[go: up one dir, main page]

CO2019006565A2 - Novedoso conjugado de amanitina - Google Patents

Novedoso conjugado de amanitina

Info

Publication number
CO2019006565A2
CO2019006565A2 CONC2019/0006565A CO2019006565A CO2019006565A2 CO 2019006565 A2 CO2019006565 A2 CO 2019006565A2 CO 2019006565 A CO2019006565 A CO 2019006565A CO 2019006565 A2 CO2019006565 A2 CO 2019006565A2
Authority
CO
Colombia
Prior art keywords
conjugate
novel
amatoxin
amino acid
binding moiety
Prior art date
Application number
CONC2019/0006565A
Other languages
English (en)
Inventor
Torsten Hechler
Michael Kulke
Christian Lutz
Andreas Pahl
CHRISTOPH MüLLER
Werner Simon
Anikó Pálfi
Original Assignee
Heidelberg Pharma Res Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Res Gmbh filed Critical Heidelberg Pharma Res Gmbh
Publication of CO2019006565A2 publication Critical patent/CO2019006565A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6831—Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La invención se refiere a un conjugado que comprende (a) una amatoxina que comprende un aminoácido 4 con una posición 6'-desoxi; y (ii) un aminoácido 8 con una posición S-desoxi; (b) un resto de unión a BCMA que comprende (i) los dominios variables del anticuerpo humanizado J22.9-ISY, y (ii) una región constante de cadena pesada que comprende una mutación D265C; y (c) un enlazador escindible por la proteasa que enlaza dicha amatoxina y dicho resto de unión a diana. La invención se refiere además a una composición farmacéutica que comprende dicho conjugado, particularmente, para el uso en el tratamiento del mieloma múltiple.
CONC2019/0006565A 2016-12-23 2019-06-20 Novedoso conjugado de amanitina CO2019006565A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16206849 2016-12-23
PCT/EP2017/084431 WO2018115466A1 (en) 2016-12-23 2017-12-22 Amanitin antibody conjugates

Publications (1)

Publication Number Publication Date
CO2019006565A2 true CO2019006565A2 (es) 2019-09-18

Family

ID=57680140

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0006565A CO2019006565A2 (es) 2016-12-23 2019-06-20 Novedoso conjugado de amanitina

Country Status (24)

