CO4700289A1 - TACHYCININ AMIDA ANTAGONISTS WHO HAVE TACHYCININ ANTAGONIST ACTIVITY - Google Patents
TACHYCININ AMIDA ANTAGONISTS WHO HAVE TACHYCININ ANTAGONIST ACTIVITYInfo
- Publication number
- CO4700289A1 CO4700289A1 CO95058767A CO95058767A CO4700289A1 CO 4700289 A1 CO4700289 A1 CO 4700289A1 CO 95058767 A CO95058767 A CO 95058767A CO 95058767 A CO95058767 A CO 95058767A CO 4700289 A1 CO4700289 A1 CO 4700289A1
- Authority
- CO
- Colombia
- Prior art keywords
- tachycinin
- amida
- antagonists
- sulfur
- methyl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 2
- 241000670727 Amida Species 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 239000011593 sulfur Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- -1 N-METHYL CARBAMOYL Chemical class 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1. UN COMPUESTO DE LA FORMULA I FIGURA 1 EN LA QUE R1 ES FENILO MONO O DISUSTITUIDO POR UNO O DOS MIEMBROS SELECCIONADOS DEL GRUPO QUE CONSISTE DE HALOGENO, NITRO, CIANO, TRIFLUOROMETILO, HIDROZI, METOXI, HIDROXIMETILO, METOXIMETILO, METOXICARBO- LO, CARBAMOILO Y N-METILCARBAMOILO, n ES CERO o 1 X1 ES OXIGENO, AZUFRE O =NCN, X2 Y X3 SON CADA UNO INDEPENDIENTEMENTE OXIGENO O AZUFRE, R2 ES HIDROGENO O METILO, R3 ES FENILO, FENILO SUSTITUIDO CON HALO, 2-NAFTI- LO, 1H-INDOL-3-ILO O 1-METIL-INDOL-3-ILO, Z ES -N(CH3)o -CH2-, R4 ES FENILO, 3,5-BIS(TRIFLUOROMETIL)FENILO O PI- RIDILO, Y R5 ES HIDROGENO, FENILO 3,5-BIS(TRIFLUOROMETIL) FENILO O PIRIDILO, POR LO QUE, CUANDO X3 ES AZUFRE, Z ES -N(CH3)-, O UNA SAL DE ADICION DE ACIDO DEL MISMO.1. A COMPOUND OF FORMULA I FIGURE 1 IN WHICH R1 IS MONO PHENYLUS OR DISSTITUTED BY ONE OR TWO SELECTED MEMBERS OF THE GROUP THAT CONSISTS OF HALOGEN, NITRO, CIANO, TRIFLUOROMETILO, HIDROZIME, METHYLOX, CARBAMOIL AND N-METHYL CARBAMOYL, n IS ZERO or 1 X1 IS OXYGEN, SULFUR O = NCN, X2 AND X3 ARE EACH INDEPENDENTLY OXYGEN OR SULFUR, R2 IS HYDROGEN OR METHYL, R3 IS FENYL-FUTHYL-SUBSTITUTE LO, 1H-INDOL-3-ILO OR 1-METHYL-INDOL-3-ILO, Z ES -N (CH3) or -CH2-, R4 ES FENILO, 3,5-BIS (TRIFLUOROMETIL) FENILO OR PI- RIDILO, AND R5 IS HYDROGEN, PHENYL 3,5-BIS (TRIFLUOROMETIL) PHENYL OR PYRIDILE, SO, WHEN X3 IS SULFUR, Z IS -N (CH3) -, OR AN ADDITION SALT OF THE SAME ACID.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9425085.9A GB9425085D0 (en) | 1994-12-13 | 1994-12-13 | Organic compounds |
| GBGB9426016.3A GB9426016D0 (en) | 1994-12-22 | 1994-12-22 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4700289A1 true CO4700289A1 (en) | 1998-12-29 |
Family
ID=26306161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO95058767A CO4700289A1 (en) | 1994-12-13 | 1995-12-12 | TACHYCININ AMIDA ANTAGONISTS WHO HAVE TACHYCININ ANTAGONIST ACTIVITY |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0797583A1 (en) |
| JP (1) | JPH10511935A (en) |
| AR (1) | AR001332A1 (en) |
| AU (1) | AU4343796A (en) |
| BR (1) | BR9509997A (en) |
| CA (1) | CA2204130A1 (en) |
| CO (1) | CO4700289A1 (en) |
| CZ (1) | CZ179097A3 (en) |
| FI (1) | FI971685L (en) |
| HU (1) | HUT77002A (en) |
| IL (1) | IL116323A0 (en) |
| NO (1) | NO972526D0 (en) |
| PE (1) | PE38997A1 (en) |
| PL (1) | PL320217A1 (en) |
| SK (1) | SK74697A3 (en) |
| TR (1) | TR199501568A2 (en) |
| WO (1) | WO1996018643A1 (en) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6117855A (en) * | 1996-10-07 | 2000-09-12 | Merck Sharp & Dohme Ltd. | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent |
| ATE333879T1 (en) * | 1996-10-07 | 2006-08-15 | Merck Sharp & Dohme | CNS-PENETRATING NK-1 RECEPTOR ANTAGONISTS AS AN ANTIDEPRESSANT AND/OR ANXIOLYTIC |
| WO2000048623A1 (en) | 1999-02-18 | 2000-08-24 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
| RU2309953C2 (en) | 1999-11-03 | 2007-11-10 | Эймр Текнолоджи, Инк. | Aryl- and heteroaryl-substituted tetrahydroisoquinolines, pharmaceutical composition and method for treatment based on thereof |
| US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| CN100430401C (en) | 2000-07-11 | 2008-11-05 | Amr科技公司 | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
| KR101389246B1 (en) | 2004-07-15 | 2014-04-24 | 브리스톨-마이어스스퀴브컴파니 | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
| UA95454C2 (en) | 2005-07-15 | 2011-08-10 | Амр Текнолоджи, Інк. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| KR20080048502A (en) | 2005-09-29 | 2008-06-02 | 머크 앤드 캄파니 인코포레이티드 | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| MX2009007200A (en) | 2007-01-10 | 2009-07-15 | Angeletti P Ist Richerche Bio | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors. |
| CN101641099A (en) | 2007-01-24 | 2010-02-03 | 葛兰素集团有限公司 | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
