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CO2022002374A2 - Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos - Google Patents

Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos

Info

Publication number
CO2022002374A2
CO2022002374A2 CONC2022/0002374A CO2022002374A CO2022002374A2 CO 2022002374 A2 CO2022002374 A2 CO 2022002374A2 CO 2022002374 A CO2022002374 A CO 2022002374A CO 2022002374 A2 CO2022002374 A2 CO 2022002374A2
Authority
CO
Colombia
Prior art keywords
inhibitory compounds
making
methods
rip1
compounds
Prior art date
Application number
CONC2022/0002374A
Other languages
English (en)
Inventor
Yan Chen
Jiaxin Yu
Simon Shaw
Ihab Darwish
Vanessa Taylor
Somasekhar Bhamidipati
Zhushou Luo
Rao Kolluri
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of CO2022002374A2 publication Critical patent/CO2022002374A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente descripción se describen compuestos inhibidores de quinasa, tales como compuestos inhibidores de quinasa de proteína 1 que interactúa con el receptor (RIP1), así como también composiciones farmacéuticas y combinaciones que comprenden tales compuestos inhibidores. Los compuestos, composiciones farmacéuticas y/o combinaciones descritos pueden usarse para tratar o prevenir una enfermedad o afección asociada a la quinasa, particularmente una enfermedad o afección asociada a RIP1.
CONC2022/0002374A 2019-09-06 2022-02-28 Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos CO2022002374A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962897223P 2019-09-06 2019-09-06
US201962932404P 2019-11-07 2019-11-07
US202063001016P 2020-03-27 2020-03-27
US202063004290P 2020-04-02 2020-04-02
US202063004319P 2020-04-02 2020-04-02
PCT/US2020/049527 WO2021046437A1 (en) 2019-09-06 2020-09-04 Rip1 inhibitory compounds and methods for making and using the same

Publications (1)

Publication Number Publication Date
CO2022002374A2 true CO2022002374A2 (es) 2022-08-09

Family

ID=72613994

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0002374A CO2022002374A2 (es) 2019-09-06 2022-02-28 Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos

Country Status (20)

Country Link
US (1) US11564930B2 (es)
EP (1) EP4025575B1 (es)
JP (2) JP7493586B2 (es)
KR (1) KR102793185B1 (es)
CN (1) CN114728958B (es)
AU (1) AU2020341708B2 (es)
BR (1) BR112022002378A2 (es)
CA (1) CA3149729A1 (es)
CO (1) CO2022002374A2 (es)
CR (1) CR20220075A (es)
DO (1) DOP2022000042A (es)
EC (1) ECSP22016567A (es)
IL (1) IL290781A (es)
JO (1) JOP20220056A1 (es)
MX (1) MX2022002717A (es)
MY (1) MY198690A (es)
PE (1) PE20221762A1 (es)
PH (1) PH12022550537A1 (es)
TW (1) TW202122397A (es)
WO (1) WO2021046437A1 (es)

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US10975064B2 (en) 2018-05-03 2021-04-13 Rigel Pharmaceuticals, Inc. RIP1 inhibitory compounds and methods for making and using the same
PH12022550537A1 (en) 2019-09-06 2023-03-20 Rigel Pharmaceuticals Inc Rip1 inhibitory compounds and methods for making and using the same.
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AR121717A1 (es) 2020-04-02 2022-06-29 Rigel Pharmaceuticals Inc Inhibidores de rip1k
TWI824259B (zh) 2020-07-01 2023-12-01 美商雷傑製藥公司 Rip1k抑制劑
TW202300490A (zh) 2021-03-11 2023-01-01 美商雷傑製藥公司 雜環rip1激酶抑制劑
TW202311261A (zh) * 2021-05-14 2023-03-16 大陸商中國醫藥研究開發中心有限公司 氮呯類稠環化合物及其醫藥用途
US20240294523A1 (en) * 2021-06-11 2024-09-05 Genfleet Therapeutics (Shanghai) Inc. Heterocyclic lactam compound, and preparation method therefor and pharmaceutical use thereof
WO2023138317A1 (zh) * 2022-01-21 2023-07-27 中国科学院上海药物研究所 具有ripk1抑制活性的化合物、其制备方法及其用途
CN115201250B (zh) * 2022-09-14 2022-11-25 中铁三局集团第三工程有限公司 一种冷再生沥青混合料热可逆老化程度的量化方法
US20250000872A1 (en) 2023-06-26 2025-01-02 Eli Lilly And Company Formulations and dosing regimens for rip1 kinase inhibitors for treating autoimmune and inflammatory diseases
WO2025153090A1 (zh) * 2024-01-19 2025-07-24 无锡奕拓医药科技有限责任公司 一种多并环化合物、其药物组合物及其用途

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Also Published As

Publication number Publication date
CR20220075A (es) 2022-07-14
ECSP22016567A (es) 2022-08-31
US20210069208A1 (en) 2021-03-11
US11564930B2 (en) 2023-01-31
JP7493586B2 (ja) 2024-05-31
EP4025575B1 (en) 2025-12-17
KR20220042206A (ko) 2022-04-04
PE20221762A1 (es) 2022-11-11
AU2020341708B2 (en) 2024-01-04
MY198690A (en) 2023-09-16
MX2022002717A (es) 2022-08-10
CN114728958B (zh) 2025-05-02
KR102793185B1 (ko) 2025-04-09
BR112022002378A2 (pt) 2022-06-14
JP2022546605A (ja) 2022-11-04
EP4025575A1 (en) 2022-07-13
DOP2022000042A (es) 2022-08-15
TW202122397A (zh) 2021-06-16
AU2020341708A1 (en) 2022-03-17
JOP20220056A1 (ar) 2023-01-30
JP2024050568A (ja) 2024-04-10
CA3149729A1 (en) 2021-03-11
IL290781A (en) 2022-04-01
CN114728958A (zh) 2022-07-08
PH12022550537A1 (en) 2023-03-20
WO2021046437A1 (en) 2021-03-11

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