Country Link
US (1) US11446388B2 (es)
EP (1) EP3558390B1 (es)
JP (1) JP7038717B2 (es)
KR (1) KR102455175B1 (es)
CN (1) CN110099698B (es)
AU (1) AU2017380099B2 (es)
BR (1) BR112019012937A2 (es)
CA (1) CA3044508A1 (es)
CL (1) CL2019001740A1 (es)
CO (1) CO2019006565A2 (es)
DK (1) DK3558390T3 (es)
ES (1) ES3000471T3 (es)
FI (1) FI3558390T3 (es)
HR (1) HRP20241686T1 (es)
HU (1) HUE069487T2 (es)
LT (1) LT3558390T (es)
MX (1) MX2019007604A (es)
PL (1) PL3558390T3 (es)
PT (1) PT3558390T (es)
RS (1) RS66317B1 (es)
RU (1) RU2755728C2 (es)
SI (1) SI3558390T1 (es)
WO (1) WO2018115466A1 (es)
ZA (1) ZA201903062B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019522050A (ja) 2016-06-17 2019-08-08 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 細胞の枯渇のための組成物および方法
US12023319B2 (en) 2016-12-23 2024-07-02 Bayer Pharma Aktiengesellschaft Carboxylic acid aromatic amides
JOP20190156B1 (ar) 2016-12-23 2023-09-17 Bayer Pharma AG أميدات عطرية لحمض الكربوكسيليك بصفتها مضادات لمستقبلة البراديكينين b1
US10576161B2 (en) 2017-01-20 2020-03-03 Magenta Therapeutics, Inc. Compositions and methods for the depletion of CD137+ cells
AU2018317611B2 (en) * 2017-08-18 2022-03-10 Systimmune, Inc. Non-natural amatoxin-type antibody conjugate
KR20200094181A (ko) 2017-11-29 2020-08-06 마젠타 테라퓨틱스 인코포레이티드 Cd5+ 세포를 고갈시키기 위한 조성물 및 방법
JP2021521202A (ja) * 2018-04-13 2021-08-26 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング 固形腫瘍の治療のための標的化されたアマトキシン複合体
JP2021532116A (ja) * 2018-07-23 2021-11-25 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. 同種異系の細胞療法における抗−ｃｄ５抗体薬物コンジュゲート（ａｄｃ）の使用
CA3115680A1 (en) * 2018-10-23 2020-04-30 Magenta Therapeutics, Inc. Fc silenced antibody drug conjugates (adcs) and uses thereof
WO2020216947A1 (en) * 2019-04-24 2020-10-29 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
CN114144201B (zh) * 2019-05-23 2024-10-01 海德堡医药研究有限责任公司 含可裂解连接基的抗体药物缀合物
BR112022001546A2 (pt) * 2019-07-30 2022-03-22 Jiangsu Hansoh Pharmaceutical Group Co Ltd Anticorpo anti-bcma, fragmento de ligação ao antígeno do mesmo e uso médico do mesmo
AR120218A1 (es) * 2019-10-15 2022-02-02 Heidelberg Pharma Res Gmbh Conjugados de amatoxina y anticuerpo específico de linfocitos b
WO2021102322A1 (en) * 2019-11-21 2021-05-27 Unnatural Products Inc. Cell-permeable cyclic peptides and uses thereof
CN116096752B (zh) 2020-06-05 2025-10-28 卫材R&D管理有限公司 抗bcma抗体-药物缀合物及其使用方法
EP4240424A1 (en) 2020-11-04 2023-09-13 Heidelberg Pharma Research GmbH Composition comprising a combination of immune checkpoint inhibitor and antibody-amatoxin conjugate for use in cancer therapy
US20250326855A1 (en) 2021-03-05 2025-10-23 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
CN117241832A (zh) 2021-03-19 2023-12-15 海德堡医药研究有限责任公司 B淋巴细胞特异性的鹅膏毒素抗体缀合物
EP4380604A1 (en) 2021-08-05 2024-06-12 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
US20230355792A1 (en) 2022-04-07 2023-11-09 Heidelberg Pharma Research Gmbh Methods of improving the therapeutic index
CN114839284B (zh) * 2022-04-14 2024-03-26 中国疾病预防控制中心职业卫生与中毒控制所 非疾病诊断目的的鹅膏毒肽检测方法
EP4353220A1 (en) 2022-10-12 2024-04-17 Pierre Fabre Medicament Use of a liquid aqueous composition for solubilization and stabilization of an antibody-drug conjugate
CN120187759A (zh) 2022-11-01 2025-06-20 海德堡医药研究有限责任公司 抗gucy2c抗体及其用途
KR20250152101A (ko) 2023-03-13 2025-10-22 하이델베르크 파마 리서치 게엠베하 암 치료에의 사용을 위한 피하 투여 항체-약물 접합체

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
ATE521366T1 (de) * 2006-05-27 2011-09-15 Faulstich Heinz Dr Anwendung von amatoxin-konjugaten und phallotoxin-konjugaten mit makromolekülen zur krebstherapie und therapie von entzündungen
EP2416805B1 (en) 2009-04-08 2013-07-24 Heinz Dr. Faulstich Amatoxin antibody conjugates for the treatment of cancer
EP3192529B1 (en) 2009-04-08 2020-03-25 Faulstich, Heinz, Dr. Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
WO2010115290A1 (en) 2009-04-09 2010-10-14 Aqua Rehab Inc. Device and method for sealing a junction between a main pipe and a lateral pipe connected thereto
US20110256157A1 (en) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines and conjugates thereof
ES2402254T3 (es) * 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
EP2497499A1 (en) 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
EP2684865A1 (en) * 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins
EP2914628A1 (en) 2012-11-01 2015-09-09 Max-Delbrück-Centrum für Molekulare Medizin An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases
US9243058B2 (en) * 2012-12-07 2016-01-26 Amgen, Inc. BCMA antigen binding proteins
EP2774624A1 (en) 2013-03-04 2014-09-10 Heidelberg Pharma GmbH Amatoxin derivatives
CN105377304B (zh) * 2014-03-10 2018-05-15 海德堡医药有限责任公司 鹅膏毒肽衍生物
KR102526945B1 (ko) 2014-04-30 2023-04-27 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 Ｃｄ269에 대한 인간화 항체
CN107105709B (zh) 2014-10-24 2021-04-30 杜邦营养生物科学有限公司 脯氨酸耐受性三肽基肽酶在饲料添加剂组合物中的用途
PT3268047T (pt) * 2015-03-09 2023-12-05 Heidelberg Pharma Res Gmbh Conjugados amatoxina-anticorpo
EP3222292A1 (en) * 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Amanitin conjugates
US10111966B2 (en) * 2016-06-17 2018-10-30 Magenta Therapeutics, Inc. Methods for the depletion of CD117+ cells

