CO4950618A1 - Inhibidores de proteasas - Google Patents
Inhibidores de proteasasInfo
- Publication number
- CO4950618A1 CO4950618A1 CO98024945A CO98024945A CO4950618A1 CO 4950618 A1 CO4950618 A1 CO 4950618A1 CO 98024945 A CO98024945 A CO 98024945A CO 98024945 A CO98024945 A CO 98024945A CO 4950618 A1 CO4950618 A1 CO 4950618A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- het
- alkenyl
- formula
- compound
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000524 functional group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4575897P | 1997-05-06 | 1997-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4950618A1 true CO4950618A1 (es) | 2000-09-01 |
Family
ID=21939723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98024945A CO4950618A1 (es) | 1997-05-06 | 1998-05-06 | Inhibidores de proteasas |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1003846A4 (no) |
| JP (1) | JP2001525804A (no) |
| KR (1) | KR20010012256A (no) |
| CN (1) | CN1255161A (no) |
| AR (1) | AR013079A1 (no) |
| AU (1) | AU7562598A (no) |
| BR (1) | BR9809306A (no) |
| CA (1) | CA2288868A1 (no) |
| CO (1) | CO4950618A1 (no) |
| HU (1) | HUP0002247A3 (no) |
| IL (1) | IL132088A0 (no) |
| NO (1) | NO995434D0 (no) |
| NZ (1) | NZ337889A (no) |
| PE (1) | PE71599A1 (no) |
| PL (1) | PL336856A1 (no) |
| TR (1) | TR199902766T2 (no) |
| UY (1) | UY25143A1 (no) |
| WO (1) | WO1998050533A1 (no) |
| ZA (1) | ZA983762B (no) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5150165A1 (es) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
| DZ3083A1 (fr) * | 1999-02-19 | 2004-06-02 | Smithkline Beecham Corp | Composés nouveaux inhibiteurs de protéases, procédé pour leur préparation et compositions pharmaceutiques les conentant. |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| US6596715B1 (en) * | 1999-11-10 | 2003-07-22 | Smithkline Beecham Corporation | Protease inhibitors |
| WO2002032879A1 (en) * | 2000-10-19 | 2002-04-25 | Naeja Pharmaceutical Inc. | Dihydropyrimidine derivatives as cysteine protease inhibitors |
| CA2429001A1 (en) * | 2000-11-17 | 2002-11-07 | Medivir Ab | Cysteine protease inhibitors |
| CA2428863A1 (en) * | 2000-11-17 | 2002-05-23 | Medivir Uk Limited | Cysteine protease inhibitors |
| EP1362052B1 (en) * | 2001-01-17 | 2007-03-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| IL156775A0 (en) * | 2001-01-17 | 2004-02-08 | Amura Therapeutics Ltd | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
| EP1358176A2 (en) * | 2001-01-17 | 2003-11-05 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| WO2003037892A1 (en) * | 2001-10-29 | 2003-05-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
| ATE424401T1 (de) * | 2002-07-16 | 2009-03-15 | Amura Therapeutics Ltd | Pyrrolderivate als hemmstoffe von cystein proteasen |
| KR100962972B1 (ko) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
| SG153714A1 (en) | 2003-08-06 | 2009-07-29 | Senomyx Inc | T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds |
| AU2016206281B2 (en) * | 2003-08-06 | 2017-11-30 | Senomyx, Inc. | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
| US7915300B2 (en) | 2004-01-08 | 2011-03-29 | Medivir Ab | Cysteine protease inhibitors |
| MX2008002363A (es) * | 2005-08-17 | 2008-03-18 | Schering Corp | Ligandos novedosos de cinasa basados en quinolina de alta afinidad. |
| GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| MX2009012847A (es) * | 2007-06-13 | 2009-12-08 | Bristol Myers Squibb Co | Analogos dipeptidicos como inhibidores de factores de coagulacion. |
| US7893067B2 (en) | 2007-06-27 | 2011-02-22 | Medivir Ab | Cysteine protease inhibitors |
| EP2240491B1 (en) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES |
| GB0817424D0 (en) | 2008-09-24 | 2008-10-29 | Medivir Ab | Protease inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3190431B2 (ja) * | 1991-07-01 | 2001-07-23 | 三菱化学株式会社 | ケトン誘導体 |
| JPH05140063A (ja) * | 1991-11-19 | 1993-06-08 | Suntory Ltd | ジペプチド誘導体及びそれを有効成分とする骨疾患の予防及び治療剤 |
| CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
| JP2848232B2 (ja) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | アルデヒド誘導体 |
| JP3599287B2 (ja) * | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | スルホンアミド誘導体 |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
| PL328877A1 (en) * | 1995-10-30 | 1999-03-01 | Smithkline Beecham Corp | Method of inhibiting cathepsin k |
| TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| WO1998004539A1 (en) * | 1996-07-29 | 1998-02-05 | Mitsubishi Chemical Corporation | Oxygenic heterocyclic derivatives |
-
1998
- 1998-05-04 AR ARP980102069A patent/AR013079A1/es unknown
- 1998-05-05 ZA ZA983762A patent/ZA983762B/xx unknown
- 1998-05-05 PE PE1998000336A patent/PE71599A1/es not_active Application Discontinuation
- 1998-05-06 BR BR9809306-1A patent/BR9809306A/pt not_active Application Discontinuation
- 1998-05-06 CA CA002288868A patent/CA2288868A1/en not_active Abandoned
- 1998-05-06 JP JP54804998A patent/JP2001525804A/ja active Pending
- 1998-05-06 EP EP98923299A patent/EP1003846A4/en not_active Withdrawn
- 1998-05-06 TR TR1999/02766T patent/TR199902766T2/xx unknown
- 1998-05-06 PL PL98336856A patent/PL336856A1/xx unknown
- 1998-05-06 CO CO98024945A patent/CO4950618A1/es unknown
- 1998-05-06 CN CN98804791A patent/CN1255161A/zh active Pending
- 1998-05-06 WO PCT/US1998/003200 patent/WO1998050533A1/en not_active Ceased
- 1998-05-06 HU HU0002247A patent/HUP0002247A3/hu unknown
- 1998-05-06 KR KR1019997010207A patent/KR20010012256A/ko not_active Withdrawn
- 1998-05-06 NZ NZ337889A patent/NZ337889A/en unknown
- 1998-05-06 AU AU75625/98A patent/AU7562598A/en not_active Abandoned
- 1998-05-06 IL IL13208898A patent/IL132088A0/xx unknown
- 1998-08-17 UY UY25143A patent/UY25143A1/es unknown
-
1999
- 1999-11-05 NO NO995434A patent/NO995434D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995434L (no) | 1999-11-05 |
| IL132088A0 (en) | 2001-03-19 |
| HUP0002247A3 (en) | 2003-01-28 |
| TR199902766T2 (xx) | 2000-02-21 |
| PL336856A1 (en) | 2000-07-17 |
| AU7562598A (en) | 1998-11-27 |
| NZ337889A (en) | 2001-09-28 |
| JP2001525804A (ja) | 2001-12-11 |
| UY25143A1 (es) | 1998-11-27 |
| KR20010012256A (ko) | 2001-02-15 |
| HUP0002247A2 (hu) | 2001-05-28 |
| EP1003846A1 (en) | 2000-05-31 |
| AR013079A1 (es) | 2000-12-13 |
| NO995434D0 (no) | 1999-11-05 |
| ZA983762B (en) | 1998-11-06 |
| EP1003846A4 (en) | 2002-11-13 |
| WO1998050533A1 (en) | 1998-11-12 |
| BR9809306A (pt) | 2000-07-04 |
| CN1255161A (zh) | 2000-05-31 |
| PE71599A1 (es) | 1999-09-15 |
| CA2288868A1 (en) | 1998-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4950618A1 (es) | Inhibidores de proteasas | |
| PT91926A (pt) | Processo para a preparacao de novos inibidores de peptidase | |
| AR041729A1 (es) | Compuesto de cefemo | |
| ES2058091T3 (es) | Derivados de acido 3-pirrolidiniltio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilico y procedimientos para su preparacion. | |
| DK0687253T3 (da) | Hidtil ukendte 4-aminopyridiner, fremgangsmåde til deres fremstilling samt lægemidler indeholdende disse forbindelser | |
| AR017164A1 (es) | Derivados de la benzamidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, los medicamentos y laspreparaciones farmaceuticas que contienen estos derivados de la benzamidina, y un procedimiento para obtener estas preparaciones farmaceuticas. | |
| CA2328780A1 (en) | Dihydropyrimidines | |
| GR3030311T3 (en) | Peptide derivatives of the boronic acid having protease inhibiting activity, process for their production and pharmaceutical compositions comprising them. | |
| AR045768A1 (es) | Compuestos de cefem y sus sales farmaceuticamente aceptables | |
| MXPA03000547A (es) | Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares. | |
| HUP9702403A2 (hu) | Eljárás vírusellenes proteáz inhibitorok intermedierjeinek előállítására | |
| ATE141606T1 (de) | Cephemverbindungen und verfahren zu ihrer herstellung | |
| PT92540A (pt) | Processo para a preparacao de derivados de anfotericina b | |
| PT1268398E (pt) | Novo processo de sintese de esteres da n-[(s)-1-carboxibutil]-(s)-alanina e aplicacao a sintese do perindopril | |
| ES2057415T3 (es) | Derivados biciclicos. | |
| DE60100207D1 (de) | Verfahren zu Synthese von N-(mercaptoacyl)-aminosäure Derivaten von alfasubstituierte Acrylsäuren an | |
| PT1292597E (pt) | Derivados de podofilotoxina carbamato e tiocarbamato processo para a sua preparacao e as composicoes farmaceuticas que os contem | |
| DK0619817T3 (da) | Hidtil ukendte farmaceutisk aktive flaviliumforbindelser | |
| EP0911336A4 (no) | ||
| AR010366A1 (es) | Proceso para la produccion de compuestos de amina utiles como medicamentos. | |
| AR004401A1 (es) | Derivados de la tirosina, procedimiento para prepararlos y preparaciones farmaceuticas que los contienen. | |
| MY155266A (en) | Selective thrombin inhibitors |