| WO2008120653A1 (en) | 2007-04-02 | 2008-10-09 | Banyu Pharmaceutical Co., Ltd. | Indoledione derivative |
| EP3103791B1 (en) | 2007-06-27 | 2018-01-31 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| JP2011515343A (en) | 2008-03-03 | 2011-05-19 | タイガー ファーマテック | Tyrosine kinase inhibitor |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| CN102458123A (en) | 2009-05-12 | 2012-05-16 | 阿尔巴尼分子研究公司 | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| CN102595902B (en) | 2009-05-12 | 2015-04-29 | 阿尔巴尼分子研究公司 | 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro Isoquinolines and their uses |
| CN102638982B (en) | 2009-05-12 | 2015-07-08 | 百时美施贵宝公司 | (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3, Crystal form of 4-tetrahydroisoquinoline and its use |
| JP5099731B1 (en) | 2009-10-14 | 2012-12-19 | メルク・シャープ・アンド・ドーム・コーポレーション | Substituted piperidines that increase p53 activity and uses thereof |
| EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| CN107090456B (en) | 2010-08-02 | 2022-01-18 | 瑟纳治疗公司 | Inhibition of beta 1 gene expression using short interfering nucleic acids mediated by RNA interference of catenin (cadherin-associated protein) |
| LT2606134T (en) | 2010-08-17 | 2019-07-25 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
| WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| EP2615916B1 (en) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel erk inhibitors |
| ES2663009T3 (en) | 2010-10-29 | 2018-04-10 | Sirna Therapeutics, Inc. | Inhibition of RNA-mediated gene expression using short interference nucleic acids (ANic) |
| US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
| JP2014514321A (en) | 2011-04-21 | 2014-06-19 | メルク・シャープ・アンド・ドーム・コーポレーション | Insulin-like growth factor 1 receptor inhibitor |
| EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| EP3358013B1 (en) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| US9233979B2 (en) | 2012-09-28 | 2016-01-12 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| RU2660349C2 (en) | 2012-11-28 | 2018-07-05 | Мерк Шарп И Доум Корп. | Compositions and methods for treatment of malignant tumour |
| BR112015013611A2 (en) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | compound and pharmaceutical composition |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| WO2018071283A1 (en) | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
| WO2019094312A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| EP3833668B1 (en) | 2018-08-07 | 2025-03-19 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| MA53287A (en) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme | PRMT5 INHIBITORS |
| WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164372A (en) * | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
| JPH05186498A (en) * | 1991-12-27 | 1993-07-27 | Japan Tobacco Inc | Proline derivative |
-
1995
- 1995-12-11 PE PE1995286859A patent/PE38997A1/en not_active Application Discontinuation
- 1995-12-11 IL IL11632395A patent/IL116323A0/en unknown
- 1995-12-12 CA CA002204130A patent/CA2204130A1/en not_active Abandoned
- 1995-12-12 BR BR9509997A patent/BR9509997A/en not_active Application Discontinuation
- 1995-12-12 PL PL95320217A patent/PL320217A1/en unknown
- 1995-12-12 JP JP8518261A patent/JPH10511935A/en active Pending
- 1995-12-12 CO CO95058767A patent/CO4700289A1/en unknown
- 1995-12-12 FI FI971685A patent/FI971685L/en not_active Application Discontinuation
- 1995-12-12 CZ CZ971790A patent/CZ179097A3/en unknown
- 1995-12-12 EP EP95942131A patent/EP0797583A1/en not_active Withdrawn
- 1995-12-12 AU AU43437/96A patent/AU4343796A/en not_active Abandoned
- 1995-12-12 WO PCT/EP1995/004910 patent/WO1996018643A1/en not_active Ceased
- 1995-12-12 SK SK746-97A patent/SK74697A3/en unknown
- 1995-12-12 HU HU9701897A patent/HUT77002A/en unknown
- 1995-12-13 AR AR33458995A patent/AR001332A1/en unknown
- 1995-12-13 TR TR95/01568A patent/TR199501568A2/en unknown
-
1997
- 1997-06-03 NO NO972526A patent/NO972526D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996018643A1 (en) | 1996-06-20 |
| CA2204130A1 (en) | 1996-06-20 |
| FI971685A0 (en) | 1997-04-18 |
| CZ179097A3 (en) | 1997-10-15 |
| BR9509997A (en) | 1997-12-30 |
| MX9703957A (en) | 1997-09-30 |
| FI971685A7 (en) | 1997-08-13 |
| JPH10511935A (en) | 1998-11-17 |
| NO972526L (en) | 1997-06-03 |
| EP0797583A1 (en) | 1997-10-01 |
| TR199501568A2 (en) | 1996-07-21 |
| HUT77002A (en) | 1998-03-02 |
| IL116323A0 (en) | 1996-03-31 |
| AR001332A1 (en) | 1997-10-22 |
| FI971685L (en) | 1997-08-13 |
| SK74697A3 (en) | 1997-11-05 |
| PL320217A1 (en) | 1997-09-15 |
| PE38997A1 (en) | 1997-10-02 |
| NO972526D0 (en) | 1997-06-03 |
| AU4343796A (en) | 1996-07-03 |
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