CO4810374A1 - NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITY - Google Patents
NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITYInfo
- Publication number
- CO4810374A1 CO4810374A1 CO98060225A CO98060225A CO4810374A1 CO 4810374 A1 CO4810374 A1 CO 4810374A1 CO 98060225 A CO98060225 A CO 98060225A CO 98060225 A CO98060225 A CO 98060225A CO 4810374 A1 CO4810374 A1 CO 4810374A1
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- mammal
- independently
- compound
- case
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000001139 anti-pruritic effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 2
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un método de tratamiento de prurito en un mamífero que necesitade ello, que comprende administrar a dicho mamífero una cantidad eficaz de un compuesto de un inhibidor de PDE4 , distinto de CP 80633. El método según la reivindicación 1, en el que el inhibidor de PDE4 es un compuesto de la fórmula: en la que: R1 y R2 , independientemente en cada caso, representan alquilo o -(CH2 )m -A; m representa cero o el número entero 1, 2 ó 3; A representa un radical hidrocarbonado cíclico no sustituido o sustituido; R3 representa un átomo de halógeno, un grupo nitro o un grupo -NR4 R5 ; R4 y R5 , independientemente en cada caso, representan hidrógeno, alquilo o alquilcarbonilo, o R4 y R5 junto con el nitrógeno al que están unidos forman un anillo heterocíclico opcionalmente sustituido; y sus sales farmacéuticamente aceptables.A method of treating pruritus in a mammal in need thereof, comprising administering to said mammal an effective amount of a compound of a PDE4 inhibitor, other than CP 80633. The method according to claim 1, wherein the PDE4 inhibitor it is a compound of the formula: wherein: R1 and R2, independently in each case, represent alkyl or - (CH2) m -A; m represents zero or the integer 1, 2 or 3; A represents an unsubstituted or substituted cyclic hydrocarbon radical; R3 represents a halogen atom, a nitro group or a -NR4 R5 group; R4 and R5, independently in each case, represent hydrogen, alkyl or alkylcarbonyl, or R4 and R5 together with the nitrogen to which they are attached form an optionally substituted heterocyclic ring; and its pharmaceutically acceptable salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6374697P | 1997-10-17 | 1997-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4810374A1 true CO4810374A1 (en) | 1999-06-30 |
Family
ID=22051225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98060225A CO4810374A1 (en) | 1997-10-17 | 1998-10-16 | NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITY |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1030666A4 (en) |
| JP (1) | JP2001520196A (en) |
| KR (1) | KR20010031149A (en) |
| CN (1) | CN1306426A (en) |
| AR (1) | AR015966A1 (en) |
| AU (1) | AU740875B2 (en) |
| BR (1) | BR9814080A (en) |
| CA (1) | CA2306985A1 (en) |
| CO (1) | CO4810374A1 (en) |
| CZ (1) | CZ20001376A3 (en) |
| HU (1) | HUP0003792A3 (en) |
| IL (1) | IL135581A0 (en) |
| NO (1) | NO20001847D0 (en) |
| NZ (1) | NZ503551A (en) |
| PL (1) | PL341062A1 (en) |
| TR (1) | TR200001040T2 (en) |
| WO (1) | WO1999020280A1 (en) |
| ZA (1) | ZA989450B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| WO2002060896A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
| CA2436551A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
| PL364135A1 (en) | 2001-01-31 | 2004-12-13 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| US20030175314A1 (en) * | 2001-11-19 | 2003-09-18 | Didriksen Erik Johannes | Pharmaceutical composition for dermal application |
| US20060258703A1 (en) * | 2003-07-17 | 2006-11-16 | Ono Pharmaceutical Co., Ltd. | Remedy for pruritus comprising piperidine derivative as the active ingredient |
| JP2005187458A (en) * | 2003-12-04 | 2005-07-14 | Santen Pharmaceut Co Ltd | Itchiness-treating agent consisting of cilomilast or its salt as active ingredient |
| WO2005053672A1 (en) * | 2003-12-04 | 2005-06-16 | Santen Pharmaceutical Co., Ltd. | Remedy for pruritus comprising cilomilast or salt thereof as the active ingredient |
| CN101103030B (en) * | 2004-02-14 | 2010-10-13 | 史密丝克莱恩比彻姆公司 | Medicaments with HM74A receptor activity |
| JP2008137892A (en) * | 2005-03-04 | 2008-06-19 | Eisai Co Ltd | Antipruritic agent |
| JP2009504592A (en) | 2005-08-10 | 2009-02-05 | スミスクライン・ビーチャム・コーポレイション | Xanthine derivatives as selective HM74A agonists |
| EP1992622B1 (en) * | 2006-02-21 | 2011-07-27 | Eisai R&D Management Co., Ltd. | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative |
| TWI404709B (en) * | 2006-02-21 | 2013-08-11 | Eisai R&D Man Co Ltd | 4-(3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives |
| WO2008099887A1 (en) | 2007-02-16 | 2008-08-21 | Eisai R & D Management Co., Ltd. | Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
| CA2696727A1 (en) | 2007-08-17 | 2009-02-26 | Eisai R&D Management Co., Ltd. | Method for producing quinazoline derivative |
| AU2008290001B2 (en) | 2007-08-17 | 2012-08-09 | Eisai R & D Management Co., Ltd. | Novel preparation for external use |
| WO2013002196A1 (en) | 2011-06-28 | 2013-01-03 | 田辺三菱製薬株式会社 | Novel pharmaceutical composition |
| SI3251675T1 (en) | 2015-01-30 | 2021-08-31 | Shanton Pharma Pte. Ltd. | Prevention or treatment of uric acid or gout disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992011260A1 (en) * | 1990-12-21 | 1992-07-09 | Beecham Group Plc | Xanthine derivatives |
| EP0889886B1 (en) * | 1996-03-26 | 2002-09-18 | ALTANA Pharma AG | Novel phenanthridines substituted in the 6 position |
| JP2000510134A (en) * | 1996-05-15 | 2000-08-08 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | New imidazopyridine |
| JP2001514640A (en) * | 1997-03-07 | 2001-09-11 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | New tetrazole |
| SK122199A3 (en) * | 1997-03-18 | 2000-12-11 | Basf Ag | Methods and compositions for modulating responsiveness to corticosteroids |
| DE69811492T2 (en) * | 1997-06-03 | 2004-02-05 | Altana Pharma Ag | BENZONAPHTHYRIDINE |
-
1998
- 1998-10-15 AR ARP980105131A patent/AR015966A1/en not_active Application Discontinuation
- 1998-10-16 CZ CZ20001376A patent/CZ20001376A3/en unknown
- 1998-10-16 NZ NZ503551A patent/NZ503551A/en unknown
- 1998-10-16 CN CN98810066A patent/CN1306426A/en active Pending
- 1998-10-16 JP JP2000516677A patent/JP2001520196A/en not_active Withdrawn
- 1998-10-16 HU HU0003792A patent/HUP0003792A3/en unknown
- 1998-10-16 CA CA002306985A patent/CA2306985A1/en not_active Abandoned
- 1998-10-16 KR KR1020007004053A patent/KR20010031149A/en not_active Withdrawn
- 1998-10-16 PL PL98341062A patent/PL341062A1/en unknown
- 1998-10-16 EP EP98953608A patent/EP1030666A4/en not_active Withdrawn
- 1998-10-16 IL IL13558198A patent/IL135581A0/en unknown
- 1998-10-16 TR TR2000/01040T patent/TR200001040T2/en unknown
- 1998-10-16 AU AU10938/99A patent/AU740875B2/en not_active Ceased
- 1998-10-16 BR BR9814080-9A patent/BR9814080A/en not_active IP Right Cessation
- 1998-10-16 WO PCT/US1998/021886 patent/WO1999020280A1/en not_active Ceased
- 1998-10-16 CO CO98060225A patent/CO4810374A1/en unknown
- 1998-10-16 ZA ZA989450A patent/ZA989450B/en unknown
-
