CO5590905A2 - Composiciones farmaceuticas que comprenden compuestos activos de vitamina d - Google Patents
Composiciones farmaceuticas que comprenden compuestos activos de vitamina dInfo
- Publication number
- CO5590905A2 CO5590905A2 CO04061816A CO04061816A CO5590905A2 CO 5590905 A2 CO5590905 A2 CO 5590905A2 CO 04061816 A CO04061816 A CO 04061816A CO 04061816 A CO04061816 A CO 04061816A CO 5590905 A2 CO5590905 A2 CO 5590905A2
- Authority
- CO
- Colombia
- Prior art keywords
- pharmaceutical composition
- composition according
- phase component
- emulsion
- water
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 9
- 150000001875 compounds Chemical class 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 239000000839 emulsion Substances 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 150000003626 triacylglycerols Chemical class 0.000 abstract 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000008172 hydrogenated vegetable oil Substances 0.000 abstract 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 239000003925 fat Substances 0.000 abstract 1
- 229940013317 fish oils Drugs 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- -1 vitamin D compound Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1.- Una composición farmacéutica que comprende: (a) un componente en fase lipofílica, (b) uno o más tensoactivos, y (c) un compuesto activo de vitamina D;en donde la composición es una emulsión preconcentrada, la cual, al ser diluida con agua en una relación de agua con respecto a la composición de aproximadamente 1: 1 ó más de agua, forma una emulsión que tiene una absorbancia mayor de 0.3 a 400 nanómetros. 2.- La composición farmacéutica de conformidad con la reivindicación 1, en donde la emulsión que se forma al diluir la emulsión preconcentrada con agua, es una emulsión con glóbulos de tamaño submicrónico.3.- La composición farmacéutica de conformidad con la reivindicación 1, en donde además comprende un componente de fase hidrofílica.4.- La composición farmacéutica de conformidad con la reivindicación 3, en donde el componente de fase hidrofílica comprende 1,2-propilenglicol.5.- La composición farmacéutica de conformidad con la reivindicación 4, en donde el componente de fase hidrofílica además comprende un alcanol de 1 a 5 átomos de carbono.6.- La composición farmacéutica de conformidad con la reivindicación 5, en donde el alcanol de 1 a 5 átomos de carbono es etanol.7.- La composición farmacéutica de conformidad con la reivindicación 1, en donde el componente de fase lipofílica comprende un monoglicérido, diglicérido o triglicérido.8.- La composición farmacéutica de conformidad con la reivindicación 7, en donde el componente de fase lipofílica comprende un triglicérido.9.- La composición farmacéutica de conformidad con la reivindicación 8, en donde el triglicérido se selecciona del grupo que consiste de aceites vegetales, aceites de pescado, grasas animales, aceites vegetales hidrogenados, aceites vegetales parcialmente hidrogenados, triglicéridos sintéticos, triglicéridos modificados, triglicéridos fraccionados y mezclas de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33455401P | 2001-12-03 | 2001-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5590905A2 true CO5590905A2 (es) | 2005-12-30 |
Family
ID=23307754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04061816A CO5590905A2 (es) | 2001-12-03 | 2004-06-29 | Composiciones farmaceuticas que comprenden compuestos activos de vitamina d |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20030191093A1 (es) |
| EP (1) | EP1461044A4 (es) |
| JP (1) | JP2005515996A (es) |
| KR (1) | KR20050044655A (es) |
| CN (1) | CN100391464C (es) |
| AU (1) | AU2002363959B2 (es) |
| BR (1) | BR0214679A (es) |
