (es) * | 2001-10-04 | 2004-08-11 | Elan Pharm Inc | Hidroxipropilaminas. |
| EA200400648A1 (ru) * | 2001-11-08 | 2005-04-28 | Элан Фармасьютикалз, Инк. | N, n'-замещенные производные 1,3-диамино-2-гидроксипропана |
| GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
-
2003
- 2003-06-20 AU AU2003249344A patent/AU2003249344A1/en not_active Abandoned
- 2003-06-20 WO PCT/US2003/019585 patent/WO2004000821A1/en not_active Ceased
- 2003-06-20 DE DE60315664T patent/DE60315664D1/de not_active Expired - Lifetime
- 2003-06-20 PL PL03374999A patent/PL374999A1/xx unknown
- 2003-06-20 JP JP2004516055A patent/JP2005533811A/ja active Pending
- 2003-06-20 BR BR0312439-8A patent/BR0312439A/pt not_active IP Right Cessation
- 2003-06-20 CN CNB038144476A patent/CN1324017C/zh not_active Expired - Fee Related
- 2003-06-20 US US10/600,100 patent/US7115747B2/en not_active Expired - Fee Related
- 2003-06-20 MX MXPA04012630A patent/MXPA04012630A/es active IP Right Grant
- 2003-06-20 EA EA200401510A patent/EA008389B1/ru unknown
- 2003-06-20 CA CA002489988A patent/CA2489988A1/en not_active Abandoned
- 2003-06-20 EP EP03761206A patent/EP1532123B1/en not_active Expired - Lifetime
- 2003-06-20 AT AT03761206T patent/ATE370131T1/de not_active IP Right Cessation
- 2003-06-20 NZ NZ537390A patent/NZ537390A/en unknown
-
2004
- 2004-12-14 IL IL16576304A patent/IL165763A0/xx unknown
- 2004-12-16 NO NO20045497A patent/NO20045497L/no not_active Application Discontinuation
-
2005
- 2005-01-20 CO CO05004558A patent/CO5670350A2/es not_active Application Discontinuation
-
2006
- 2006-10-03 US US11/538,155 patent/US20070105921A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE370131T1 (de) | 2007-09-15 |
| BR0312439A (pt) | 2005-05-10 |
| CN1324017C (zh) | 2007-07-04 |
| DE60315664D1 (de) | 2007-09-27 |
| AU2003249344A1 (en) | 2004-01-06 |
| NO20045497L (no) | 2005-03-07 |
| EA008389B1 (ru) | 2007-04-27 |
| PL374999A1 (en) | 2005-11-14 |
| EP1532123A1 (en) | 2005-05-25 |
| WO2004000821A1 (en) | 2003-12-31 |
| NZ537390A (en) | 2006-07-28 |
| MXPA04012630A (es) | 2005-09-30 |
| HK1081543A1 (zh) | 2006-05-19 |
| US7115747B2 (en) | 2006-10-03 |
| JP2005533811A (ja) | 2005-11-10 |
| CA2489988A1 (en) | 2003-12-31 |
| IL165763A0 (en) | 2006-01-15 |
| US20070105921A1 (en) | 2007-05-10 |
| EA200401510A1 (ru) | 2005-06-30 |
| CN1662510A (zh) | 2005-08-31 |
| US20040063965A1 (en) | 2004-04-01 |
| NO20045497D0 (no) | 2004-12-16 |
| EP1532123B1 (en) | 2007-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |