CO5640113A2 - Amidas de acido pieprazinil o piepridinilamin-sulfamico como inhibidores de la sulfatasa esteroidal - Google Patents
Amidas de acido pieprazinil o piepridinilamin-sulfamico como inhibidores de la sulfatasa esteroidalInfo
- Publication number
- CO5640113A2 CO5640113A2 CO04096497A CO04096497A CO5640113A2 CO 5640113 A2 CO5640113 A2 CO 5640113A2 CO 04096497 A CO04096497 A CO 04096497A CO 04096497 A CO04096497 A CO 04096497A CO 5640113 A2 CO5640113 A2 CO 5640113A2
- Authority
- CO
- Colombia
- Prior art keywords
- carbon atoms
- aryl
- r4ss
- r3ss
- aminocarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1.- Un compuesto de la fórmula:en donde cualquiera de: - R1 y R2, junto con el átomo de nitrógeno con el que están unidos, son piperazinilo, en donde el segundo átomo de nitrógeno está sustituido por alcoxilo(de 1 a 6 átomos de carbono) -carbonilo, o por arilo (de 6 a 18 átomos de carbono), cuyo arilo (de 6 a 18 átomos de carbono) está sustituido por uno o más de halógeno, haloalquilo (de 1 a 6 átomos de carbono), por ejemplo CF3, ó aminocarbonilo;ó - R1 es hidrógeno y R2 es piperidinilo, unido por medio de un átomo de carbono del anillo de piperidinilo, en donde el átomo de nitrógeno está sustituido por alcoxilo(de 1 a 6 átomos de carbono)-carbonilo, o por arilo (de 6 a 18 átomos de carbono), y R3 es arilo (de 6 a 18 átomos de carbono) ó arilo (de 6 a 18 átomos de carbono) -alquilo (de 1 a 4 átomos de carbono), cuyo arilo está sustituido por uno o más de halógeno, aminocarbonilo, ó haloalquilo (de 1 a 6 átomos de carbono).2.- Un compuesto de la reivindicación 1, seleccionado a partir del grupo que consiste en los compuestos de la fórmula:en donde: a. R3ss es 3, 5-bis (trifluorometil) fenilo, y R4ss es 2-aminocarbonil-5-trifluorometilfenilo, b. R3ss es 2,3-diclorofenilo, R4ss es 2-aminocarbonil-5-trifluorometilfenilo, c. R3ss es 3,5-diclorofenilo, R4ss es 2-amino-carbonil-5-trifluorometilfenilo, y d. R3ss es 3,5-bis(trifluorometil)fenilo, y R4ss es terbutoxicarbonilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207500A GB0207500D0 (en) | 2002-03-28 | 2002-03-28 | Organic compounds |
| GB0225679A GB0225679D0 (en) | 2002-11-04 | 2002-11-04 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5640113A2 true CO5640113A2 (es) | 2006-05-31 |
Family
ID=28676499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04096497A CO5640113A2 (es) | 2002-03-28 | 2004-09-28 | Amidas de acido pieprazinil o piepridinilamin-sulfamico como inhibidores de la sulfatasa esteroidal |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7439362B2 (es) |
| EP (1) | EP1492782A1 (es) |
| JP (1) | JP4580652B2 (es) |
| KR (1) | KR20040094877A (es) |
| CN (1) | CN1293065C (es) |
| AR (1) | AR039156A1 (es) |
| AU (1) | AU2003226732B2 (es) |
| BR (1) | BR0308795A (es) |
| CA (1) | CA2480686A1 (es) |
| CO (1) | CO5640113A2 (es) |
| IL (1) | IL164267A0 (es) |
| MX (1) | MXPA04009453A (es) |
| MY (1) | MY136880A (es) |
| NO (1) | NO20044321L (es) |
| NZ (1) | NZ535617A (es) |
| PE (1) | PE20040167A1 (es) |
| PL (1) | PL372602A1 (es) |
| RU (1) | RU2329258C2 (es) |
| TW (1) | TW200306806A (es) |
| WO (1) | WO2003082842A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0505541D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
