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CO5261610A1 - COMPOUNDS - Google Patents

COMPOUNDS

Info

Publication number
CO5261610A1
CO5261610A1 CO00084362A CO00084362A CO5261610A1 CO 5261610 A1 CO5261610 A1 CO 5261610A1 CO 00084362 A CO00084362 A CO 00084362A CO 00084362 A CO00084362 A CO 00084362A CO 5261610 A1 CO5261610 A1 CO 5261610A1
Authority
CO
Colombia
Prior art keywords
optionally substituted
optionally
alkyl
independently selected
heteroatoms independently
Prior art date
Application number
CO00084362A
Other languages
Spanish (es)
Inventor
Shue Youe-Kong
Daniel Carcanague
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5261610A1 publication Critical patent/CO5261610A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de la fórmula I o una sal o solvato farmacéuticamente aceptable del mismo, <EMI FILE="00084362_1" ID="1" IMF=JPEG >donde: A contiene opcionalmente N como un heteroátomo; W es un anillo heterocíclico de 5- o 6-miembros que contiene N como un heteroátomo y unido por dicho heteroátomo y que contiene opcionalmente 1, 2 o 3 heteroátomos adicionales independientemente seleccionados entre O, N y S, el anillo es opcionalmente substituido y opcionalmente fusionado a un anillo carbocíclico o anillo heterocíclico opcionalmente substituido de 3-, 4-, 5-, 6-, 7-, o 8-miembros que contiene 1, 2 o 3 heteroátomos independientemente seleccionados entre O, N y S; X es S, SO, SO2, NH, N(alquil C1-6), O o CH2; R1 es -(CH2)a-R3, -((CH2)bO)c-R3, -(CH2)d-R3AND#39, (CH2)e-O-(CH2)f-R3AND#39, R3 o R3AND#39; R2 es alquil C1-6, O(cicloalquil C3-8), O(alquil C1-6), Hal, Chal3, CHHal2, CH2Hal, OCHal3, OCHHal2 o OCH2Hal, donde Hal representa halógeno; NR4R5, donde R4 y R5 independientemente representa H o alquil C1-8, o NR4R5 representa un anillo heterocíclico C1-8 opcionalmente substituido que contiene opcionalmente 1, 2 o 3 heteroátomos adicionales independientemente seleccionados entre O, N y S; H; COORAND#39 o CORAND#39, RAND#39 que representa H o C1-6 alquil; o CH2CH; R3 es H; C1-6 alquil; cicloalquil C3-8 opcionalmente substituido que contiene opcionalmente 1, 2 o 3 heteroátomos independientemente seleccionados entre C, N y S; una estructura de anillos aromáticos C5-10 opcionalmente substituida con N y S opcionalmente; o una estructura de anillos heterocíclicos mono-o bi-cíclicos opcionalmente substituida de 5-, 6-, 7-, 8-, 9- o 10-miembros que contiene 1, 2, 3, 4 o 5 heteroátomos independientemente seleccionados entre O, N y S; R3AND#39 es -Z-M donde Z representa O, S o NH y M representa H, una estructura de anillos heterocíclicos mono-o bi-cíclico, opcionalmente substituida de 5-, 6-, 7-, 8-, 9- o 10-miembros que contiene 1, 2, 3, 4, 5 o 6 heteroátomos independientemente seleccionados entre O, N y S, o ...A compound of the formula I or a pharmaceutically acceptable salt or solvate thereof, <EMI FILE = "00084362_1" ID = "1" IMF = JPEG> where: A optionally contains N as a heteroatom; W is a 5- or 6-membered heterocyclic ring containing N as a heteroatom and linked by said heteroatom and optionally containing 1, 2 or 3 additional heteroatoms independently selected from O, N and S, the ring is optionally substituted and optionally fused to an optionally substituted carbocyclic ring or heterocyclic ring of 3-, 4-, 5-, 6-, 7-, or 8-members containing 1, 2 or 3 heteroatoms independently selected from O, N and S; X is S, SO, SO2, NH, N (C1-6 alkyl), O or CH2; R1 is - (CH2) a-R3, - ((CH2) bO) c-R3, - (CH2) d-R3AND # 39, (CH2) eO- (CH2) f-R3AND # 39, R3 or R3AND # 39 ; R2 is C1-6 alkyl, O (C3-8 cycloalkyl), O (C1-6 alkyl), Hal, Chal3, CHHal2, CH2Hal, OCHal3, OCHHal2 or OCH2Hal, where Hal represents halogen; NR4R5, where R4 and R5 independently represents H or C1-8 alkyl, or NR4R5 represents an optionally substituted C1-8 heterocyclic ring optionally containing 1, 2 or 3 additional heteroatoms independently selected from O, N and S; H; COORAND # 39 or CORAND # 39, RAND # 39 representing H or C1-6 alkyl; or CH2CH; R3 is H; C1-6 alkyl; optionally substituted C3-8 cycloalkyl optionally containing 1, 2 or 3 heteroatoms independently selected from C, N and S; a C5-10 aromatic ring structure optionally substituted with N and S optionally; or an optionally substituted 5-, 6-, 7-, 8-, 9- or 10-membered mono- or bi-cyclic heterocyclic ring structure containing 1, 2, 3, 4 or 5 heteroatoms independently selected from O, N and S; R3AND # 39 is -ZM where Z represents O, S or NH and M represents H, a mono-or bi-cyclic heterocyclic ring structure, optionally substituted with 5-, 6-, 7-, 8-, 9- or 10 -members containing 1, 2, 3, 4, 5 or 6 heteroatoms independently selected from O, N and S, or ...