2000
- 2000-04-10 NO NO20001847A patent/NO20001847D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2306985A1 (en) | 1999-04-29 |
| EP1030666A1 (en) | 2000-08-30 |
| HUP0003792A3 (en) | 2001-12-28 |
| CZ20001376A3 (en) | 2002-06-12 |
| IL135581A0 (en) | 2001-05-20 |
| AU740875B2 (en) | 2001-11-15 |
| NZ503551A (en) | 2002-05-31 |
| BR9814080A (en) | 2000-09-26 |
| EP1030666A4 (en) | 2002-10-16 |
| AR015966A1 (en) | 2001-05-30 |
| TR200001040T2 (en) | 2001-01-22 |
| HUP0003792A2 (en) | 2001-10-28 |
| CN1306426A (en) | 2001-08-01 |
| NO20001847L (en) | 2000-04-10 |
| AU1093899A (en) | 1999-05-10 |
| ZA989450B (en) | 1999-04-19 |
| NO20001847D0 (en) | 2000-04-10 |
| KR20010031149A (en) | 2001-04-16 |
| JP2001520196A (en) | 2001-10-30 |
| WO1999020280A1 (en) | 1999-04-29 |
| PL341062A1 (en) | 2001-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4810374A1 (en) | NEW USE OF COMPOUNDS FOR ANTI-PRURITIC ACTIVITY | |
| AR044719A1 (en) | DERIVATIVES OF PHENYL AND PIRIDINYL, ITS USE, A PROCESS TO PREPARE THEM, AND MEDICATIONS CONTAINING THEM | |
| CO5140087A1 (en) | DERIVATIVES OF 3-PHENYL-PYRIDINE YOUR SYNTHESIS PROCEDURE AND MEDICINES CONTAINING THEM | |
| AR010331A1 (en) | COMPOUNDS DERIVED FROM 6-PHENYLPYRIDYL-2-AMINE USEFUL AS INHIBITORS US, PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS, AND METHODS OF TREATMENT USING THESE COMPOUNDS. | |
| AR029614A1 (en) | DERIVATIVES OF 4-PHENYL-PYRIDINE, ITS USE, A PROCESS TO PREPARE THEM, AND MEDICATIONS CONTAINING THEM | |
| AR002746A1 (en) | PIRIMIDINE-DERIVED COMPOUNDS CONDENSED WITH A HETERO-CYCLIC RING AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUNDS. | |
| ECSP088550A (en) | NEW COMPOUNDS THAT ARE ERK INHIBITORS | |
| AR035548A1 (en) | ORGANIC COMPOUNDS | |
| CO5060482A1 (en) | BIARILO THERAPEUTIC DERIVATIVES | |
| DE69310501D1 (en) | CHINOLYLBENZOFURAN DERIVATIVES AS LEUKOTRIA ANTAGONISTS | |
| ES2039242T3 (en) | A PROCEDURE FOR THE PREPARATION OF NEW PIPERIDINE DERIVATIVES. | |
| CO5160347A1 (en) | CARBAMIC ACID DERIVATIVES | |
| ATE280763T1 (en) | MATRIX METALLOPROTEINASE INHIBITORS | |
| ES2123652T3 (en) | 7- (2-AMINOETIL) -BENZOTIAZOLONAS. | |
| ATE120955T1 (en) | BENZYLIDENE-MALONONITRILE DERIVATIVES FOR INHIBITING PROLIFERATIVE PROCESSES IN MAMMAL CELLS. | |
| CO4950553A1 (en) | 7-TETRAHYDROISOKINOLIN COMPOUNDS AND PROCEDURE FOR THE PREPARATION | |
| AR003469A1 (en) | 2- (4-SUBSTITUTED) -BENCILAMINO-2-METHYL-PROPANAMIDES, ITS USE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| AR012603A1 (en) | PROTEASE INHIBITOR, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT; AND SYNTHESIS INTERMEDIARIES | |
| PE20011134A1 (en) | 4-FLUORALKYL-2H-BENZOPYRANES WITH ANTIESTROGENIC EFFECT, METHOD FOR OBTAINING THEM, PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM AND THEIR USE TO OBTAIN MEDICINES | |
| AR016644A1 (en) | COMPOUNDS OF 2-AMINOPIRIDINAS WITH ALCOXI RAMIFIED SUBSTITUTES, PHARMACEUTICAL COMPOSITION AND USE FOR THE MANUFACTURE OF MEDICINES | |
| NO964698D0 (en) | Bicyclic amine derivatives as inhibitors of nitric oxide synthetase | |
| MX9400253A (en) | DERIVATIVES OF PIPERAZINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| ES2077998T3 (en) | DERIVATIVES OF 2-AMINOPYRIMIDINE-4-CARBOXAMIDE, ITS PREPARATION AND ITS THERAPEUTIC APPLICATION. | |
| CO5160261A1 (en) | SUBSTITUTED BIFENYL DERIVATIVES THAT ARE NK-1 ANTAGONISTS, THEIR SYNTHESIS PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| NZ332030A (en) | Sulfonamide substituted chromans, processes for their preparation, their use as a medicament and pharmaceutical preparations comprising them |