| CA (1) | CA2469119A1 (es) |
| CO (1) | CO5590905A2 (es) |
| EA (1) | EA008072B1 (es) |
| HU (1) | HUP0501186A2 (es) |
| IL (1) | IL162213A0 (es) |
| MX (1) | MXPA04005260A (es) |
| NO (1) | NO20042807L (es) |
| NZ (1) | NZ533695A (es) |
| WO (1) | WO2003047595A1 (es) |
| ZA (1) | ZA200404735B (es) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| JP2005515996A (ja) * | 2001-12-03 | 2005-06-02 | ノバセア インコーポレイティッド | 活性型ビタミンｄ化合物を含む薬学的組成物 |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| CN100386083C (zh) * | 2002-11-06 | 2008-05-07 | 诺瓦西股份有限公司 | 用维生素d类化合物制备治疗骨髓发育不良综合症药物的方法 |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| WO2004047673A2 (en) * | 2002-11-21 | 2004-06-10 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| ZA200510025B (en) * | 2003-06-11 | 2007-03-28 | Novacea Inc | Pharmaceutical compositions comprising active vitamin D compounds |
| WO2005016872A1 (en) * | 2003-06-11 | 2005-02-24 | Novacea, Inc. | Treatment of lung cancer with active vitamin d compounds in combination with other treatments |
| WO2004110151A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc. | Treatment of cancer with active vitamin d compounds in combination with radiotherapeutic agents and treatments |
| AU2004247108A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents |
| CH698144B1 (fr) * | 2003-09-24 | 2009-05-29 | Bioxell Spa | Analogue de la vitamine D3 |
| US7332482B2 (en) | 2003-09-24 | 2008-02-19 | Bioxell S.P.A. | Method for treating benign prostatic hyperplasia |
| US20070129340A1 (en) * | 2004-02-06 | 2007-06-07 | Chugai Seiyaku Kabushiki Kaisha | Ed-71 preparation |
| PT1729797E (pt) | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
| US20070275934A1 (en) * | 2004-05-10 | 2007-11-29 | Curd John G | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
| CA2566346A1 (en) * | 2004-05-10 | 2005-11-24 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin d compounds |
| US20080069814A1 (en) * | 2005-01-05 | 2008-03-20 | Novacea, Inc. | Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof |
| MX2007013029A (es) * | 2005-04-22 | 2008-01-11 | Novacea Inc | Tratamiento, prevencion y mejora de trastornos pulmonares asociados con la quimioterapia o radioterapia con compuestos activos de vitamina d o substancias mimeticas de los mismos. |
| JP5140586B2 (ja) | 2005-07-29 | 2013-02-06 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 滅菌パンクレアチン粉末の製法 |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| FR2892936A1 (fr) * | 2005-11-10 | 2007-05-11 | Galderma Res & Dev | Composition pharmaceutique ou cosmetique, et procede de solubilisation mixte pour preparer la composition. |
| EP1993559B1 (en) | 2006-02-03 | 2016-06-22 | OPKO Renal, LLC | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| ES2670029T3 (es) | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
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| JP2010525080A (ja) | 2007-04-25 | 2010-07-22 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
| CA2684778C (en) | 2007-04-25 | 2017-09-05 | Cytochroma Inc. | Methods and compounds for vitamin d therapy |
| HRP20231142T3 (hr) * | 2007-04-25 | 2024-01-05 | Eirgen Pharma Ltd. | Kontrolirano oslobađanje 25-hidroksivitamina d |
| CA2683628C (en) | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| BRPI0909185A2 (pt) | 2008-03-20 | 2015-08-25 | Virun Inc | Derivado de vitamina e e seus usos |
| WO2009117152A1 (en) * | 2008-03-20 | 2009-09-24 | Virun, Inc. | Emulsions including a peg-derivative of tocopherol |
| ES2954932T3 (es) | 2008-04-02 | 2023-11-27 | Eirgen Pharma Ltd | Métodos, composiciones, usos y kits útiles para la deficiencia de vitamina D y trastornos relacionados |
| CN102770121B (zh) * | 2009-12-22 | 2014-10-15 | 利奥制药有限公司 | 包含溶剂混合物和维生素d衍生物或类似物的药物组合物 |