| GB0505539D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
| GB0511190D0 (en) * | 2005-06-01 | 2005-07-06 | Sterix Ltd | Use |
| WO2009037539A2 (en) | 2007-09-17 | 2009-03-26 | Preglem S.A. | Treatment of oestrogen dependant conditions in pre-menopausal women |
| WO2017137423A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Improved sulfamide linkers for use in bioconjugates |
| WO2017137456A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| US11590239B2 (en) | 2016-02-08 | 2023-02-28 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting CD30 tumours and method for improving therapeutic index of antibody-conjugates |
| US20220267260A1 (en) * | 2016-11-29 | 2022-08-25 | Epizyme, Inc. | Compounds containing a sulfonic group as kat inhibitors |
| EP3983388A1 (en) * | 2019-06-12 | 2022-04-20 | Nodthera Limited | Sulfonamide derivatives and uses thereof |
| CN110590896B (zh) * | 2019-11-04 | 2022-08-30 | 上海高准医药有限公司 | 雌酚酮硫酸酯哌嗪的制备方法 |
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| US478328A (en) * | 1892-07-05 | Glass-heating oven | ||
| US51547A (en) * | 1865-12-19 | Improvement in guide and tuck-marker for sewing-machines | ||
| US183459A (en) * | 1876-10-17 | Improvement in hinges | ||
| US89089A (en) * | 1869-04-20 | Improved car-coupling | ||
| US71516A (en) * | 1867-11-26 | William b | ||
| US876846A (en) * | 1907-05-28 | 1908-01-14 | Stephen W Smith | Road-machine. |
| US1122242A (en) * | 1912-05-13 | 1914-12-29 | Sanitary Can Company | Can-body-feeding device. |
| US2103610A (en) * | 1935-04-30 | 1937-12-28 | Sofal Ltd | Alloy steels |
| DE876846C (de) * | 1943-06-01 | 1953-05-18 | Bayer Ag | Verfahren zur Herstellung von Abkoemmlingen des Sulfondiamids |
| US3004487A (en) * | 1959-12-07 | 1961-10-17 | Bank Of America Nat Trust & Savings Ass | Imprinters |
| GB1593609A (en) | 1978-01-31 | 1981-07-22 | Christiaens Sa A | Pyridine sulfonamides |
| FR2510106A1 (fr) | 1981-07-27 | 1983-01-28 | Rhone Poulenc Agrochimie | Composes herbicides derives d'acides phenoxybenzoiques, et leurs procedes de preparation et d'utilisation |
| DK101683A (da) | 1982-03-12 | 1983-09-13 | Duphar Int Res | Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf |
| US5238923A (en) * | 1989-05-26 | 1993-08-24 | Warner-Lambert Company | Amino-substituted heterocycles as renin inhibitors |
| US5256632A (en) | 1990-05-30 | 1993-10-26 | Bayer Aktiengesellschaft | Herbicidal sulphonylated carboxamides |
| IL99537A (en) | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
| FR2716883B1 (fr) | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
| FR2716882B1 (fr) | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| AU3128195A (en) | 1994-07-20 | 1996-02-16 | Merck & Co., Inc. | Piperidines and hexahydro-1h-azepines spiro substituted at the 4-position promote release of growth hormone |
| AU3577995A (en) | 1994-10-04 | 1996-04-26 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives and their use as acat-inhibitors |
| WO1997020820A1 (en) | 1995-12-01 | 1997-06-12 | Novartis Ag | Heteroaryl compounds |