Also Published As

Publication number Publication date
US20190328899A1 (en) 2019-10-31
AU2017380099B2 (en) 2024-07-11
KR102455175B1 (ko) 2022-10-17
PL3558390T3 (pl) 2025-03-03
JP7038717B2 (ja) 2022-03-18
RS66317B1 (sr) 2025-01-31
AU2017380099A1 (en) 2019-06-13
CN110099698B (zh) 2023-02-17
NZ753846A (en) 2024-12-20
BR112019012937A2 (pt) 2019-12-10
HUE069487T2 (hu) 2025-03-28
WO2018115466A1 (en) 2018-06-28
CA3044508A1 (en) 2018-06-28
PT3558390T (pt) 2024-10-29
MX2019007604A (es) 2019-08-16
FI3558390T3 (fi) 2024-12-18
EP3558390B1 (en) 2024-10-09
SI3558390T1 (sl) 2025-01-31
RU2019119442A (ru) 2020-12-21
US11446388B2 (en) 2022-09-20
EP3558390A1 (en) 2019-10-30
LT3558390T (lt) 2024-11-11
ES3000471T3 (en) 2025-02-28
CL2019001740A1 (es) 2019-12-06
DK3558390T3 (da) 2025-01-06
RU2019119442A3 (es) 2021-03-04
JP2020504736A (ja) 2020-02-13
CN110099698A (zh) 2019-08-06
KR20190100190A (ko) 2019-08-28
HRP20241686T1 (hr) 2025-02-14
ZA201903062B (en) 2023-08-30
RU2755728C2 (ru) 2021-09-20

Similar Documents

Publication Publication Date Title
CO2019006565A2 (es) Novedoso conjugado de amanitina
CY1124834T1 (el) Αναστολεις της αλληλεπιδρασης της μηνινης-mll
CL2023002105A1 (es) Dominios variables de anticuerpo que se dirigen a cd33 y sus usos
CL2023000895A1 (es) Receptores quiméricos de dll3 y métodos para su uso
CO2020010345A2 (es) Dominios variables de anticuerpos que se dirigen al receptor nkg2d
CL2020000263A1 (es) Conjugado de anticuerpo monoclonal contra bcma-fármaco.
PE20210167A1 (es) Proteinas de union multiespecificas y mejoras con estas
MX395074B (es) Anticuerpos anti-axl, fragmentos de anticuerpos y sus inmunoconjugados y usos de los mismos
MX2023006380A (es) Anticuerpos anti-bcma unicamente de cadena pesada.
PE20181805A1 (es) Composiciones y anticuerpos anti-tim-3
AR117913A2 (es) Conjugado fármaco-anticuerpo, composición farmacéutica y sus usos
BR112021019334A2 (pt) Anticorpos de cadeia pesada que se ligam ao psma
CO2018011195A2 (es) Composiciones que comprenden una coformulación de anticuerpos anti-pd-l1 y anti-ctla-4
PH12018501419B1 (en) Pharmaceutical composition comprising bispecific antibody constructs
CL2024002319A1 (es) Anticuerpo de cadena pesada que se unen a cd22; composición farmacéutica; y su uso.
PE20170665A1 (es) Anticuerpos anti-tau humanizados
CO2017000754A2 (es) Anticuerpo monoclonal anti-ctla4 o fragmento de unión a antígeno del mismo, y una composición farmacéutica del mismo
MX2020012679A (es) Compuestos de amino-pirazincarboxamida, conjugados, y usos de los mismos.
EA202091161A1 (ru) Конъюгаты антител против cd22 с майтанзином, их комбинации и способы применения
PE20171180A1 (es) Anticuerpos anti-pd-1 y sus metodos de uso
NZ734892A (en) Amatoxin-antibody conjugates
BR112021024956A2 (pt) Anticorpos multiespecíficos de cadeia pesada que se ligam a cd22 e cd3
CY1125181T1 (el) Ανοσοσυζευγματα που στοχευουν adam9 και μεθοδοι χρησης αυτων
BR112019000693A2 (pt) composições de muc1- car e métodos para uso
EA202192146A1 (ru) Антитела к клаудину 6 и их применение