| CA2792330C (en) * | 2010-03-23 | 2017-01-03 | Virun, Inc | Nanoemulsion including a peg-derivative of vitamin e and a sucrose fatty acid ester |
| WO2011123476A1 (en) | 2010-03-29 | 2011-10-06 | Cytochroma Inc. | Methods and compositions for reducing parathyroid levels |
| WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
| DK2680826T3 (en) | 2011-03-02 | 2017-10-09 | D3 Pharma Ltd | VITAMIN D COMPOSITION |
| EP2811847B1 (en) | 2012-02-10 | 2017-12-13 | Virun, Inc. | Beverage compositions containing non-polar compounds |
| EP2819998B1 (en) * | 2012-03-01 | 2022-04-06 | Array BioPharma Inc. | Crystalline forms of 1-(3-tert-butyl-1-p-tolyl-1h-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1h-indazol-5-yloxy)benzyl)urea hydrochloride |
| CN102648917A (zh) * | 2012-04-25 | 2012-08-29 | 杨烨 | 维生素d3在制备治疗多发性骨髓瘤药物中的应用 |
| US9849088B2 (en) | 2012-05-10 | 2017-12-26 | Painreform Ltd. | Depot formulations of a hydrophobic active ingredient and methods for preparation thereof |
| CN103784419B (zh) * | 2012-10-31 | 2016-03-30 | 成都国弘医药有限公司 | 一种含有骨化三醇的软胶囊及其制备方法 |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
| US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
| KR101542364B1 (ko) * | 2014-10-31 | 2015-08-07 | 대화제약 주식회사 | 탁산을 포함하는 경구 투여용 약학 조성물 |
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| CN108883120A (zh) | 2016-03-28 | 2018-11-23 | 欧普科爱尔兰环球控股有限公司 | 维生素d治疗方法 |
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| CN109289041B (zh) * | 2018-11-22 | 2021-11-26 | 福州大学 | 一种维生素d-胰岛素纳米缓释经皮制剂及其制备方法 |
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-
2002
- 2002-12-03 JP JP2003548850A patent/JP2005515996A/ja not_active Withdrawn
- 2002-12-03 HU HU0501186A patent/HUP0501186A2/hu unknown
- 2002-12-03 IL IL16221302A patent/IL162213A0/xx unknown
- 2002-12-03 WO PCT/US2002/038483 patent/WO2003047595A1/en not_active Ceased
- 2002-12-03 EA EA200400765A patent/EA008072B1/ru not_active IP Right Cessation
- 2002-12-03 EP EP02798476A patent/EP1461044A4/en not_active Withdrawn
- 2002-12-03 AU AU2002363959A patent/AU2002363959B2/en not_active Ceased
- 2002-12-03 CN CNB028240014A patent/CN100391464C/zh not_active Expired - Fee Related
- 2002-12-03 CA CA002469119A patent/CA2469119A1/en not_active Abandoned
- 2002-12-03 US US10/308,176 patent/US20030191093A1/en not_active Abandoned
- 2002-12-03 MX MXPA04005260A patent/MXPA04005260A/es not_active Application Discontinuation
- 2002-12-03 BR BR0214679-7A patent/BR0214679A/pt not_active IP Right Cessation
- 2002-12-03 KR KR1020047008472A patent/KR20050044655A/ko not_active Ceased
-
2004
- 2004-06-15 ZA ZA200404735A patent/ZA200404735B/en unknown
- 2004-06-25 NZ NZ533695A patent/NZ533695A/en unknown
- 2004-06-29 CO CO04061816A patent/CO5590905A2/es not_active Application Discontinuation
- 2004-07-02 NO NO20042807A patent/NO20042807L/no not_active Application Discontinuation
-
2006
- 2006-09-07 US US11/516,713 patent/US20070003614A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2469119A1 (en) | 2003-06-12 |
| IL162213A0 (en) | 2005-11-20 |
| AU2002363959A1 (en) | 2003-06-17 |
| JP2005515996A (ja) | 2005-06-02 |
| CN1646136A (zh) | 2005-07-27 |
| MXPA04005260A (es) | 2005-03-23 |
| HUP0501186A2 (en) | 2006-05-29 |
| ZA200404735B (en) | 2005-06-15 |
| EA200400765A1 (ru) | 2004-12-30 |
| EP1461044A1 (en) | 2004-09-29 |
| NO20042807L (no) | 2004-07-02 |
| EP1461044A4 (en) | 2007-06-13 |
| KR20050044655A (ko) | 2005-05-12 |
| US20030191093A1 (en) | 2003-10-09 |
| BR0214679A (pt) | 2004-12-14 |
| AU2002363959B2 (en) | 2007-12-13 |
| EA008072B1 (ru) | 2007-02-27 |
| WO2003047595A1 (en) | 2003-06-12 |
| US20070003614A1 (en) | 2007-01-04 |
| CN100391464C (zh) | 2008-06-04 |
| NZ533695A (en) | 2007-04-27 |
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