CO00084362A 1999-11-09 2000-11-07 COMPOUNDS CO5261610A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9904045A SE9904045D0 (en) 1999-11-09 1999-11-09 Compounds

Publications (1)

Publication Number Publication Date
CO5261610A1 true CO5261610A1 (en) 2003-03-31

Family

ID=20417651

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00084362A CO5261610A1 (en) 1999-11-09 2000-11-07 COMPOUNDS

Country Status (4)

Country Link
AU (1) AU1564701A (en)
CO (1) CO5261610A1 (en)
SE (1) SE9904045D0 (en)
WO (1) WO2001034578A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000648A1 (en) * 2000-06-28 2002-01-03 Ssp Co., Ltd. Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts
AR035966A1 (en) * 2001-05-18 2004-07-28 Altana Pharma Ag A BENCILAMINOPIRIMIDINE COMPOUND, A MEDICINAL PRODUCT THAT INCLUDES IT AND THE USE OF IT
JP4185097B2 (en) * 2003-03-13 2008-11-19 出光興産株式会社 Novel nitrogen-containing heterocyclic derivative and organic electroluminescence device using the same
EP2222661B1 (en) 2007-11-20 2016-04-20 Merck Sharp & Dohme Corp. Non-nucleoside reverse transcriptase inhibitors
PT2924034T (en) 2010-03-30 2017-01-06 Merck Canada Inc Pharmaceutical composition comprising a non-nucleoside reverse transcriptase inhibitor
JO3470B1 (en) 2012-10-08 2020-07-05 Merck Sharp & Dohme 5-phenoxy-3h-pyrimidin-4-one derivatives and their use as hiv reverse transcriptase inhibitors
CA2944187C (en) 2014-04-01 2018-06-19 Merck Sharp & Dohme Corp. Prodrugs of hiv reverse transcriptase inhibitors
CN106432098B (en) * 2016-09-07 2018-09-18 华中师范大学 Carbamate compound and its preparation method and application
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS632986A (en) * 1986-06-23 1988-01-07 Kanebo Ltd Novel piperazine derivative and antiulcer agent containing said compound as active ingredient
CA2196076A1 (en) * 1994-07-28 1996-02-08 Gerhard Grundler Acyl imidazopyridines

Also Published As

Publication number Publication date
AU1564701A (en) 2001-06-06
WO2001034578A1 (en) 2001-05-17
SE9904045D0 (en) 1999-11-09

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