CO5040090A1 - Inhibidores de proteasas - Google Patents
Inhibidores de proteasasInfo
- Publication number
- CO5040090A1 CO5040090A1 CO99036559A CO99036559A CO5040090A1 CO 5040090 A1 CO5040090 A1 CO 5040090A1 CO 99036559 A CO99036559 A CO 99036559A CO 99036559 A CO99036559 A CO 99036559A CO 5040090 A1 CO5040090 A1 CO 5040090A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- group
- cycloalkyl
- het
- alkynyl
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical class [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8905698P | 1998-06-12 | 1998-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5040090A1 true CO5040090A1 (es) | 2001-05-29 |
Family
ID=22215426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99036559A CO5040090A1 (es) | 1998-06-12 | 1999-06-10 | Inhibidores de proteasas |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1086083A4 (fr) |
| JP (1) | JP2002517485A (fr) |
| AR (1) | AR018652A1 (fr) |
| AU (1) | AU4564499A (fr) |
| CA (1) | CA2334652A1 (fr) |
| CO (1) | CO5040090A1 (fr) |
| DZ (1) | DZ2815A1 (fr) |
| MA (1) | MA24877A1 (fr) |
| PE (1) | PE20000725A1 (fr) |
| WO (1) | WO1999064399A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| JP2003513924A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
| US6596715B1 (en) | 1999-11-10 | 2003-07-22 | Smithkline Beecham Corporation | Protease inhibitors |
| US6583137B1 (en) | 1999-11-10 | 2003-06-24 | Smithkline Beecham Corporation | Protease inhibitors |
| CA2404206A1 (fr) | 2000-03-21 | 2001-09-27 | Smithkline Beecham Corporation | Inhibiteur de proteinase |
| WO2002080920A1 (fr) * | 2001-04-06 | 2002-10-17 | Axys Pharmaceuticals, Inc. | Arylacetamido-cetobenzoxazole comme inhibiteurs de la cysteine protease |
| WO2003062192A1 (fr) | 2002-01-17 | 2003-07-31 | Smithkline Beecham Corporation | Derives de cetoamides a substitution cycloalkyle, utiles comme inhibiteurs de cathepsine k |
| EP2240491B1 (fr) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | DÉRIVÉS DE TÉTRAHYDROFURO(2,3-b)PYRROL-3-ONE COMME INHIBITEURS DE CYSTÉINE PROTÉINASES |
| CN117940420A (zh) | 2021-09-14 | 2024-04-26 | 勃林格殷格翰国际有限公司 | 3-苯氧基氮杂环丁烷-1-基-杂芳基吡咯烷衍生物及其作为药物的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2175218A1 (fr) * | 1993-11-09 | 1995-05-18 | Gregori J. Morriello | Piperidines, pyrrolidines et hexahydro-1h-azepines favorisant la liberation de l'hormone de croissance |
| US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
-
1999
- 1999-06-09 DZ DZ990115A patent/DZ2815A1/fr active
- 1999-06-10 AR ARP990102767A patent/AR018652A1/es unknown
- 1999-06-10 CO CO99036559A patent/CO5040090A1/es unknown
- 1999-06-10 MA MA25619A patent/MA24877A1/fr unknown
- 1999-06-11 CA CA002334652A patent/CA2334652A1/fr not_active Abandoned
- 1999-06-11 EP EP99928614A patent/EP1086083A4/fr not_active Withdrawn
- 1999-06-11 WO PCT/US1999/013334 patent/WO1999064399A1/fr not_active Ceased
- 1999-06-11 PE PE1999000518A patent/PE20000725A1/es not_active Application Discontinuation
- 1999-06-11 AU AU45644/99A patent/AU4564499A/en not_active Abandoned
- 1999-06-11 JP JP2000553408A patent/JP2002517485A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MA24877A1 (fr) | 1999-12-31 |
| AR018652A1 (es) | 2001-11-28 |
| WO1999064399A1 (fr) | 1999-12-16 |
| DZ2815A1 (fr) | 2003-12-01 |
| AU4564499A (en) | 1999-12-30 |
| EP1086083A4 (fr) | 2001-09-26 |
| PE20000725A1 (es) | 2000-09-28 |
| EP1086083A1 (fr) | 2001-03-28 |
| JP2002517485A (ja) | 2002-06-18 |
| CA2334652A1 (fr) | 1999-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2196636T3 (es) | Ciclohexenocarboxilatos como inhibidores de la neuraminidasa. | |
| DK1075258T3 (da) | Hidtil ukendte fedtsyreanaloger til behandling af adipositas | |
| EA200400815A1 (ru) | Контролируемый синтез зипразидона и его композиции | |
| CO5040090A1 (es) | Inhibidores de proteasas | |
| DK0915866T3 (da) | Forbedret fremgangsmåde til syntese af beskyttende estere af (S)-3,4-dihydroxysmørsyre | |
| EA200400986A1 (ru) | Гетероциклические трипептиды в качестве ингибиторов вируса гепатита c | |
| CO5580746A2 (es) | Derivados de fenil-piperazina como inhibidores de la reabsorcion de la serotonina | |
| UY26820A1 (es) | Derivados de ciclopentil-glutaramida como inhibidores de endopeptidasa neutra | |
| DK0747374T3 (da) | Sulfonamidsubstituerede benzopyraner som kaliumkanalaktivatorer | |
| ATE347539T1 (de) | Wässrige harzzusammensetzung | |
| TR199701254T1 (xx) | 5-HT al�� inhibit�r�n�n selektif 5-HT1A antagonistiyle kombinasyonu. | |
| IL155604A0 (en) | Tripeptidyl peptidase inhibitors | |
| EA200400748A1 (ru) | Агонисты рецепторов, активируемых пероксисомным пролифератором | |
| ATE225771T1 (de) | Prostaglandin-pharmazeutische-zusammensetzungen | |
| PE20090548A1 (es) | Compuestos aza-biciclohexano como inhibidores de trombina | |
| TW200716534A (en) | Novel resorcinol derivatives | |
| EP1201641A3 (fr) | Compositions d'esters de l'acide (méth)acrylique contenant des groupes éthers vinyliques et procédé pour leur production | |
| NO944121L (no) | Epoksyravsyrederivater | |
| BR0114156A (pt) | Forma amorfa de inibidor de ciclo de célula | |
| DE69314041D1 (de) | Cyanoguanidine als kaliumkanalblocker | |
| CO4970804A1 (es) | Nuevos derivados de la vitamina d3 | |
| CO5080758A1 (es) | DERIVADOS DE 3-(2-oxo-[1,3´]BIPIRROLODINIL-3-ILIDENMETIL | |
| DE60116514D1 (de) | Amlodipin-hemimaleat | |
| EA199700395A1 (ru) | Способ получения ингибиторов протеазы вируса иммунодефицита человека | |
| BR0208513A (pt) | Processo de preparação de benazepril |