CO5150201A1 - PIPERIDINE DERIVATIVES - Google Patents
PIPERIDINE DERIVATIVESInfo
- Publication number
- CO5150201A1 CO5150201A1 CO99055221A CO99055221A CO5150201A1 CO 5150201 A1 CO5150201 A1 CO 5150201A1 CO 99055221 A CO99055221 A CO 99055221A CO 99055221 A CO99055221 A CO 99055221A CO 5150201 A1 CO5150201 A1 CO 5150201A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- alkoxy
- piperidine derivatives
- alkenyloxy
- cycloalkyl
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de la fórmula general<EMI FILE="99055221_1" ID="1" IMF=JPEG >en dondeR1 es tetrahidronaftilo;o -(CH2)nC6H5-R4 en donde n es 0-4 y R4 es H, alquilo de C1-C6 o alcoxilo de C1-C6;o cicloalquilo de C5-C12, opcionalmente sustituido por alquilo de C1-C6,R2 es H, OH, alcoxilo de C1-C6, alqueniloxilo de C1-C6, o alquilo de C1-C6;R3 es cicloalquilo de C5-C7 o fenilo, opcionalmente sustituido por OH, halógeno, alcoxilo de C1-C6, alqueniloxilo de C1-C6, alquilo de C1-C6, u -0-(CH2)n-C6H5 en donde n es 0-3;y a sus sales de adición de ácido farmacéuticamente aceptables.Compounds of the general formula <EMI FILE = "99055221_1" ID = "1" MFI = JPEG> where R1 is tetrahydronaphthyl; or - (CH2) nC6H5-R4 where n is 0-4 and R4 is H, C1- alkyl C6 or C1-C6 alkoxy; or C5-C12 cycloalkyl, optionally substituted by C1-C6 alkyl, R2 is H, OH, C1-C6 alkoxy, C1-C6 alkenyloxy, or C1-C6 alkyl; R3 it is C5-C7 cycloalkyl or phenyl, optionally substituted by OH, halogen, C1-C6 alkoxy, C1-C6 alkenyloxy, C1-C6 alkyl, or -0- (CH2) n-C6H5 where n is 0- 3; and its pharmaceutically acceptable acid addition salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98116852 | 1998-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5150201A1 true CO5150201A1 (en) | 2002-04-29 |
Family
ID=8232585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99055221A CO5150201A1 (en) | 1998-09-07 | 1999-09-01 | PIPERIDINE DERIVATIVES |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1109786A1 (en) |
| JP (1) | JP2002524446A (en) |
| KR (1) | KR20010073115A (en) |
| CN (1) | CN1316994A (en) |
| AR (1) | AR022083A1 (en) |
| AU (1) | AU5858199A (en) |
| BR (1) | BR9913106A (en) |
| CA (1) | CA2343168A1 (en) |
| CO (1) | CO5150201A1 (en) |
| MA (1) | MA26683A1 (en) |
| PE (1) | PE20001028A1 (en) |
| TR (1) | TR200100660T2 (en) |
| WO (1) | WO2000014067A1 (en) |
| ZA (1) | ZA200101830B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2157148B1 (en) * | 1998-11-18 | 2002-03-01 | Faes Fabrica Espanola De Produ | NEW 4-SUBSTITUTED PIPERIDINS. |
| JP4056977B2 (en) | 2002-03-29 | 2008-03-05 | 田辺三菱製薬株式会社 | Sleep disorder drug |
| JP2005289816A (en) | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | Benzimidazole derivatives |
| ITMI20031349A1 (en) * | 2003-07-01 | 2005-01-02 | Ufpeptides S R L | ANTAGONISTS OF THE NOP RECEPTOR AND THEIR THERAPEUTIC USES. |
| ITFE20060036A1 (en) * | 2006-11-23 | 2008-05-24 | Ufpeptides Srl | NOP RECEPTOR AGONISTS FOR THE TREATMENT OF DISCINESIA FROM LEVODOPA |
| CN101547923A (en) | 2006-12-07 | 2009-09-30 | 弗·哈夫曼-拉罗切有限公司 | Spiro-piperidine derivatives as VIA receptor antagonists |
| CN101541797A (en) | 2006-12-07 | 2009-09-23 | 弗·哈夫曼-拉罗切有限公司 | Spiro-piperidine derivatives |
| KR20090078367A (en) | 2006-12-08 | 2009-07-17 | 에프. 호프만-라 로슈 아게 | Indole |
| WO2008068184A1 (en) | 2006-12-08 | 2008-06-12 | F. Hoffmann-La Roche Ag | Indoles which act as via receptor antagonists |
| EP2097376A2 (en) | 2006-12-22 | 2009-09-09 | F. Hoffmann-Roche AG | Spiro-piperidine derivatives |
| CN101671293B (en) * | 2009-10-12 | 2012-01-11 | 南开大学 | Alpha-glycosidase inhibitor compound in silkworm excrement total alkaloid and application thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132710A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| FI792076A7 (en) * | 1978-07-05 | 1981-01-01 | Ciba Geigy Ag | Process for the preparation of novel phenylpiperidine derivatives. |
| DE3614907A1 (en) * | 1986-05-02 | 1987-11-05 | Basf Ag | N-SUBSTITUTED PYRROLIDONE AND PIPERIDINE DERIVATIVES AND THEIR SALTS |
| WO1991009594A1 (en) * | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| GB9100505D0 (en) * | 1991-01-10 | 1991-02-20 | Shell Int Research | Piperidine derivatives |
| WO1993000313A2 (en) * | 1991-06-27 | 1993-01-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
| CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
-
1999
- 1999-09-01 CO CO99055221A patent/CO5150201A1/en unknown
- 1999-09-02 EP EP99946090A patent/EP1109786A1/en not_active Withdrawn
- 1999-09-02 WO PCT/EP1999/006442 patent/WO2000014067A1/en not_active Ceased
- 1999-09-02 KR KR1020017002822A patent/KR20010073115A/en not_active Ceased
- 1999-09-02 PE PE1999000886A patent/PE20001028A1/en not_active Application Discontinuation
- 1999-09-02 BR BR9913106-4A patent/BR9913106A/en not_active IP Right Cessation
- 1999-09-02 CN CN99810642A patent/CN1316994A/en active Pending
- 1999-09-02 TR TR2001/00660T patent/TR200100660T2/en unknown
- 1999-09-02 CA CA002343168A patent/CA2343168A1/en not_active Abandoned
- 1999-09-02 AU AU58581/99A patent/AU5858199A/en not_active Abandoned
- 1999-09-02 JP JP2000568826A patent/JP2002524446A/en active Pending
- 1999-09-03 MA MA25753A patent/MA26683A1/en unknown
- 1999-09-06 AR ARP990104471A patent/AR022083A1/en unknown
-
2001
- 2001-03-05 ZA ZA200101830A patent/ZA200101830B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR200100660T2 (en) | 2001-06-21 |
| KR20010073115A (en) | 2001-07-31 |
| EP1109786A1 (en) | 2001-06-27 |
| AU5858199A (en) | 2000-03-27 |
| BR9913106A (en) | 2001-05-08 |
| MA26683A1 (en) | 2004-12-20 |
| PE20001028A1 (en) | 2000-10-12 |
| JP2002524446A (en) | 2002-08-06 |
| CN1316994A (en) | 2001-10-10 |
| CA2343168A1 (en) | 2000-03-16 |
| WO2000014067A1 (en) | 2000-03-16 |
| ZA200101830B (en) | 2002-06-05 |
| AR022083A1 (en) | 2002-09-04 |
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