| DE19621482A1 (de) | 1996-05-29 | 1997-12-04 | Hoechst Ag | Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19621483A1 (de) | 1996-05-29 | 1997-12-04 | Hoechst Ag | Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| JP2001523226A (ja) | 1997-04-14 | 2001-11-20 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Ｘａ因子阻害剤 |
| BR9914018A (pt) | 1998-09-22 | 2001-07-03 | Yamanouchi Pharmaceuticals Co | Derivado de cianofenila |
| CA2362778A1 (en) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| JP2003500390A (ja) | 1999-05-24 | 2003-01-07 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子阻害剤 |
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| DK1226127T3 (da) | 2000-05-04 | 2009-10-19 | Basf Se | Substituerede phenylsulfamoylcarboxamider |
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| WO2003004487A1 (en) | 2001-07-02 | 2003-01-16 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
-
2003
- 2003-03-26 AR ARP030101062A patent/AR039156A1/es unknown
- 2003-03-26 PE PE2003000308A patent/PE20040167A1/es not_active Application Discontinuation
- 2003-03-27 BR BR0308795-6A patent/BR0308795A/pt not_active IP Right Cessation
- 2003-03-27 JP JP2003580309A patent/JP4580652B2/ja not_active Expired - Fee Related
- 2003-03-27 MX MXPA04009453A patent/MXPA04009453A/es active IP Right Grant
- 2003-03-27 CA CA002480686A patent/CA2480686A1/en not_active Abandoned
- 2003-03-27 NZ NZ535617A patent/NZ535617A/en unknown
- 2003-03-27 RU RU2004131822/04A patent/RU2329258C2/ru not_active IP Right Cessation
- 2003-03-27 WO PCT/EP2003/003214 patent/WO2003082842A1/en not_active Ceased
- 2003-03-27 EP EP03745281A patent/EP1492782A1/en not_active Withdrawn
- 2003-03-27 US US10/509,259 patent/US7439362B2/en not_active Expired - Fee Related
- 2003-03-27 KR KR10-2004-7015312A patent/KR20040094877A/ko not_active Ceased
- 2003-03-27 PL PL03372602A patent/PL372602A1/xx unknown
- 2003-03-27 TW TW092106942A patent/TW200306806A/zh unknown
- 2003-03-27 AU AU2003226732A patent/AU2003226732B2/en not_active Ceased
- 2003-03-27 CN CNB038083361A patent/CN1293065C/zh not_active Expired - Fee Related
- 2003-03-27 IL IL16426703A patent/IL164267A0/xx unknown
- 2003-03-28 MY MYPI20031151A patent/MY136880A/en unknown
-
2004
- 2004-09-28 CO CO04096497A patent/CO5640113A2/es unknown
- 2004-10-12 NO NO20044321A patent/NO20044321L/no not_active Application Discontinuation
-
2008
- 2008-09-16 US US12/211,525 patent/US20090042899A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4580652B2 (ja) | 2010-11-17 |
| CA2480686A1 (en) | 2003-10-09 |
| PE20040167A1 (es) | 2004-05-26 |
| MY136880A (en) | 2008-11-28 |
| BR0308795A (pt) | 2005-01-18 |
| CN1293065C (zh) | 2007-01-03 |
| NZ535617A (en) | 2006-04-28 |
| RU2329258C2 (ru) | 2008-07-20 |
| EP1492782A1 (en) | 2005-01-05 |
| PL372602A1 (en) | 2005-07-25 |
| AU2003226732B2 (en) | 2006-12-21 |
| US20060052393A1 (en) | 2006-03-09 |
| NO20044321L (no) | 2004-10-12 |
| US7439362B2 (en) | 2008-10-21 |
| KR20040094877A (ko) | 2004-11-10 |
| WO2003082842A1 (en) | 2003-10-09 |
| MXPA04009453A (es) | 2005-01-25 |
| AR039156A1 (es) | 2005-02-09 |
| IL164267A0 (en) | 2005-12-18 |
| TW200306806A (en) | 2003-12-01 |
| RU2004131822A (ru) | 2005-07-10 |
| JP2005526812A (ja) | 2005-09-08 |
| CN1646509A (zh) | 2005-07-27 |
| US20090042899A1 (en) | 2009-02-12 |
| AU2003226732A1 (en) | 2003-10-13 |
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